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EP1839662A4 - ANTITUMOR AGENT - Google Patents

ANTITUMOR AGENT

Info

Publication number
EP1839662A4
EP1839662A4 EP06711726A EP06711726A EP1839662A4 EP 1839662 A4 EP1839662 A4 EP 1839662A4 EP 06711726 A EP06711726 A EP 06711726A EP 06711726 A EP06711726 A EP 06711726A EP 1839662 A4 EP1839662 A4 EP 1839662A4
Authority
EP
European Patent Office
Prior art keywords
antitumor agent
cancer
tumor
neuroastrocytic
leukemia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP06711726A
Other languages
German (de)
French (fr)
Japanese (ja)
Other versions
EP1839662B1 (en
EP1839662A1 (en
Inventor
Koji Yoshinaga
Daisuke Kawasaki
Yutaka Emori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zeria Pharmaceutical Co Ltd
Original Assignee
Zeria Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeria Pharmaceutical Co Ltd filed Critical Zeria Pharmaceutical Co Ltd
Priority to PL06711726T priority Critical patent/PL1839662T3/en
Priority to SI200630680T priority patent/SI1839662T1/en
Publication of EP1839662A1 publication Critical patent/EP1839662A1/en
Publication of EP1839662A4 publication Critical patent/EP1839662A4/en
Application granted granted Critical
Publication of EP1839662B1 publication Critical patent/EP1839662B1/en
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

An antitumor agent, a medicine, which is useful for the treatment or prevention of digestive cancer, leukemia, pituitary tumor, small-cell lung cancer, thyroid cancer, and neuroastrocytic tumor. The antitumor agent contains as an active ingredient either a 1,5-benzodiazepine derivative represented by the general formula (1): (wherein R1 represents C1-6 alkyl; R2 represents phenyl or cyclohexyl; and Y represents a single bond or C1-4 alkylene) or a pharmaceutically acceptable salt thereof.
EP06711726A 2005-01-19 2006-01-16 Antitumor agent Not-in-force EP1839662B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PL06711726T PL1839662T3 (en) 2005-01-19 2006-01-16 Antitumor agent
SI200630680T SI1839662T1 (en) 2005-01-19 2006-01-16 Antitumor agent

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005011158 2005-01-19
PCT/JP2006/300445 WO2006077793A1 (en) 2005-01-19 2006-01-16 Antitumor agent

Publications (3)

Publication Number Publication Date
EP1839662A1 EP1839662A1 (en) 2007-10-03
EP1839662A4 true EP1839662A4 (en) 2008-05-21
EP1839662B1 EP1839662B1 (en) 2010-03-24

Family

ID=36692183

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06711726A Not-in-force EP1839662B1 (en) 2005-01-19 2006-01-16 Antitumor agent

Country Status (18)

Country Link
US (5) US20080161293A1 (en)
EP (1) EP1839662B1 (en)
JP (1) JP4957250B2 (en)
KR (1) KR101285047B1 (en)
CN (1) CN101102776B (en)
AU (1) AU2006207152B2 (en)
BR (1) BRPI0606459A2 (en)
CA (1) CA2594482C (en)
DE (1) DE602006013094D1 (en)
DK (1) DK1839662T3 (en)
ES (1) ES2341728T3 (en)
HK (1) HK1116064A1 (en)
PL (1) PL1839662T3 (en)
PT (1) PT1839662E (en)
RU (1) RU2391982C2 (en)
SI (1) SI1839662T1 (en)
TW (1) TWI399206B (en)
WO (1) WO2006077793A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1839662T3 (en) * 2005-01-19 2010-08-31 Zeria Pharm Co Ltd Antitumor agent
TWI459948B (en) * 2008-05-15 2014-11-11 Zeria Pharm Co Ltd The use of a 1,5-benzodiazepine derivative or a pharmaceutically acceptable salt thereof for the manufacture of a pain therapeutic agent composition
CN102170907A (en) 2008-08-05 2011-08-31 东丽株式会社 Pharmaceutical composition for treatment and prevention of cancer
WO2010016527A1 (en) 2008-08-05 2010-02-11 東レ株式会社 Cancer detection method
CA2757208A1 (en) 2009-03-31 2010-10-07 Zeria Pharmaceutical Co., Ltd. Method for manufacturing 1,5-benzodiazepine derivative
MX349907B (en) 2011-08-04 2017-08-18 Toray Industries Method for detecting pancreatic cancer.
DK2876446T3 (en) 2012-07-19 2019-03-11 Toray Industries Method for detecting cancer
JP6002835B2 (en) * 2013-03-27 2016-10-05 大鵬薬品工業株式会社 Antitumor agent containing low-dose irinotecan hydrochloride hydrate
RU2678138C2 (en) 2013-08-09 2019-01-23 Торэй Индастриз, Инк. Pharmaceutical composition for treatment and/or prevention of cancer
CN103435562B (en) * 2013-08-26 2016-02-24 华东理工大学 6-replaces Benzodiazepine-2,4-cyclohexadione compounds and uses thereof
CN106163527A (en) 2013-11-22 2016-11-23 Cl生物科技有限责任公司 For treating and preventing the gastrin antagonists of osteoporosis
CN108395410A (en) * 2018-05-09 2018-08-14 日照市普达医药科技有限公司 A kind of anilinoquinazoline compound and its application in antitumor drug
CN114948927B (en) * 2021-02-20 2024-10-15 无锡九基生物科技有限公司 Application of 3-benzofuranone derivative containing benzylidene in preparation of antitumor drugs

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0945445A1 (en) * 1996-12-10 1999-09-29 Zeria Pharmaceutical Co., Ltd. 1,5-benzodiazepine derivatives
EP1234818A1 (en) * 1999-12-02 2002-08-28 Zeria Pharmaceutical Co., Ltd. Calcium salts of 1,5-benzodiazepine derivatives, process for producing the salts and drugs containing the same
EP1391203A1 (en) * 2001-05-11 2004-02-25 Yamanouchi Pharmaceutical Co. Ltd. Antitumor agents

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5218115A (en) * 1991-04-10 1993-06-08 Merck & Co., Inc. Cholecystokinin antagonists
JPH0840908A (en) * 1994-07-28 1996-02-13 Yamanouchi Pharmaceut Co Ltd Cancerous cell proliferation inhibitor
JP2000026434A (en) * 1998-06-05 2000-01-25 Zeria Pharmaceut Co Ltd New 1,5-benzodiazepine derivatives
AU4564200A (en) * 1999-04-29 2000-11-17 Aventis Pharma S.A. Method for treating cancer using camptothecin derivatives and 5-fluorouracil
TWI310684B (en) * 2000-03-27 2009-06-11 Bristol Myers Squibb Co Synergistic pharmaceutical kits for treating cancer
PL1839662T3 (en) * 2005-01-19 2010-08-31 Zeria Pharm Co Ltd Antitumor agent

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0945445A1 (en) * 1996-12-10 1999-09-29 Zeria Pharmaceutical Co., Ltd. 1,5-benzodiazepine derivatives
EP1234818A1 (en) * 1999-12-02 2002-08-28 Zeria Pharmaceutical Co., Ltd. Calcium salts of 1,5-benzodiazepine derivatives, process for producing the salts and drugs containing the same
EP1391203A1 (en) * 2001-05-11 2004-02-25 Yamanouchi Pharmaceutical Co. Ltd. Antitumor agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2006077793A1 *

Also Published As

Publication number Publication date
US20170151256A1 (en) 2017-06-01
TW200637561A (en) 2006-11-01
CN101102776B (en) 2011-08-24
AU2006207152B2 (en) 2011-02-24
CN101102776A (en) 2008-01-09
AU2006207152A1 (en) 2006-07-27
ES2341728T3 (en) 2010-06-25
RU2007131435A (en) 2009-02-27
EP1839662B1 (en) 2010-03-24
US20080161293A1 (en) 2008-07-03
TWI399206B (en) 2013-06-21
KR20070095930A (en) 2007-10-01
JP4957250B2 (en) 2012-06-20
SI1839662T1 (en) 2010-07-30
JPWO2006077793A1 (en) 2008-06-19
CA2594482A1 (en) 2006-07-27
HK1116064A1 (en) 2008-12-19
PT1839662E (en) 2010-04-28
US20100143366A1 (en) 2010-06-10
RU2391982C2 (en) 2010-06-20
US20100086553A1 (en) 2010-04-08
EP1839662A1 (en) 2007-10-03
PL1839662T3 (en) 2010-08-31
WO2006077793A1 (en) 2006-07-27
DE602006013094D1 (en) 2010-05-06
CA2594482C (en) 2013-10-01
DK1839662T3 (en) 2010-05-10
BRPI0606459A2 (en) 2009-06-30
KR101285047B1 (en) 2013-07-10
US20180318314A1 (en) 2018-11-08

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