[go: up one dir, main page]

EP1381672A4 - Biosynthesis of polyketide synthase substrates - Google Patents

Biosynthesis of polyketide synthase substrates

Info

Publication number
EP1381672A4
EP1381672A4 EP02725059A EP02725059A EP1381672A4 EP 1381672 A4 EP1381672 A4 EP 1381672A4 EP 02725059 A EP02725059 A EP 02725059A EP 02725059 A EP02725059 A EP 02725059A EP 1381672 A4 EP1381672 A4 EP 1381672A4
Authority
EP
European Patent Office
Prior art keywords
biosynthesis
polyketide synthase
synthase substrates
substrates
polyketide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02725059A
Other languages
German (de)
French (fr)
Other versions
EP1381672A1 (en
Inventor
Chaitan Khosla
Blaine Pfeifer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BOARD OF TRUSTEES OF
TRUSTEES OF BOARD OF
Original Assignee
BOARD OF TRUSTEES OF
TRUSTEES OF BOARD OF
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/798,033 external-priority patent/US20020045220A1/en
Application filed by BOARD OF TRUSTEES OF, TRUSTEES OF BOARD OF filed Critical BOARD OF TRUSTEES OF
Publication of EP1381672A1 publication Critical patent/EP1381672A1/en
Publication of EP1381672A4 publication Critical patent/EP1381672A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1288—Transferases for other substituted phosphate groups (2.7.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • C12P17/189—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms containing the rifamycin nucleus

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
EP02725059A 2001-02-28 2002-02-28 Biosynthesis of polyketide synthase substrates Withdrawn EP1381672A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US798033 1985-11-14
US09/798,033 US20020045220A1 (en) 1999-10-13 2001-02-28 Biosynthesis of polyketide synthase substrates
US35521102P 2002-02-08 2002-02-08
US355211P 2002-02-08
PCT/US2002/006399 WO2002068613A1 (en) 2001-02-28 2002-02-28 Biosynthesis of polyketide synthase substrates

Publications (2)

Publication Number Publication Date
EP1381672A1 EP1381672A1 (en) 2004-01-21
EP1381672A4 true EP1381672A4 (en) 2006-01-25

Family

ID=26998747

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02725059A Withdrawn EP1381672A4 (en) 2001-02-28 2002-02-28 Biosynthesis of polyketide synthase substrates

Country Status (4)

Country Link
EP (1) EP1381672A4 (en)
JP (1) JP2005506044A (en)
CA (1) CA2438798A1 (en)
WO (1) WO2002068613A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7413878B2 (en) 2002-07-15 2008-08-19 Kosan Biosciences, Inc. Recombinant host cells expressing atoAD and capable of making a polyketide using a starter unit
US20110008831A1 (en) * 2005-05-26 2011-01-13 Cytos Biotechnology Ag Scalable fermentation process
US20130295631A1 (en) * 2010-10-01 2013-11-07 The Board Of Trustees Of The University Of Illinois Combinatorial design of highly efficient heterologous pathways
US8852902B2 (en) 2010-11-22 2014-10-07 The Regents Of The University Of California Producing a trimethylpentanoic acid using hybrid polyketide synthases
US10233431B2 (en) 2014-02-26 2019-03-19 The Regents Of The University Of California Producing 3-hydroxycarboxylic acid and ketone using polyketide synthases
CN109843907A (en) * 2016-10-17 2019-06-04 新南创新有限公司 Recombinate Microcystin production
CN111944734B (en) * 2019-05-17 2023-01-10 中国科学院微生物研究所 Method for improving yield of streptomycete polyketide
CN111394277B (en) * 2020-03-05 2022-06-24 福建省微生物研究所 A strain for preparing rapamycin derivatives by microbial transformation and its application

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000020601A2 (en) * 1998-10-02 2000-04-13 Kosan Biosciences, Inc. Polyketide synthase enzymes and recombinant dna constructs therefor
WO2001027306A2 (en) * 1999-10-13 2001-04-19 The Board Of Trustees Of The Leland Stanford Junior University Biosynthesis of polyketide synthase substrates
WO2001031035A2 (en) * 1999-10-27 2001-05-03 Kosan Biosciences, Inc. Heterologous production of polyketides

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5672491A (en) * 1993-09-20 1997-09-30 The Leland Stanford Junior University Recombinant production of novel polyketides
US6033883A (en) * 1996-12-18 2000-03-07 Kosan Biosciences, Inc. Production of polyketides in bacteria and yeast

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000020601A2 (en) * 1998-10-02 2000-04-13 Kosan Biosciences, Inc. Polyketide synthase enzymes and recombinant dna constructs therefor
WO2001027306A2 (en) * 1999-10-13 2001-04-19 The Board Of Trustees Of The Leland Stanford Junior University Biosynthesis of polyketide synthase substrates
WO2001031035A2 (en) * 1999-10-27 2001-05-03 Kosan Biosciences, Inc. Heterologous production of polyketides

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
See also references of WO02068613A1 *
STASSI D L ET AL: "Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 95, no. 13, 23 June 1998 (1998-06-23), pages 7305 - 7309, XP002131683, ISSN: 0027-8424 *
VANEK Z ET AL: "OVERPRODUCTION OF MICROBIAL PRODUCTS FACTS AND IDEAS", BIOTECHNOLOGY ADVANCES, vol. 8, no. 1, 1990, 2ND INTERNATIONAL SYMPOSIUM ON OVERPRODUCTION OF MICROBIAL PRODUCTS (OMP), CESKE BUDEJOVICE, CZECHOS, pages 1 - 27, XP002343918, ISSN: 0734-9750 *

Also Published As

Publication number Publication date
EP1381672A1 (en) 2004-01-21
CA2438798A1 (en) 2002-09-06
JP2005506044A (en) 2005-03-03
WO2002068613A1 (en) 2002-09-06

Similar Documents

Publication Publication Date Title
AU2002244638A1 (en) Fumaric acid derivatives as NF-kappaB inhibitors
AU2002329667A1 (en) Specific inhibition of gene expression by small double stranded rnas
AU2003234600A1 (en) tRNA SYNTHASE: MODULATORS OF ANGIOGENESIS
AU2003901797A0 (en) Manipulation of condensed tannin biosynthesis
EP1363702A4 (en) Methods of inhibiting kinases
IL200471A0 (en) Spinosyn-producing polyketide synthases
AUPQ815400A0 (en) Modification of lignin biosynthesis
AU2002311758A1 (en) Carotenoid biosynthesis
AU2002321994A1 (en) Recombinant narbonolide polyketide synthase
AU2003270900A1 (en) Antisense modulation of microsomal prostaglandin e2 synthase expression
EP1381672A4 (en) Biosynthesis of polyketide synthase substrates
EP1278882A4 (en) Overproduction hosts for biosynthesis of polyketides
AU2001250428A1 (en) Genes of the 1-desoxy-d-xylulose biosynthesis path
AU2002306734A1 (en) Inhibitors of plasmepsins
AU2002258125A1 (en) Engineered biosynthesis of novel polyenes
AU2002360394A1 (en) Facilitation of rna interference
AU2002302775A1 (en) Autocatalytic coating method
AU2002255647A1 (en) Biosynthesis of polyketide synthase substrates
AU2001275012A1 (en) Design of polyketide synthase genes
AU2002305868A1 (en) Inhibitors of reggamma
AU2002323048A1 (en) Phytochelatin synthase
AU2002343427A1 (en) Antisense modulation of sphingosine-1-phosphate lyase expression
AU2003279244A8 (en) Biosynthesis of hif
AU2002242093A1 (en) Inhibitors of glycosyltransferase enzymes
AU2002357904A1 (en) Biosynthesis of cyclic siloxanes

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20030828

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

A4 Supplementary search report drawn up and despatched

Effective date: 20051214

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20060322