EP1924596A4 - Albumin fusion proteins - Google Patents
Albumin fusion proteinsInfo
- Publication number
- EP1924596A4 EP1924596A4 EP06813242A EP06813242A EP1924596A4 EP 1924596 A4 EP1924596 A4 EP 1924596A4 EP 06813242 A EP06813242 A EP 06813242A EP 06813242 A EP06813242 A EP 06813242A EP 1924596 A4 EP1924596 A4 EP 1924596A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- fusion proteins
- albumin fusion
- albumin
- proteins
- fusion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70752105P | 2005-08-12 | 2005-08-12 | |
| US71238605P | 2005-08-31 | 2005-08-31 | |
| US73272405P | 2005-11-03 | 2005-11-03 | |
| US77691406P | 2006-02-28 | 2006-02-28 | |
| US78136106P | 2006-03-13 | 2006-03-13 | |
| US81018206P | 2006-06-02 | 2006-06-02 | |
| US81368206P | 2006-06-15 | 2006-06-15 | |
| PCT/US2006/029391 WO2007021494A2 (en) | 2005-08-12 | 2006-07-31 | Albumin fusion proteins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP1924596A2 EP1924596A2 (en) | 2008-05-28 |
| EP1924596A4 true EP1924596A4 (en) | 2009-07-29 |
Family
ID=37758042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP06813242A Withdrawn EP1924596A4 (en) | 2005-08-12 | 2006-07-31 | Albumin fusion proteins |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1924596A4 (en) |
| JP (1) | JP2009504157A (en) |
| KR (1) | KR20080071119A (en) |
| AU (1) | AU2006280312A1 (en) |
| BR (1) | BRPI0614761A2 (en) |
| CA (1) | CA2618476A1 (en) |
| EC (1) | ECSP088262A (en) |
| IL (1) | IL189246A0 (en) |
| MA (1) | MA29836B1 (en) |
| MX (1) | MX2008001865A (en) |
| NO (1) | NO20081233L (en) |
| TN (1) | TNSN08064A1 (en) |
| WO (1) | WO2007021494A2 (en) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9526733D0 (en) | 1995-12-30 | 1996-02-28 | Delta Biotechnology Ltd | Fusion proteins |
| WO2001077137A1 (en) | 2000-04-12 | 2001-10-18 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US20080194481A1 (en) * | 2001-12-21 | 2008-08-14 | Human Genome Sciences, Inc. | Albumin Fusion Proteins |
| EP2277889B1 (en) | 2001-12-21 | 2014-07-09 | Human Genome Sciences, Inc. | Fusion proteins of albumin and interferon beta |
| CA2554089C (en) | 2004-02-09 | 2013-10-22 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| EP1816201A1 (en) | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Modified coagulation factor VIIa with extended half-life |
| WO2007146038A2 (en) | 2006-06-07 | 2007-12-21 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| BRPI0716744A2 (en) * | 2006-09-14 | 2016-10-04 | Human Genome Sciences Inc | albumin fusion proteins |
| CN107011431B (en) | 2007-01-30 | 2020-11-06 | 埃皮瓦克斯公司 | Regulatory T cell epitopes, compositions and uses thereof |
| JP5685529B2 (en) | 2008-06-13 | 2015-03-18 | プロイェクト、デ、ビオメディシナ、シーマ、ソシエダッド、リミターダＰｒｏｙｅｃｔｏ Ｄｅ Ｂｉｏｍｅｄｉｃｉｎａ Ｃｉｍａ， Ｓ．Ｌ． | Complexes for the administration of compounds having biological activity |
| JP2012515222A (en) | 2009-01-16 | 2012-07-05 | テバ ファーマシューティカル インダストリーズ リミテッド | Stable preparation of recombinant human albumin-human granulocyte colony stimulating factor fusion protein |
| US8716448B2 (en) | 2009-02-03 | 2014-05-06 | Amunix Operating Inc. | Coagulation factor VII compositions and methods of making and using same |
| ES2630253T3 (en) | 2009-02-11 | 2017-08-18 | Albumedix A/S | Albumin variants and conjugates |
| KR20100100254A (en) * | 2009-03-05 | 2010-09-15 | (주)바이오큐어팜 | Composition for preventing or treating cancer comprising human serum albumin-timp-2 fusion protein and anti-cancer agent |
| US8748380B2 (en) * | 2009-10-30 | 2014-06-10 | Novozymes Biopharma Dk A/S | Albumin variants |
| US10233228B2 (en) | 2010-04-09 | 2019-03-19 | Albumedix Ltd | Albumin derivatives and variants |
| US8691771B2 (en) | 2010-05-21 | 2014-04-08 | Merrimack Pharmaceuticals, Inc. | Bi-specific fusion proteins for tissue repair |
| EP2682128B1 (en) * | 2011-02-28 | 2017-11-08 | National Cerebral and Cardiovascular Center | Atrial natriuretic peptide or brain natriuretic peptide for use in preventing metastasis |
| CN104011072B (en) | 2011-05-05 | 2018-10-12 | 阿尔布梅迪克斯医疗有限公司 | albumin variants |
| US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
| CA2838833A1 (en) | 2011-06-10 | 2012-12-13 | Biogen Idec Ma Inc. | Pro-coagulant compounds and methods of use thereof |
| CA2811250C (en) | 2011-10-21 | 2015-08-11 | Abbvie Inc. | Methods for treating hcv |
| US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
| SE1450019A1 (en) | 2011-10-21 | 2014-01-10 | Abbvie Inc | Methods for treating HCV comprising at least two direct-acting antiviral agents, ribavirin but not interferon |
| US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
| EP2780364A2 (en) | 2011-11-18 | 2014-09-24 | Eleven Biotherapeutics, Inc. | Proteins with improved half-life and other properties |
| US11370827B2 (en) | 2012-01-12 | 2022-06-28 | Bioverativ Therapeutics Inc. | Chimeric factor VIII polypeptides and uses thereof |
| PT3564260T (en) | 2012-02-15 | 2023-01-18 | Bioverativ Therapeutics Inc | Factor viii compositions and methods of making and using same |
| EP2822577B1 (en) | 2012-02-15 | 2019-02-06 | Bioverativ Therapeutics Inc. | Recombinant factor viii proteins |
| ES2664328T3 (en) | 2012-03-16 | 2018-04-19 | Albumedix A/S | Albumin variants |
| AU2013270682A1 (en) | 2012-06-08 | 2014-12-11 | Biogen Ma Inc. | Procoagulant compounds |
| CA2875247A1 (en) | 2012-06-08 | 2013-12-12 | Biogen Idec Ma Inc. | Chimeric clotting factors |
| CN103525695B (en) * | 2012-07-04 | 2015-05-20 | 长沙中生众捷生物技术有限公司 | Portable kidney function detecting system |
| CN110054699A (en) | 2012-07-11 | 2019-07-26 | 比奥贝拉蒂治疗公司 | Factor IX compound with XTEN and vWF ELISA albumen, and application thereof |
| US10391152B2 (en) | 2012-10-18 | 2019-08-27 | Bioverativ Therapeutics Inc. | Methods of using a fixed dose of a clotting factor |
| BR112015010318A2 (en) | 2012-11-08 | 2017-08-22 | Albumedix As | ALBUMIN VARIANTS |
| RS64664B1 (en) | 2013-02-15 | 2023-11-30 | Bioverativ Therapeutics Inc | Optimized factor viii gene |
| KR20150118123A (en) | 2013-02-16 | 2015-10-21 | 노보자임스 바이오파마 디케이 에이/에스 | Pharmacokinetic animal model |
| US10588949B2 (en) | 2013-03-15 | 2020-03-17 | Bioverativ Therapeutics Inc. | Factor IX polypeptide formulations |
| CN105392495A (en) | 2013-06-28 | 2016-03-09 | 比奥根Ma公司 | Thrombin cleavable linkers with XTEN and uses thereof |
| TW202003554A (en) | 2013-08-14 | 2020-01-16 | 美商百歐維拉提夫治療公司 | Factor VIII-XTEN fusions and uses thereof |
| HUE057005T2 (en) | 2013-09-25 | 2022-04-28 | Bioverativ Therapeutics Inc | Column virus inactivation procedures |
| EP3065769A4 (en) | 2013-11-08 | 2017-05-31 | Biogen MA Inc. | Procoagulant fusion compound |
| DK3091997T5 (en) | 2014-01-10 | 2024-10-14 | Bioverativ Therapeutics Inc | CHIMERIC FACTOR VIII PROTEINS AND USES THEREOF |
| US11008561B2 (en) | 2014-06-30 | 2021-05-18 | Bioverativ Therapeutics Inc. | Optimized factor IX gene |
| EA201700181A1 (en) | 2014-10-14 | 2017-09-29 | Галозим, Инк. | COMPOSITIONS OF ADENOSINDEMINASE-2 (ADA-2), THEIR OPTIONS AND METHODS OF USE |
| MA40835A (en) | 2014-10-23 | 2017-08-29 | Biogen Ma Inc | ANTI-GPIIB / IIIA ANTIBODIES AND THEIR USES |
| MA40861A (en) | 2014-10-31 | 2017-09-05 | Biogen Ma Inc | ANTI-GLYCOPROTEIN IIB / IIIA ANTIBODIES |
| BR112018002150A2 (en) | 2015-08-03 | 2018-09-18 | Bioverativ Therapeutics Inc | factor ix fusion proteins and methods of manufacturing and using them |
| US10633428B2 (en) | 2015-08-20 | 2020-04-28 | Albumedix Ltd | Albumin variants and conjugates |
| ES2863278T3 (en) | 2015-10-02 | 2021-10-11 | Silver Creek Pharmaceuticals Inc | Bispecific therapeutic proteins for tissue repair |
| CN105254766B (en) * | 2015-10-26 | 2018-10-16 | 中国航天员科研训练中心 | Application of the Mecano growth factor MGF E domain peptides in regulation and control memory related gene and miRNA expression |
| HRP20221089T1 (en) | 2016-02-01 | 2022-11-25 | Bioverativ Therapeutics Inc. | Optimized factor viii genes |
| EP3448392A4 (en) | 2016-04-28 | 2020-01-15 | Emory University | ALCYNE-CONTAINING NUCLEOTIDES AND NUCLEOSIDES THERAPEUTIC COMPOSITIONS AND USES THEREOF |
| WO2018082758A1 (en) | 2016-11-04 | 2018-05-11 | Aarhus Universitet | Identification and treatment of tumors characterized by an overexpression of the neonatal fc receptor |
| IL308416B2 (en) | 2016-12-02 | 2025-08-01 | Bioverativ Therapeutics Inc | Methods for treating hemophilic arthritis using chimeric blood clotting factors |
| US12257288B2 (en) | 2016-12-02 | 2025-03-25 | Bioverativ Therapeutics Inc. | Methods of inducing immune tolerance to clotting factors |
| EP3562840A1 (en) | 2016-12-16 | 2019-11-06 | Biogen MA Inc. | Stabilized proteolytically activated growth differentiation factor 11 |
| CR20190389A (en) | 2017-01-31 | 2019-11-26 | Bioverativ Therapeutics Inc | Factor ix fusion proteins and methods of making and using same |
| WO2018193033A1 (en) * | 2017-04-20 | 2018-10-25 | Novo Nordisk A/S | Methods of purification of albumin fusion proteins |
| TWI904068B (en) | 2017-08-09 | 2025-11-11 | 美商生物化學醫療公司 | Nucleic acid molecules and uses thereof |
| WO2019152692A1 (en) | 2018-02-01 | 2019-08-08 | Bioverativ Therapeutics, Inc. | Use of lentiviral vectors expressing factor viii |
| BR112020022164A2 (en) | 2018-05-18 | 2021-02-02 | Bioverativ Therapeutics Inc. | methods of treating hemophilia a |
| CA3104686A1 (en) | 2018-07-03 | 2020-01-09 | Bristol-Myers Squibb Company | Fgf-21 formulations |
| CA3108799A1 (en) | 2018-08-09 | 2020-02-13 | Bioverativ Therapeutics Inc. | Nucleic acid molecules and uses thereof for non-viral gene therapy |
| AU2019393880A1 (en) | 2018-12-06 | 2021-07-15 | Bioverativ Therapeutics Inc. | Use of lentiviral vectors expressing factor IX |
| WO2021067389A1 (en) | 2019-09-30 | 2021-04-08 | Bioverativ Therapeutics Inc. | Lentiviral vector formulations |
| EP4171657A1 (en) | 2020-06-24 | 2023-05-03 | Bioverativ Therapeutics Inc. | Methods for the removal of free factor viii from preparations of lentiviral vectors modified to express said protein |
| WO2022030580A1 (en) * | 2020-08-06 | 2022-02-10 | 国立大学法人宮崎大学 | Novel long-acting adrenomedullin derivative, method for producing same and pharmaceutical use thereof |
| US12487299B2 (en) | 2022-06-20 | 2025-12-02 | Shanghai United Imaging Healthcare Co., Ltd. | Magnetic resonance imaging devices and radiation therapy systems including the magnetic resonance imaging devices |
| US20250333481A1 (en) * | 2022-10-11 | 2025-10-30 | Jcr Pharmaceuticals Co., Ltd. | Fusion protein of serum albumin and physiologically-active protein |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003060071A2 (en) * | 2001-12-21 | 2003-07-24 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| WO2005003296A2 (en) * | 2003-01-22 | 2005-01-13 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| WO2005077042A2 (en) * | 2004-02-09 | 2005-08-25 | Human Genome Sciences, Inc. | Albumin fusion proteins |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060051859A1 (en) * | 2004-09-09 | 2006-03-09 | Yan Fu | Long acting human interferon analogs |
-
2006
- 2006-07-31 EP EP06813242A patent/EP1924596A4/en not_active Withdrawn
- 2006-07-31 JP JP2008526056A patent/JP2009504157A/en not_active Withdrawn
- 2006-07-31 WO PCT/US2006/029391 patent/WO2007021494A2/en not_active Ceased
- 2006-07-31 KR KR1020087006077A patent/KR20080071119A/en not_active Withdrawn
- 2006-07-31 MX MX2008001865A patent/MX2008001865A/en not_active Application Discontinuation
- 2006-07-31 AU AU2006280312A patent/AU2006280312A1/en not_active Abandoned
- 2006-07-31 CA CA002618476A patent/CA2618476A1/en not_active Abandoned
- 2006-07-31 BR BRPI0614761-5A patent/BRPI0614761A2/en not_active IP Right Cessation
-
2008
- 2008-02-04 IL IL189246A patent/IL189246A0/en unknown
- 2008-02-11 TN TNP2008000064A patent/TNSN08064A1/en unknown
- 2008-03-07 MA MA30727A patent/MA29836B1/en unknown
- 2008-03-10 NO NO20081233A patent/NO20081233L/en not_active Application Discontinuation
- 2008-03-12 EC EC2008008262A patent/ECSP088262A/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003060071A2 (en) * | 2001-12-21 | 2003-07-24 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| WO2005003296A2 (en) * | 2003-01-22 | 2005-01-13 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| WO2005077042A2 (en) * | 2004-02-09 | 2005-08-25 | Human Genome Sciences, Inc. | Albumin fusion proteins |
Also Published As
| Publication number | Publication date |
|---|---|
| TNSN08064A1 (en) | 2009-07-14 |
| WO2007021494A3 (en) | 2007-07-26 |
| MA29836B1 (en) | 2008-10-03 |
| IL189246A0 (en) | 2008-08-07 |
| WO2007021494A2 (en) | 2007-02-22 |
| KR20080071119A (en) | 2008-08-01 |
| EP1924596A2 (en) | 2008-05-28 |
| MX2008001865A (en) | 2008-04-15 |
| AU2006280312A1 (en) | 2007-02-22 |
| JP2009504157A (en) | 2009-02-05 |
| CA2618476A1 (en) | 2007-02-22 |
| NO20081233L (en) | 2008-05-09 |
| BRPI0614761A2 (en) | 2009-05-19 |
| ECSP088262A (en) | 2008-05-30 |
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