EP1474528A4 - METHODS OF DIAGNOSIS OF PROSTATE CANCER, COMPOSITIONS AND METHODS OF EXAMINING PROSTATE CANCER MODULATORS - Google Patents
METHODS OF DIAGNOSIS OF PROSTATE CANCER, COMPOSITIONS AND METHODS OF EXAMINING PROSTATE CANCER MODULATORSInfo
- Publication number
- EP1474528A4 EP1474528A4 EP01983958A EP01983958A EP1474528A4 EP 1474528 A4 EP1474528 A4 EP 1474528A4 EP 01983958 A EP01983958 A EP 01983958A EP 01983958 A EP01983958 A EP 01983958A EP 1474528 A4 EP1474528 A4 EP 1474528A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- methods
- prostate cancer
- diagnosis
- compositions
- examining
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57434—Specifically defined cancers of prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Hospice & Palliative Care (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07075380A EP1847620A3 (en) | 2000-10-13 | 2001-10-12 | Methods of diagnosis of prostate cancer, compositions and methods of screening for modulators of prostate cancer |
Applications Claiming Priority (21)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US687576 | 1984-12-28 | ||
US733288 | 1985-05-10 | ||
US68757600A | 2000-10-13 | 2000-10-13 | |
US73374200A | 2000-12-08 | 2000-12-08 | |
US73328800A | 2000-12-08 | 2000-12-08 | |
US733742 | 2000-12-08 | ||
US26395701P | 2001-01-24 | 2001-01-24 | |
US263957P | 2001-01-24 | ||
US27679101P | 2001-03-16 | 2001-03-16 | |
US27688801P | 2001-03-16 | 2001-03-16 | |
US276888P | 2001-03-16 | ||
US276791P | 2001-03-16 | ||
US28192201P | 2001-04-06 | 2001-04-06 | |
US281922P | 2001-04-06 | ||
US28621401P | 2001-04-24 | 2001-04-24 | |
US286214P | 2001-04-24 | ||
US847046 | 2001-04-30 | ||
US09/847,046 US20020068036A1 (en) | 2000-10-13 | 2001-04-30 | Novel methods of diagnosis of prostate cancer and/or breast cancer, compositions, and methods of screening for prostate cancer and /or breast cancer modulators |
US28858901P | 2001-05-04 | 2001-05-04 | |
US288589P | 2001-05-04 | ||
PCT/US2001/032045 WO2002030268A2 (en) | 2000-10-13 | 2001-10-12 | Methods of diagnosis of prostate cancer, compositions and methods of screening for modulators of prostate cancer |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP07075380A Division EP1847620A3 (en) | 2000-10-13 | 2001-10-12 | Methods of diagnosis of prostate cancer, compositions and methods of screening for modulators of prostate cancer |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1474528A2 EP1474528A2 (en) | 2004-11-10 |
EP1474528A4 true EP1474528A4 (en) | 2006-06-14 |
Family
ID=27581207
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP01983958A Withdrawn EP1474528A4 (en) | 2000-10-13 | 2001-10-12 | METHODS OF DIAGNOSIS OF PROSTATE CANCER, COMPOSITIONS AND METHODS OF EXAMINING PROSTATE CANCER MODULATORS |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1474528A4 (en) |
JP (1) | JP2005506033A (en) |
AU (1) | AU2002215345A1 (en) |
CA (1) | CA2425569A1 (en) |
MX (1) | MXPA03003151A (en) |
WO (1) | WO2002030268A2 (en) |
Families Citing this family (139)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69840669D1 (en) | 1997-04-10 | 2009-04-30 | Stichting Katholieke Univ | PCA3, PCA3 GENES AND METHOD OF USE THEREOF |
US20030149531A1 (en) | 2000-12-06 | 2003-08-07 | Hubert Rene S. | Serpentine transmembrane antigens expressed in human cancers and uses thereof |
WO1999062941A2 (en) | 1998-06-01 | 1999-12-09 | Urogenesys, Inc. | Serpentine transmembrane antigens expressed in human cancers and uses thereof |
US6833438B1 (en) | 1999-06-01 | 2004-12-21 | Agensys, Inc. | Serpentine transmembrane antigens expressed in human cancers and uses thereof |
US7037667B1 (en) | 1998-06-01 | 2006-05-02 | Agensys, Inc. | Tumor antigen useful in diagnosis and therapy of prostate and colon cancer |
DK1222266T3 (en) | 1999-09-29 | 2006-07-10 | Diagnocure Inc | PCA3 messenger RNA in benign and malignant prostate tissue |
US7361338B2 (en) | 1999-10-05 | 2008-04-22 | Agensys, Inc. | Methods to inhibit growth of prostate cancer cells |
US6790631B1 (en) | 1999-10-05 | 2004-09-14 | Agensys, Inc. | G protein-coupled receptor up-regulated in prostate cancer and uses thereof |
US20020048777A1 (en) | 1999-12-06 | 2002-04-25 | Shujath Ali | Method of diagnosing monitoring, staging, imaging and treating prostate cancer |
US20090176722A9 (en) | 2000-01-28 | 2009-07-09 | Shiv Srivastava | Androgen-regulated PMEPA1 gene and polypeptides |
AU2001287639A1 (en) * | 2000-07-28 | 2002-02-13 | Ulrich Wissenbach | Trp8, trp9 and trp10, markers for cancer |
EP1337667A2 (en) | 2000-11-16 | 2003-08-27 | Cedars-Sinai Medical Center | Profiling tumor specific markers for the diagnosis and treatment of neoplastic disease |
WO2002055701A2 (en) * | 2000-12-15 | 2002-07-18 | Millennium Pharm Inc | Human sugar transporter proteins, potassium channel proteins, phospholipid transporter proteins and methods of use thereof |
AU2002246708A1 (en) | 2000-12-15 | 2002-08-12 | Agensys, Inc. | Nucleic acid and encoded zinc transporter protein entitled 108p5h8 useful in treatment and detection of cancer |
US20060035237A1 (en) | 2002-08-26 | 2006-02-16 | Markowitz Sanford D | Methods and compositions for categorizing patients |
US7118912B2 (en) * | 2002-08-26 | 2006-10-10 | Case Western Reserve University | Methods and compositions for categorizing patients |
US7081516B2 (en) | 2002-08-26 | 2006-07-25 | Case Western Reserve University | Methods for categorizing patients |
CA2439702A1 (en) * | 2001-03-05 | 2002-09-19 | Aventis Pharma S.A. | Nucleic acids of the human abcc11 gene, vectors containing such nucleic acids and uses thereof |
EP2280030A3 (en) | 2001-04-10 | 2011-06-15 | Agensys, Inc. | Nucleic acids and corresponding proteins useful in the detection and treatment of various cancers |
US6897024B2 (en) | 2001-05-31 | 2005-05-24 | Stichting Katholieke Universiteit More Particularly The University Medical Centre Nijmegen | Nucleic acid molecules comprising the promoter for PCA3, and uses thereof |
EP2000545B1 (en) | 2001-06-20 | 2011-08-31 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of lung tumor |
US20050272120A1 (en) | 2001-06-20 | 2005-12-08 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
CA2458915A1 (en) | 2001-08-31 | 2003-03-13 | Agensys, Inc. | Nucleic acid and corresponding protein entitled 205p1b5 useful in treatment and detection of cancer |
US7494646B2 (en) | 2001-09-06 | 2009-02-24 | Agensys, Inc. | Antibodies and molecules derived therefrom that bind to STEAP-1 proteins |
ES2532757T3 (en) | 2001-09-06 | 2015-03-31 | Agensys, Inc. | Nucleic acid and corresponding protein called STEAP-1 useful in the treatment and detection of cancer |
JP2005519137A (en) * | 2001-09-17 | 2005-06-30 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | Methods for using 46828 human acyl-CoA synthetase |
US20030100034A1 (en) * | 2001-10-16 | 2003-05-29 | Millennium Pharmaceuticals, Inc. | 9136, a human aldehyde dehydrogenase family member and uses therefor |
WO2003054512A2 (en) * | 2001-12-20 | 2003-07-03 | Tularik Inc. | Identification of an amplified gene and target for drug intervention |
US20030235533A1 (en) * | 2002-02-19 | 2003-12-25 | Idec Pharmaceuticals Corporation | Prostate specific genes and the use thereof in design or therapeutics |
WO2005067629A2 (en) * | 2004-01-06 | 2005-07-28 | Avalon Pharmaceuticals | Cancer-linked genes as targets for chemotherapy |
US20040162236A1 (en) * | 2002-04-01 | 2004-08-19 | John Alsobrook | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
EP1361433A3 (en) * | 2002-04-09 | 2005-02-23 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Method for estimating therapeutic efficacy of tumor necrosis factor (TNF) |
CA2485138C (en) * | 2002-05-10 | 2015-04-28 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Androgen-regulated pmepa1 gene and methods of using the same to inhibit cancer cell growth |
DE10234901A1 (en) * | 2002-07-26 | 2004-02-12 | Metagen Pharmaceuticals Gmbh | New nucleic acids encoding Mrp4, useful in the diagnosis of prostatic, bladder and ovarian tumors, also in screening for specific binding agents, and potential therapeutic agents |
US7408048B2 (en) | 2002-08-09 | 2008-08-05 | Melbourne Health | Mammalian grainyhead transcription factors |
US20040081653A1 (en) | 2002-08-16 | 2004-04-29 | Raitano Arthur B. | Nucleic acids and corresponding proteins entitled 251P5G2 useful in treatment and detection of cancer |
WO2004018648A2 (en) * | 2002-08-26 | 2004-03-04 | Case Western Reserve University | Methods for treating patients and identifying therapeutics |
EP1573331A1 (en) * | 2002-12-09 | 2005-09-14 | Bayer HealthCare AG | Diagnostics and therapeutics for diseases associated with phosphodiesterase 9a1 (pde9a1) |
JP4824540B2 (en) | 2003-02-07 | 2011-11-30 | ダイアノキュアー インク. | How to detect prostate cancer in a sample |
JP2004357702A (en) * | 2003-05-09 | 2004-12-24 | Research Association For Biotechnology | New protein and dna encoding the same |
US7473531B1 (en) | 2003-08-08 | 2009-01-06 | Colora Corporation | Pancreatic cancer targets and uses thereof |
US7294704B2 (en) | 2003-08-15 | 2007-11-13 | Diadexus, Inc. | Pro108 antibody compositions and methods of use and use of Pro108 to assess cancer risk |
PT2489364E (en) | 2003-11-06 | 2015-04-16 | Seattle Genetics Inc | Monomethylvaline compounds conjugated to antibodies |
WO2005083086A2 (en) * | 2004-02-27 | 2005-09-09 | Oncotherapy Science, Inc. | Epha4 as therapeutic target of prc and pdaca |
PL1742966T3 (en) | 2004-04-22 | 2014-04-30 | Agensys Inc | Antibodies and molecules derived therefrom that bind to steap-1 proteins |
WO2005106488A2 (en) * | 2004-04-28 | 2005-11-10 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with g protein-coupled beta-2 adrenoceptor (adrb2) |
EP2286844A3 (en) | 2004-06-01 | 2012-08-22 | Genentech, Inc. | Antibody-drug conjugates and methods |
EP1794314A2 (en) * | 2004-07-23 | 2007-06-13 | Bayer HealthCare AG | Diagnostics and therapeutics for diseases associated with vasoactive intestinal peptide receptor 1 (vpac1) |
US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
ES2579805T3 (en) | 2004-09-23 | 2016-08-16 | Genentech, Inc. | Antibodies and conjugates engineered with cysteine |
EP1817059A2 (en) | 2004-12-01 | 2007-08-15 | Genentech, Inc. | Conjugates of 1,8-bis-naphthalimides with an antibody |
CA2491067A1 (en) | 2004-12-24 | 2006-06-24 | Stichting Katholieke Universiteit | Mrna rations in urinary sediments and/or urine as a prognostic marker for prostate cancer |
WO2006074914A2 (en) * | 2005-01-13 | 2006-07-20 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Human rna helicase and therapeutic uses thereof |
ES2459466T3 (en) | 2005-02-25 | 2014-05-09 | Oncotherapy Science, Inc. | Peptide vaccines for lung cancers expressing TTK, URLC10 or KOC1 polypeptides |
RU2639543C9 (en) | 2006-10-27 | 2018-06-14 | Дженентек, Инк. | Antibodies and immunoconjugates and their applications |
WO2008154249A2 (en) * | 2007-06-08 | 2008-12-18 | Genentech, Inc. | Gene expression markers of tumor resistance to her2 inhibitor treatment |
US9551033B2 (en) | 2007-06-08 | 2017-01-24 | Genentech, Inc. | Gene expression markers of tumor resistance to HER2 inhibitor treatment |
WO2009032292A1 (en) * | 2007-09-06 | 2009-03-12 | Case Western Reserve University | Methods for diagnosing and treating cancers |
JP5589274B2 (en) * | 2007-10-25 | 2014-09-17 | 東レ株式会社 | Immune inducer |
DK3106873T3 (en) * | 2007-10-25 | 2019-09-23 | Toray Industries | METHOD OF DETECTING CANCER |
AU2014240339B2 (en) * | 2007-10-25 | 2017-07-13 | Toray Industries, Inc. | Method for detection of cancer |
WO2010009124A2 (en) | 2008-07-15 | 2010-01-21 | Genentech, Inc. | Anthracycline derivative conjugates, process for their preparation and their use as antitumor compounds |
TWI580431B (en) | 2008-08-19 | 2017-05-01 | 腫瘤療法 科學股份有限公司 | HIG2 and URLC10 epitope peptides and vaccines containing the peptides |
TW201008574A (en) | 2008-08-19 | 2010-03-01 | Oncotherapy Science Inc | INHBB epitope peptides and vaccines containing the same |
WO2011031870A1 (en) | 2009-09-09 | 2011-03-17 | Centrose, Llc | Extracellular targeted drug conjugates |
MA34277B1 (en) | 2010-04-15 | 2013-06-01 | Spirogen Developments Sarl | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF |
JP2013533732A (en) * | 2010-05-03 | 2013-08-29 | ジェネンテック, インコーポレイテッド | Compositions and methods for tumor diagnosis and treatment |
MX336540B (en) | 2010-06-08 | 2016-01-22 | Genentech Inc | Cysteine engineered antibodies and conjugates. |
CN103313990B (en) | 2010-11-17 | 2016-07-20 | 基因泰克公司 | Alanyl maytansinol antibody coupling matter |
KR101992502B1 (en) | 2011-05-12 | 2019-06-24 | 제넨테크, 인크. | Multiple reaction monitoring lc-ms/ms method to detect therapeutic antibodies in animal samples using framework signature peptides |
ES2556584T3 (en) | 2011-10-14 | 2016-01-19 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
WO2013130093A1 (en) | 2012-03-02 | 2013-09-06 | Genentech, Inc. | Biomarkers for treatment with anti-tubulin chemotherapeutic compounds |
DK2906296T3 (en) | 2012-10-12 | 2018-05-22 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
LT2906253T (en) | 2012-10-12 | 2018-10-10 | Adc Therapeutics Sa | Pyrrolobenzodiazepine - anti-psma antibody conjugates |
PL2906298T3 (en) | 2012-10-12 | 2019-04-30 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
WO2014057074A1 (en) | 2012-10-12 | 2014-04-17 | Spirogen Sàrl | Pyrrolobenzodiazepines and conjugates thereof |
PT2906251T (en) | 2012-10-12 | 2017-12-04 | Medimmune Ltd | Pyrrolobenzodiazepine-anti-cd22 antibody conjugates |
WO2014057120A1 (en) | 2012-10-12 | 2014-04-17 | Adc Therapeutics Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
ES2680153T3 (en) | 2012-10-12 | 2018-09-04 | Adc Therapeutics Sa | Anti-PSMA-pyrrolobenzodiazepine antibody conjugates |
CN110627797A (en) | 2012-12-21 | 2019-12-31 | 麦迪穆有限责任公司 | Asymmetric pyrrolobenzodiazepine dimers for the treatment of proliferative and autoimmune diseases |
EA031585B1 (en) | 2012-12-21 | 2019-01-31 | Медимьюн Лимитед | Pyrrolobenzodiazepines and conjugates thereof |
CN105209077B (en) | 2013-03-13 | 2019-06-11 | 麦迪穆有限责任公司 | Pyrrolobenzodiazepines Zhuo and its conjugate |
CN105142674B (en) | 2013-03-13 | 2018-11-13 | 麦迪穆有限责任公司 | Pyrrolobenzodiazepines Zhuo and its conjugate |
EA027910B1 (en) | 2013-03-13 | 2017-09-29 | Медимьюн Лимитед | Pyrrolobenzodiazepines and conjugates thereof |
JP2016521966A (en) * | 2013-03-15 | 2016-07-28 | メタマーク ジェネティクス, インコーポレイテッド | Compositions and methods for cancer prognosis |
CN105636612B (en) | 2013-08-12 | 2020-01-14 | 基因泰克公司 | Antibody-drug conjugates and methods of use and treatment |
EP3054986B1 (en) | 2013-10-11 | 2019-03-20 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
GB201317982D0 (en) | 2013-10-11 | 2013-11-27 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
EP3054983B1 (en) | 2013-10-11 | 2019-03-20 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
WO2015052534A1 (en) | 2013-10-11 | 2015-04-16 | Spirogen Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
BR112016013258A2 (en) | 2013-12-16 | 2018-01-16 | Genentech Inc | antibody-drug conjugate, pharmaceutical composition, method for treating cancer and kit |
CA2928952A1 (en) | 2013-12-16 | 2015-06-25 | Genentech, Inc. | Peptidomimetic compounds and antibody-drug conjugates thereof |
CN107106700B (en) | 2013-12-16 | 2020-10-30 | 基因泰克公司 | Peptidomimetic compounds and antibody-drug conjugates thereof |
US20150252425A1 (en) * | 2014-03-05 | 2015-09-10 | Caldera Health Ltd. | Gene expression profiling for the diagnosis of prostate cancer |
EP3193940A1 (en) | 2014-09-10 | 2017-07-26 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
TW201625688A (en) | 2014-09-12 | 2016-07-16 | 建南德克公司 | Cysteine engineered antibodies and conjugates |
GB201416112D0 (en) | 2014-09-12 | 2014-10-29 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
WO2016040825A1 (en) | 2014-09-12 | 2016-03-17 | Genentech, Inc. | Anthracycline disulfide intermediates, antibody-drug conjugates and methods |
CN107073136A (en) | 2014-09-17 | 2017-08-18 | 健泰科生物技术公司 | Pyrrolobenzodiazepines Zhuo and its antibody disulphide conjugate |
KR20170101895A (en) | 2014-11-25 | 2017-09-06 | 에이디씨 테라퓨틱스 에스에이 | Pyrrolobenzodiazepine-antibody conjugates |
CA2969689A1 (en) | 2014-12-03 | 2016-06-09 | Genentech, Inc. | Quaternary amine compounds and antibody-drug conjugates thereof |
GB201506402D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
GB201510684D0 (en) * | 2015-06-17 | 2015-08-05 | Almac Diagnostics Ltd | Gene signatures predictive of metastatic disease |
MA43345A (en) | 2015-10-02 | 2018-08-08 | Hoffmann La Roche | PYRROLOBENZODIAZEPINE ANTIBODY-DRUG CONJUGATES AND METHODS OF USE |
MA43354A (en) | 2015-10-16 | 2018-08-22 | Genentech Inc | CONJUGATE DRUG CONJUGATES WITH CLOUDY DISULPHIDE |
MA45326A (en) | 2015-10-20 | 2018-08-29 | Genentech Inc | CALICHEAMICIN-ANTIBODY-DRUG CONJUGATES AND METHODS OF USE |
GB201601431D0 (en) | 2016-01-26 | 2016-03-09 | Medimmune Ltd | Pyrrolobenzodiazepines |
GB201602359D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
GB201602356D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
CN108700598A (en) | 2016-03-25 | 2018-10-23 | 豪夫迈·罗氏有限公司 | Multiplex Total Antibody and Antibody Conjugated Drug Quantification Assay |
GB201607478D0 (en) | 2016-04-29 | 2016-06-15 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
WO2017201449A1 (en) | 2016-05-20 | 2017-11-23 | Genentech, Inc. | Protac antibody conjugates and methods of use |
CN109313200B (en) | 2016-05-27 | 2022-10-04 | 豪夫迈·罗氏有限公司 | Bioanalytical methods for characterizing site-specific antibody-drug conjugates |
CN109476648B (en) | 2016-06-06 | 2022-09-13 | 豪夫迈·罗氏有限公司 | Sevelamer antibody-drug conjugates and methods of use |
WO2018031662A1 (en) | 2016-08-11 | 2018-02-15 | Genentech, Inc. | Pyrrolobenzodiazepine prodrugs and antibody conjugates thereof |
CN110139674B (en) | 2016-10-05 | 2023-05-16 | 豪夫迈·罗氏有限公司 | Method for preparing antibody drug conjugates |
GB201617466D0 (en) | 2016-10-14 | 2016-11-30 | Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
GB201702031D0 (en) | 2017-02-08 | 2017-03-22 | Medlmmune Ltd | Pyrrolobenzodiazepine-antibody conjugates |
CA3047683C (en) | 2017-02-08 | 2020-03-10 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
SG11201909218RA (en) | 2017-04-03 | 2019-11-28 | Hoffmann La Roche | Antibodies binding to steap-1 |
AU2018255876B2 (en) | 2017-04-18 | 2020-04-30 | Medimmune Limited | Pyrrolobenzodiazepine conjugates |
US20200129637A1 (en) | 2017-04-20 | 2020-04-30 | Adc Therapeutics Sa | Combination therapy with an anti-axl antibody-drug conjugate |
UA127900C2 (en) | 2017-06-14 | 2024-02-07 | Ейдісі Терапьютікс Са | Dosage regimes for the administration of an anti-cd19 adc |
EP3668874B1 (en) | 2017-08-18 | 2021-12-22 | Medimmune Limited | Pyrrolobenzodiazepine conjugates |
AU2018337815A1 (en) | 2017-09-20 | 2020-03-12 | Ph Pharma Co., Ltd. | Thailanstatin analogs |
GB201803342D0 (en) | 2018-03-01 | 2018-04-18 | Medimmune Ltd | Methods |
GB201806022D0 (en) | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
WO2020010305A1 (en) * | 2018-07-05 | 2020-01-09 | The Board Of Regents Of The University Of Oklahoma | Gene signatures for cancer characterization and methods of use |
GB201814281D0 (en) | 2018-09-03 | 2018-10-17 | Femtogenix Ltd | Cytotoxic agents |
CN113056287A (en) | 2018-10-24 | 2021-06-29 | 豪夫迈·罗氏有限公司 | Conjugated chemical degradation inducers and methods of use |
GB201818576D0 (en) * | 2018-11-14 | 2018-12-26 | Io Biotech Aps | Arginase 2 polypeptides |
EP3894427A1 (en) | 2018-12-10 | 2021-10-20 | Genentech, Inc. | Photocrosslinking peptides for site specific conjugation to fc-containing proteins |
GB201901197D0 (en) | 2019-01-29 | 2019-03-20 | Femtogenix Ltd | G-A Crosslinking cytotoxic agents |
BR112021018260A2 (en) | 2019-03-15 | 2021-11-23 | Medimmune Ltd | Azetidobenzodiazepine dimers and conjugates comprising the same for use in the treatment of cancer |
GB2597532A (en) | 2020-07-28 | 2022-02-02 | Femtogenix Ltd | Cytotoxic compounds |
TW202432187A (en) | 2022-12-23 | 2024-08-16 | 美商建南德克公司 | Cereblon degrader conjugates, and uses thereof |
WO2024220546A2 (en) | 2023-04-17 | 2024-10-24 | Peak Bio, Inc. | Antibodies and antibody-drug conjugates and methods of use and synthetic processes and intermediates |
CN119215114A (en) * | 2024-12-03 | 2024-12-31 | 浙江理工大学 | Application of lily extracellular vesicles in preparing tumor therapeutic drugs |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995028498A1 (en) * | 1994-04-15 | 1995-10-26 | The Trustees Of Columbia University In The City Of New York | Method for molecular staging of prostate cancer |
US5858673A (en) * | 1996-06-24 | 1999-01-12 | Charlotte-Mecklenburg Hospital Authority | Method for detecting prostate cells |
WO1999037811A1 (en) * | 1998-01-21 | 1999-07-29 | Urocor, Inc. | Biomarkers and targets for diagnosis, prognosis and management of prostate disease |
WO1999042622A1 (en) * | 1998-02-23 | 1999-08-26 | Dana-Farber Cancer Institute, Inc. | Method for identifying mismatch repair glycosylase reactive sites, compound and uses thereof_____________________________________ |
WO1999064594A2 (en) * | 1998-06-11 | 1999-12-16 | Chiron Corporation | Genes and gene expression products that are differentially regulated in prostate cancer |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2001241408A1 (en) * | 2000-01-31 | 2001-08-07 | Human Genome Sciences, Inc. | Nucleic acids, proteins, and antibodies |
WO2001060860A2 (en) * | 2000-02-17 | 2001-08-23 | Millennium Predictive Medicine, Inc. | Genes differentially expressed in human prostate cancer and their use |
-
2001
- 2001-10-12 JP JP2002533718A patent/JP2005506033A/en active Pending
- 2001-10-12 CA CA 2425569 patent/CA2425569A1/en not_active Abandoned
- 2001-10-12 MX MXPA03003151A patent/MXPA03003151A/en unknown
- 2001-10-12 EP EP01983958A patent/EP1474528A4/en not_active Withdrawn
- 2001-10-12 AU AU2002215345A patent/AU2002215345A1/en not_active Abandoned
- 2001-10-12 WO PCT/US2001/032045 patent/WO2002030268A2/en not_active Application Discontinuation
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995028498A1 (en) * | 1994-04-15 | 1995-10-26 | The Trustees Of Columbia University In The City Of New York | Method for molecular staging of prostate cancer |
US5858673A (en) * | 1996-06-24 | 1999-01-12 | Charlotte-Mecklenburg Hospital Authority | Method for detecting prostate cells |
WO1999037811A1 (en) * | 1998-01-21 | 1999-07-29 | Urocor, Inc. | Biomarkers and targets for diagnosis, prognosis and management of prostate disease |
WO1999042622A1 (en) * | 1998-02-23 | 1999-08-26 | Dana-Farber Cancer Institute, Inc. | Method for identifying mismatch repair glycosylase reactive sites, compound and uses thereof_____________________________________ |
WO1999064594A2 (en) * | 1998-06-11 | 1999-12-16 | Chiron Corporation | Genes and gene expression products that are differentially regulated in prostate cancer |
Non-Patent Citations (7)
Title |
---|
CARLISLE A J ET AL: "Development of a prostate cDNA microarray and statistical gene expression analysis package", MOLECULAR CARCINOGENESIS, ALAN LISS, NEW YORK, NY,, US, vol. 28, no. 1, May 2000 (2000-05-01), pages 12 - 22, XP002225396, ISSN: 0899-1987 * |
DATABASE EMBL [online] 21 November 1996 (1996-11-21), "zk91c02.s1 Soares_pregnant_uterus_NbHPU Homo sapiens cDNA clone IMAGE:490178 3', mRNA sequence.", XP002339482, retrieved from EBI accession no. EM_HUM:HSAA21266 Database accession no. HSAA21266 * |
DATABASE NETAFFX [online] Affymetrix; 12 April 2006 (2006-04-12), XP002376990, retrieved from HTTPS://WWW.AFFYMETRIX.COM/ANALYSIS/NETAFFX/FULLRECORD.AFFX?PK=HUGENEFL%3AU41060_AT * |
ELEK J ET AL: "MICROARRAY-BASED EXPRESSION PROFILING IN PROSTATE TUMORS", IN VIVO - INTERNATIONAL JOURNAL OF IN VIVO RESEARCH, GB, vol. 14, no. 1, January 2000 (2000-01-01), pages 173 - 182, XP001027452, ISSN: 0258-851X * |
GREEN C ET AL: "Human Breast Cancer, estrogen regulated LIV-1 protein (LIV-1) mRNA, partial cds", ENTREZ NUCLEOTIDE, 6 April 1996 (1996-04-06), XP002175106 * |
LADEANA HILLIER ET AL: "Generation and analysis of 280,000 human expressed sequence tags", PCR METHODS AND APPLICATIONS, COLD SPRING HARBOR, NY, US, vol. 6, no. 9, September 1996 (1996-09-01), pages 807 - 828, XP002140684, ISSN: 1054-9803 * |
XU JIANGCHUN ET AL: "Identification of differentially expressed genes in human prostate cancer using subtraction and microarray", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 60, no. 6, 15 March 2000 (2000-03-15), pages 1677 - 1682, XP002198982, ISSN: 0008-5472 * |
Also Published As
Publication number | Publication date |
---|---|
JP2005506033A (en) | 2005-03-03 |
CA2425569A1 (en) | 2002-04-18 |
MXPA03003151A (en) | 2003-08-19 |
EP1474528A2 (en) | 2004-11-10 |
AU2002215345A1 (en) | 2002-04-22 |
WO2002030268A2 (en) | 2002-04-18 |
WO2002030268A3 (en) | 2004-08-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1474528A4 (en) | METHODS OF DIAGNOSIS OF PROSTATE CANCER, COMPOSITIONS AND METHODS OF EXAMINING PROSTATE CANCER MODULATORS | |
WO2002040634A3 (en) | Expression miniarrays and uses thereof | |
DE60233157D1 (en) | TWO-CHAMBER PACEMAKER SYSTEM FOR THE DIAGNOSIS AND REMEDY OF ARRHYTHMIES | |
EP1257287A4 (en) | COMPOUNDS AND METHODS FOR EARLY DIAGNOSIS OF EGG CANCER | |
DE60210880D1 (en) | Combined bipolar forceps and scissors instrument | |
NO20023402D0 (en) | Mixtures and Methods for the Treatment and Diagnosis of Prostate Cancer | |
NO20010196D0 (en) | Compositions and Methods for Therapy and Diagnosis of Prostate Cancer | |
DE59900101D1 (en) | Medical instrument for tissue preparation | |
NO20016427D0 (en) | Compositions and Methods for the Treatment of Diagnosis of Lung Cancer | |
YU37304A (en) | Specific binding agents of human angiopoietin-2 | |
DE60115874D1 (en) | INSTRUMENT FOR SURGICAL TREATMENT | |
DE69932191D1 (en) | Device for the examination of body fluid | |
DE59912963D1 (en) | MEDICAL INSTRUMENT FOR PREPARING TISSUE | |
EP1516049A4 (en) | COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF LUNG CANCER | |
EP1446013A4 (en) | COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF LUNG CANCER | |
DE60032784D1 (en) | MARKER PROTEINS FOR PROSTATE CANCER | |
DE60001555D1 (en) | AQUEOUS SOLUTION FOR PRESERVING TISSUE AND ORGANS | |
AU2002339439A1 (en) | Use of heparin-binding domain of fibronectin for diagnosis and treatment of cancer | |
ATE259379T1 (en) | FLUORESCEIN ISOTHIOCYANATE (FITC) SINISTRINE, ITS PREPARATION AND USE | |
PL366066A1 (en) | Compositions and methods of treatment and diagnosis of breast cancer | |
DE60221115D1 (en) | COMPOSITIONS AND METHODS FOR USE OF FIBRONECTIN FRAGMENTS IN CANCER DIAGNOSIS | |
DE50104761D1 (en) | MEASURING ARRANGEMENT FOR THE INVESTIGATION OF A TISSUE SECTION OF A PATIENT | |
DE60119731D1 (en) | IMMUNOLOGICAL TEST AND SET FOR THE DIAGNOSIS OF PROSTATADENO CARCINOMA | |
DE60134158D1 (en) | COMPOSITIONS AND METHODS FOR THERAPY AND DIAGNOSIS OF LUNG CANCER | |
DE69938729D1 (en) | METHOD FOR DIAGNOSIS OF BONE MEASURES FROM MALIGNANT TUMORS |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20030428 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR |
|
AX | Request for extension of the european patent |
Extension state: AL LT LV MK RO SI |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20060517 |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: GARVAN INSTITUTE OF MEDICAL RESEARCH |
|
17Q | First examination report despatched |
Effective date: 20061103 |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: CEDARS-SINAI MEDICAL CENTER Owner name: GARVAN INSTITUTE OF MEDICAL RESEARCH |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: ANGUS, DAVID B. Inventor name: HEVEZI, PETER Inventor name: AFAR, DANIEL Inventor name: WILSON, KEITH, E. Inventor name: MACK, DAVID, H. Inventor name: GISH, KURT, C. |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20070914 |