EP1325123A4 - STENOSE- OR RESEARCH INHIBITION BY P-SELECTIN ANTAGONISTS - Google Patents

STENOSE- OR RESEARCH INHIBITION BY P-SELECTIN ANTAGONISTS

Info

Publication number: EP1325123A4
Authority: EP; European Patent Office
Prior art keywords: stenose; selectin antagonists; inhibition; research; research inhibition
Prior art date: 2000-09-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP00963389A

Other languages

German (de)

French (fr)

Other versions

EP1325123A1 (en

Inventor

Anjali Kumar

Robert G Schuab

Jean-Francois Tanguay

Yahye Merhi

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Institut de Cardiologie de Montreal

Genetics Institute LLC

Montreal Heart Inst

Original Assignee

Institut de Cardiologie de Montreal

Genetics Institute LLC

Montreal Heart Inst

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-09-12

Filing date

2000-09-12

Publication date

2004-07-21

2000-09-12 Application filed by Institut de Cardiologie de Montreal, Genetics Institute LLC, Montreal Heart Inst filed Critical Institut de Cardiologie de Montreal

2003-07-09 Publication of EP1325123A1 publication Critical patent/EP1325123A1/en

2004-07-21 Publication of EP1325123A4 publication Critical patent/EP1325123A4/en

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/7056—Lectin superfamily, e.g. CD23, CD72
- C07K14/70564—Selectins, e.g. CD62
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Immunology (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Cell Biology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EP00963389A 2000-09-12 2000-09-12 STENOSE- OR RESEARCH INHIBITION BY P-SELECTIN ANTAGONISTS Withdrawn EP1325123A4 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US2000/025007 WO2002022820A1 (en)	2000-09-12	2000-09-12	Inhibition of stenosis or restenosis by p-selectin antagonists

Publications (2)

Publication Number	Publication Date
EP1325123A1 EP1325123A1 (en)	2003-07-09
EP1325123A4 true EP1325123A4 (en)	2004-07-21

Family

ID=21741767

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP00963389A Withdrawn EP1325123A4 (en)	2000-09-12	2000-09-12	STENOSE- OR RESEARCH INHIBITION BY P-SELECTIN ANTAGONISTS

Country Status (3)

Country	Link
EP (1)	EP1325123A4 (en)
AU (1)	AU2000274809A1 (en)
WO (1)	WO2002022820A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2003097658A2 (en)	2002-05-16	2003-11-27	Glycomimetics, Inc.	Compounds and methods for inhibiting selectin-mediated function
US7361644B2 (en)	2003-11-19	2008-04-22	Glycomimetics, Inc.	Specific antagonist for both E- and P-selectins
MY148646A (en)	2004-05-10	2013-05-15	Abgenomics Cooperatief Ua	Anti-psgl-1 antibodies
CN102617708B (en)	2004-05-11	2016-05-18	艾比吉诺米克斯合作公司	The epi-position of T-cell death-inducing
AU2006280101B2 (en)	2005-08-09	2012-06-28	Glycomimetics, Inc.	Glycomimetic inhibitors of the PA-IL lectin, PA-IIL lectin or both the lectins from Pseudomonas
SI1934236T1 (en)	2005-09-02	2013-02-28	Glycomimetics, Inc.	Heterobifunctional pan-selectin inhibitors
WO2009126556A1 (en)	2008-04-08	2009-10-15	Glycomimetics, Inc.	Pan-selectin inhibitor with enhanced pharmacokinetic activity
WO2012037034A1 (en)	2010-09-14	2012-03-22	Glycomimetics, Inc.	E-selectin antagonists
PH12013502568B1 (en)	2011-06-13	2018-08-10	Abgenomics Coop U A	Anti-psgl-1 antibodies and uses thereof
WO2013096926A1 (en)	2011-12-22	2013-06-27	Glycomimetics, Inc.	E-selectin antagonist compounds, compositions, and methods of use
SI2928476T1 (en)	2012-12-07	2018-06-29	Glycomimetics, Inc.	Compounds, compositions and methods using e-selectin antagonists for mobilization of hematopoietic cells
DK3227310T3 (en)	2014-12-03	2019-09-30	Glycomimetics Inc	HETEROBIFUNCTIONAL INHIBITORS OF E-SELECTINES AND CXCR4-CHEMOKIN RECEPTORS
CA3009836A1 (en)	2016-01-22	2017-07-27	Glycomimetics, Inc.	Glycomimetic inhibitors of pa-il and pa-iil lectins
WO2017151708A1 (en)	2016-03-02	2017-09-08	Glycomimetics, Inc.	Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin
US11433086B2 (en)	2016-08-08	2022-09-06	Glycomimetics, Inc.	Combination of T-cell checkpoint inhibitors with inhibitors of e-selectin or CXCR4, or with heterobifunctional inhibitors of both E-selectin and CXCR4
JP7069136B2 (en)	2016-10-07	2022-05-17	グリコミメティクス，インコーポレイテッド	Extremely potent multimeric E-selectin antagonist
EP3596096A1 (en)	2017-03-15	2020-01-22	GlycoMimetics, Inc.	Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists
EP3717013A1 (en)	2017-11-30	2020-10-07	GlycoMimetics, Inc.	Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
WO2019133878A1 (en)	2017-12-29	2019-07-04	Glycomimetics, Inc.	Heterobifunctional inhibitors of e-selectin and galectin-3
BR112020018184A2 (en)	2018-03-05	2021-02-02	Glycomimetics, Inc.	compound uses
WO2020139962A1 (en)	2018-12-27	2020-07-02	Glycomimetics, Inc.	Heterobifunctional inhibitors of e-selectin and galectin-3

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1995033484A1 (en) *	1994-06-03	1995-12-14	Center For Blood Research, Inc.	Method for treating and preventing atherosclerosis
WO1999043834A2 (en) *	1998-02-27	1999-09-02	Genetics Institute, Inc.	P-selectin ligand protein, including tetrameric fusion proteins
WO2001075107A2 (en) *	2000-03-31	2001-10-11	Genetics Institute, Llc.	Use of p-selectin glycoprotein ligand-1 (psgl-1) and fragments thereof for the inhibition of thrombosis

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK1396542T3 (en) *	1992-10-23	2011-06-06	Genetics Inst Llc	P-selectin ligand protein
WO1995030001A2 (en) *	1994-04-28	1995-11-09	Genetics Institute, Inc.	Novel p-selectin ligand protein
MXPA98000968A (en) *	1995-08-03	2002-07-15	Univ Oklahoma	Peptide and o-glycan inhibitors of selectin mediated inflammation.
MXPA00012586A (en) *	1998-06-16	2004-05-21	Univ Oklahoma	Glycosulfopeptides and methods of synthesis and use thereof.

2000
- 2000-09-12 AU AU2000274809A patent/AU2000274809A1/en not_active Abandoned
- 2000-09-12 WO PCT/US2000/025007 patent/WO2002022820A1/en not_active Application Discontinuation
- 2000-09-12 EP EP00963389A patent/EP1325123A4/en not_active Withdrawn

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1995033484A1 (en) *	1994-06-03	1995-12-14	Center For Blood Research, Inc.	Method for treating and preventing atherosclerosis
WO1999043834A2 (en) *	1998-02-27	1999-09-02	Genetics Institute, Inc.	P-selectin ligand protein, including tetrameric fusion proteins
WO2001075107A2 (en) *	2000-03-31	2001-10-11	Genetics Institute, Llc.	Use of p-selectin glycoprotein ligand-1 (psgl-1) and fragments thereof for the inhibition of thrombosis

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BIENVENU J G ET AL: "Effect of a recombinant soluble P-selectin glycoprotein ligand-1 on restenosis following arterial injury by repeat angioplasty in pigs", CANADIAN JOURNAL OF CARDIOLOGY, vol. 16, no. Supplement F, September 2000 (2000-09-01), 53rd Annual Meeting of the Canadian Cardiovascular Society;Vancouver, British Columbia, Canada; October 20-November 01, 2000, pages 213F - 214F, XP009031375, ISSN: 0828-282X *
BIENVENU JEAN-GUY ET AL: "Effect of a recombinant soluble P-Selectin Glycoprotein Ligand-1 chimera on restenosis following arterial injury by repeat angioplasty in pigs", JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol. 35, no. 2 suppl. A, February 2000 (2000-02-01), 29th Annual Scientific Session of the American College of Cardiology.;Anaheim, California, USA; March 12-15, 2000, pages 16A, XP001180900, ISSN: 0735-1097 *
BIENVENU JEAN-GUY ET AL: "Effect of recombinant P-Selectin-Glycoprotein-Ligand-Ig on platelet and neutrophil adhesion following repeat angioplasty in pigs", CIRCULATION, vol. 100, no. 18 SUPPL., 2 November 1999 (1999-11-02), 72nd Scientific Sessions of the American Heart Association;Atlanta, Georgia, USA; November 7-10, 1999, pages I.610, XP009031374, ISSN: 0009-7322 *
CARON A ET AL: "Effect of selectin blockade on porcine and human platelet-neutrophil binding", FASEB JOURNAL, vol. 13, no. 5 PART 2, 15 March 1999 (1999-03-15), Annual Meeting of the Professional Research Scientists on Experimental Biology 99;Washington, D.C., USA; April 17-21, 1999, pages A838, XP009031371, ISSN: 0892-6638 *
KUMAR A ET AL: "RECOMBINANT SOLUBLE FORM OF PSGL-1 ACCELERATES THROMBOLYSIS AND PREVENTS REOCCLUSION IN A PORCINE MODEL", CIRCULATION, AMERICAN HEART ASSOCIATION, DALLAS, TX, US, vol. 99, no. 10, 16 March 1999 (1999-03-16), pages 1363 - 1369, XP001034254, ISSN: 0009-7322 *
KUMAR ET AL.: "Remodeling and neointimal formation in the carotid artery of normal and P-selectin-deficient mice", CIRCULATION, vol. 96, 1997, pages 4333 - 4342 *
MERHI YAHYE ET AL: "Selectin blockade reduces neutrophil interaction with platelets at the site of deep arterial injury by angioplasty in pigs", ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, vol. 19, no. 2, February 1999 (1999-02-01), pages 372 - 377, XP002282340, ISSN: 1079-5642 *
See also references of WO0222820A1 *
WAKEFIELD T W ET AL: "VENOUS THROMBOSIS PROPHYLAXIS BY INFLAMMATORY INHIBITION WITHOUT ANTICOAGULATION THERAPY", JOURNAL OF VASCULAR SURGERY, C.V. MOSBY CO., ST. LOUIS, MO, US, vol. 31, no. 2, February 2000 (2000-02-01), pages 309 - 324, XP001034251, ISSN: 0741-5214 *

Also Published As

Publication number	Publication date
WO2002022820A1 (en)	2002-03-21
EP1325123A1 (en)	2003-07-09
AU2000274809A1 (en)	2002-03-26

Publication	Publication Date	Title
EP1325123A4 (en)	2004-07-21	STENOSE- OR RESEARCH INHIBITION BY P-SELECTIN ANTAGONISTS
MX242679B (en)	2006-12-14	INSECTED ANTRANILAMIDS.
DE50108085D1 (en)	2005-12-22	openers
FI20000004A0 (en)	2000-01-03	Flavonoidilääke ...
DE60114852D1 (en)	2005-12-15	CHINAZOLIN DERIVATIVES AS ALPHA-1 ADRENERGE ANTAGONISTS
ID29755A (en)	2001-10-11	COMPOUND ORGANOSYLICONE
FI20000457L (en)	2001-08-29	Padlock arrangement
BR0105913B1 (en)	2009-05-05	box connection structure.
TR200100070A3 (en)	2001-08-21	Compound
ITUD20000151A1 (en)	2002-02-08	CENTRATOR FOR STRIKER
ATA9712000A (en)	2002-06-15	MULTIBAY TANK
ES1045191Y (en)	2001-06-01	PERFECTED MODULAR HOUSE.
DE50105162D1 (en)	2005-03-03	Long padlock
ES1046958Y (en)	2001-07-01	FUMIGADOR DEPOSIT.
IT1319699B1 (en)	2003-10-23	DEVICE TO PREVENT THE WRINKLE FORMATION.
UA4571S (en)	2001-02-15	JAR
UA4574S (en)	2001-02-15	JAR
UA4575S (en)	2001-02-15	JAR
UA4573S (en)	2001-02-15	JAR
UA4572S (en)	2001-02-15	JAR
ITSA20000007A1 (en)	2001-10-03	DIVIDING PASTURATOR FLOAT.
EE00224U1 (en)	2000-07-17	The foundation
FI20002106A0 (en)	2000-09-25	tank lock
ITRM20000040U1 (en)	2001-09-06	EASY PLAYNET.
IT251770Y1 (en)	2004-01-20	PARAPET STRUCTURE.

Legal Events

Date	Code	Title	Description
2003-05-23	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2003-07-09	17P	Request for examination filed	Effective date: 20030414
2003-07-09	AK	Designated contracting states	Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2003-07-09	AX	Request for extension of the european patent	Extension state: AL LT LV MK RO SI
2004-01-14	RIN1	Information on inventor provided before grant (corrected)	Inventor name: MERHI, YAHYE Inventor name: TANGUAY, JEAN-FRANCOIS Inventor name: SCHUAB, ROBERT, G. Inventor name: KUMAR, ANJALI
2004-07-21	A4	Supplementary search report drawn up and despatched	Effective date: 20040609
2004-11-17	17Q	First examination report despatched	Effective date: 20040930
2007-03-07	17Q	First examination report despatched	Effective date: 20040930
2008-01-04	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2008-02-06	18D	Application deemed to be withdrawn	Effective date: 20070817