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EP1365438A3 - Mass Spectrometer - Google Patents

Mass Spectrometer Download PDF

Info

Publication number
EP1365438A3
EP1365438A3 EP02257117A EP02257117A EP1365438A3 EP 1365438 A3 EP1365438 A3 EP 1365438A3 EP 02257117 A EP02257117 A EP 02257117A EP 02257117 A EP02257117 A EP 02257117A EP 1365438 A3 EP1365438 A3 EP 1365438A3
Authority
EP
European Patent Office
Prior art keywords
ions
fragment
ion trap
mass
collision cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP02257117A
Other languages
German (de)
French (fr)
Other versions
EP1365438B1 (en
EP1365438A2 (en
Inventor
John Brian Hoyes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Micromass UK Ltd
Original Assignee
Micromass UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0211373.6A external-priority patent/GB0211373D0/en
Priority claimed from GB0222055A external-priority patent/GB2389704B/en
Application filed by Micromass UK Ltd filed Critical Micromass UK Ltd
Priority to EP08013533A priority Critical patent/EP2001039B1/en
Publication of EP1365438A2 publication Critical patent/EP1365438A2/en
Publication of EP1365438A3 publication Critical patent/EP1365438A3/en
Application granted granted Critical
Publication of EP1365438B1 publication Critical patent/EP1365438B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/4205—Device types
    • H01J49/421—Mass filters, i.e. deviating unwanted ions without trapping
    • H01J49/4215—Quadrupole mass filters
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/426—Methods for controlling ions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Electron Tubes For Measurement (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

A mass spectrometer is disclosed wherein ions having a particular desired charge state are selected by operating an ion mobility spectrometer 4 in combination with a quadrupole mass filter 5. Precursor ions are fragmented or reacted to form product ions in a collision cell ion trap 6 and sent back upstream to an upstream ion trap 2. The fragment or product ions are then passed through the ion mobility spectrometer 4 wherein they become temporally separated according to their ion mobility. Fragment or product ions are then re-trapped in the collision cell ion trap 6 before being released therefrom in packets. A pusher electrode 8 of a time of flight mass analyser is energised a predetermined period of time after a packet of ions is released from the collision cell ion trap 6. Accordingly, it is possible to select multiply charged precursor ions from a background of singly charged ions, fragment them, and mass analyse the fragment ions with a near 100% duty cycle across the whole mass range.
EP02257117A 2002-05-17 2002-10-14 Mass Spectrometer comprising an Ion Mobility Spectrometer and a Mass Filter Expired - Lifetime EP1365438B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP08013533A EP2001039B1 (en) 2002-05-17 2002-10-14 Mass spectrometer

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB0211373 2002-05-17
GBGB0211373.6A GB0211373D0 (en) 2002-05-17 2002-05-17 Mass spectrometer
GBGB0212641.5A GB0212641D0 (en) 2002-05-17 2002-05-31 Mass spectrometer
GB0212641 2002-05-31
GB0222055 2002-09-23
GB0222055A GB2389704B (en) 2002-05-17 2002-09-23 Mass Spectrometer

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP08013533A Division EP2001039B1 (en) 2002-05-17 2002-10-14 Mass spectrometer
EP08013533.8 Division-Into 2008-07-28

Publications (3)

Publication Number Publication Date
EP1365438A2 EP1365438A2 (en) 2003-11-26
EP1365438A3 true EP1365438A3 (en) 2006-04-12
EP1365438B1 EP1365438B1 (en) 2010-09-08

Family

ID=29407326

Family Applications (2)

Application Number Title Priority Date Filing Date
EP08013533A Expired - Lifetime EP2001039B1 (en) 2002-05-17 2002-10-14 Mass spectrometer
EP02257117A Expired - Lifetime EP1365438B1 (en) 2002-05-17 2002-10-14 Mass Spectrometer comprising an Ion Mobility Spectrometer and a Mass Filter

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP08013533A Expired - Lifetime EP2001039B1 (en) 2002-05-17 2002-10-14 Mass spectrometer

Country Status (3)

Country Link
EP (2) EP2001039B1 (en)
CA (1) CA2407957C (en)
GB (1) GB2390478B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2390478B (en) * 2002-05-17 2004-06-02 Micromass Ltd Mass spectrometer
US7064319B2 (en) * 2003-03-31 2006-06-20 Hitachi High-Technologies Corporation Mass spectrometer
DE102004014582B4 (en) * 2004-03-25 2009-08-20 Bruker Daltonik Gmbh Ion optical phase volume compression
GB0408751D0 (en) * 2004-04-20 2004-05-26 Micromass Ltd Mass spectrometer
GB0424426D0 (en) 2004-11-04 2004-12-08 Micromass Ltd Mass spectrometer
GB0801309D0 (en) 2008-01-24 2008-03-05 Micromass Ltd Mass spectrometer
EP3069376A2 (en) * 2013-11-12 2016-09-21 Micromass UK Limited Method of isolating ions
WO2015071648A2 (en) * 2013-11-12 2015-05-21 Micromass Uk Limited Ion trap mass spectrometers
GB201319952D0 (en) * 2013-11-12 2013-12-25 Micromass Ltd Methods of isolating ions
US11424113B2 (en) 2014-06-11 2022-08-23 Micromass Uk Limited Two dimensional MS/MS acquisition modes
GB201410346D0 (en) * 2014-06-11 2014-07-23 Micromass Ltd Two dimensional msms acquisition modes
US9147565B1 (en) * 2014-12-30 2015-09-29 Morpho Detection, Llc Ion mobility spectrometer and method of using the same
WO2016170371A1 (en) * 2015-04-23 2016-10-27 Micromass Uk Limited Separating ions in an ion trap
US10832897B2 (en) * 2018-10-19 2020-11-10 Thermo Finnigan Llc Methods and devices for high-throughput data independent analysis for mass spectrometry using parallel arrays of cells
CN109755096B (en) * 2018-12-31 2020-11-06 聚光科技(杭州)股份有限公司 Screening type time-of-flight mass spectrometer and detection method
US11293898B2 (en) 2020-02-06 2022-04-05 Thermo Finnigan Llc Duty cycle improvement for a mass spectrometer using ion mobility separation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000070335A2 (en) * 1999-05-17 2000-11-23 Advanced Research & Technology Institute Ion mobility and mass spectrometer
US20020014586A1 (en) * 1997-06-02 2002-02-07 Clemmer David E. Instrument for separating ions in time as functions of preselected ion mobility and ion mass

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5689111A (en) * 1995-08-10 1997-11-18 Analytica Of Branford, Inc. Ion storage time-of-flight mass spectrometer
US6498342B1 (en) * 1997-06-02 2002-12-24 Advanced Research & Technology Institute Ion separation instrument
WO1999038193A1 (en) * 1998-01-23 1999-07-29 Analytica Of Branford, Inc. Mass spectrometry with multipole ion guide
CA2391060C (en) * 2001-06-21 2011-08-09 Micromass Limited Mass spectrometer
GB2390478B (en) * 2002-05-17 2004-06-02 Micromass Ltd Mass spectrometer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020014586A1 (en) * 1997-06-02 2002-02-07 Clemmer David E. Instrument for separating ions in time as functions of preselected ion mobility and ion mass
WO2000070335A2 (en) * 1999-05-17 2000-11-23 Advanced Research & Technology Institute Ion mobility and mass spectrometer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HARDEN C S ET AL: "DETECTION OF METHYL ISOCYANATE IN AIR WITH THE USE OF HAND-HELD IONMOBILITY SPECTROMETERS", August 1997, FIELD ANALYTICAL CHEMISTRY AND TECHNOLOGY, WILEY, NEW YORK, NY,, US, PAGE(S) 285-294, ISSN: 1086-900X, XP000944904 *

Also Published As

Publication number Publication date
CA2407957A1 (en) 2003-11-17
CA2407957C (en) 2010-12-14
EP2001039B1 (en) 2012-03-28
EP2001039A1 (en) 2008-12-10
EP1365438B1 (en) 2010-09-08
EP1365438A2 (en) 2003-11-26
GB0321698D0 (en) 2003-10-15
GB2390478B (en) 2004-06-02
GB2390478A (en) 2004-01-07

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