EP1421097A4 - COMPOSITIONS AND METHODS CONCERNING THE DAPTOMYCIN BIOSYNTHESEGENCLUSTER - Google Patents

COMPOSITIONS AND METHODS CONCERNING THE DAPTOMYCIN BIOSYNTHESEGENCLUSTER

Info

Publication number: EP1421097A4
Authority: EP; European Patent Office
Prior art keywords: biosynthesegencluster; daptomycin; compositions; methods concerning; concerning
Prior art date: 2001-08-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP02759231A

Other languages

German (de)

French (fr)

Other versions

EP1421097A2 (en

Inventor

Vivian Pak Woon Miao

Paul Brian

Richard H Baltz

Marie Francoise Coeffet-Legal

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Cubist Pharmaceuticals LLC

Original Assignee

Cubist Pharmaceuticals LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-06

Filing date

2002-07-31

Publication date

2005-07-06

2001-10-17 Priority claimed from PCT/US2001/032354 external-priority patent/WO2002059322A2/en

2002-07-31 Application filed by Cubist Pharmaceuticals LLC filed Critical Cubist Pharmaceuticals LLC

2004-05-26 Publication of EP1421097A2 publication Critical patent/EP1421097A2/en

2005-07-06 Publication of EP1421097A4 publication Critical patent/EP1421097A4/en

Status Withdrawn legal-status Critical Current

Links

108010013198 Daptomycin Proteins 0.000 title 1
DOAKLVKFURWEDJ-QCMAZARJSA-N daptomycin Chemical compound C([C@H]1C(=O)O[C@H](C)[C@@H](C(NCC(=O)N[C@@H](CCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@H](CO)C(=O)N[C@H](C(=O)N1)[C@H](C)CC(O)=O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)CCCCCCCCC)C(=O)C1=CC=CC=C1N DOAKLVKFURWEDJ-QCMAZARJSA-N 0.000 title 1
229960005484 daptomycin Drugs 0.000 title 1
239000000203 mixture Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes

Landscapes

Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Biophysics (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

EP02759231A 2001-08-06 2002-07-31 COMPOSITIONS AND METHODS CONCERNING THE DAPTOMYCIN BIOSYNTHESEGENCLUSTER Withdrawn EP1421097A4 (en)

Applications Claiming Priority (7)

Application Number	Priority Date	Filing Date	Title
US31038501P	2001-08-06	2001-08-06
US310385P		2001-08-06
WOPCT/US01/32354		2001-10-17
PCT/US2001/032354 WO2002059322A2 (en)	2000-10-17	2001-10-17	Compositions and methods relating to the daptomycin biosynthetic gene cluster
US37986602P	2002-05-10	2002-05-10
US379866P		2002-05-10
PCT/US2002/024310 WO2003014297A2 (en)	2001-08-06	2002-07-31	Compositions and methods relating to the daptomycin biosynthetic gene cluster

Publications (2)

Publication Number	Publication Date
EP1421097A2 EP1421097A2 (en)	2004-05-26
EP1421097A4 true EP1421097A4 (en)	2005-07-06

Family

ID=27359112

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP02759231A Withdrawn EP1421097A4 (en)	2001-08-06	2002-07-31	COMPOSITIONS AND METHODS CONCERNING THE DAPTOMYCIN BIOSYNTHESEGENCLUSTER

Country Status (3)

Country	Link
EP (1)	EP1421097A4 (en)
CA (1)	CA2456552A1 (en)
WO (1)	WO2003014297A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2008519848A (en) *	2004-11-12	2008-06-12	キュービストファーマシューティカルズ，インコーポレイテッド	Anti-infective lipopeptide
CN101830970B (en) *	2009-03-12	2012-06-27	成都雅途生物技术有限公司	Purification and preparation method of high-purity Daptomycin
CN102260700B (en) *	2010-09-24	2014-03-26	天津大学	Construction method and application of streptomyces roseosporus gene engineering bacteria HP-ORF53-55
CN102206694B (en) *	2011-04-06	2013-10-16	山东新时代药业有限公司	Slow-release composition containing capric acid
US9970036B2 (en)	2013-03-15	2018-05-15	Modular Genetics, Inc.	Generation of acyl amino acids
WO2017011592A1 (en)	2015-07-13	2017-01-19	Modular Genetics, Inc.	Generation of acyl alcohols
CN110408603B (en) *	2019-08-01	2022-09-23	上海交通大学	A54145C1 mutant with altered fatty acyl selectivity and its construction and application
CN113717909B (en) *	2020-05-26	2024-11-05	杭州中美华东制药有限公司	A daptomycin high-yield strain and its application
CN111575251B (en) *	2020-05-29	2022-03-11	上海交通大学	Construction of dptC1 mutant for daptomycin biosynthesis
CN112089823B (en) *	2020-09-25	2024-02-06	珠海中科先进技术研究院有限公司	Composition of aureobasidin A and nystatin and composite ointment, gel and spray thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5827689A (en) *	1996-11-13	1998-10-27	Smithkline Beecham Corporation	FabD polynucleotides
US6258934B1 (en) *	1997-01-24	2001-07-10	Smithkline Beecham Corporation	FabD

2002
- 2002-07-31 EP EP02759231A patent/EP1421097A4/en not_active Withdrawn
- 2002-07-31 WO PCT/US2002/024310 patent/WO2003014297A2/en active Application Filing
- 2002-07-31 CA CA002456552A patent/CA2456552A1/en not_active Abandoned

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5827689A (en) *	1996-11-13	1998-10-27	Smithkline Beecham Corporation	FabD polynucleotides
US6258934B1 (en) *	1997-01-24	2001-07-10	Smithkline Beecham Corporation	FabD

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 15 October 1997 (1997-10-15), "Streptomyces roseosporus daptomycin biosynthetic protein subunit gene, partial cds.", XP002313744, retrieved from EBI accession no. EM_PRO:AF021262 Database accession no. AF021262 *
MCHENNEY M A ET AL: "Molecular cloning and physical mapping of the daptomycin gene cluster from streptomyces roseosporus", JOURNAL OF BACTERIOLOGY, WASHINGTON, DC, US, vol. 180, no. 1, January 1998 (1998-01-01), pages 143 - 151, XP002961809, ISSN: 0021-9193 *
See also references of WO03014297A2 *

Also Published As

Publication number	Publication date
WO2003014297A2 (en)	2003-02-20
CA2456552A1 (en)	2003-02-20
WO2003014297A3 (en)	2003-05-22
EP1421097A2 (en)	2004-05-26

Publication	Publication Date	Title
ATE368018T1 (en)	2007-08-15	PLASTER COMPOSITIONS AND ASSOCIATED METHODS
DE60206653D1 (en)	2006-02-23	FLAME RESISTANT RESIN COMPOSITIONS AND METHODS
DE60134851D1 (en)	2008-08-28	HARDENABLE COMPOSITIONS AND COMPATIBILITY AGENTS
DE60003250D1 (en)	2003-07-17	Cleaning compositions and cleaning methods
DE60229770D1 (en)	2008-12-18	FRICTION-REDUCING COMPOSITION AND METHOD
DE60138711D1 (en)	2009-06-25	ANTIBODIES TO IL-12, COMPOSITIONS, PROCESSES AND USES
DE60207627D1 (en)	2006-01-05	Coating and coating composition
DE60310912D1 (en)	2007-02-15	DETERGENT COMPOSITIONS AND COMPONENTS THEREOF
EP1298180A4 (en)	2005-03-09	HYDROFUGE AND OLEOFUE COMPOSITION
ATE452540T1 (en)	2010-01-15	COMPOSITION AND METHOD
ATE324387T1 (en)	2006-05-15	CLEAR AND FLEXIBLE POLYPROPENE COMPOSITIONS
AU2002357119A8 (en)	2003-06-30	Mitocidal compositions and methods
FI20010780A0 (en)	2001-04-12	Improved compositions
DE60042883D1 (en)	2009-10-15	COMPOSITIONS AND METHODS OF MODIFYING THE TRANSFORMATION
EP1680535A4 (en)	2008-05-07	GALVANIZATION COMPOSITIONS AND GALVANIZATION PROCESSES
DE60231762D1 (en)	2009-05-07	Compositions for cleaning and disinfecting hard surfaces
DE60233444D1 (en)	2009-10-01	PARTS ATTACHMENT AND PART-ATTACHING METHOD
BR0210619A (en)	2006-05-23	composition
DE69918842D1 (en)	2004-08-26	DISINFECTION COMPOSITIONS AND METHODS
IS7081A (en)	2003-12-16	composition
EP1450752A4 (en)	2006-03-01	MULTIVALENT STREPTOCOCCULAR VACCINE COMPOSITIONS AND APPLICATION METHODS
DE60208700D1 (en)	2006-04-06	SCHÄLGERÄT AND ASSOCIATED PROCEDURES
EP1455841A4 (en)	2004-12-08	OSTEOPONTIN-RELATED COMPOSITIONS AND METHODS
DE60234410D1 (en)	2009-12-31	ERROR-EFFECTIVE PROCEDURE
EP1421097A4 (en)	2005-07-06	COMPOSITIONS AND METHODS CONCERNING THE DAPTOMYCIN BIOSYNTHESEGENCLUSTER

Legal Events

Date	Code	Title	Description
2004-04-09	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2004-05-26	17P	Request for examination filed	Effective date: 20040305
2004-05-26	AK	Designated contracting states	Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
2004-05-26	AX	Request for extension of the european patent	Extension state: AL LT LV MK RO SI
2005-04-13	RIC1	Information provided on ipc code assigned before grant	Ipc: 7C 12Q 1/68 B Ipc: 7C 12P 21/06 B Ipc: 7C 12N 5/02 B Ipc: 7C 12N 5/00 B Ipc: 7C 12N 1/16 B Ipc: 7C 12N 1/14 B Ipc: 7C 12N 1/20 B Ipc: 7C 12N 15/74 B Ipc: 7C 07H 21/04 A
2005-07-06	A4	Supplementary search report drawn up and despatched	Effective date: 20050513
2006-09-06	17Q	First examination report despatched	Effective date: 20050729
2009-12-05	GRAP	Despatch of communication of intention to grant a patent	Free format text: ORIGINAL CODE: EPIDOSNIGR1
2010-09-17	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2010-10-20	18D	Application deemed to be withdrawn	Effective date: 20100429