EP1287159A4 - ENZYMATIC TREATMENT OF LACTOSERUM PROTEINS FOR OBTAINING ANTI-HYPERTENSION PEPTIDES, PRODUCTS OBTAINED AND TREATMENT OF HYPERTENSION IN MAMMALS - Google Patents

ENZYMATIC TREATMENT OF LACTOSERUM PROTEINS FOR OBTAINING ANTI-HYPERTENSION PEPTIDES, PRODUCTS OBTAINED AND TREATMENT OF HYPERTENSION IN MAMMALS

Info

Publication number: EP1287159A4
Authority: EP; European Patent Office
Prior art keywords: hypertension; treatment; mammals; peptides; products obtained
Prior art date: 2000-05-08
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP01933181A

Other languages

German (de)

French (fr)

Other versions

EP1287159A1 (en

Inventor

Martin E Davis

Anand Rao

Sylvie Gauthier

Yves Pouliot

Line Gourley

Ann Francoise Allain

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Davisco Foods International Inc

Original Assignee

Davisco Foods International Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-08

Filing date

2001-05-08

Publication date

2005-02-09

2000-05-08 Priority claimed from US09/567,283 external-priority patent/US6630320B1/en

2000-10-30 Priority claimed from US09/702,068 external-priority patent/US6998259B1/en

2001-05-08 Application filed by Davisco Foods International Inc filed Critical Davisco Foods International Inc

2003-03-05 Publication of EP1287159A1 publication Critical patent/EP1287159A1/en

2005-02-09 Publication of EP1287159A4 publication Critical patent/EP1287159A4/en

Status Withdrawn legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
- A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
- A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
- A23J3/341—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins
- A23J3/343—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins of dairy proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/556—Angiotensin converting enzyme inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Zoology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
Wood Science & Technology (AREA)
Nutrition Science (AREA)
Molecular Biology (AREA)
Food Science & Technology (AREA)
Polymers & Plastics (AREA)
Vascular Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Heart & Thoracic Surgery (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Cardiology (AREA)
General Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Peptides Or Proteins (AREA)

EP01933181A 2000-05-08 2001-05-08 ENZYMATIC TREATMENT OF LACTOSERUM PROTEINS FOR OBTAINING ANTI-HYPERTENSION PEPTIDES, PRODUCTS OBTAINED AND TREATMENT OF HYPERTENSION IN MAMMALS Withdrawn EP1287159A4 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US567283		2000-05-08
US09/567,283 US6630320B1 (en)	2000-05-08	2000-05-08	Treatment of hypertension in mammals with hydrolyzed whey proteins
US702068		2000-10-30
US09/702,068 US6998259B1 (en)	1999-05-20	2000-10-30	Enzymatic treatment of whey proteins for the production of antihypertensive peptides and the resulting products
PCT/US2001/014797 WO2001085984A1 (en)	2000-05-08	2001-05-08	Enzymatic treatment of whey proteins for the production of antihypertensive peptides, the resulting products and treatment of hypertension in mammals

Publications (2)

Publication Number	Publication Date
EP1287159A1 EP1287159A1 (en)	2003-03-05
EP1287159A4 true EP1287159A4 (en)	2005-02-09

Family

ID=27074429

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP01933181A Withdrawn EP1287159A4 (en)	2000-05-08	2001-05-08	ENZYMATIC TREATMENT OF LACTOSERUM PROTEINS FOR OBTAINING ANTI-HYPERTENSION PEPTIDES, PRODUCTS OBTAINED AND TREATMENT OF HYPERTENSION IN MAMMALS

Country Status (7)

Country	Link
EP (1)	EP1287159A4 (en)
JP (1)	JP2004519204A (en)
AU (1)	AU2001259625A1 (en)
CA (1)	CA2415688A1 (en)
MX (1)	MXPA02011018A (en)
NZ (1)	NZ523036A (en)
WO (1)	WO2001085984A1 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK1087668T3 (en)	1998-06-17	2005-01-24	New Zealand Dairy Board	Bioactive whey protein hydrolyzate
CA2489942A1 (en)	2002-07-01	2004-01-08	Unilever Plc	Satiety inducing composition
EP1466529A1 (en) *	2003-04-07	2004-10-13	Chr. Hansen A/S	Composition with heart rate reducing properties
US7718171B2 (en)	2003-04-07	2010-05-18	Chr. Hansen A/S	Reducing heart rate in mammals using milk derived fermentation products produced using Lactobacillus helveticus
WO2004098310A1 (en) *	2003-05-05	2004-11-18	Unilever N.V.	Peptides having an ace inhibiting effect
ES2253036B1 (en)	2003-07-31	2007-07-16	Consejo Sup. Investig. Cientificas	BIOACTIVE PEPTIDES DERIVED FROM PROTEINS OF THE EGG CLEAR BY ENZYMATIC HYDROLYSIS.
RU2006125434A (en) *	2003-12-15	2008-01-27	Юнилевер Н.В. (Nl)	PEPTIDES WITH ACE-INHIBITING ACTION
EP1685764A1 (en)	2005-01-27	2006-08-02	Globus Egg Sciences B.V.	Anti-hypertensive functional food products
NL1026931C2 (en) *	2004-08-31	2006-03-01	Friesland Brands Bv	ACE-inhibiting whey hydrolysates.
US7883697B1 (en)	2004-09-03	2011-02-08	Chr-Hansen A/S	Fermented milk or vegetable proteins comprising receptor ligand and uses thereof
FR2876389B1 (en) *	2004-10-13	2007-05-25	Viridis Sa	HYDROLYSATS OF WHITE PROTEINS FROM LUZERNE
ES2319475B1 (en)	2005-06-08	2010-02-16	Consejo Superior Investig. Cientificas	BIOACTIVE PEPTIDES IDENTIFIED IN ENZYMATIC HYDROLYZES OF LACTEE CASEINS AND PROCEDURE OF OBTAINING.
DE102008032828A1 (en)	2008-07-02	2010-01-07	Technische Universität Dresden	Tryptophan-containing peptides from alpha-lactalbumin with hypotensive and vasoprotective action for biofunctional foods
CA2910067C (en)	2013-04-25	2023-10-17	Crucell Holland B.V.	Stabilized soluble pre-fusion rsv f polypeptides
EP3319633B1 (en)	2015-07-07	2020-11-11	Janssen Vaccines & Prevention B.V.	Vaccine against rsv
AU2016289496B2 (en)	2015-07-07	2021-02-04	Janssen Vaccines & Prevention B.V.	Stabilized soluble pre-fusion RSV F polypeptides
DK3439672T3 (en)	2016-04-05	2021-02-15	Janssen Vaccines & Prevention Bv	STABILIZED SOLUBLE PREFUSION RSV-F PROTEINS
SG11201807912SA (en)	2016-04-05	2018-10-30	Janssen Vaccines & Prevention Bv	Vaccine against rsv
EP3464331B1 (en)	2016-05-30	2020-10-28	Janssen Vaccines & Prevention B.V.	Stabilized pre-fusion rsv f proteins
US11229692B2 (en)	2017-05-17	2022-01-25	Janssen Vaccines & Prevention B.V.	Methods and compositions for inducing protective immunity against RSV infection
WO2018210871A1 (en)	2017-05-17	2018-11-22	Janssen Vaccines & Prevention B.V.	Methods and compositions for inducing protective immunity against rsv infection
US11229695B2 (en)	2017-09-15	2022-01-25	Janssen Vaccines & Prevention B.V.	Method for the safe induction of immunity against RSV

Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH04282400A (en) *	1991-03-12	1992-10-07	Calpis Food Ind Co Ltd:The	Angiotensin converting enzyme inhibitor peptide
JPH06345664A (en) *	1993-06-11	1994-12-20	Takako Tomita	New composition for suppressing elevation of blood pressure
EP0671126A1 (en) *	1992-11-30	1995-09-13	Morinaga Milk Industry Co., Ltd.	Low-phosphorus whey protein, process for producing the same, hydrolyzate of purified low-phosphorus whey protein, and process for producing the same
EP0821968A2 (en) *	1996-08-02	1998-02-04	The Calpis Food Industry Co., Ltd.	Antihypertensive agent and method for preparing same
JPH1033115A (en) *	1996-07-24	1998-02-10	Nouchikusangiyou Shinko Jigyodan	Whey beverage and its production

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3149199B2 (en) *	1991-03-12	2001-03-26	カルピス株式会社	Angiotensin converting enzyme inhibitory peptide

2001
- 2001-05-08 JP JP2001582572A patent/JP2004519204A/en active Pending
- 2001-05-08 EP EP01933181A patent/EP1287159A4/en not_active Withdrawn
- 2001-05-08 CA CA002415688A patent/CA2415688A1/en not_active Abandoned
- 2001-05-08 MX MXPA02011018A patent/MXPA02011018A/en unknown
- 2001-05-08 WO PCT/US2001/014797 patent/WO2001085984A1/en not_active Application Discontinuation
- 2001-05-08 NZ NZ523036A patent/NZ523036A/en unknown
- 2001-05-08 AU AU2001259625A patent/AU2001259625A1/en not_active Abandoned

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH04282400A (en) *	1991-03-12	1992-10-07	Calpis Food Ind Co Ltd:The	Angiotensin converting enzyme inhibitor peptide
EP0671126A1 (en) *	1992-11-30	1995-09-13	Morinaga Milk Industry Co., Ltd.	Low-phosphorus whey protein, process for producing the same, hydrolyzate of purified low-phosphorus whey protein, and process for producing the same
JPH06345664A (en) *	1993-06-11	1994-12-20	Takako Tomita	New composition for suppressing elevation of blood pressure
JPH1033115A (en) *	1996-07-24	1998-02-10	Nouchikusangiyou Shinko Jigyodan	Whey beverage and its production
EP0821968A2 (en) *	1996-08-02	1998-02-04	The Calpis Food Industry Co., Ltd.	Antihypertensive agent and method for preparing same

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ABUBAKAR A ET AL: "Structural analysis of new antihypertensive peptides derived from cheese whey protein by proteinase K digestion.", JOURNAL OF DAIRY SCIENCE. DEC 1998, vol. 81, no. 12, December 1998 (1998-12-01), pages 3131 - 3138, XP002937027, ISSN: 0022-0302 *
DATABASE WPI Section Ch Week 199248, Derwent World Patents Index; Class B04, AN 1992-392238, XP002311023 *
DATABASE WPI Section Ch Week 199510, Derwent World Patents Index; Class B04, AN 1995-070230, XP002311025 *
DATABASE WPI Section Ch Week 199816, Derwent World Patents Index; Class B04, AN 1998-172040, XP002311024 *
MULLALLY MARGARET M ET AL: "Angiotensin-I-converting enzyme inhibitory activities of gastric and pancreatic proteinase digests of whey proteins", INTERNATIONAL DAIRY JOURNAL, vol. 7, no. 5, May 1997 (1997-05-01), pages 299 - 303, XP000853725, ISSN: 0958-6946 *
PIHLANTO-LEPPALA ANNE ET AL: "Angiotensin I converting enzyme inhibitory peptides derived from bovine milk proteins", INTERNATIONAL DAIRY JOURNAL, vol. 8, no. 4, April 1998 (1998-04-01), pages 325 - 331, XP000853723, ISSN: 0958-6946 *
See also references of WO0185984A1 *

Also Published As

Publication number	Publication date
NZ523036A (en)	2004-04-30
MXPA02011018A (en)	2004-08-19
WO2001085984A1 (en)	2001-11-15
JP2004519204A (en)	2004-07-02
CA2415688A1 (en)	2001-11-15
AU2001259625A1 (en)	2001-11-20
EP1287159A1 (en)	2003-03-05

Publication	Publication Date	Title
EP1287159A4 (en)	2005-02-09	ENZYMATIC TREATMENT OF LACTOSERUM PROTEINS FOR OBTAINING ANTI-HYPERTENSION PEPTIDES, PRODUCTS OBTAINED AND TREATMENT OF HYPERTENSION IN MAMMALS
PT1171143E (en)	2005-03-31	PHARMACEUTICAL OR COSMETIC OR NUTRACEUTICAL COMPOSITION FOR A PRIMARY EXTRACT OF TREMOCH AND PHARMACEUTICAL OR NUTRACEUTIC COMPOSITION UNDERSTANDING THE ABOVE EXTRACT
DE60130791D1 (en)	2007-11-15	AMPHIPHILE LIPID NANOPARTICLES FOR PEPTIDE AND / OR PROTEIN INKORPORATION
AU2001284856A1 (en)	2002-02-18	Method and system for rapid biomolecular recognition of amino acids and protein sequencing
MXPA04000480A (en)	2004-07-23	Process for the hydrolysis of milk proteins.
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WO2004007695A3 (en)	2005-04-07	Lactobacilli expressing biologically active polypeptides and uses thereof
HK1053673A1 (en)	2003-10-31	Methods of protein destabilization and uses thereof
FR2841747B1 (en)	2004-08-20	MILK PROTEIN ISOLATE AND PROCESS FOR ITS PREPARATION
DE60120903D1 (en)	2006-08-03	Hypoallergenic foods for inducing oral tolerance to soy proteins
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AU2001257274A1 (en)	2001-11-07	A method of treating soy proteins and a soy protein product produced by this method
WO2003014078A3 (en)	2003-12-24	Muc7d1 peptides as antifungal and antibacterial agents
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ATE427355T1 (en)	2009-04-15	HUMAN ALPHA2-DELTA4 CALCIUM CHANNEL SUBUNIT CODING CDNA
WO2001051011A3 (en)	2002-04-11	Condensation products of proteins, whereby azelaic acid is used

Legal Events

Date	Code	Title	Description
2003-01-17	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2003-03-05	17P	Request for examination filed	Effective date: 20021206
2003-03-05	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
2003-03-05	AX	Request for extension of the european patent	Extension state: AL LT LV MK RO SI
2005-01-07	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN
2005-02-02	RIC1	Information provided on ipc code assigned before grant	Ipc: 7A 61P 9/12 B Ipc: 7C 12Q 1/37 B Ipc: 7C 12Q 1/34 A
2005-02-09	A4	Supplementary search report drawn up and despatched	Effective date: 20041228
2005-02-23	18W	Application withdrawn	Effective date: 20041209