EP1670901A4 - Procede de differentiation in vitro de cellules souches neuronales, de neurones moteurs et de neurones de dopamine provenant de cellules souches embryonnaires de primates - Google Patents

Procede de differentiation in vitro de cellules souches neuronales, de neurones moteurs et de neurones de dopamine provenant de cellules souches embryonnaires de primates

Info

Publication number: EP1670901A4
Authority: EP; European Patent Office
Prior art keywords: stem cells; neurons; vitro differentiation; primate embryonic; embryonic stem
Prior art date: 2003-08-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP04782339A

Other languages

German (de)

English (en)

Other versions

EP1670901A2 (fr

Inventor

Su-Chun Zhang

James A Thomson

Ian David Duncan

Xue-Jun Li

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Wisconsin Alumni Research Foundation

Original Assignee

Wisconsin Alumni Research Foundation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-08-29

Filing date

2004-08-27

Publication date

2007-09-05

2004-08-27 Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation

2006-06-21 Publication of EP1670901A2 publication Critical patent/EP1670901A2/fr

2007-09-05 Publication of EP1670901A4 publication Critical patent/EP1670901A4/fr

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0619—Neurons
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0623—Stem cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
- C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/44—Thiols, e.g. mercaptoethanol
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/46—Amines, e.g. putrescine
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/90—Polysaccharides
- C12N2501/91—Heparin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

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Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Zoology (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Neurology (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Microbiology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Cell Biology (AREA)
Developmental Biology & Embryology (AREA)
Animal Behavior & Ethology (AREA)
Reproductive Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Gynecology & Obstetrics (AREA)
Psychology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

EP04782339A 2003-08-29 2004-08-27 Procede de differentiation in vitro de cellules souches neuronales, de neurones moteurs et de neurones de dopamine provenant de cellules souches embryonnaires de primates Withdrawn EP1670901A4 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US49883103P	2003-08-29	2003-08-29
US49957003P	2003-09-02	2003-09-02
PCT/US2004/027841 WO2005021720A2 (fr)	2003-08-29	2004-08-27	Procede de differentiation in vitro de cellules souches neuronales, de neurones moteurs et de neurones de dopamine provenant de cellules souches embryonnaires de primates

Publications (2)

Publication Number	Publication Date
EP1670901A2 EP1670901A2 (fr)	2006-06-21
EP1670901A4 true EP1670901A4 (fr)	2007-09-05

Family

ID=34278616

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP04782339A Withdrawn EP1670901A4 (fr)	2003-08-29	2004-08-27	Procede de differentiation in vitro de cellules souches neuronales, de neurones moteurs et de neurones de dopamine provenant de cellules souches embryonnaires de primates

Country Status (8)

Country	Link
EP (1)	EP1670901A4 (fr)
JP (2)	JP2007503811A (fr)
KR (2)	KR20060115351A (fr)
AU (1)	AU2004269361B2 (fr)
CA (1)	CA2536588C (fr)
GB (1)	GB2421029B (fr)
IL (2)	IL173832A (fr)
WO (1)	WO2005021720A2 (fr)

Families Citing this family (28)

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US8153424B2 (en)	2001-10-03	2012-04-10	Wisconsin Alumni Research Foundation	Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells
US7588937B2 (en)	2001-10-03	2009-09-15	Wisconsin Alumni Research Foundation	Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells
US7632679B2 (en)	2002-07-16	2009-12-15	The Trustees Of Columbia University In The City Of New York	Systems and methods for screening for modulators of neural differentiation
JP4792290B2 (ja) *	2005-12-27	2011-10-12	財団法人東京都医学総合研究所	神経幹細胞の製造方法
AU2007257594B2 (en)	2006-03-07	2012-11-01	Geeta Shroff	Compositions comprising human embryonic stem cells and their derivatives, methods of use, and methods of preparation
KR100838013B1 (ko) *	2006-06-07	2008-06-12	제일약품주식회사	인간배아줄기세포로부터 단계적 선별법을 통해 고수율로신경전구세포, 신경세포 및 기능성 도파민신경세포를생성하는 방법
US8481313B2 (en)	2008-04-22	2013-07-09	Regenerative Research Foundation	Retinal pigment epithelial stem cells
KR101168053B1 (ko) *	2009-11-06	2012-07-24	연세대학교 산학협력단	효율적이고 보편적인 전분화능 줄기세포의 신경세포 분화 유도방법
WO2012013936A1 (fr)	2010-07-30	2012-02-02	Cambridge Enterprise Limited	Corticogénèse de cellules pluripotentes humaines
EP2694644B1 (fr)	2011-03-30	2018-01-24	Cellular Dynamics International, Inc.	Amorçage de cellules souches pluripotentes pour la différentiation neurale
JP6015112B2 (ja) *	2012-05-11	2016-10-26	株式会社ニコン	細胞評価装置、細胞評価方法およびプログラム
EP4220360B9 (fr) *	2015-11-12	2024-10-16	F. Hoffmann-La Roche AG	Oligonucléotides pour induire l'expression de paternal ube3a
WO2017123806A1 (fr)	2016-01-12	2017-07-20	Cedars-Sinai Medical Center	Procédé de suivi non destructeur de processus biologiques dans des systèmes de culture de tissu microfluidiques
EP3411472A4 (fr)	2016-02-01	2020-01-22	Cedars-Sinai Medical Center	Systèmes et procédés de mise en croissance de cellules intestinales dans des dispositifs microfluidiques
JPWO2017209290A1 (ja) *	2016-06-03	2019-04-11	国立大学法人京都大学	多能性幹細胞由来運動ニューロンの製造及びその用途
JP6376196B2 (ja) *	2016-09-29	2018-08-22	株式会社ニコン	細胞評価装置、細胞評価方法およびプログラム
WO2018140647A1 (fr)	2017-01-25	2018-08-02	Cedars-Sinai Medical Center	Induction in vitro de différenciation de type mammaire à partir de cellules souches pluripotentes humaines
US11767513B2 (en)	2017-03-14	2023-09-26	Cedars-Sinai Medical Center	Neuromuscular junction
US11414648B2 (en)	2017-03-24	2022-08-16	Cedars-Sinai Medical Center	Methods and compositions for production of fallopian tube epithelium
CN108048399B (zh) *	2017-11-13	2021-03-23	昆明医科大学	一种meth诱导树鼩多巴胺神经元原代细胞自噬的方法
JP2019106895A (ja) *	2017-12-15	2019-07-04	インダストリー‐ユニバーシティーコーぺレーションファンデーションハンヤンユニバーシティ	神経幹細胞または神経前駆細胞からドーパミン神経細胞への分化方法
EP3768823A4 (fr)	2018-03-23	2022-03-09	Cedars-Sinai Medical Center	Procédés d'utilisation de cellules des îlots pancréatiques
WO2019195800A1 (fr)	2018-04-06	2019-10-10	Cedars-Sinai Medical Center	Nouvelle technique de différenciation pour générer des neurones dopaminergiques à partir de cellules souches pluripotentes induites
WO2019195798A1 (fr) *	2018-04-06	2019-10-10	Cedars-Sinai Medical Center	Modèles de maladie neurodégénérative dérivés de cellules souches pluripotentes humaines sur une puce microfluidique
WO2019236082A1 (fr) *	2018-06-06	2019-12-12	The Regents Of The University Of California	Compositions de cellules souches neurales et procédés de traitement de troubles neurodégénératifs
JP6798533B2 (ja) *	2018-07-26	2020-12-09	株式会社ニコン	細胞評価装置、インキュベータおよびプログラム
KR20220052946A (ko) *	2019-09-06	2022-04-28	각고호우징 게이오기주크	글리아 전구 세포를 포함하는 세포 응집체의 제조 방법
JP7235027B2 (ja) *	2020-11-16	2023-03-08	株式会社ニコン	細胞評価装置、インキュベータおよびプログラム

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WO2001083715A2 (fr) *	2000-05-01	2001-11-08	THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the Secretary,	Derivation de neurones dopaminergiques du mesencephale de cellules souches embryonnaires
WO2001088104A2 (fr) *	2000-05-17	2001-11-22	Geron Corporation	Populations de progeniteurs neuronaux
US20030068819A1 (en) *	2001-10-03	2003-04-10	Su-Chun Zhang	Method of in vitro differentiation of transplantatable neural precursor cells from primate embryonic stem cells

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2004
- 2004-08-27 EP EP04782339A patent/EP1670901A4/fr not_active Withdrawn
- 2004-08-27 WO PCT/US2004/027841 patent/WO2005021720A2/fr active Application Filing
- 2004-08-27 GB GB0605851A patent/GB2421029B/en not_active Expired - Lifetime
- 2004-08-27 JP JP2006524872A patent/JP2007503811A/ja not_active Withdrawn
- 2004-08-27 KR KR1020067004226A patent/KR20060115351A/ko not_active Application Discontinuation
- 2004-08-27 KR KR1020087028900A patent/KR20080109943A/ko not_active Application Discontinuation
- 2004-08-27 AU AU2004269361A patent/AU2004269361B2/en not_active Expired
- 2004-08-27 CA CA2536588A patent/CA2536588C/fr not_active Expired - Lifetime
2006
- 2006-02-20 IL IL173832A patent/IL173832A/en active IP Right Grant
2009
- 2009-04-28 IL IL198450A patent/IL198450A/en active IP Right Grant
2010
- 2010-01-28 JP JP2010017013A patent/JP5529561B2/ja not_active Expired - Lifetime

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WO2001088104A2 (fr) *	2000-05-17	2001-11-22	Geron Corporation	Populations de progeniteurs neuronaux
US20030068819A1 (en) *	2001-10-03	2003-04-10	Su-Chun Zhang	Method of in vitro differentiation of transplantatable neural precursor cells from primate embryonic stem cells

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LI X ET AL: "Differentiation of human embryonic stem cells into motoneurons.", SOCIETY FOR NEUROSCIENCE ABSTRACT VIEWER AND ITINERARY PLANNER, 2003, 33RD ANNUAL MEETING OF THE SOCIETY OF NEUROSCIENCE; NEW ORLEANS, LA, USA; NOVEMBER 08-12, 2003, pages ABSTRACT NO. 347.7, XP009087528, Retrieved from the Internet <URL:http://sfn.scholarone.com> [retrieved on 30070730] *
LI XUE-JUN ET AL: "Specification of motoneurons from human embryonic stem cells", NATURE BIOTECHNOLOGY, vol. 23, no. 2, February 2005 (2005-02-01), pages 215 - 221, XP009087451, ISSN: 1087-0156 *
MUJTABA T ET AL: "Lineage-restricted neural precursors can be isolated from both the mouse neural tube and cultured ES cells", DEVELOPMENTAL BIOLOGY, ACADEMIC PRESS, NEW YORK, NY, US, vol. 214, no. 1, 1 October 1999 (1999-10-01), pages 113 - 127, XP002216609, ISSN: 0012-1606 *
See also references of WO2005021720A2 *
YAN YIPING ET AL: "Directed differentiation of dopaminergic neuronal subtypes from human embryonic stem cells", STEM CELLS (MIAMISBURG), vol. 23, no. 6, June 2005 (2005-06-01), pages 781 - 790, XP009087442, ISSN: 1066-5099 *

Also Published As

Publication number	Publication date
JP2010162024A (ja)	2010-07-29
CA2536588C (fr)	2018-04-24
JP5529561B2 (ja)	2014-06-25
GB0605851D0 (en)	2006-05-03
JP2007503811A (ja)	2007-03-01
IL198450A (en)	2011-01-31
IL173832A (en)	2011-02-28
IL173832A0 (en)	2006-07-05
AU2004269361A1 (en)	2005-03-10
AU2004269361B2 (en)	2010-05-20
WO2005021720A2 (fr)	2005-03-10
EP1670901A2 (fr)	2006-06-21
GB2421029A (en)	2006-06-14
CA2536588A1 (fr)	2005-03-10
KR20060115351A (ko)	2006-11-08
WO2005021720A3 (fr)	2005-05-19
GB2421029B (en)	2008-04-09
KR20080109943A (ko)	2008-12-17

Publication	Publication Date	Title
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