EP1931387A4 - PHARMACEUTICAL FORMULATIONS OF BIODEGRADABLE MICROPARTICLES HAVING IMPROVED RELEASE RATES - Google Patents

PHARMACEUTICAL FORMULATIONS OF BIODEGRADABLE MICROPARTICLES HAVING IMPROVED RELEASE RATES

Info

Publication number: EP1931387A4
Authority: EP; European Patent Office
Prior art keywords: pharmaceutical formulations; release rates; improved release; biodegradable microparticles; microparticles
Prior art date: 2005-09-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP06803043A

Other languages

German (de)

French (fr)

Other versions

EP1931387A2 (en

Inventor

Eliot M Slovin

Joseph T Persyn

Joseph A Mcdonough

Neal K Vail

Darren E Barlow

Albert M Zwiener

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Southwest Research Institute SwRI

Original Assignee

Southwest Research Institute SwRI

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-09-07

Filing date

2006-09-06

Publication date

2012-07-11

2005-09-07 Priority claimed from US11/220,430 external-priority patent/US7758778B2/en

2005-09-07 Priority claimed from US11/221,337 external-priority patent/US7261529B2/en

2005-09-07 Priority claimed from US11/220,807 external-priority patent/US9693967B2/en

2006-09-06 Application filed by Southwest Research Institute SwRI filed Critical Southwest Research Institute SwRI

2008-06-18 Publication of EP1931387A2 publication Critical patent/EP1931387A2/en

2012-07-11 Publication of EP1931387A4 publication Critical patent/EP1931387A4/en

Status Withdrawn legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Inorganic Chemistry (AREA)
Ophthalmology & Optometry (AREA)
Medicinal Preparation (AREA)

EP06803043A 2005-09-07 2006-09-06 PHARMACEUTICAL FORMULATIONS OF BIODEGRADABLE MICROPARTICLES HAVING IMPROVED RELEASE RATES Withdrawn EP1931387A4 (en)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
US22044505A	2005-09-07	2005-09-07
US22043105A	2005-09-07	2005-09-07
US11/220,430 US7758778B2 (en)	2005-09-07	2005-09-07	Methods for preparing biodegradable microparticle formulations containing pharmaceutically active agents
US11/221,337 US7261529B2 (en)	2005-09-07	2005-09-07	Apparatus for preparing biodegradable microparticle formulations containing pharmaceutically active agents
US11/220,807 US9693967B2 (en)	2005-09-07	2005-09-07	Biodegradable microparticle pharmaceutical formulations exhibiting improved released rates
PCT/US2006/034722 WO2007030545A2 (en)	2005-09-07	2006-09-06	Biodegradable microparticle pharmaceutical formulations exhibiting improved release rates

Publications (2)

Publication Number	Publication Date
EP1931387A2 EP1931387A2 (en)	2008-06-18
EP1931387A4 true EP1931387A4 (en)	2012-07-11

Family

ID=37836422

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP06803043A Withdrawn EP1931387A4 (en)	2005-09-07	2006-09-06	PHARMACEUTICAL FORMULATIONS OF BIODEGRADABLE MICROPARTICLES HAVING IMPROVED RELEASE RATES

Country Status (7)

Country	Link
EP (1)	EP1931387A4 (en)
JP (1)	JP2009507845A (en)
KR (1)	KR20080059175A (en)
AU (1)	AU2006287499A1 (en)
BR (1)	BRPI0615563A2 (en)
CA (1)	CA2621395A1 (en)
WO (1)	WO2007030545A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2956345B1 (en) *	2010-02-17	2012-02-03	Ab7 Ind	PROCESS FOR THE PREPARATION OF BIODEGRADABLE POLYMER GRANULES LOADED WITH ACTIVE LIPOPHILIC COMPOUNDS AND ACTIVE BIODEGRADABLE PRODUCTS OBTAINED
UA111162C2 (en)	2010-08-04	2016-04-11	Флекшен Терап'Ютікс, Інк.	INJECTION COMPOSITION OF TRIAMCINOLONE ACETONIDE FOR TREATMENT OF PAIN
JP5926270B2 (en)	2010-10-26	2016-05-25	アルコンリサーチ，リミテッド	Contact lens for ophthalmoscopic surgery
CA2843139C (en) *	2011-08-04	2019-09-24	Flexion Therapeutics, Inc.	Corticosteroids for the treatment of joint pain
JP2015532928A (en) *	2012-09-20	2015-11-16	アキナ，インク．Ａｋｉｎａ，Ｉｎｃ．	Biodegradable microcapsules containing filler material
EP3233056B1 (en) *	2014-12-15	2023-11-15	The Johns Hopkins University	Sunitinib formulations and methods for use thereof in treatment of ocular disorders
JP7527562B2 (en)	2020-08-24	2024-08-05	学校法人福岡大学	Manufacturing method of microcapsules

Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4256677A (en) *	1976-04-12	1981-03-17	Magnavox Government And Industrial Electronics Co.	Apparatus and method for making small spheres
US5665428A (en) *	1995-10-25	1997-09-09	Macromed, Inc.	Preparation of peptide containing biodegradable microspheres by melt process
WO2004041251A1 (en) *	2002-11-04	2004-05-21	Ocean Nutrition Canada Limited	Microcapsules having multiple shells and method for the preparation thereof
WO2005018794A1 (en) *	2003-08-22	2005-03-03	Danisco A/S	Microcapsules

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4675140A (en) *	1984-05-18	1987-06-23	Washington University Technology Associates	Method for coating particles or liquid droplets
US5643594A (en) *	1992-05-29	1997-07-01	The Regents Of The University Of California	Spin encapsulation apparatus and method of use
SE505146C2 (en) *	1995-10-19	1997-06-30	Biogram Ab	Particles for delayed release
RU2005129278A (en) *	2003-02-20	2006-01-27	Алькон, Инк. (Ch)	PREPARATORY GLUCOCORTICOIDS FOR THE TREATMENT OF PATHOLOGICAL EYE ANGIOGENESIS
JP4487141B2 (en) *	2003-08-20	2010-06-23	参天製薬株式会社	Drug delivery system for microtenon subcapsular administration
US7585517B2 (en) *	2003-09-18	2009-09-08	Macusight, Inc.	Transscleral delivery
US8277831B2 (en) *	2004-02-17	2012-10-02	Advanced Technologies And Regenerative Medicine, Llc.	Drug-enhanced adhesion prevention

2006
- 2006-09-06 KR KR1020087008002A patent/KR20080059175A/en not_active Ceased
- 2006-09-06 WO PCT/US2006/034722 patent/WO2007030545A2/en active Application Filing
- 2006-09-06 JP JP2008530171A patent/JP2009507845A/en active Pending
- 2006-09-06 AU AU2006287499A patent/AU2006287499A1/en not_active Abandoned
- 2006-09-06 EP EP06803043A patent/EP1931387A4/en not_active Withdrawn
- 2006-09-06 CA CA002621395A patent/CA2621395A1/en not_active Abandoned
- 2006-09-06 BR BRPI0615563-4A patent/BRPI0615563A2/en not_active IP Right Cessation

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4256677A (en) *	1976-04-12	1981-03-17	Magnavox Government And Industrial Electronics Co.	Apparatus and method for making small spheres
US5665428A (en) *	1995-10-25	1997-09-09	Macromed, Inc.	Preparation of peptide containing biodegradable microspheres by melt process
WO2004041251A1 (en) *	2002-11-04	2004-05-21	Ocean Nutrition Canada Limited	Microcapsules having multiple shells and method for the preparation thereof
WO2005018794A1 (en) *	2003-08-22	2005-03-03	Danisco A/S	Microcapsules

Also Published As

Publication number	Publication date
JP2009507845A (en)	2009-02-26
KR20080059175A (en)	2008-06-26
EP1931387A2 (en)	2008-06-18
WO2007030545A2 (en)	2007-03-15
BRPI0615563A2 (en)	2011-05-24
CA2621395A1 (en)	2007-03-15
AU2006287499A1 (en)	2007-03-15
WO2007030545A3 (en)	2007-11-08

Publication	Publication Date	Title
EP1931387A4 (en)	2012-07-11	PHARMACEUTICAL FORMULATIONS OF BIODEGRADABLE MICROPARTICLES HAVING IMPROVED RELEASE RATES
EP1895991A4 (en)	2012-11-07	Modified release formulations of anti-irritability drugs
EP1883406A4 (en)	2009-11-04	COMPOSITIONS AND METHODS FOR PROLONGED RELEASE OF BETA-ALANINE
HUE053838T2 (en)	2021-07-28	Sustained release formulations of nalbuphine
IL216401A0 (en)	2011-12-29	Sustained release of antinfectives
IL192990A0 (en)	2009-02-11	Methods and compositions of targeted drug development
ZA200807304B (en)	2009-07-29	Modified release formulations and methods of treating inflammatory bowel disease
SI2120585T1 (en)	2013-05-31	Long term sustained release pharmaceutical composition containing aqueous suspension of bisphosphonate
PL2179098T3 (en)	2019-08-30	Toilet flusher having electromechanically induced release of active agent
HUE040391T2 (en)	2019-03-28	Slow release drug formulations made of microparticles
ZA200810178B (en)	2009-12-30	Pharmaceutical compositions for sustained release of phenyephrine
ZA200705533B (en)	2008-08-27	Sustained release composition of protein drug
FR2915683B1 (en)	2009-08-07	SELF-PRECIPITANT PHARMACEUTICAL FORMULATIONS FOR MODIFIED RELEASE OF ACTIVE INGREDIENTS
BRPI0615135A2 (en)	2016-09-13	drug compositions containing controlled release hypromellose matrices
EP2361907A4 (en)	2012-07-25	THE FIVE CRYSTALLINE FORMS OF NICOUSAMIDE, PREPARATION METHODS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
BRPI0906184A2 (en)	2017-07-18	method of preparing biodegradable microparticles containing medicaments
IL198170A0 (en)	2009-12-24	Robust sustained release formulations of oxymorphone and methods of use thereof
IL198169A0 (en)	2009-12-24	Robust sustained release formulations of oxymorphone
EP1931327A4 (en)	2010-02-17	CYCLOPROPYL COMPOUNDS AND COMPOSITIONS FOR RELEASING ACTIVE AGENTS
GB0722040D0 (en)	2007-12-19	Sustained release methotrexate formulations and methods of use thereof
EP1846037A4 (en)	2008-03-12	Methods of treating various conditions by administration of sustained release l-arginine
HK1120426A (en)	2009-04-03	Biodegradable microparticle pharmaceutical formulations exhibiting improved release rates
BRPI0716344A2 (en)	2014-03-11	PHARMACEUTICAL COMPOSITION OF RELEASE TIME LATE COMBINATION

Legal Events

Date	Code	Title	Description
2008-05-16	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2008-06-18	17P	Request for examination filed	Effective date: 20080311
2008-06-18	AK	Designated contracting states	Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
2008-08-06	RIN1	Information on inventor provided before grant (corrected)	Inventor name: ZWIENER, ALBERT, M. Inventor name: SLOVIN, ELIOT, M. Inventor name: VAIL, NEAL, K. Inventor name: MCDONOUGH, JOSEPH, A. Inventor name: BARLOW, DARREN, E. Inventor name: PERSYN, JOSEPH, T.
2009-04-03	REG	Reference to a national code	Ref country code: HK Ref legal event code: DE Ref document number: 1120426 Country of ref document: HK
2012-07-11	A4	Supplementary search report drawn up and despatched	Effective date: 20120613
2012-07-11	RIC1	Information provided on ipc code assigned before grant	Ipc: A61K 47/00 20060101AFI20120606BHEP Ipc: A61K 9/16 20060101ALI20120606BHEP Ipc: A61K 47/32 20060101ALI20120606BHEP Ipc: A61K 9/52 20060101ALI20120606BHEP Ipc: A61K 9/00 20060101ALI20120606BHEP Ipc: A61K 47/30 20060101ALI20120606BHEP
2012-07-25	DAX	Request for extension of the european patent (deleted)
2013-09-18	17Q	First examination report despatched	Effective date: 20130820
2014-05-02	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2014-06-04	18D	Application deemed to be withdrawn	Effective date: 20140103
2015-04-02	REG	Reference to a national code	Ref country code: HK Ref legal event code: WD Ref document number: 1120426 Country of ref document: HK