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EP1935392A1 - Syringe coupling device for a safe coupling of syringes of different type - Google Patents

Syringe coupling device for a safe coupling of syringes of different type Download PDF

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Publication number
EP1935392A1
EP1935392A1 EP06126404A EP06126404A EP1935392A1 EP 1935392 A1 EP1935392 A1 EP 1935392A1 EP 06126404 A EP06126404 A EP 06126404A EP 06126404 A EP06126404 A EP 06126404A EP 1935392 A1 EP1935392 A1 EP 1935392A1
Authority
EP
European Patent Office
Prior art keywords
syringes
adapter
syringe adapter
syringe
baffles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP06126404A
Other languages
German (de)
French (fr)
Other versions
EP1935392B1 (en
Inventor
Klaus-Dieter Beller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meckel-Spenglersan GmbH
Original Assignee
Meckel-Spenglersan GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE102005030510A priority Critical patent/DE102005030510A1/en
Application filed by Meckel-Spenglersan GmbH filed Critical Meckel-Spenglersan GmbH
Priority to DE200650004538 priority patent/DE502006004538D1/en
Priority to AT06126404T priority patent/ATE439114T1/en
Priority to EP06126404A priority patent/EP1935392B1/en
Publication of EP1935392A1 publication Critical patent/EP1935392A1/en
Application granted granted Critical
Publication of EP1935392B1 publication Critical patent/EP1935392B1/en
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Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/431—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
    • B01F25/451—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture
    • B01F25/4512—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture with reciprocating pistons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/44—Mixers with shaking, oscillating, or vibrating mechanisms with stirrers performing an oscillatory, vibratory or shaking movement
    • B01F31/441—Mixers with shaking, oscillating, or vibrating mechanisms with stirrers performing an oscillatory, vibratory or shaking movement performing a rectilinear reciprocating movement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/50—Movable or transportable mixing devices or plants
    • B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
    • B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/50—Movable or transportable mixing devices or plants
    • B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
    • B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
    • B01F33/50112—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held of the syringe or cartridge type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/712—Feed mechanisms for feeding fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/714—Feed mechanisms for feeding predetermined amounts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/716—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components
    • B01F35/7161—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components the containers being connected coaxially before contacting the contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/716—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components
    • B01F35/7163—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components the containers being connected in a mouth-to-mouth, end-to-end disposition, i.e. the openings are juxtaposed before contacting the contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/7174—Feed mechanisms characterised by the means for feeding the components to the mixer using pistons, plungers or syringes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2055—Connecting means having gripping means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2065—Connecting means having aligning and guiding means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms

Definitions

  • the invention relates to an adapter for the secure and stable connection of two syringes of unequal design for the preparation of means to be administered by syringe, such as diagnostics, therapeutics and modified autologous blood.
  • Two syringes can be connected together so that the inside of the first and second syringes communicate with each other via the adapter.
  • Echo contrast agents and therapeutics e.g. Lyophilisates
  • autologous blood treatment it is often necessary in the administration of diagnostics, such as e.g. Echo contrast agents and therapeutics, e.g. Lyophilisates and in the autologous blood treatment to achieve a homogenization of the means to produce homogeneous suspensions or emulsions, or in agents such as echo contrast agents containing surfactants to promote the formation of microbubbles.
  • a mixing device for microbubble echo contrast agent in which a syringe is inextricably linked to a mixing chamber, the mixing walls on their inner walls also for the deflection of the flowing through Medium and which is connected to a syringe containing the medium in which the microbubbles are to be generated in order to generate the microbubbles by pumping the medium back and forth through the mixing chamber.
  • the defined volume of the mixing chamber makes it possible to produce a defined number of microbubbles when an equal agitation power, ie back and forth, is present.
  • the present invention seeks to provide an adapter of the type described above with improved properties and thus to eliminate the disadvantages described above.
  • an adapter which, with the use of two syringes of the same or different design, enables the safe and effective introduction of energy for mixing different media.
  • the adapter according to the invention stabilizes the syringes during vigorous pumping of the substances between the syringes and prevents the breakage of the system at the level of the adapter and in the area of the syringe cone.
  • the basic idea of the adapter according to the invention is that not only the cone of the syringe is fixed in the adapter, but also a portion of the syringe barrel is partially enclosed by the adapter and thus stabilized.
  • the hole in the adapter is not round, as expected, but elongated. This allows the stable guidance and fixation to about half the circumference of the syringe plunger of any design.
  • the adapter In order to enable the universal applicability of the adapter according to the invention and thus of the mixing device, it is proposed to design the adapter such that the respective connections are designed as Luer-Lock female-female or Luer-Lock male-female or Luer-Lock male-male. That is, either the free ends are both formed as female terminals, as in the example shown or one end as a male terminal with a corresponding outer cone and the other end as a female terminal. Or both free ends are designed as male connectors. Furthermore, it is preferred that the adapter in the connection area in such a way that it can be mounted on commercial syringes with Luer-Lock-cone according to DIN 13090, especially for syringes sizes 2 ml to 50 ml.
  • adapter can be provided in the manufacture or subsequently with mixing elements.
  • static or flexible resistors, baffles or diaphragms are introduced into the flow channel.
  • the syringe adapter according to the invention has on each side two staggered, merging holes with the purpose to lead and fix not identical syringes when connecting. In the intersection of the merging holes of the flow channel is positioned with a smaller diameter.
  • the walls of the larger holes fix and stabilize the syringes during the mixing process and prevent the breaking or breaking off.
  • the walls of the pilot holes should reach at least the 1 ml mark of the syringes. As the wall height increases, the stability of the system increases.
  • the syringe adapter is characterized in that in the thinner flow channel arbitrarily shaped baffles, obstacles, resistors are installed. These baffles, obstacles, resistors can be insoluble connected to the syringe adapter or be positioned as cuttable replaceable in the flow channel. By specifying the construction volume of the baffles, obstacles, resistors, the gas volume in the flow channel can be defined.
  • the invention provides an adapter for commercial syringes, which allows various substances (liquid, gaseous) under well-defined conditions by means of two syringes effectively and reproducibly mix or energize.
  • the quality of the mixture or energization is easily reproducible and representable by means of variable baffles and resistors.
  • the invention thus also relates to the use of the syringe adapter according to the invention for mixing substances by means of two syringes.
  • the syringe adapter according to the invention enables a reproducible and thus necessarily properly feasible effective mixing of appropriate diagnostics and therapeutics at a defined predetermined docking amount of gas.
  • the syringe adapter according to the invention is not only suitable for a specific therapeutic or diagnostic agent for treatment, but in a universal manner for a variety of means to be administered by injection composed of liquid, pasty or liquid and powdery or liquid, pasty and gaseous media and must be homogenized.
  • the adapter of the first embodiment in FIG. 1 and FIG. 2 has a central channel with bar-like baffles.

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

At each end of the adapter, two offset bores transition into each other. The channel connecting them, is smaller in cross section than the bores. The two connections at the ends of the adapter, are in female luer-lock form (F-F), or alternatively are male/female (M-F). In addition, static or flexible resistances, baffles or orifices are included. These are connected permanently with the adapter, or are interchangeable.

Description

Die Erfindung betrifft einen Adapter für die sichere und stabile Verbindung zweier Spritzen ungleicher Bauart für die Zubereitung von mittels einer Spritze zu verabreichenden Mitteln, wie Diagnostika, Therapeutika und modifiziertes Eigenblut.The invention relates to an adapter for the secure and stable connection of two syringes of unequal design for the preparation of means to be administered by syringe, such as diagnostics, therapeutics and modified autologous blood.

Zwei Spritzen können so miteinander verbunden werden, so dass das Innere der ersten und zweiten Spritze über den Adapter miteinander kommunizieren.Two syringes can be connected together so that the inside of the first and second syringes communicate with each other via the adapter.

Im medizinischen Bereich ist es vielfach erforderlich, bei der Verabreichung von Diagnostika, wie z.B. Echokontrastmittel und Therapeutika, wie z.B. Lyophilisate und bei der Eigenblut-Behandlung eine Homogenisierung der Mittel zu erreichen, homogene Suspensionen oder Emulsionen herzustellen oder bei Mitteln, wie Echokontrastmitteln, die oberflächenaktive Stoffe enthalten, die Bildung von Mikrobläschen zu fördern.In the medical field, it is often necessary in the administration of diagnostics, such as e.g. Echo contrast agents and therapeutics, e.g. Lyophilisates and in the autologous blood treatment to achieve a homogenization of the means to produce homogeneous suspensions or emulsions, or in agents such as echo contrast agents containing surfactants to promote the formation of microbubbles.

Aus der Patentschrift DE 44 32 993 C1 ist eine Mischeinrichtung für Spritzen bekannt, bei der ein Adapter zum Verbinden der beiden Spritzen eingesetzt wird, wobei der durchgehende Fließkanal des Adapters eine zentrale Mischkammer aufweist.From the patent DE 44 32 993 C1 a mixing device for syringes is known, in which an adapter for connecting the two syringes is used, wherein the continuous flow channel of the adapter has a central mixing chamber.

Auch die Druckschrift EP 0 266 058 A2 zeigt eine Mischeinrichtung mit zwei Spritzen und einem die beiden Spritzen miteinander verbindenden Adapter, wobei der Fließkanal des Adapters einen konstanten Querschnitt aufweist. Diese Anordnung dient zum gleichmäßigen Vermischen eines pulvrigen Materials mit einem flüssigen Material zum Herstellen einer Kollagen-Mineral-Knochenreparatur.Also the publication EP 0 266 058 A2 shows a mixing device with two syringes and an adapter connecting the two syringes with each other, wherein the flow channel of the adapter has a constant cross-section. This arrangement serves to uniformly mix a powdery material with a liquid material to produce a collagen mineral bone repair.

Am Markt befindet sich ein einfacher hülsenförmiger Adapter, der in seiner Grundbestimmung darauf ausgelegt ist, medizinische Schläuche zu verbinden (Combidyn Adapter der Firma B.Braun Melsungen).The market is a simple sleeve-shaped adapter, which is designed in its basic provision to connect medical tubing (Combidyn adapter B.Braun Melsungen).

Aus der Schrift WO 92/11928 A1 ist eine Mischvorrichtung für Mikrobläschen-Echokontrastmittel bekannt, bei der eine Spritze mit einer Mischkammer unlösbar verbunden ist, die an ihren Innenwänden ebenfalls Mischelemente zur Umlenkung des durchströmenden Mediums aufweist und die mit einer Spritze, enthaltend das Medium, in dem die Mikrobläschen erzeugt werden sollen, verbunden wird, um durch Hin- und Herpumpen des Mediums durch die Mischkammer hindurch, die Mikrobläschen zu erzeugen. Das definierte Volumen der Mischkammer ermöglicht hierbei eine definierte Anzahl von Mikrobläschen zu erzeugen, wenn eine gleiche Agitationsleistung, d. h. hin- und herpumpen, vorliegt.From the Scriptures WO 92/11928 A1 a mixing device for microbubble echo contrast agent is known in which a syringe is inextricably linked to a mixing chamber, the mixing walls on their inner walls also for the deflection of the flowing through Medium and which is connected to a syringe containing the medium in which the microbubbles are to be generated in order to generate the microbubbles by pumping the medium back and forth through the mixing chamber. The defined volume of the mixing chamber makes it possible to produce a defined number of microbubbles when an equal agitation power, ie back and forth, is present.

Die bekannten Mischeinrichtungen gemäß DE 44 32 993 C1 , EP 0 266 058 A2 und Combidyn Adapter erfüllen ihre Funktion dann sicher und zuverlässig, wenn gleichartige Spritzen verwendet werden und die Bewegung beim vielfachem Hin- und Herpumpen streng axial verläuft. Die Verwendung gleichartiger Spritzen wird explizit empfohlen ( DE 44 32 993 C1 ). Werden beim Hin- und Herpumpen und bei großen Pumpdrücken die Spritzen nur leicht verkantet d.h. die Pumpbewegung wird nicht streng axial ausgeführt werden die Adapter undicht bzw. brechen. Es kann auch zum Bruch der Spritzen am Konus kommen. Die Combidyn Adapter sind für diese Belastung per se nicht ausgelegt, da sie nur zur statischen Verbindung von Schläuchen vorgesehen sind. In der Medizin kommen Spritzen mit zentriertem Konus und Spritzen mit seitlich versetztem Konus zum Einsatz. Werden Spritzen unterschiedlicher Bauart mit dem Adapter verbunden, liegen die Kolbenachsen der zwei Spritzen zwangläufig nicht mehr in einer Achse und das Hin- und Herpumpen wird erschwert und die Zerstörung des Adapters ist vorprogrammiert, da das System in einer Verbiegung ausweicht.The known mixing devices according to DE 44 32 993 C1 . EP 0 266 058 A2 and Combidyn adapters perform their function safely and reliably when similar syringes are used and the movement is strictly axial with multiple reciprocating pumping. The use of similar syringes is explicitly recommended ( DE 44 32 993 C1 ). When pumping back and forth and at high pumping pressures, the syringes are only slightly tilted ie the pumping movement is not strictly carried out axially, the adapter leaking or breaking. It can also come to break the syringes on the cone. The Combidyn adapters are not designed for this load per se, as they are only intended for the static connection of hoses. In medicine, syringes with centered cone and syringes with laterally offset cone are used. If syringes of different types are connected to the adapter, the piston axes of the two syringes are inevitably no longer in one axis and the reciprocating pumping is made more difficult and the destruction of the adapter is preprogrammed, since the system evades in a bend.

Davon ausgehend liegt der Erfindung die Aufgabe zugrunde, ein Adapter der eingangs angegebenen Art mit einer verbesserten Eigenschaften zu schaffen und damit die oben beschriebenen Nachteile zu eliminieren.On this basis, the present invention seeks to provide an adapter of the type described above with improved properties and thus to eliminate the disadvantages described above.

Die Aufgabe wurde gemäß den Merkmalen der Patentansprüche gelöst.The problem has been solved according to the features of the claims.

Erfindungsgemäß wurde ein Adapter bereitgestellt, der beim Einsatz von zwei Spritzen gleicher oder unterschiedlicher Bauart das sichere und effektive Einbringung von Energie zum Vermischen unterschiedlicher Medien ermöglicht. Der erfindungsgemäße Adapter stabilisiert die Spritzen beim kräftiges Hin- und Herpumpen der Substanzen zwischen den Spritzen und verhindert das Durchbrechen des System auf Höhe des Adapters und im Bereich des Spritzenkonus.According to the invention, an adapter has been provided which, with the use of two syringes of the same or different design, enables the safe and effective introduction of energy for mixing different media. The adapter according to the invention stabilizes the syringes during vigorous pumping of the substances between the syringes and prevents the breakage of the system at the level of the adapter and in the area of the syringe cone.

Überraschenderweise hat sich herausgestellt, dass diese Stabilisierung auch dann eintritt, wenn nicht gleiche Spritzentypen verwendet werden, sonder Spritzen unterschiedlicher Bauart.Surprisingly, it has been found that this stabilization also occurs when not the same syringe types are used, but syringes of different types.

Die Grundidee des erfindungsgemäßen Adapters besteht darin, dass nicht nur der Konus der Spritzen im Adapter fixiert ist, sondern auch ein Anteil des Spritzenzylinders vom Adapter teilweise umschlossen und damit stabilisiert wird. Die Bohrung im Adapter ist nicht wie zu erwarten rund, sondern länglich . Dies ermöglicht die stabile Führung und Fixierung auf etwa die Hälfte des Umfanges des Spritzenkolbens beliebiger Bauart.The basic idea of the adapter according to the invention is that not only the cone of the syringe is fixed in the adapter, but also a portion of the syringe barrel is partially enclosed by the adapter and thus stabilized. The hole in the adapter is not round, as expected, but elongated. This allows the stable guidance and fixation to about half the circumference of the syringe plunger of any design.

Um die universelle Anwendbarkeit des erfindungsgemäßen Adapters und damit der Mischeinrichtung zu ermöglichen, wird vorgeschlagen, den Adapter so zugestalten, dass die jeweiligen Anschlüsse als Luer- Lock weiblich-weiblich oder Luer-Lock männlich-weiblich oder Luer-Lock männlich-männlich ausgebildet sind. Das heißt, entweder sind die freien Enden beide als weibliche Anschlüsse, wie in dem gezeigten Beispiel oder ein Ende als männlicher Anschluss mit einem entsprechenden Außenkegel und das andere Ende als weiblicher Anschluss ausgebildet. Oder beide freien Enden sind als männliche Anschlüsse ausgebildet. Des weiteren ist bevorzugt, den Adapter im Anschlussbereich so auszubilden, dass er an handelsübliche Spritzen mit Luer-Lock-Kegel nach, DIN 13090, insbesondere für Spritzen der Größen 2 ml bis 50 ml montiert werden kann.In order to enable the universal applicability of the adapter according to the invention and thus of the mixing device, it is proposed to design the adapter such that the respective connections are designed as Luer-Lock female-female or Luer-Lock male-female or Luer-Lock male-male. That is, either the free ends are both formed as female terminals, as in the example shown or one end as a male terminal with a corresponding outer cone and the other end as a female terminal. Or both free ends are designed as male connectors. Furthermore, it is preferred that the adapter in the connection area in such a way that it can be mounted on commercial syringes with Luer-Lock-cone according to DIN 13090, especially for syringes sizes 2 ml to 50 ml.

Ein nicht zu übersehender Vorteil der Erfindung ist darin zu sehen, dass der Adapter bei der Herstellung oder nachträglich mit Mischelementen versehen werden kann. Hierzu werden in den Fließkanal statische oder flexible Widerstände, Schikanen oder Blenden eingebracht.A not to be overlooked advantage of the invention is the fact that the adapter can be provided in the manufacture or subsequently with mixing elements. For this purpose, static or flexible resistors, baffles or diaphragms are introduced into the flow channel.

Der erfindungsgemäße Spritzen-Adapter besitzt auf jeder Seite zwei versetzte, ineinander übergehende Bohrungen mit dem Zweck, auch nicht baugleiche Spritzen beim Verbinden zu führen und zu fixieren. In der Schnittmenge der ineinander übergehenden Bohrungen ist der Fließkanal mit kleinerem Durchmesser positioniert. Die Wände der größeren Bohrungen fixieren und stabilisieren die Spritzen während des Mischvorganges und verhindern das Durchbrechen oder Abbrechen. Die Wände der Führungsbohrungen sollen mindest bis zur 1-ml Markierung der Spritzen reichen. Mit zunehmender Wandhöhe steigt die Stabilität des Systems.The syringe adapter according to the invention has on each side two staggered, merging holes with the purpose to lead and fix not identical syringes when connecting. In the intersection of the merging holes of the flow channel is positioned with a smaller diameter. The walls of the larger holes fix and stabilize the syringes during the mixing process and prevent the breaking or breaking off. The walls of the pilot holes should reach at least the 1 ml mark of the syringes. As the wall height increases, the stability of the system increases.

Gemäß einer bevorzugten Ausführungsform der Erfindung ist der Spritzen-Adapter dadurch gekennzeichnet, dass im dünneren Fließkanal beliebig geformte Schikanen, Hindernisse, Widerstände eingebaut sind. Diese Schikanen, Hindernisse, Widerstände können unlöslich mit dem Spritzen-Adapter verbunden sein oder aber als Stecklinge wechselbar im Fließkanal positioniert sein. Über die Vorgabe des Bauvolumens der Schikanen, Hindernisse, Widerstände kann das Gasvolumen im Fließkanal definiert werden.According to a preferred embodiment of the invention, the syringe adapter is characterized in that in the thinner flow channel arbitrarily shaped baffles, obstacles, resistors are installed. These baffles, obstacles, resistors can be insoluble connected to the syringe adapter or be positioned as cuttable replaceable in the flow channel. By specifying the construction volume of the baffles, obstacles, resistors, the gas volume in the flow channel can be defined.

Die Erfindung stellt einen Adapter für handelsübliche Spritzen bereit, der es gestattet, verschiedenste Stoffe (flüssig, gasförmig) unter genau definierten Vorgaben mittels zweier Spritzen effektiv und reproduzierbar zu durchmischen oder mit Energie zu beaufschlagen. Die Qualität der durch Mischung bzw. Energiebeaufschlagung ist mittels der variablen Schikanen und Widerstände auf einfachem Wege reproduzierbar und darstellbar. Gegenstand der Erfindung ist somit auch die Verwendung des erfindungsgemäßen Spritzen-Adapters zur Mischung von Stoffen mittels zweier Spritzen.The invention provides an adapter for commercial syringes, which allows various substances (liquid, gaseous) under well-defined conditions by means of two syringes effectively and reproducibly mix or energize. The quality of the mixture or energization is easily reproducible and representable by means of variable baffles and resistors. The invention thus also relates to the use of the syringe adapter according to the invention for mixing substances by means of two syringes.

Der erfindungsgemäße Spritzenadapter ermöglicht eine reproduzierbare und damit zwangsläufig ordnungsgemäß durchführbare effektive Durchmischung von entsprechenden Diagnostika und Therapeutika bei definiert vorgegebener einzuarbeitender Gasmenge.The syringe adapter according to the invention enables a reproducible and thus necessarily properly feasible effective mixing of appropriate diagnostics and therapeutics at a defined predetermined einzuarbeitender amount of gas.

Der erfindungsgemäße Spritzenadapter ist nicht nur auf ein spezielles Therapeutikum oder diagnostisches Mittel zur Aufbereitung geeignet, sondern in universeller Weise für die unterschiedlichsten mittels einer Injektion zu verabreichenden Mittel geeignet, die aus flüssigen, pastösen oder flüssigen und pulvrigen oder flüssigen, pastösen und gasförmigen Medien zusammengesetzt und homogenisiert werden müssen.The syringe adapter according to the invention is not only suitable for a specific therapeutic or diagnostic agent for treatment, but in a universal manner for a variety of means to be administered by injection composed of liquid, pasty or liquid and powdery or liquid, pasty and gaseous media and must be homogenized.

Die Erfindung soll anhand eines Ausführungsbeispiels näher beschrieben werden, ohne sie auf dieses Beispiel zu begrenzen.The invention will be described with reference to an embodiment, without limiting it to this example.

Ausführungsbeispielembodiment

Ein Ausführungsbeispiel des erfindungsgemäßen Adapters wird anhand der Figuren beschrieben. In diesen zeigt:

Figur 1
eine erste Ausführungsform des Adapters in Frontalebene und Seitenschnitt,
Figur 2
eine erste Ausführungsform des Adapters in 3-D Animation,
Figur 3
eine Fotomontage der Verbindung zweier baugleicher Spritzen, wobei die Spritzenkoni exzentrisch angeordnet sind,
Figur 4
eine Fotomontage der Verbindung zweier baugleicher Spritzen, wobei die Spritzenkoni zentrisch angeordnet sind und
Figur 5
eine Fotomontage der Verbindung zweier nicht baugleicher Spritzen Spritzenkonus einmal zentrisch und einmal exzentrisch angeordnet
An embodiment of the adapter according to the invention will be described with reference to FIGS. In these shows:
FIG. 1
a first embodiment of the adapter in the frontal plane and side section,
FIG. 2
a first embodiment of the adapter in 3-D animation,
FIG. 3
a photomontage of the connection of two identical syringes, wherein the syringe cones are arranged eccentrically ,
FIG. 4
a photomontage of the connection of two identical syringes, the syringe cones are arranged centrally and
FIG. 5
a photomontage of the connection of two syringes not identical syringe cone once centric and once arranged eccentric

Der Adapter der ersten Ausführungsform in Figur 1 und Figur 2 weist einen Zentralkanal mit balkenartigen Schikanen auf. Die größeren Bohrungen für die Aufnahme und Fixierung der Spritzenzylinder ergeben sich aus der Schnittmenge zweier gleich großer Bohrungen. Diese Gesamtbohrung an jeder Seite des Adapters ist damit nicht rund.The adapter of the first embodiment in FIG. 1 and FIG. 2 has a central channel with bar-like baffles. The larger holes for receiving and fixing the syringe barrel resulting from the intersection of two equal holes. This total hole on each side of the adapter is therefore not round.

Claims (9)

Spritzen-Adapter, umfassend auf jeder Seite zwei versetzte, ineinander übergehende Bohrungen, wobei eine längliche Bohrung ausgebildet wird, die in der Schnittmenge der beiden ineinander übergehenden Bohrungen ein Fließkanal mit kleinerem Durchmesser als dem Durchmesser der Bohrungen enthält.Syringe adapter, comprising on each side two offset, merging holes, wherein an elongated bore is formed, which contains in the intersection of the two merging holes a flow channel with a smaller diameter than the diameter of the holes. Spritzen-Adapter nach Anspruch 1, dadurch gekennzeichnet, dass die jeweiligen Anschlüsse als Luer- Lock weiblich-weiblich oder Luer-Lock männlich-weiblich oder Luer-Lock männlich-männlich ausgebildet sind.Syringe adapter according to claim 1, characterized in that the respective terminals are designed as Luer-Lock female-female or Luer-Lock male-female or Luer-Lock male-male. Spritzen-Adapter nach Anspruch 1, dadurch gekennzeichnet, dass Luer-Lock-Kegel nach DIN 13090 angeschlossen werden können.Syringe adapter according to claim 1, characterized in that Luer-lock cone according to DIN 13090 can be connected. Spritzen-Adapter nach einem der Ansprüche 1 bis 3, dadurch gekennzeichnet, dass er zusätzlich statische oder flexible Widerstände, Schikanen oder Blenden enthält.Syringe adapter according to one of claims 1 to 3, characterized in that it additionally contains static or flexible resistors, baffles or diaphragms. Spritzen-Adapter nach Anspruch 2, dadurch gekennzeichnet, dass die Schikanen, Hindernisse, Widerstände unlöslich mit dem Spritzen-Adapter verbunden sind oder aber dass die Schikanen, Hindernisse, Widerstände als Stecklinge und wechselbar im Fließkanal positioniert sind.Syringe adapter according to claim 2, characterized in that the baffles, obstacles, resistors are insoluble connected to the syringe adapter or that the baffles, obstacles, resistors are positioned as cuttings and changeable in the flow channel. Spritzen-Adapter nach Anspruch 5, dadurch gekennzeichnet, dass über die Vorgabe des Bauvolumens der Schikanen, Hindernisse, Widerstände das Gasvolumen im Fließkanal definiert werden kann.Syringe adapter according to claim 5, characterized in that on the specification of the construction volume of baffles, obstacles, resistors, the gas volume can be defined in the flow channel. Verwendung des Spritzen-Adapters gemäß einem der Ansprüche 1 bis 6 zur Mischung von Stoffen mittels zweier Spritzen.Use of the syringe adapter according to one of claims 1 to 6 for the mixing of substances by means of two syringes. Verwendung nach Anspruch 7 zur Durchmischung von Diagnostika und Therapeutika bei definiert vorgegebener einzuarbeitender Gasmenge.Use according to claim 7 for the mixing of diagnostics and therapeutics at a defined predetermined amount of gas to be incorporated. Verwendung nach Anspruch 7 zur Zusammensetzung oder Homogenisierung für unterschiedliche mittels einer Injektion zu verabreichenden Mittel, die aus flüssigen, pastösen oder flüssigen und pulvrigen oder flüssigen, pastösen und gasförmigen Medien bestehen.Use according to claim 7 for the composition or homogenization of different agents to be administered by injection, consisting of liquid, pasty or liquid and powdery or liquid, pasty and gaseous media.
EP06126404A 2005-06-30 2006-12-18 Syringe coupling device for a safe coupling of syringes of different type Active EP1935392B1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DE102005030510A DE102005030510A1 (en) 2005-06-30 2005-06-30 Adapter element for joining two syringes, comprising wide insertion area and connecting duct
DE200650004538 DE502006004538D1 (en) 2006-12-18 2006-12-18 Syringe adapter for secure connection of syringes of unequal design
AT06126404T ATE439114T1 (en) 2005-06-30 2006-12-18 SYRINGE ADAPTER FOR A SECURE CONNECTION OF SYRINGES OF UNSAME DESIGN
EP06126404A EP1935392B1 (en) 2005-06-30 2006-12-18 Syringe coupling device for a safe coupling of syringes of different type

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005030510A DE102005030510A1 (en) 2005-06-30 2005-06-30 Adapter element for joining two syringes, comprising wide insertion area and connecting duct
EP06126404A EP1935392B1 (en) 2005-06-30 2006-12-18 Syringe coupling device for a safe coupling of syringes of different type

Publications (2)

Publication Number Publication Date
EP1935392A1 true EP1935392A1 (en) 2008-06-25
EP1935392B1 EP1935392B1 (en) 2009-08-12

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AT (1) ATE439114T1 (en)
DE (1) DE102005030510A1 (en)

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US9707319B2 (en) * 2013-06-20 2017-07-18 Nordson Corporation Device and method for improving hydration of a biomaterial
US10576020B2 (en) 2015-06-18 2020-03-03 Neomed, Inc. Syringe-to-syringe coupler
US10773067B2 (en) 2014-09-08 2020-09-15 Neomed, Inc. Enteral connectors having coupling features
USD825746S1 (en) 2015-06-18 2018-08-14 Neomed, Inc. Syringe-to-syringe coupler
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Also Published As

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DE102005030510A1 (en) 2007-01-18
EP1935392B1 (en) 2009-08-12
ATE439114T1 (en) 2009-08-15

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