EP1833739A2 - Multi-component discharge device for liquid and powdery materials - Google Patents

Abstract

The invention relates to a multi-component discharge device for liquid and powdery materials, which comprises a blister part (2) which is provided with at least two chambers (3-6) which are closed by means of a film and which are arranged in an adjacent manner, and a blister base (7) which is provided with at least one discharge part (13, 14) which acts upon said chambers. Channels (8, 9; 10, 11) which are closed to the outlet or channels comprising welded points (8F, 9F; 10F, 11F) are arranged between the chambers which are arranged downstream and/or between the last chambers in relation to the outlet and the blister part is secured to the blister base such that the welded points (8F, 9F; 10F, 11F) are flexible in such a manner that the material can pass through. The inventive discharge device (1) comprises a static mixer (12). The use of discharge parts for the simultaneous discharge of the chamber rows and the integration of a mixer is produced by enables a discharge device to be produced which enables substances to be discharged in a precise manner and to be mixed with economical elements in order to meet the requirements set out in the claims in the medical field.

Description

 Multi-component discharge device for liquid and powdery substances

The present invention relates to a multi-component discharge device for liquid and powdery substances according to the preamble of claim 1. Such discharge devices are based on the blister system and are described for example in EP-B-1 108 656. A further discharge device for the single discharge of the components is described in WO98 / 01360.

Common to both prior art documents is that the dispensing or stamping member can act on at least two containers at a time to approximately simultaneously

Allow discharge of the two components and that the components then open into a common outlet.

While it may still be sufficient for simple applications such as in cosmetics or in the mixing of low-viscosity substances that the two substances are mixed together in a common outlet, it is of great importance, especially in the application in medicine or in dental technology, that the Substances in a well-defined ratio to each other are well mixed and it is therefore the object of the present invention to provide a discharge device for single use, with which the substances are well mixed in an exact ratio to each other. ^"This" object ^~ wiFd with ^"VoFrichtung according to claim 1 dissolved. It is a further object of the invention to provide a discharge device with chambers whose volume can be increased and which are suitable to receive tablets or the like components. A discharge device which achieves this object is defined in claim 19.

Further advantages and variants are defined in the dependent claims. The invention will be explained in more detail below with reference to drawings of exemplary embodiments.

Fig. 1 shows a perspective view of a first

Embodiment of a discharge device according to the invention,

FIG. 1A shows an embodiment of FIG. 1, FIG.

FIGS. 2 to 4 schematically show the process of discharging the substances;

5 shows a further embodiment variant,

6 shows a discharge device with a leveling device,

6A shows a detail enlargement of FIG. 6,

Fig. 7 shows a variant with an integrated mixer, ^"~

7A shows a detail enlargement of FIG. 7, 8-10 show a perspective view of another embodiment in section and in the closed position,

11-14 show further embodiments,

15 shows in a section along line XV-XV of FIG. 14 a variant of a chamber surface,

FIG. 16 shows a further variant of the blister part with a tablet container in a section according to line XVI-XVI in FIG. 17, FIG.

FIG. 17 shows the discharge device of FIG. 16 from above,

Figure 18 shows a further shaping of the blister pad and the discharge parts, and

Figure 19 shows a perspective view of an embodiment with expandable chambers.

In Fig. 1, a first embodiment of a discharge device 1 is shown, which has a film part, hereinafter called Blisterteil 2, with four chambers 3, 4 and 5, 6, which is arranged on a Blisterunterlage 7 such that through channels 8 and 9 interconnected chambers 3, 4 and 5, 6 with seams 8S and 9S are vershrloss ^~ en ^~ . Di ^{~~ ~} ed ^'em' Αustragende chambers 3 and 5 nearer each have a channel 10 and 11 with Auslassnahtstelle 1os IIS and which open into a static mixer 12th Instead of welding, the channels between the chambers or the outlet can also be closed by sealing or by another method, or the two layers - blister part and blister base - be connected to each other. It is important that the suture or closure sites are such that they are resilient in pressure application to the chambers such that the contents of one chamber can be transferred to the other chamber. As a rule, this happens because the seams separate from the blister base. But it could also be, for example, detachable welding or splices in the channels. The following is an example of all sorts of seams in channels that release under pressure to give a passage.

When using the discharge device, d. H. in the application of pressure on the chambers 4 and 6, the seams 8S and 9S are released from the pad and the contents of the chambers 4 and 6 enters the chambers 3 and 5. Upon further application of pressure to the chambers 3 and 5 reach the already vorgemisehten Substances via the dissolved outlet 1OS and IIS into the mixer 12.

The blister pad 7 close in the present

Embodiment two discharge parts 13 and 14, which may be formed as the blister pack also as a molded part and which are connected via joints 15, and 16 with the blister pad, and first discharge 13. The exree questioning part ^" T3 ^" has a ^" Ve ^' rri ^' egelungsknöpf 17 which fits into a corresponding opening 18 in the blister part 2 and blister pad 7. iD ~~

2 to 4, the individual discharge steps are shown, wherein in Fig. 2, the two discharge parts 13 and 14 are first folded over the hinge 15 and the hinge 16, then the first discharge part 13 on the two with respect to the rear mixer Chambers 4 and 6 is pressed, whereby the components from these chambers get over the now yielding seams in the front chambers 3 and 5 and the locking button 17 engages, whereupon the second discharge part 14 is folded down about hinge 16 to the two mixed substances from the Press chambers 3 and 5 into and through the mixer via the likewise yielding outlet seams 1OS and IIS.

The folding of the discharge parts and their depression can be done either by hand or via a dispensing device, which is designed to receive the discharge and fold the discharge and depress. But it is also possible to use a dispenser that acts directly and sequentially on the chambers.

In Fig. IA an embodiment of the chambers 20, 21 and 22, 23 is shown, in which these chambers taper towards the outlet end in order to allow the most uniform and complete discharge.

In Fig. 5 is shown by way of example, that the chambers may have different dimensions, the chambers 24 and 25 of blister 28 are smaller than the zereimeteir ge-vorhergehend- and ^{" 'also' smaller"} than ^"" dϊe ^{~ "äήderen" ~} Chambers 26 and 27 and also may have another shape. The remaining parts of this discharge device are the same as shown in FIG. 1. In Figs. 6 and 6A, a discharge device 29 is provided with a leveling device 30, as described, for example, in WO2004 / 100854 of the same Applicant. In Fig. 6 and in the detail enlargement 6A, only a few essential elements of the device are described, wherein the remaining parts may be as previously described. It is the blister part 31 with the chambers 32 and 33, the channels 34 and 35 with the seams 34S and 35S, the blister pad 7 and the two

Discharge parts 13 and 14 plotted, wherein FIG. 6 in deviation from FIG. 1 is a view from below, d. H. on the blister pad 7 is. The blister pad includes an outlet portion 43 having the outlets 43A and 43B. Between the blister channels 34 and 35 and the outlets 43A and 43B are each a throttle or drop images in the form of a narrow transition channel 35 D. This makes it possible to form individual drops. This is necessary in the case of too high a pressure to prevent spewing of the low-viscosity components.

In Fig. 6A can be seen the level-compensating device 30 with the two balancing chambers 36 and 37 and the filter 38 and the input part 3OE, as described in the aforementioned WO application by the same applicant. The

Compensating device makes it possible to ensure that existing air can escape and any level differences are compensated before a mixer is put on. It is first discharged until ^■ ent ^"both" Compon ^{~: ~ s' ~ ~} irr the ^"off" greichsKammerh ^"siclrEbaf" are ^~ can, after which the level-compensating device removed and mounted a mixer. The use of such a level-compensating device requires the use of a separate mixer, as shown enlarged in Fig. 7A, wherein the mixer 39 has a locking member 40 with paragraph 41, one or more five catch 42 of the Auslasteil 43 of

Blisterunterlage the discharge device 44 engages behind. As a result, the connection between the mixer and blister pad is removable only when parts of the device are destroyed. The outlet part likewise has the transition duct 35D, which opens into the outlet 43A or 43B.

However, the mixer inlet part and the outlet part of the discharge device can also be designed such that the mixer can be detachably mounted.

The blister pad 45 of the device 44 of FIGS. 7 and 7A has, for each outlet channel 10 and 11 or 35, a hydrophobic filter 46 incorporated in an opening 20. The hydrophobic filter allows the air contained in the system to escape prior to discharge, with the components flowing around the filter as if in a bypass after the channel junctions have been released again.

With the exemplary embodiment according to FIGS. 8 to 10, a simple filling of the blister chambers after connecting the blister part to the base is possible. In the view of the pad according to FIGS. 8 and 10, the device 47 contains a blister pad 48, the four filling passages

-30- -.. 49A ^ D ^"" aufweist7 d ^"hr" for ^{"j ~ ny"} comber ^"a" Be ^{'fülϊurigs-} passage. After joining the blister part 50 to the blister pad 48 by welding, sealing or the like method, the chambers through the Filling passages 49A-D filled and closed with the fastened to tabs 52A-D closures 5IA-D, as shown in FIG. 10 can be seen. But it is also possible to use separate closures and it does not necessarily need a filling passage for each chamber

FIGS. 11 to 13 show a small section of the possible great variety of variations. In Fig. 11, the discharge device 53 has two adjacent chambers 55 and 56, which require only one discharge part 54 in order to discharge the material from the two chambers 55 and 56.

In Figures 1, 12 or 13, the chambers are arranged in two rows, one row having two or three adjacent chambers, and two rows being arranged one behind the other with respect to the outlet, resulting in two or three columns. It is obvious that both the number of chambers in a row and the number of chambers in a column can vary, i. can be more than three, or two. For each row a discharge part is necessary, which is connected via a joint with another discharge part or with the blister pad.

The discharge devices 57 and 59 according to FIGS. 12 or 13, it is possible, the device analogue according to FIG. 1 to discharge, where the components of the rear chambers reach the anterior chambers, and then completely through the ^{"ECN ~~ ~ ~} Aete 58Ä, ^"5" 8B, ^"5" 8CTmIt the Aüslass ^{"-_Nrähfsteiren"} 58 ^{'S ~ by'} to be discharged to the mixer. in figures 12 and 13, two lock buttons are indicated 17 and 17A, in which openings 18 and 18A are pluggable. In FIG. 14, starting from FIG. 1, it is shown that the mixer 60, or its housing, can be formed integrally with the blister pad 61 of the device 62. The remaining elements may be as shown in FIG. 1, 13 or as any of the other figures.

With regard to the forms of the chambers, it can be seen that a great diversity is conceivable. Instead of square, oval or tapered chambers, for example, round chambers can be used. The tapered shape of the chambers 55 and 56 of FIG. 11 ensures that a more uniform discharge of the substances is ensured.

Often, it is advantageous to allow for volume balance by partially folding or concave-forming the upstream chambers on the film side with respect to the mixer in order to be filled when the contents are transferred from the back to the front chambers. In this case, in the latter case, as shown in Figure 15, the previously concave point 77K of the front chamber 77 is pushed out to then become convex, resulting in an increase in volume. Needless to say, the material of the blister part must be selected accordingly

Another increase in volume is shown in Figure 19, in which the blister 70 of the discharge apparatus 69 with respect to the rear outlet chambers 72 and 74 and two front chambers 71 and 73 of --Blis1rerte ± l ^~ 70 ^~ au ^~ fwelst ^{' "who"} äüf ^"" Bϊiste ^' ruήΕTerTage ^' T are attached. The front chambers 71 and 73 have annular zones 75, 76, respectively, the inside of which is weaker with the blister pad as in the case of the seams sealed, welded or glued, so that the inside of the zones dissolves when transferring the contents of the rear chambers in the front chambers and allows an increase in volume of the front chambers. The width of the annular zone depends on the desired volume increase.

A further variant of the blister part 82 is shown in FIGS. 16 and 17, wherein a container 78 is arranged in a front chamber or in the front chamber (m) 80, in which a tablet 79, for example in the form of a lyophilisate, can be introduced dissolves in the fluid coming from the posterior chamber. The container in the chamber may be shaped to receive the tablet, but not so closed as to prevent the inflowing liquid from reaching the tablet.

The edge of the Behätnis can also be connected to the blister pad to close the container. In this case, the edge of the container must be connected to the base in such a way that, like the sealed channels 83, it separates between the chambers 84 and between the chambers 80 and the outlet upon penetration of the liquid and releases the tablet.

Contains a discharge device with chambers whose volume increases upon entry of liquid and / or at least one ^{"^ iritegrrertes'} TäbTe ^{'t' tenbehallϊnrs", "is} also advantageous without the corresponding mixer. For better handling of the device when discharging by hand, according to Figure 18 on the blister pad 66 and on the discharge, or on the discharge parts 67 and 68 of the discharge 65, recesses 63 and 64 are attached as finger pads to the fingers to the optimal Positions to position.

It will be understood from the description that the devices described are particularly advantageous for single-dose medical applications, but may be used in, for example, dental technology or industry where only small amounts of, for example, adhesive are used. This is especially true for systems whose components are not long-term stable and need to be premixed or dissolved just before use, before they can be mixed and discharged. All applications have in common that no plug is required, even if a mixer is used.

Claims

claims 1. A multi-component discharge device for liquid and powdery substances, comprising a blister part (2, 19, 28, 31, 50, 70, 81) with at least two juxtaposed, closed by a film chambers (3-6, 20-23, 24 - 27, 32, 33, 55, 56, 71, 74, 77, 80) and a blister pad (7, 45, 61, 66) having at least one discharge member (13, 14, 67, 68) acting on the chambers, wherein between downstream chambers and / or between the channels (8, 9; 10, 11; 34, 35; 58A, 58B, 58C; 83, 84) closed at the outlet and the outlet, or channels with seams (8S, 9S; 1S, HS, 34S, 35S, 58S) and the blister portion is secured to the blister pad such that the closed locations or seams are compliant upon pressure on the chambers such that the material can pass therethrough, characterized in that the dispensing device ( 1; 29; 44; 47; 53; 57; 59; 62; 65; 69; 82) includes a static mixer (12; 39,60) Senior Citizen. 2. Discharge device according to claim 1, characterized in that the mixer (12) is removably attached to the blister pad (7). 3. Discharge device according to claim 1, characterized in that the mixer (39) is not detachably attached to the blister pad (45). ^""" 4 ^" . ^The conveyor according to claim 1, characterized in that the mixer (60) is made in one piece with the blister base (61). 5. Discharge device according to one of claims 1 to 4, characterized in that the blister part of the discharge device (53) has two chambers (55, 56) and a discharge part (54). 6. Discharge device according to one of claims 1 to 5, characterized in that the blister part (2, 28, 31, 50) of the discharge device (1, 29, 44, 47, 57, 59) at least two with respect to the outlet arranged one behind the other A series of chambers (3, 5, 4, 6), each row containing at least one chamber and successively from discharge members (13 and 14) are acted upon and the discharge parts with each other and with the blister pad articulated (15, 16) are connected. 7. Discharge device according to one of claims 1 to 4 or 6, characterized in that the blister pad (7) and the blister pad next discharge part (13) at least one locking means (17, 17 A, 18, 18 A). 8. Discharge device according to one of claims 1 to 7, characterized in that the chambers are approximately rectangular (3-6, 24, 25) or square 26, 27), or tapering towards the outlet (20-23 / 55, 56 ) or are formed round. 9. Discharge device according to one of claims 1 to 8, characterized in that respect to the outlet 7 ^~ 3f ^{~ are} connected to the blister pad (7) via ^" annular zones ^" (75, 76), the connection between the zone inside and the blister pad being transferred from the material to the blister pad back in the front chambers of the blister pad is detachable to increase the volume of the anterior chambers. 10. Discharge device according to one of claims 1 to 8, characterized in that the surface of the chamber (80) on the film side a concave point (77K), or the chamber is folded on the film side to effect an increase in volume during filling. 11. Discharge device according to one of claims 1 to 10, characterized in that chambers of the blister pad (48) have filling passages (49A-D) which are closable by a respective closure (51A-D) arranged on the blister pad or with a separate closure part. 12. Discharge device according to one of claims 1 to 11, characterized in that it further comprises a dispensing device which is adapted to fold the discharge parts and to press on the rows of chambers. 13. Discharge device according to one of claims 1 to 11, characterized in that it further comprises a discharge device, which is designed to act directly and successively on the rows of chambers. 14. Discharge device according to one of claims 1 to 13, characterized in that the blister pad (45) at least ^{^} a hydrophobic ^" filter (46). 15. Discharge device according to one of claims 1 to 14, characterized in that at the outlet (30E) a filling level Compensating device (30) can be connected, wherein the level-compensating device has at least two compensation chambers (36, 37). 5 16. Discharge device according to one of claims 1 to 15, characterized in that in front of the mixer means (35D) are provided, which serve the separation of drops. 17. Discharge device according to one of claims 1 to 16, 10, characterized in that on the blister pad (66) and on the discharge part, or the discharge parts (67, 68) of the discharge device (65), recesses (63, 64) as finger pads are attached. 18. Dispensing device according to one of claims 1 to 17, characterized in that at least one of the front chambers (80) contains a container (78) for storing a further component (79) which is arranged such that when discharging liquid in the Get hold of the container 2.0 can to resolve the component. 19. Multi-component discharge device for liquid and powdery substances, with a blister part (81) arranged with at least two side by side, by means of a 25 film sealed chambers (80) and a blister pad (7) with at least one acting on the chambers discharge part, wherein between subordinate chambers and / or between the last with respect to the outlet chambers and the outlet closed channels (83, 84) or channels with -30 - Sewing ^" eir ^~ ang ^~ eö ^" rdnet ^" are ^" and ^" πääs ^"" BTisterteϊl ^{" is} mounted on the blister pad such that the closed areas or seams are yielding to pressure on the chambers such that the material pass through can, characterized in that at least one of the front chambers (80) is adapted to change the volume under the action of an incoming liquid. 20. Discharge device according to claim 19, characterized in that the at least one front chamber (80) contains a container (78) for storing a further component (79), which is arranged such that when discharging liquid can enter the container to to dissolve the component. 21. Discharge device according to claim 19 or 20, characterized in that the front relative to the outlet chambers (71, 73) via annular zones (75, 76) are connected to the blister pad (7), wherein the connection between the zone inside and the blister pad when transferring the material from the rear to the front chambers of the blister pad is releasable to increase the volume of the front chambers. 22. Discharge device according to one of claims 19 to 21, characterized in that the surface of the chamber 80) on the film side has a concave location (77K), or the chamber is folded on the film side to cause an increase in volume during filling.