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• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
  • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
  • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
  • C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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  • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P25/00—Drugs for disorders of the nervous system
  • A61P25/22—Anxiolytics
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P25/00—Drugs for disorders of the nervous system
  • A61P25/24—Antidepressants
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P25/00—Drugs for disorders of the nervous system
  • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P3/00—Drugs for disorders of the metabolism
  • A61P3/04—Anorexiants; Antiobesity agents
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
  • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
  • C07C211/16—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings other than six-membered aromatic rings
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C2601/00—Systems containing only non-condensed rings
  • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring

Definitions

• the present invention is concerned with sibutramine, N- ⁇ l-[l-(4-chlorophenyl)cyclobutyl]-3- methylbutyl ⁇ -N,N-dimethyl-amine, compositions containing the same and uses thereof.
• Sibutramine has the following structural formula
• sibutramine hydrochloride The synthesis of sibutramine hydrochloride is described in Example 11 of both US 4746680 and US 4806570, wherein crystalline sibutramine hydrochloride is prepared from l-[l-(4- chlorophenyl)cyclobutyl ⁇ -3-methylbutyl-amine free base.
• Sibutramine hydrochloride monohydrate is described in US 4929629, which describes the preparation of sibutramine hydrochloride monohydrate from sibutramine hydrochloride, or from sibutramine free base.
• Examples 12 and 13 of US 4929629 describe preparation of sibutramine hydrochloride monohydrate from sibutramine free base as the starting material, but no teaching is given in Examples 12 and 13 of US 4929629 as to the crystalline or otherwise amorphous nature of the sibutramine free base starting material.
• Sibutramine hydrochloride is a well-known antidepressant drug and is also useful as an anorectic agent, for the treatment of chemical dependencies, anxiety-related disorders and premature ejaculation.
• Sibutramine hydrochloride is a neuronal monoamine reuptake inhibitor and more particularly inhibits the reuptake of norepinephrine and, to a lesser extent, serotonin and dopamine, for example as described by Buckett et al., Prog. Neuro- psychopharm. & Biol. Psychiat, 12:575-584, 1988; and King et al., J. Clin. Pharm., 26:607- 611, 1989.
• sibutramine free base may be obtained as a pure crystalline product, which may easily be handled and conveniently be formulated into tablets and other pharmaceutical forms. Furthermore, it has surprisingly been found that a very good and efficient purification of sibutramine can be obtained during manufacture of sibutramine, for example as the hydrochloride salt, by liberation and crystallisation of sibutramine free base.
• sibutramine free base in crystalline form.
• sibutramine free base in crystalline form having an X-ray diffraction pattern, or substantially the same X-ray diffraction pattern, as shown in Figure 1. More particularly, sibutramine free base, in crystalline form, according to the present invention, can be characterized as having an X-ray diffraction pattern with characteristic peaks (2 ⁇ ): 14.1989, 14.6800, 14.9092, 17.3331, 20.3059 and 24.2082.
• Sibutramine free base, in crystalline form, according to the present invention is preferably more than about 99.5% w/w pure and more preferably more than about 99.8% w/w pure (peak area).
• Sibutramine free base, in crystalline form, according to the present invention is preferably further characterised as having a melting point in the range of about 52-57°C (DSC; open capsule) and DSC characteristics as shown in Figure 2.
• Sibutramine free base, in crystalline form, according to the present invention has therapeutic utility in the inhibition neuronal monoamine reuptake, in particular norepinephrine reuptake and to a lesser extent serotonin and dopamine reuptake.
• Sibutramine free base, in crystalline form, according to the present invention is suitable for inclusion in pharmaceutical compositions for use in the treatment of disease states prevented, ameliorated or eliminated by administration of a neuronal monoamine reuptake inhibitor and is also suitable for use in methods of treating a patient suffering from or susceptible to disease states prevented, ameliorated or eliminated by administration of a neuronal monoamine reuptake inhibitor.
• sibutramine free base, in crystalline form, according to the present invention is useful for treating depression and is also useful as an anorectic agent, for the treatment of chemical dependencies, anxiety-related disorders and premature ejaculation.
• the present invention further provides, therefore, a pharmaceutically acceptable composition for administering to a patient, including humans, suffering from, or susceptible to, a disease state prevented, ameliorated or eliminated by the administration of a neuronal monoamine reuptake inhibitor, which composition comprises a therapeutically effective amount of sibutramine free base, in crystalline form, together with a pharmaceutically acceptable carrier, diluent or excipient therefor.
• terapéuticaally effective amount means an amount of sibutramine free base, in crystalline form, which is capable of preventing, ameliorating or eliminating a disease state for which administration of a neuronal monoamine reuptake inhibitor is indicated.
• composition it is meant that the carrier, diluent or excipient is compatible with sibutramine free base, in crystalline form, and not deleterious to a recipient thereof.
• Sibutramine free base, in crystalline form, according to the present invention has been found to be suitable for formulation into stable solid compositions exhibiting good release properties.
• compositions of the present invention may be administered in any suitable way and in any suitable form, for example orally (preferred) in the form of tablets, capsules, powders or syrups, or parenterally in the form of conventional sterile solutions for injection.
• the pharmaceutical compositions of the present invention may be prepared by conventional methods known in the art.
• tablets may be prepared by mixing sibutramine free base, in crystalline form, according to the present invention, with known adjuvants and / or diluents and subsequently compressing the mixture in a conventional tabletting machine.
• adjuvants or diluents can comprise corn starch, potato starch, talcum, magnesium stearate, gelatine, lactose, gums, and the like.
• Other adjuvants or additives such as colourings, aroma enhancers, preservatives and the like may be used provided that they are compatible with sibutramine free base, in crystalline form, as described above.
• Solutions for injections may be prepared according to the present invention by dissolving sibutramine free base, in crystalline form, and possible additives in a part of a solvent for injection, preferably sterile water, adjusting the solution to the desired volume, sterilisation of the solution and filling in suitable ampoules or vials.
• a solvent for injection preferably sterile water
• Any suitable additives conventionally used in the art may be added, such as tonicity agents, preservatives, antioxidants and the like.
• the particular dosage form of sibutramine free base, in crystalline form, required to treat a disease state prevented, ameliorated or eliminated by the administration of a neuronal monoamine reuptake inhibitor as described herein in a patient, including humans, will depend on the particular disease state or condition, and the symptoms and severity thereof. Dosage, routes of administration, and frequency of dosing are best decided by an attending physician.
• compositions according to the present invention are, however, preferably made so as to be administrable by the oral or parenteral route.
• the present invention further provides sibutramine free base, in crystalline form, for use in the manufacture of a medicament for the treatment of a disease state prevented, ameliorated or eliminated by the administration of a neuronal monoamine reuptake inhibitor as described herein.
• the present invention also provides a method of treating a disease state prevented, ameliorated or eliminated by the administration of a neuronal monoamine reuptake inhibitor in a patient in need of such treatment, which method comprises admimstering to the patient a therapeutically effective amount of sibutramine free base, in crystalline form, substantially as hereinbefore described.
• Sibutramine free base, in crystalline form, according to the present invention is also useful as an intermediate in the preparation of pharmaceutically acceptable salts of sibutramine.
• the present invention therefore, further provides use of sibutramine free base, in crystalline form, as an intermediate for the preparation of pharmaceutically acceptable salts of sibutramine.
• the present invention also provides a process of preparing a pharmaceutically acceptable salt of sibutramine, preferably the hydrochloride salt, wherein sibutramine free base, in crystalline form, is converted to a pharmaceutically acceptable salt of sibutramine.
• the present invention further provides a sibutramine salt, preferably the hydrochloride salt of sibutramine, prepared by a process according to the present invention substantially as hereinbefore described.
• the pharmaceutically acceptable salts of sibutramine may be prepared according to the present invention from sibutramine free base, in crystalline form, by methods known in the art. More particularly, sibutramine free base, in crystalline form, may be reacted with an appropriate amount of acid in a water miscible solvent, such as acetone, ethanol or the like, with subsequent isolation of the salt by concentration and cooling; alternatively, sibutramine free base, in crystalline form, may be reacted with an excess of an acid in a water immiscible solvent, such as ethylether, ethylacetate, dichloromethane or the like, with the salt separating spontaneously.
• a water miscible solvent such as acetone, ethanol or the like
• Sibutramine hydrochloride thus obtained by a process according to the present invention has a very high purity, preferably a purity of more than about 99.8% w/w, and more preferably more than about 99.9% w/w.
• Other salts of sibutramine, for example sibutramine oxalate, may also be obtained in a very pure form according to the present invention.
• the present invention also provides a process of preparing sibutramine free base in crystalline form, which process comprises dissolving a sibutramine salt in a first organic solvent medium, adding thereto a base, separating therefrom sibutramine free base and crystallising sibutramine free base from a second organic solvent medium.
• the salt of sibutramine from which sibutramine free base, in crystalline form, according to the present invention is prepared may be any convenient salt, such as the hydrochloride, sulphate, oxalate, phosphate, or any other convenient salt.
• the hydrochloride salt is employed.
• Other suitable salts are salts of organic acids.
• the sibutramine crude salt may include impurities, which will need to be removed or which it is desired to remove.
• the sibutramine crude salt may be a salt separated directly from a preparatory reaction mixture, or it may have been subjected to some initial or simultaneous purification, for example re-crystallisation, treatment with activated carbon or silica gel or the like.
• the sibutramine crude salt may be prepared by any of the above-mentioned processes or processes known in the art.
• the sibutramine crude salt may be isolated by precipitation or it may exist in a solvent, for example in a mixture resulting directly from the synthesis thereof.
• a crude mixture comprising sibutramine free base may be obtained directly from the synthesis thereof according to any of the above mentioned processes or it may be subjected to initial or simultaneous purification, for example re-crystallisation, treatment with activated carbon or silica gel or the like.
• Sibutramine free base may be liberated from a sibutramine crude salt by dissolving the crude salt in a first organic solvent medium, adding a base, followed by purification and extraction. Alternatively it may be isolated from a crude mixture of the base by purification and extraction.
• the first organic solvent medium may comprise toluene, ethyl acetate or any other suitable solvent and the base may be any conventional base, preferably sodium hydroxide or ammonia.
• Sibutramine free base is collected by separation of the organic phase, evaporation of the solvent in order to obtain the base (typically in the form of an oil) and then crystallisation of sibutramine free base from a second suitable solvent medium, such as an alkane, including n-heptane, hexane, isooctane and the like, and C 1-4 alcohols, such as methanol, ethanol, isopropanol and the like.
• a second suitable solvent medium such as an alkane, including n-heptane, hexane, isooctane and the like, and C 1-4 alcohols, such as methanol, ethanol, isopropanol and the like.
• Figure 1 X-ray diffraction pattern of sibutramine free base, in crystalline form, according to the present invention.
• Figure 2 DSC trace showing the melting point of sibutramine free base, in crystalline form, according to the present invention being in the range of 52-57°C.
• N- ⁇ l-[l-(4-Chlorophenyl)cyclobutyl]-3-methylbutyl ⁇ -N.N-dimethyl-amine hydrochloride (101 grams, 0.25 mole) was suspended in water (500 ml) and toluene (500 ml). NaOH (60 ml. 5 N (aq)) was added and the mixture (pH>10) was stirred for 15 minutes before the phases were separated. The organic phase was washed with water (2x100 ml) and filtered through a pad of filter help. The volatiles were removed in vacuo and the title compound was obtained as an oil. n-Heptane (400 ml) was added and the mixture was heated to 70°C. On cooling crystals formed. The white crystals of the title compound were filtered off and dried at ambient temperature over night in vacuo. Yield: 75.4 grams (93%). DSC (onset, open capsule): 52-57°C. Purity: (>99.8% (peak area)).
• N- ⁇ l-[l-(4-Chlorophenyl)cyclobutyl]-3-methylbutyl ⁇ -N,N-dimethyl-amine) as a hydrochloride was suspended in water (500 ml) and ethylacetate (500 ml). NaOH (60 ml, 5N (aq)) was added and the mixture (pH>10) was stirred for 15 minutes before the phases were separated. The organic phase was washed with water (2x100 ml) and filtered through a pad of filter help. The volatiles were removed in vacuo and the title compound was obtained as an oil. N-hexane (150 ml) was added and the mixture was heated to 50°C. On cooling crystals formed. The white crystals of the title compound were filtered off and dried at ambient temperature over night in vacuo. Yield: 68 grams (93%). DSC (onset, open capsule): 52-57°C. Purity: (>99.8% (peak area)).
• This Example refers to wet granulation and preparation of tablets of sibutramine free base.
• the batch size was 200 g and the granulation was performed in a small-scale laboratory high shear mixer (Micromixer).
• Sibutramine free base was sieved through a sieve aperture of 0.3 mm.
• the ingredients of the intragranular phase were mixed at 600 rpm. 25 ml of purified water was added in 30 seconds and the granulation terminated after a total processing time of 3 minutes.
• the granulate was wet sieved through a 0.7 mm sieve aperture and dried at 40°C in 30 minutes to equilibrium relative humidity of 32%.
• the dried granulate was finally sieved through a 0.7 mm sieve aperture.
• the dried granulate was mixed for 3 minutes with the extragranular phase (6-7) in a Turbula mixer and finally mixed with the lubricant (8) for 30 seconds.
• Tablets were produced on a single punch tabletting machine and it was seen that the tablets produced had satisfactory technical properties.
• This Example refers to melt granulation and preparation of tablets of sibutramine free base.
• the batch size was 200g. Sibutramine free base was sieved through a sieve aperture of 0.3 mm.
• the granulation was performed in a small-scale laboratory high shear mixer (Micromixer).
• the ingredients of the intra-granular phase were mixed at 1200 ⁇ m.
• the jacket temperature was 80°C.
• the granulation process was terminated after 3.5 minutes.
• the granulate was sieved through a sieve aperture of 1.0 mm and mixed with the extragranular phase (4, 5) for 3 minutes and with the lubricant (6) for 30 seconds.
• composition of the resulting tablets Composition of the resulting tablets.
• This Example refers to preparation of capsules of sibutramine free base.
• Sibutramine free base capsules 15mg.
• the granules were dried to LOD of less than 2.0%w/w and sized.
• the sized granules were filled into size 1 capsules.

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