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EP1651036A1 - Hochkonzentrierte topische pyrethroidhaltige insektizide - Google Patents

Hochkonzentrierte topische pyrethroidhaltige insektizide

Info

Publication number
EP1651036A1
EP1651036A1 EP04779925A EP04779925A EP1651036A1 EP 1651036 A1 EP1651036 A1 EP 1651036A1 EP 04779925 A EP04779925 A EP 04779925A EP 04779925 A EP04779925 A EP 04779925A EP 1651036 A1 EP1651036 A1 EP 1651036A1
Authority
EP
European Patent Office
Prior art keywords
insecticide
preparation
group
insecticidal
insecticidal preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP04779925A
Other languages
English (en)
French (fr)
Inventor
Ian Cottrell
Albert Ahn
Richard Fisher
Christine M. Monro
Pierre R. Joseph
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Summit VetPharm LLC
Original Assignee
Hartz Mountain Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hartz Mountain Corp filed Critical Hartz Mountain Corp
Publication of EP1651036A1 publication Critical patent/EP1651036A1/de
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof

Definitions

  • the invention relates generally to insecticides and more particularly to a topical insecticide, such as one suitable to use on house pets such as dogs.
  • insecticide when the animal is a house pet, there is a further complication in that the insecticide should be safe for human contact. It should also not lead to staining of furniture, carpeting and the like. Finally, even if safe, topical insecticides for house pets should not be irritating or lead to rashes, hair loss or exhibit other unpleasant side effects.
  • a topical insecticide particularly one for use on pets, especially dogs.
  • Formulations in accordance with the invention can be safe to use and can avoid many common deleterious side effects of conventional topical insecticides.
  • the invention provides a topical insecticide which contains a combination of insecticides and insect growth regulators which can be effective to kill fleas, flea eggs, flea larvae, ticks, tick eggs, tick larvae and tick nymphs.
  • the selection of the combination of insecticides and insect growth regulators produces an insecticide having high insecticidal activity while allowing for a lower total amount of insecticide to be applied to the animal, compared to the effectiveness and amount required of the individual insecticides when used alone to achieve the same kill rate.
  • the compositions derived herein can also be useful to improve the speed of result and decrease the reoccurrence, compared to other formulations.
  • the invention can provide an insecticidal composition which contains a combination of a first insecticide component in an insecticidally effective amount to achieve at least, e.g., an 80%, preferably 90% kill rate for fleas, a second insecticide component in an insecticidally effective amount to achieve at least, e.g. an 80%, preferably 90% kill rate for ticks, and a growth regulating effective amount of an insect growth regulator (IGR).
  • the second insecticide is not a neo-nicotinoid, which is considered only effective against fleas.
  • the combination of the two insecticide components and the insect growth regulator increases the effectiveness of the first and second insecticide compared to the effectiveness of the first and second insecticides when used alone and reduces the effective amount of the first and second insecticide compared to the effective amount of the first and second insecticide when used alone.
  • at least one of the two insecticide components in the composition is a pyrethroid and in other preferred embodiments, the first and second insecticide components in the composition are pyrethroids.
  • the first insecticide component in the composition comprises permethrin
  • Alternative embodiments of the invention can include cyphenothrin or fenpropathrin.
  • the second insecticide component comprises a (tetrahydro-3- furanyl)methylamine derivative of formula (1), identified below.
  • an active ingredient e.g., permethrin
  • the identification of an active ingredient, e.g., permethrin is intended to also refer to other pharmaceutically active forms of the active ingredient, such as esters, salts, hydrochlorides, acid or base forms, isomers and so forth.
  • the first insecticide component comprises permethrin or phenothrin.
  • the second insecticide component comprises a chloronicotinyl insecticide, preferably acetamiprid.
  • Other chloronicotinyl insecticides that can be utilized in the insecticide formulation include, but are not limited to nitenpyram and imidacloprid, thiamethoxam, and clothianidin.
  • the first insecticide component comprises permethrin or phenothrin
  • the second insecticide component comprises dinotefuran, acetamiprid, nitenpyram, imidacloprid, or bifenthrin.
  • the second component is advantageously in combination with an isoparaffinic solvent such as Isopar®, available commercially from EXXON and/or tripropylene glycol methyl ether (TPM), dipropylene glycol methyl ether, propylene glycol methyl ether, ethyl lactate, propylene carbonate and/or safflower oil.
  • Isopar® isoparaffinic solvent
  • the second insecticide is dinotefuran
  • Isopar and safflower oil are preferably not included in the solvent solution.
  • the first and second insecticides can be stored separately from each other in a package or container having two associated, preferably attached, but individual chambers to prevent the mixing of the insecticides prior to the administration of the formulation. Prior to administration, the packages containing the two insecticides in their respective separate chambers are opened, and the two insecticides are dispensed simultaneously or at least at about the same time, to the animal.
  • the insect growth regulator in the composition is pyriproxyfen or methoprene.
  • the insect growth regulator is packaged in the same chamber as either the first insecticide or the second insecticide or in yet another container.
  • Pyriproxyfen or methoprene are insecticides that act as an insect growth inhibitor (IGR) by preventing flea eggs from hatching.
  • IGR insect growth inhibitor
  • triphenyl phosphate (TPP) is added to the insecticide composition, preferably in an amount less than the insecticidally effective amount of the first and second insecticide in the composition.
  • Triphenyl phosphate can be packaged in the same container as either the first insecticide or the second insecticide.
  • the selection of the chamber depends on the solvent in which the insecticide is solubilized. [0015] Accordingly, it is an object of the invention to provide an improved topical insecticide composition that is highly effective against fleas, flea larvae, flea eggs, and ticks. [0016] Another object of the invention is the provision of methods for controlling insect infestation.
  • Another object of the invention is to provide a topical insecticide that works more rapidly and/or more permanently than other insecticides.
  • insecticidal compositions which contain a combination of insecticides and insect growth regulators effective to kill fleas and ticks, including flea eggs, flea larvae, and adult fleas and ticks, tick eggs, tick larvae and tick nymphs, are provided.
  • insecticides that are highly effective against fleas and combining them with insecticides that are highly effective against ticks, the total amount of insecticide is optimized.
  • compositions containing permethrin in accordance with the invention are particularly advantageous for use on dogs, compared to their use on cats.
  • the insecticidal compositions in accordance with the invention comprise a combination of a first insecticide component in an insecticidally effective amount to preferably achieve at least an 80% kill rate for fleas, a second insecticide component in an insecticidally effective amount to preferably achieve at least an 80% kill rate for ticks, and an insecticidally effective amount of an insect growth regulator (IGR).
  • IGR insect growth regulator
  • the combination of the first and second insecticide components with an insect growth regulator advantageously results in an insecticidal composition having a higher insecticidal activity against fleas, flea larvae, flea eggs and ticks compared to a composition containing either the first or second insecticide or the insect growth regulator alone.
  • the first insecticide component in the composition is in an insecticidally effective amount to achieve at least an 80% kill rate for fleas, more preferably at least a 90% kill rate for fleas, even more preferably at least a 95% kill rate for fleas, and most preferably, at least a 99% kill rate for fleas.
  • the second insecticide component in the composition is in an insecticidally effective amount to achieve at least an 80% kill rate for ticks, more preferably at least a 90% kill rate for ticks, even more preferably, at least a 95% kill rate for ticks, and most preferably, at least a 99% kill rate for ticks.
  • the first and second insecticide components in the composition are not the same insecticide and at least one of the two insecticides in the composition is a pyrethrin or a synthetic pyrethroid. In other preferred embodiments of the invention, the first and second insecticide components in the composition are both pyrethroids. It should of course be understood that additional pyrethroids or non- pyrethroid insecticides can also be included.
  • the first insecticide component is a pyrethroid
  • the second insecticide component is a neo-nicotinoid.
  • the first insecticide component in the composition comprises a pyrethroid, preferably permethrin.
  • Other embodiments of the invention include cyphenothrin and/or fenpropathrin as the first insecticide component.
  • the second insecticide component preferably comprises a neo-nicotinoid comprising a (tetrahydro-3-furanyl)methylamine derivative of following formula (1).
  • the (tetrahydro-3- furanyl)methylamine derivatives of the formula (1) have an excellent insecticidal activity even in the absence of a pyridylmethyl group or a thiazolylmethyl group in their molecular structure.
  • Xi, X 2 , X 3 , X 4 , X 5 , X 6 and X 7 each represent each a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms
  • R ⁇ represents a hydrogen atom, an alkyl group having from 1 to 5 carbon atoms, an alkenyl group having 3 carbon atoms, a benzyl group, an alkoxyalkyl group having from 2 to 4 carbon atoms (in its whole group), an alkyloxycarbonyl group having from 1 to 3 carbon atoms, a phenoxy carbonyl group, an alkylcarbonyl group having from 1 to 6 carbon atoms, an alkenylcarbonyl group having from 2 to 3 carbon atoms, a cycloalkylcarbonyl group having from 3 to 6 carbon atoms, a benzoyl group, a benzoyl group substituted by alkyl group(s) having from 1 to 4 carbon atoms, a be
  • X ls X 2 , X 3 , X 4 , X 5 , X 6 and X 7 each represent each a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms; Rio represents an alkyl group having from 1 to 5 carbon atoms or a benzyl group; and Rl 1 represents an alkyl group having from 1 to 5 carbon atoms or a benzyl group.
  • the (tetrahydro-3-furanyl)methylamine derivatives of the formula (1) and formula (2) according to the invention are excellent compounds having a high insecticidal activity and broad insecticidal spectrum. Further, agricultural chemicals containing the (tetrahydro-3- furanyl)methylamine derivatives of formula (1) and (2) according to the invention have outstanding characteristics as insecticides and hence are useful.
  • alkyl group for Xi, X 2 , X 3 , X , X 5 , X 6 and X 7 in the above formulae (1) and (2) include a methyl group, an ethyl group, an n-propyl group, an iso- propyl group, a tert-butyl group, and the like, preferably a methyl group.
  • alkyl group for Ri include a methyl group, an ethyl group, an n-propyl group, an iso-propyl group, an n- butyl group, an iso-butyl group, a sec- butyl group, a tert-butyl group, an n-pentyl group, and the like.
  • alkenyl group for Ri examples include a 1-propenyl group, a 2- propenyl group, and the like.
  • alkoxyalkyl group for Ri examples include a methoxymethyl group, an ethoxymethyl group, an n-propoxymethyl group, an iso-propoxymethyl group, a methoxyethyl group, an ethoxyethyl group, and the like.
  • alkyloxycarbonyl group for Ri examples include a methyloxycarbonyl group, an ethyloxycarbonyl group, an n-propyloxycarbonyl group, an iso- propyloxycarbonyl group, and the like.
  • alkylcarbonyl group for R include a methylcarbonyl group, an ethylcarbonyl group, an n-propylcarbonyl group, an iso-propylcarbonyl group, an n-butylcarbonyl group, an iso-butylcarbonyl group, a sec-butylcarbonyl group, a tert- butylcarbonyl group, an n-pentylcarbonyl group, an n-hexylcarbonyl group, and the like.
  • alkenylcarbonyl group for Rj include a vinylcarbonyl group, a 1-methylvinylcarbonyl group, and the like.
  • cycloalkylcarbonyl group for Rj include a cyclopropylcarbonyl group, a cyclobutylcarbonyl group, a cyclopentylcarbonyl group, a cyclohexylcarbonyl group, and the like.
  • benzoyl group substituted by alkyl group(s) for Rj include a 2-methylbenzoyl group, a 3-methylbenzoyl group, a 4-methylbenzoyl group, a 4- tert-butylbenzoyl group, and the like.
  • benzoyl group substituted by halogen atom(s) for Ri include a 2-chlorobenzoyl group, a 3-chlorobenzoyl group, a 4-chlorobenzoyl group, a 3,4- dichloro-benzoyl group, a 4- fluorobenzoyl group, and the like.
  • R] can take various substituents as described above, it is preferably a hydrogen atom, an alkylcarbonyl group having from 1 to 4 carbon atoms or a cyclopropylcarbonyl group.
  • alkylamino group for R 2 examples include a methylamino group, an ethylamino group, an n-propyl-amino group, an iso-propylamino group, an n- butylamino group, an iso-butylamino group, a sec-butylamino group, a tert-butylamino group, an n-pentylamino group, and the like, preferably a methylamino group.
  • di-substituted alkylamino group for R 2 include a dimethylamino group, a diethylamino group, an N-methyl-N-ethylamino group, an N-methyl-
  • N-n-propylamino group an N-methyl-N-n-butylamino group, and the like, preferably a dimethylamino group.
  • alkenylamino group for R 2 examples include a 1- propenylamino group, a 2-propenylamino group, and the like.
  • alkynylamino group for R 2 examples include a propargylamino group, and the like.
  • alkoxyalkylamino group for R 2 include a methoxymethylamino group, an ethoxymethylamino group, an n-propoxymethylamino group, an iso-propoxymethylamino group, a methoxyethylamino group, an ethoxyethylamino group, and the like.
  • alkyloxycarbonyl group denoted by Yj for R 2 include a methyloxycarbonyl group, an ethyloxy-carbonyl group, an n-propyloxycarbonyl group, an iso-propyloxy-carbonyl group, and the like.
  • alkylcarbonyl group denoted by Y ⁇ for R 2 include a methylcarbonyl group, an ethylcarbonyl group, an n-propylcarbonyl group, an iso- propylcarbonyl group, an n-butylcarbonyl group, an isobutylcarbonyl group, a sec-butyl- carbonyl group, a tertbutylcarbonyl group, an n-pentylcarbonyl group, an n-hexylcarbonyl group, and the like, preferably a methylcarbonyl group, an ethylcarbonyl group, an n- propylcarbonyl group, an iso-propylcarbonyl group, an n-butylcarbonyl group, an isobutylcarbonyl group, a sec-butylcarbonyl group and a tert-butylcarbonyl group.
  • alkenylcarbonyl group denoted by Yi for R 2 include a vinylcarbonyl group, a 1-methyl-vinylcarbonyl group, and the like.
  • cycloalkylcarbonyl group denoted by Yj for R 2 include a cyclopropylcarbonyl group, a cyclobutylcarbonyl group, a cyclopentylcarbonyl group, a cyclo- hexylcarbonyl group, and the like, preferably a cyclopropyl-carbonyl group.
  • benzoyl group substituted byalkyl group(s) denoted by Yi for R 2 include a 2-methylbenzoyl group, a 3-methylbenzoyl group, a 4-methylbenzoyl group, a 4-tert-butylbenzoyl group, and the like.
  • benzoyl group substituted by halogen atom(s) denoted by Yi for R 2 include a 2-chlorobenzoyl group, a 3-chlorobenzoyl group, a 4- chlorobenzoyl group, a 3,4-dichlorobenzoyl group, a 4-fluoro benzoyl group, and the like.
  • alkyl group denoted by Yi for R 2 include a methyl group, an ethyl group, an n-propyl group, an iso-propyl group, an n-butyl group, an iso-butyl group, a sec-butyl group, a tert-butyl group, an n-pentyl group, and the like, preferably a methyl group.
  • compounds in which Ri and Yi are concurrently an alkylcarbonyl group having from 1 to 4 carbon atoms or a cyclopropylcarbonyl group are preferred from the viewpoint of both insecticidal activity and production method.
  • the first insecticide component in the composition comprises a pyrethroid and the second insecticide component comprises a neo-nicotinoid.
  • the first insecticide component comprises cyclopropanecarboxylic acid, 3-(2,2-dichlorethenyl)-2,2-dimethyl-, (3- phenoxyphenyl)methyl ester (permethrin), and the second insecticide component comprises l- ⁇ (tetrahydro-3-furanyl)methyl ⁇ -2-nitro-3-methylguanidine (dinotefuran) or N-((6-chloro-3- pyridiny ⁇ methy ⁇ -N'-cyano-N-methyl-ethanimidanide (acetamiprid).
  • Permethrin is an acaricide that will kill ticks, and dinotefuran and acetamiprid are insecticides that will kill adult fleas.
  • the composition further contains an insect growth regulator, which is preferably pyriproxyfen or methoprene.
  • insect growth regulator which is preferably pyriproxyfen or methoprene.
  • the first insecticide component in the composition comprises 2,2-Dimethyl-3-(2-methyl-l- propenyl)cyclopropanecarboxylic acid, (3-phenoxyphenyl)methyl ester (phenothrin), and the second insecticide component comprises dinotefuran or acetamiprid.
  • Dinotefuran can be dissolved in particularly effective solvent systems such as a combination of water and ethanol or isopropanol, as disclosed in pending U.S.S.N. 10/242,552, incorporated by reference, or in phenyl methanol or ethanol, as disclosed in U.S. Patent 6,588,374, incorporated by reference, or in ethyl lactate and water combinations.
  • the composition further contains an insect growth regulator, which is preferably pyriproxyfen or methoprene.
  • the insecticide compositions of the invention contain a combination of insecticides and insect growth regulators which are effective to kill fleas, flea eggs, flea larvae, ticks, tick eggs, tick larvae and tick nymphs.
  • the selection of the first insecticide component, the second insecticide component and insect growth regulator produces an insecticide having high insecticidal acitivity.
  • the first insecticide component or the second insecticide component is an acaricide, and even more preferred, the first insecticide component or the second insecticide component is permethrin.
  • the insecticide composition may contain one or more acaricides or other physiologically active ingredients.
  • Additional acaricides that may be utilized in the insecticide composition include but are not limited to, the following class of compounds: antibiotic acaricides (nikkomycins, thuringiensin); macrocyclic lactone acaricides (tetranactin); avermectin acaricides (abamectin, doramectin, eprinomectin, ivermectin, selamectin); milbemycin acaricides (milbemectin, milbemycin oxime, moxidectin); bridged diphenyl acaricides (azobenzene, benzoximate, benzyl benzoate, bromopropylate, chlorbenside, chlorfenethol, chlorfenson, chlorfensulphide, chlorobenzilate, chloropropylate, DDT, dic
  • acaricides or other physiologically active substances that may be utilized in the insecticide composition of the present invention are acephate, Bacillus thuringiensis aizawai, Bacillus thuringiensis kurstaki, Beauveria bassiana, Bendiocarb, Bifenthrin, Carbaryl, Chlopyrifos + DDVP, Chlorpyrifos + pyrethrin, Cyfluthrin, Ethoprop, Fenamiphos, Fenoxycarb, Fipronil, Fonofos, Halofenozide, Heterorhabditis bacteriophora, Hydramethylnon, Imidacloprid, Isofenphos, Lambda-cyhalothrin, Lindane, Malathion, Myrothecium verrucaria, Permethrin, Spinosad, and Trichlorfon, Acequinocyl, Acetamiprid, Acibenzolar-S
  • one of the active ingredients for e.g., dinotefuran or permethrin, can be encapsulated or contained in micelles in the formulation.
  • topical formulations can be packaged and stored in a single container prior to administration to the animal.
  • the insecticide composition of the invention is packaged in a single dose package.
  • Single dose containers make storage and disposal more convenient for animal owners.
  • the insecticide composition is packaged in a container encompassing two associated, preferably attached but individual chambers, which are separated by a barrier, preferably plastic, plastic coated paper or metal, such as aluminum foil.
  • the first chamber and the second chamber are plastic tubes that are separate but fused together.
  • the first insecticide preferably permethrin or phenothrin
  • the second insecticide preferably dinotefuran or acetamiprid
  • the first and second chambers are separated by a barrier that prevents the interreaction of the first and second insecticides.
  • an insect growth regulator preferably methoprene or pyriproxfen, is added to the insecticide composition and placed in the same chamber with either the first insecticide or the second insecticide or even separately in yet another container.
  • the entire container containing the two insecticides in separate chambers is sealed, preferably with a tab or top, for use in opening the container prior to administration. After the container is sealed, the insecticide formulation can be safely stored in the container until administration of the insecticide formulation to the animal.
  • the container Prior to administration of the insecticide formulation to the animal, the container is opened by removing the tab or top. In one embodiment of the invention, the container is opened by twisting the tab thereby resulting in breaking or tearing of the barrier separating the two chambers, thereby allowing the two insecticides, preferably permethrin and dinotefuran, to mix prior to administration of the insecticide formulation to the animal. After the two insecticides are mixed, the two insecticides are dispensed simultaneously by squeezing or collapsing the body of the container. A dual plunger system can also be employed to administer the formulation to the animal.
  • the two insecticides need not be mixed together prior to administration of the insecticide formulation to the animal. Accordingly, in another embodiment of the invention, opening of the dual-chamber container does not result in the mixing of the two insecticides. After the container is opened, the two insecticides are dispensed onto the animal by squeezing or collapsing the container or containers, either simultaneously or sequentially. [0065] In one embodiment of the invention, the composition is packaged with instructions, advising to mix the insecticides. In other embodiments of the invention, the instructions will direct the user to mix the insecticides upon application.
  • compositions in accordance with preferred embodiments of the invention have a high concentration of insecticide, a relatively small application of a spot or line on the animal can effectively prevent and control flea and tick infestation on the animal for up to four weeks post-administration.
  • the insecticide formulation is non-toxic and does not irritate the animal's skin.
  • Applications are typically in the range of 0.5 to 10 ml. In certain embodiments of the invention, the compositions are applied in the range of about 0.05 to 0.5 ml/kg of animal body weight.
  • the insecticide composition comprises permethrin in a concentration range of between 40 to 65%, dinotefuran in a concentration range of 5 to 15%, and pyriproxyfen or methoprene in a concentration range of 1 to 3%. All percentages, unless otherwise specified, are on a weight basis. While an effective dosage of the insecticide composition needs to be applied to the animal for optimum effectiveness against fleas, flea eggs, flea larvae and ticks, the active dosages of the first insecticide and second insecticide depend upon the size of the animal. Compositions containing permethrin are particularly advantageous for use on dogs, compared to their use on cats.
  • Such composition will preferably contain at least about 1300 to 2600 mg permethrin, at least about 300 mg dinotefuran, and at least about 20 mg of pyriproxfen.
  • up to 3 ml of insecticide may be administered to a dog weighing
  • Such composition will preferably contain at least about 910 to 1800 mg permethrin, at least about 240 mg dinotefuran, and at least about 16 mg of pyriproxfen.
  • up to 2 J ml of insecticide may be administered to a dog weighing
  • Such composition will preferably contain at least about 455 to 1300 mg permethrin, at least about 210 mg dinotefuran, and at least about 14 mg of pyriproxfen.
  • up to 1.5 ml of insecticide may be administered to a dog weighing
  • the insecticide composition comprises phenothrin, dinotefuran and pyriproxfen.
  • Insecticide compositions containing phenothrin in accordance with the invention are particularly advantageous for use on both dogs and cats.
  • the insecticide composition comprises phenothrin in a concentration range of between 80 to 87%, more preferably approximately 85.7%, dinotefuran in a concentration range of 5 to 15%, and pyriproxyfen or methoprene in a concentration range of 1 to 2%. All percentages, unless other specified, are on a weight basis. The actual amount of the active dosage of phenothrin will vary depending on the size of the dog or cat.
  • the precentage of an active ingredient provided is the percentage of that active ingredient in a single solution.
  • 1 to 2% pyriproxyfen is the concentration of pyriproxfen contained in the formulation in a single chamber rather than the concentration of pyriproxyfen in the total formulation of the combined chambers.
  • up to 1 J ml of total insecticide may preferably be administered to a cat weighing less than 10 pounds and up to 1.5 ml of insecticide may be administered to a cat weighing 10 pounds or more.
  • the volume of phenothrin being administered to a cat is between about 0.25 to 0.85 ml for a cat weighing less than 10 pounds and between about 0J5 and 1.25 ml for a cat weighing 10 pounds or more.
  • a volume of 1.0 ml and 1 J ml, respectively, for a phenothrin containing product is preferred.
  • Insecticide compositions containing phenothrin are also particularly effective for use on dogs.
  • approximately up to 1.5 ml of total insecticide may be administered to a dog weighing under 30 pounds, approximately up to 3.0 ml of total insecticide may be administered to a dog weighing less than 45 pounds, approximately up to 4J ml of total insecticide may be administered to a dog weighing 41-60 pounds, approximately up to 4.6 ml of total insecticide may be administered to a dog weighing 61-90 pounds, and approximately up to 6.0 ml of total insecticide may be administered to a dog weighing over 90 pounds.
  • the amount of phenothrin in the insecticide composition is between 0.3 to 0.9 ml for a dog weighing 4 to 15 pounds, between about 0.25 to 0.85 ml for a dog weighing 16 to 30 pounds, between about 0.65 to 1.95 ml for a dog weighing 31 to 45 pounds, between about 1.0 to 3.0 ml for a dog weighing 46 to 60 pounds, between about 1J5 to 3.45 ml for a dog weighing 61 to 90 pounds, and between about 1.5 to 4.5 ml for a dog weighing more than 90 pounds.
  • the insecticide composition comprises permethrin, acetamiprid and pyriproxyfen.
  • the insecticide composition comprises permethrin in a concentration range of 45 to 65%, acetamiprid in a concentration range of 5 to 50%, and pryriproxfen in a concentration range of 0.5 to 5 %.
  • the insecticide composition comprises phenothrin, acetamiprid and pyriproxyfen.
  • the insecticide composition comprises phenothrin in a concentration range of 5 to 90%, acetamiprid in a concentration range of 5 to 50%, and pryriproxfen in a concentration range of 0.5 to 5%.
  • the insecticidal compositions of the present invention further comprises an enzyme inhibitor or a synergist such as piperonyl butoxide, N- octylbicycloheptenedicarboximide, triphenyl phosphate, which preferably increases the efficacy of the composition.
  • the insecticidal compositions also contain one or more compounds to increase the efficacy and to reduce the irritation of pyrethroid insecticides to the skin of animals.
  • the insecticidal compositions further comprise an effective amount of triphenyl phosphate (TPP) to increase efficacy, typically less than the amount of active ingredient.
  • TPP triphenyl phosphate
  • the amount of TPP to include in the composition relative to the concentration of the first and second insecticide component in the composition can be readily determined using routine experimentation to determine the optimum synergistic effect.
  • TPP triphenyl phosphate
  • the formulation should be stable for one month at 130° F, 110° F, 40° F, room temperature and 0° F. This helps ensure that the formulation remains stable under the conditions that it could meet in commerce.
  • additives to the insecticidal composition include but are not limited to fragrances, surfactants and spreading agents to increase performance such as polysorbate 20 and polysorbate 80, and isopropyl myristate.
  • Polymers such as agar, gelatin, alginate, and cationic polymers such as cationic agar, cationic cellulose, cationic acrylates, and polyoxymethylene urea may also be added to provide enrobing of the insecticide to improve safety and adhesion to skin and hair.
  • an effective amount of the insecticidal compositions as described herein may be applied to a companion animal, preferably a dog, as a foaming shampoo, dip, aerosol spray, pump spray, powder, lotion, emulsifiable concentrate, aqueous or liquid flowable, suspension concentrate and by any other methods suitable for administering topical compositions to animals.
  • the preparations are suitable for combating insect infestations which occur in animal husbandry and animal breeding in productive, breeding, zoo, laboratory, experimental animals and pets, and have a favorable toxicity to warm-blooded animals.
  • Productive and breeding animals include mammals, such as, for example, cattle, horses, sheep, pigs, goats, camels, water buffalo, donkeys, rabbits, fallow deer and reindeer, and pelt animals, such as, for example, mink, chinchilla and raccoons.
  • Laboratory and experimental animals include mice, rats, guinea pigs, hamsters, dogs and cats.
  • Pets include dogs and cats and many of the laboratory and experimental animals.
  • the formulation according to the invention is particularly preferably administered to companion animals such as dogs and cats, but can be suitable for other mammals.
  • a mixture comprising 10.0 g of (tetrahydro-3 -furanyl)methanol, 29. 5 g of trifluoromethanesulfonic anhydride, 10.0 g of pyridine and 200 ml of dichloromethane was stirred for an hour at room temperature. Water was poured into the reaction solution to separate the organic layer, which was washed with 1 N hydrochloric acid, water and a saturated saline solution, dried, and concentrated to obtain 20 g of 3-tetiahydro-furanylmethyl triflate.
  • the resulting solution can be spot applied to companion animals, such as dogs and will kill fleas, ticks and other insects.
  • Permethrin 65 g was added to a clean container.
  • Safflower oil 35 g was added with stirring until the solution was homogeneous. This solution containing permethrin and safflower oil was added to one of the chambers in the package in the appropriate volume based on the dosage required.
  • compositions containing dinotefuran and pyriproxyfen prepared according to the methodology of Example 3 are stable for at least 1 month at 130° F, 3 months at 110° F, 1 month at 40° F and 1 month at room temp, (approx. 70° F).
  • the stability of the formulation is based on the criterion of no crystal formation during a 1 month period.
  • ingredients or compounds recited in the singular are intended to include compatible mixtures of such ingredients wherever the sense permits.

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EP04779925A 2003-08-08 2004-08-03 Hochkonzentrierte topische pyrethroidhaltige insektizide Withdrawn EP1651036A1 (de)

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US49397603P 2003-08-08 2003-08-08
US55456304P 2004-03-19 2004-03-19
PCT/US2004/025004 WO2005015995A1 (en) 2003-08-08 2004-08-03 High concentration topical insecticides containing pyrethroids

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US20050245582A1 (en) 2002-09-12 2005-11-03 The Hartz Mountain Corporation High concentration topical insecticides containing pyrethroids
WO2007127959A2 (en) * 2006-04-28 2007-11-08 Summit Vetpharm, Llc High concentration topical insecticide containing insect growth regulator
MX2008013846A (es) * 2006-04-28 2009-01-20 Summit Vetpharm Llc Insecticidas topicos de alta concentracion que contienen piretroides.
US8871806B2 (en) 2012-06-06 2014-10-28 Sergeant's Pet Care Products, Inc. Methods for preventing flea allergy dermatitis in companion animals
JP5791776B1 (ja) * 2014-05-22 2015-10-07 住友商事株式会社 局所用液状殺虫剤組成物
PT3319599T (pt) 2015-07-10 2022-01-28 Ceva Sante Animale Conjunto de partes que combinam uma combinação de dinotefurano/permetrina/piriproxifeno para uso tópico e milbemicina oxime oral para controlar a propagação da dirofilariose
EP3120846A1 (de) 2015-07-24 2017-01-25 Ceva Sante Animale Zusammensetzungen und verwendungen davon zur bekämpfung von ektoparasiten bei nichtmenschlichen säugern
MX2024000617A (es) * 2021-07-16 2024-02-02 Wellmark Int Collar para pulgas y garrapatas.

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IE80657B1 (en) * 1996-03-29 1998-11-04 Merial Sas Insecticidal combination to control mammal fleas in particular fleas on cats and dogs
US6663876B2 (en) * 2002-04-29 2003-12-16 Piedmont Pharmaceuticals, Llc Methods and compositions for treating ectoparasite infestation

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WO2005015995A1 (en) 2005-02-24
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