[go: up one dir, main page]

EP1256329B1 - Straw for the preservation of small amounts of substances, notably of biological liquids - Google Patents

Straw for the preservation of small amounts of substances, notably of biological liquids Download PDF

Info

Publication number
EP1256329B1
EP1256329B1 EP02291120.0A EP02291120A EP1256329B1 EP 1256329 B1 EP1256329 B1 EP 1256329B1 EP 02291120 A EP02291120 A EP 02291120A EP 1256329 B1 EP1256329 B1 EP 1256329B1
Authority
EP
European Patent Office
Prior art keywords
straw
sheath
stopper
filaments
straw according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP02291120.0A
Other languages
German (de)
French (fr)
Other versions
EP1256329A1 (en
Inventor
Jean-Gérard Saint-Ramon
Francis Lesieur
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IMV Technologies SA
Original Assignee
IMV Technologies SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IMV Technologies SA filed Critical IMV Technologies SA
Publication of EP1256329A1 publication Critical patent/EP1256329A1/en
Application granted granted Critical
Publication of EP1256329B1 publication Critical patent/EP1256329B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D19/00—Instruments or methods for reproduction or fertilisation
    • A61D19/02—Instruments or methods for reproduction or fertilisation for artificial insemination
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D19/00—Instruments or methods for reproduction or fertilisation
    • A61D19/02—Instruments or methods for reproduction or fertilisation for artificial insemination
    • A61D19/022—Containers for animal semen, e.g. pouches or vials ; Methods or apparatus for treating or handling animal semen containers, e.g. filling or closing
    • A61D19/024—Tube-like containers, e.g. straws
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/069—Absorbents; Gels to retain a fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B01L2300/0838—Capillaries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces

Definitions

  • the present invention relates to a straw for the preservation of small amounts of substances, especially biological substances, in particular biological liquids.
  • the flakes manufactured according to this patent and used heretofore comprise a tripartite stopper constituted by two pads of a fibrous substance enclosing a powder capable of being transformed on contact with a liquid into an impermeable paste or gel adhering to the wall of the tube. by creating a waterproof cap.
  • the patent FR-A-2,753,367 proposes a straw comprising a tripartite plug comprising a hydrogel powder between two buffers, an external buffer and an internal buffer, said straw being characterized in that the length of the outer buffer is at least twice the length of the internal buffer. According to this patent the absorption of the liquid contained in the straw is only very slightly reduced compared to that seen with a flake equipped with a conventional tripartite stopper.
  • the document GB1299934 considered as the state of the art most pocket, discloses a straw for the preservation of small amounts of substances, including biological substances, consisting of a tube segment provided inside one of its ends a plug comprising gelling powder, a filiform or braided core and a sheath formed by son surrounding the gelling powder.
  • An object of the present invention is to provide a straw provided with a plug which absorbs only a small amount of a liquid contained in the straw. More specifically, an object of the invention is to provide a straw provided with a plug which absorbs only a quantity of a liquid contained therein at most equal to about 4%.
  • the present invention meets the above object and provides a straw for the preservation of small amounts of substances, especially biological substances, consisting of a tube segment provided inside one of its ends.
  • a plug comprising gelling powder, characterized in that said plug comprises a core of thermoplastic material sheathed by son constituting a sheath.
  • the yarns are synthetic, for example polyester.
  • the gelling powder is a material capable of being transformed in contact with a liquid into an impermeable paste or gel adhering to the wall of the tube by creating a tight stopper.
  • the gelling powder may for example be an alginate or polyvinyl alcohol.
  • the sheath can be made in the form of a braid.
  • the braid according to the present invention can be manufactured by braiding, knitting, weaving or wrapping yarns, for example synthetic yarns, on an extruded core made of thermoplastic material.
  • the wires of the sheath can be treated to be hydrophilic or water-repellent. They are white or colored; in the latter case, the son of the sheath are a color indicator of the contents of the straw.
  • the nucleus can also be colored, constituting here also an indicator color of the contents of the straw.
  • the gelling powder can also be colored, here also constituting a color indicator of the content of the straw.
  • the fixing of the son on the core can be effected by tension or adhesive mass.
  • a thin thermoplastic sheath may cover the whole.
  • the straw may be provided with a tripartite or monoblock plug.
  • the stopper of the straw according to the invention is tripartite.
  • the outer part which is not in direct contact with the liquid contained in the straw, consists of a core of thermoplastic material sheathed by son, for example synthetic.
  • the inner part in contact with the liquid contained in the straw, consists of a core of thermoplastic material sheathed by son, for example synthetic.
  • the intermediate part consists of gelling powder.
  • the stopper of the straw according to the invention is tripartite.
  • the outer part which is not in direct contact with the liquid contained in the straw, is a buffer, for example a braid, of standard fibrous substance, for example polyester viscose.
  • the inner part in contact with the liquid contained in the straw, consists of a core of thermoplastic material sheathed by son, for example synthetic.
  • the intermediate part consists of gelling powder.
  • the stopper of the straw according to the invention is tripartite.
  • the outer part which is not in direct contact with the liquid contained in the straw is a buffer, for example a braid, of standard fibrous substance, for example polyester viscose.
  • the inner part in contact with the liquid contained in the straw, consists of a core of thermoplastic material sheathed by son, for example synthetic, said core having a bore.
  • the intermediate part consists of gelling powder.
  • the stopper of the straw according to the invention is tripartite.
  • the outer part which is not in direct contact with the liquid contained in the straw, is a buffer, for example a braid, of standard fibrous substance, for example polyester viscose.
  • the inner part in contact with the liquid contained in the straw, consists of a core of thermoplastic material sheathed by son, for example synthetic, said core having a central braid of hydrophilic or water-repellent son.
  • the intermediate part consists of gelling powder.
  • the total length of the plug is between about 7 mm and about 14 mm.
  • the outer portion has a length of between about 3 mm and about 6 mm.
  • the inner portion has a length of between about 2 mm and about 5 mm.
  • the intermediate portion has a length of between about 1.5 mm and about 3 mm.
  • the cap of the straw according to the invention is monobloc and consists of a core of thermoplastic material sheathed by son, for example synthetic.
  • the strands of the sheath are impregnated with gelling powder.
  • the cap of the straw according to the invention is monobloc and consists of a core of thermoplastic material sheathed by son, for example synthetic and it comprises a central braid of hydrophilic or water-repellent threads impregnated with gelling powder.
  • the length of the one-piece cap according to the invention is between about 5 mm and about 14 mm.
  • the straw of the invention leads to a very low absorption of the liquid contained therein, of the order of 4% and even less.
  • the straw 1 consists of a tube segment 2 provided at one of its ends with a tripartite plug 3.
  • the outer portion 31, which is not in contact with the liquid contained in the straw, consists of a core 43 of thermoplastic material sheathed by son in a sheath 53.
  • the inner part 33 in contact with the liquid contained in the straw, consists of a core 43 made of thermoplastic material sheathed by wires in a sheath 53.
  • the intermediate portion 32 consists of gelling powder 7.
  • the straw 1 consists of a tube segment 2 provided at one of its ends with a tripartite plug 3.
  • the outer portion 31, which is not in contact with the liquid contained in the straw, is a braid of fibrous substance.
  • the inner part 33 in contact with the liquid contained in the straw, consists of a core 43 made of thermoplastic material sheathed by wires in a sheath 53.
  • the intermediate portion 32 consists of gelling powder 7.
  • the straw 1 consists of a tube segment 2 provided at one of its ends with a tripartite plug 3.
  • the outer portion 31, which is not in contact with the liquid contained in the straw, is a braid of fibrous substance.
  • the inner part 33 in contact with the liquid contained in the straw, consists of a core 43 made of thermoplastic material sheathed by wires in a sheath 53.
  • the core 43 has a bore 8.
  • the intermediate portion 32 consists of gelling powder 7.
  • the straw 1 consists of a tube segment 2 provided at one of its ends with a tripartite plug 3.
  • the outer portion 31, which is not in contact with the liquid contained in the straw, is a braid of fibrous substance.
  • the inner part 33 in contact with the liquid contained in the straw, consists of a core 43 of thermoplastic material sheathed by wires in a sheath 53.
  • the core 43 comprises a central braid 63.
  • the intermediate portion 32 consists of gelling powder 7.
  • the straw 1 consists of a tube segment 2 provided at one of its ends with a plug 3 monobloc.
  • the plug 3 consists of a core 4 made of thermoplastic material sheathed by wires constituting a sheath 5.
  • the wires of the sheath 5 are impregnated with a gelling powder 7.
  • the straw 1 consists of a tube segment 2 provided at one of its ends with a plug 3 monobloc.
  • the plug 3 consists of a core 4 made of thermoplastic material sheathed by wires forming a sheath 5 and comprising a central braid 6 made of synthetic threads impregnated with gelling powder 7.
  • the son constituting the sheath 5 are impregnated with gelling powder.

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Reproductive Health (AREA)
  • Engineering & Computer Science (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Braiding, Manufacturing Of Bobbin-Net Or Lace, And Manufacturing Of Nets By Knotting (AREA)
  • Table Equipment (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Closures For Containers (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Laminated Bodies (AREA)
  • Packages (AREA)
  • Materials For Medical Uses (AREA)

Description

La présente invention concerne une paillette pour la conservation de petites quantités de substances, notamment des substances biologiques, en particulier des liquides biologiques.The present invention relates to a straw for the preservation of small amounts of substances, especially biological substances, in particular biological liquids.

Ce type de paillette, connue sous la dénomination de "paillette française", a été divulgué pour la première fois dans le Brevet Français N° 995 878 .This type of straw, known under the name of "French straw", was disclosed for the first time in the French Patent No. 995,878 .

Les paillettes fabriquées selon ce brevet et utilisées jusqu'à présent comprennent un bouchon tripartite constitué par deux tampons d'une substance fibreuse enserrant une poudre susceptible de se transformer au contact d'un liquide en une pâte ou gel imperméable adhérant à la paroi du tube en créant un bouchon étanche.The flakes manufactured according to this patent and used heretofore comprise a tripartite stopper constituted by two pads of a fibrous substance enclosing a powder capable of being transformed on contact with a liquid into an impermeable paste or gel adhering to the wall of the tube. by creating a waterproof cap.

Les paillettes à bouchon tripartite mises au point et commercialisées par la Demanderesse donnent toute satisfaction. Néanmoins, une certaine absorption de liquide contenu dans la paillette a pu être constatée, quoique très faible, de l'ordre de 7 %.The sequins tripartite plug developed and marketed by the Applicant are very satisfactory. Nevertheless, some absorption of liquid contained in the straw has been observed, albeit very low, of the order of 7%.

Une solution qui a été proposée pour pallier le problème ci-dessus a été de remplacer le bouchon tripartite par une bille en matière plastique rigide ou métallique. Cette solution ne s'est pas avérée satisfaisante car, si l'absorption de liquide contenu dans la paillette a été réduite à zéro, de nouvelles difficultés rédhibitoires sont apparues, le bouchon n'étant plus du tout étanche aux liquides.One solution that has been proposed to overcome the above problem has been to replace the tripartite plug with a rigid or metallic plastic ball. This solution was not satisfactory because, if the absorption of liquid contained in the straw has been reduced to zero, new unacceptable difficulties have appeared, the plug being no longer liquid-tight.

Le brevet FR-A-2 753 367 propose une paillette comportant un bouchon tripartite comprenant une poudre hydrogel entre deux tampons, un tampon externe et un tampon interne, ladite paillette étant caractérisée en ce que la longueur du tampon externe est au moins deux fois supérieure à la longueur du tampon interne. Selon ce brevet l'absorption du liquide contenu dans la paillette n'est que très faiblement réduite par rapport à celle constatée avec une paillette munie d'un bouchon tripartite classique.The patent FR-A-2,753,367 proposes a straw comprising a tripartite plug comprising a hydrogel powder between two buffers, an external buffer and an internal buffer, said straw being characterized in that the length of the outer buffer is at least twice the length of the internal buffer. According to this patent the absorption of the liquid contained in the straw is only very slightly reduced compared to that seen with a flake equipped with a conventional tripartite stopper.

Le document GB1299934 , considéré comme l'état de la technique le plus poche, divulgue une paillette pour la conservation de petites quantités de substances, notamment des substances biologiques, se composant d'un segment de tube muni à l'intérieur de l'une de ses extrémités d'un bouchon comportant de la poudre gélifiante, un noyau filiforme ou tressé et une gaine formé par des fils entourant la poudre gélifiante.The document GB1299934 , considered as the state of the art most pocket, discloses a straw for the preservation of small amounts of substances, including biological substances, consisting of a tube segment provided inside one of its ends a plug comprising gelling powder, a filiform or braided core and a sheath formed by son surrounding the gelling powder.

Un objet de la présente invention est de disposer d'une paillette munie d'un bouchon qui n'absorbe qu'une faible quantité d'un liquide contenu dans la paillette. Plus précisément, un objet de l'invention est de fournir une paillette munie d'un bouchon qui n'absorbe qu'une quantité d'un liquide qui y est contenu au plus égale à environ 4 %.An object of the present invention is to provide a straw provided with a plug which absorbs only a small amount of a liquid contained in the straw. More specifically, an object of the invention is to provide a straw provided with a plug which absorbs only a quantity of a liquid contained therein at most equal to about 4%.

D'autres objets et avantages de l'invention apparaîtront à la lecture de la description ci-après.Other objects and advantages of the invention will appear on reading the description below.

La présente invention répond à l'objet ci-dessus et fournit une paillette pour la conservation de petites quantités de substances, notamment des substances biologiques, se composant d'un segment de tube muni à l'intérieur de l'une de ses extrémités d'un bouchon comportant de la poudre gélifiante, caractérisée en ce que ledit bouchon comprend un noyau en matière thermoplastique gainé par des fils constituant une gaine.The present invention meets the above object and provides a straw for the preservation of small amounts of substances, especially biological substances, consisting of a tube segment provided inside one of its ends. a plug comprising gelling powder, characterized in that said plug comprises a core of thermoplastic material sheathed by son constituting a sheath.

De préférence, les fils sont synthétiques, par exemple en polyester.Preferably, the yarns are synthetic, for example polyester.

La poudre gélifiante est une matière susceptible de se transformer au contact d'un liquide en une pâte ou gel imperméable adhérant à la paroi du tube en créant un bouchon étanche.The gelling powder is a material capable of being transformed in contact with a liquid into an impermeable paste or gel adhering to the wall of the tube by creating a tight stopper.

La poudre gélifiante peut par exemple être un alginate ou bien de l'alcool polyvinylique.The gelling powder may for example be an alginate or polyvinyl alcohol.

La gaine peut être réalisée sous forme d'une tresse.The sheath can be made in the form of a braid.

La tresse selon la présente invention peut être fabriquée par tressage, tricotage, tissage ou guipage de fils, par exemple synthétiques, sur un noyau extrudé en matière thermoplastique.The braid according to the present invention can be manufactured by braiding, knitting, weaving or wrapping yarns, for example synthetic yarns, on an extruded core made of thermoplastic material.

Les fils de la gaine peuvent être traités pour être hydrophiles ou hydrofuges. Ils sont blancs ou de couleur ; dans ce dernier cas, les fils de la gaine constituent un indicateur couleur du contenu de la paillette.The wires of the sheath can be treated to be hydrophilic or water-repellent. They are white or colored; in the latter case, the son of the sheath are a color indicator of the contents of the straw.

Le noyau peut être également coloré, constituant ici aussi un indicateur couleur du contenu de la paillette.The nucleus can also be colored, constituting here also an indicator color of the contents of the straw.

De même, la poudre gélifiante peut être aussi colorée, constituant ici aussi un indicateur couleur du contenu de la paillette.Similarly, the gelling powder can also be colored, here also constituting a color indicator of the content of the straw.

La fixation des fils sur le noyau peut être effectuée par tension ou masse adhésive. Une gaine en matière thermoplastique de faible épaisseur pourra recouvrir l'ensemble.The fixing of the son on the core can be effected by tension or adhesive mass. A thin thermoplastic sheath may cover the whole.

Selon l'invention la paillette peut être munie d'un bouchon tripartite ou monobloc.According to the invention the straw may be provided with a tripartite or monoblock plug.

Dans un premier mode de réalisation de l'invention, le bouchon de la paillette selon l'invention est tripartite.In a first embodiment of the invention, the stopper of the straw according to the invention is tripartite.

Il est constitué de trois parties sensiblement de même longueur ou de longueurs différentes.It consists of three parts of substantially the same length or different lengths.

La partie externe, qui n'est pas en contact direct avec le liquide contenu dans la paillette, est constituée d'un noyau en matière thermoplastique gainé par des fils, par exemple synthétiques.The outer part, which is not in direct contact with the liquid contained in the straw, consists of a core of thermoplastic material sheathed by son, for example synthetic.

La partie interne, en contact avec le liquide contenu dans la paillette, est constituée d'un noyau en matière thermoplastique gainé par des fils, par exemple synthétiques.The inner part, in contact with the liquid contained in the straw, consists of a core of thermoplastic material sheathed by son, for example synthetic.

La partie intermédiaire est constituée de poudre gélifiante.The intermediate part consists of gelling powder.

Dans un deuxième mode de réalisation de l'invention, le bouchon de la paillette selon l'invention est tripartite.In a second embodiment of the invention, the stopper of the straw according to the invention is tripartite.

Il est constitué de trois parties sensiblement de même longueur ou de longueurs différentes.It consists of three parts of substantially the same length or different lengths.

La partie externe, qui n'est pas en contact direct avec le liquide contenu dans la paillette, est un tampon, par exemple une tresse, en substance fibreuse standard, par exemple en polyester viscose.The outer part, which is not in direct contact with the liquid contained in the straw, is a buffer, for example a braid, of standard fibrous substance, for example polyester viscose.

La partie interne, en contact avec le liquide contenu dans la paillette, est constituée d'un noyau en matière thermoplastique gainé par des fils, par exemple synthétiques.The inner part, in contact with the liquid contained in the straw, consists of a core of thermoplastic material sheathed by son, for example synthetic.

La partie intermédiaire est constituée de poudre gélifiante.The intermediate part consists of gelling powder.

Dans un troisième mode de réalisation, le bouchon de la paillette selon l'invention est tripartite.In a third embodiment, the stopper of the straw according to the invention is tripartite.

Il est constitué de trois parties sensiblement de même longueur ou de longueurs différentes.It consists of three parts of substantially the same length or different lengths.

La partie externe, qui n'est pas en contact direct avec le liquide contenu dans la paillette est un tampon, par exemple une tresse, en substance fibreuse standard, par exemple en polyester viscose.The outer part, which is not in direct contact with the liquid contained in the straw is a buffer, for example a braid, of standard fibrous substance, for example polyester viscose.

La partie interne, en contact avec le liquide contenu dans la paillette, est constituée d'un noyau en matière thermoplastique gainé par des fils, par exemple synthétiques, ledit noyau comportant un alésage.The inner part, in contact with the liquid contained in the straw, consists of a core of thermoplastic material sheathed by son, for example synthetic, said core having a bore.

La partie intermédiaire est constituée de poudre gélifiante.The intermediate part consists of gelling powder.

Dans un quatrième mode de réalisation, le bouchon de la paillette selon l'invention est tripartite.In a fourth embodiment, the stopper of the straw according to the invention is tripartite.

Il est constitué de trois parties sensiblement de même longueur ou de longueurs différentes.It consists of three parts of substantially the same length or different lengths.

La partie externe, qui n'est pas en contact direct avec le liquide contenu dans la paillette, est un tampon, par exemple une tresse, en substance fibreuse standard, par exemple en polyester viscose.The outer part, which is not in direct contact with the liquid contained in the straw, is a buffer, for example a braid, of standard fibrous substance, for example polyester viscose.

La partie interne, en contact avec le liquide contenu dans la paillette, est constituée d'un noyau en matière thermoplastique gainé par des fils, par exemple synthétiques, ledit noyau comportant une tresse centrale en fils hydrophiles ou hydrofuges.The inner part, in contact with the liquid contained in the straw, consists of a core of thermoplastic material sheathed by son, for example synthetic, said core having a central braid of hydrophilic or water-repellent son.

La partie intermédiaire est constituée de poudre gélifiante.The intermediate part consists of gelling powder.

Dans le cas d'un bouchon tripartite, la longueur totale du bouchon est comprise entre environ 7 mm et environ 14 mm.In the case of a tripartite plug, the total length of the plug is between about 7 mm and about 14 mm.

La partie externe a une longueur comprise entre environ 3 mm et environ 6 mm.The outer portion has a length of between about 3 mm and about 6 mm.

La partie interne a une longueur comprise entre environ 2 mm et environ 5 mm.The inner portion has a length of between about 2 mm and about 5 mm.

La partie intermédiaire a une longueur comprise entre environ 1,5 mm et environ 3 mm.The intermediate portion has a length of between about 1.5 mm and about 3 mm.

Dans un cinquième mode de réalisation, le bouchon de la paillette selon l'invention est monobloc et il est constitué d'un noyau en matière thermoplastique gainé par des fils, par exemple synthétiques. Les fils de la gaine sont imprégnés de poudre gélifiante.In a fifth embodiment, the cap of the straw according to the invention is monobloc and consists of a core of thermoplastic material sheathed by son, for example synthetic. The strands of the sheath are impregnated with gelling powder.

Dans un sixième mode de réalisation, le bouchon de la paillette selon l'invention est monobloc et il est constitué d'un noyau en matière thermoplastique gainé par des fils, par exemple synthétiques et il comprend une tresse centrale en fils hydrophiles ou hydrofuges imprégnée de poudre gélifiante.In a sixth embodiment, the cap of the straw according to the invention is monobloc and consists of a core of thermoplastic material sheathed by son, for example synthetic and it comprises a central braid of hydrophilic or water-repellent threads impregnated with gelling powder.

La longueur du bouchon monobloc selon l'invention est comprise entre environ 5 mm et environ 14 mm.The length of the one-piece cap according to the invention is between about 5 mm and about 14 mm.

La paillette de l'invention conduit à une absorption très faible du liquide qui y est contenu, de l'ordre de 4 % et même moins.The straw of the invention leads to a very low absorption of the liquid contained therein, of the order of 4% and even less.

L'invention sera décrite plus en détail mais de façon non limitative en référence aux Figures annexées dans lesquelles

  • la Figure 1 représente une vue partielle d'une paillette de l'invention selon le premier mode de réalisation,
  • la Figure 2 représente une vue partielle d'une paillette de l'invention selon le deuxième mode de réalisation,
  • la Figure 3 représente une vue partielle d'une paillette de l'invention selon le troisième mode de réalisation,
  • la Figure 4 représente une vue partielle d'une paillette de l'invention selon le quatrième mode de réalisation,
  • la Figure 5 représente une vue partielle d'une paillette de l'invention selon le cinquième mode de réalisation,
  • la Figure 6 représente une vue partielle d'une paillette de l'invention selon le sixième mode de réalisation.
The invention will be described in more detail but in a nonlimiting manner with reference to the appended figures in which
  • the Figure 1 represents a partial view of a straw of the invention according to the first embodiment,
  • the Figure 2 represents a partial view of a straw of the invention according to the second embodiment,
  • the Figure 3 represents a partial view of a straw of the invention according to the third embodiment,
  • the Figure 4 represents a partial view of a straw of the invention according to the fourth embodiment,
  • the Figure 5 represents a partial view of a straw of the invention according to the fifth embodiment,
  • the Figure 6 represents a partial view of a straw of the invention according to the sixth embodiment.

En référence à la Figure 1, la paillette 1 se compose d'un segment de tube 2 muni à l'une de ses extrémités d'un bouchon 3 tripartite.With reference to the Figure 1 , the straw 1 consists of a tube segment 2 provided at one of its ends with a tripartite plug 3.

La partie externe 31, qui n'est pas en contact avec du liquide contenu dans la paillette, est constituée d'un noyau 43 en matière thermoplastique gainé par des fils en une gaine 53.The outer portion 31, which is not in contact with the liquid contained in the straw, consists of a core 43 of thermoplastic material sheathed by son in a sheath 53.

La partie interne 33, en contact avec du liquide contenu dans la paillette, est constituée d'un noyau 43 en matière thermoplastique gainé par des fils en une gaine 53.The inner part 33, in contact with the liquid contained in the straw, consists of a core 43 made of thermoplastic material sheathed by wires in a sheath 53.

La partie intermédiaire 32 est constituée de poudre gélifiante 7.The intermediate portion 32 consists of gelling powder 7.

En référence à la Figure 2, la paillette 1 se compose d'un segment de tube 2 muni à l'une de ses extrémités d'un bouchon 3 tripartite.With reference to the Figure 2 , the straw 1 consists of a tube segment 2 provided at one of its ends with a tripartite plug 3.

La partie externe 31, qui n'est pas en contact avec du liquide contenu dans la paillette, est une tresse en substance fibreuse.The outer portion 31, which is not in contact with the liquid contained in the straw, is a braid of fibrous substance.

La partie interne 33, en contact avec du liquide contenu dans la paillette, est constituée d'un noyau 43 en matière thermoplastique gainé par des fils en une gaine 53.The inner part 33, in contact with the liquid contained in the straw, consists of a core 43 made of thermoplastic material sheathed by wires in a sheath 53.

La partie intermédiaire 32 est constituée de poudre gélifiante 7.The intermediate portion 32 consists of gelling powder 7.

En référence à la Figure 3, la paillette 1 se compose d'un segment de tube 2 muni à l'une de ses extrémités d'un bouchon 3 tripartite.With reference to the Figure 3 , the straw 1 consists of a tube segment 2 provided at one of its ends with a tripartite plug 3.

La partie externe 31, qui n'est pas en contact avec du liquide contenu dans la paillette, est une tresse en substance fibreuse.The outer portion 31, which is not in contact with the liquid contained in the straw, is a braid of fibrous substance.

La partie interne 33, en contact avec du liquide contenu dans la paillette, est constituée d'un noyau 43 en matière thermoplastique gainé par des fils en une gaine 53. Le noyau 43 comporte un alésage 8.The inner part 33, in contact with the liquid contained in the straw, consists of a core 43 made of thermoplastic material sheathed by wires in a sheath 53. The core 43 has a bore 8.

La partie intermédiaire 32 est constituée de poudre gélifiante 7.The intermediate portion 32 consists of gelling powder 7.

En référence à la Figure 4, la paillette 1 se compose d'un segment de tube 2 muni à l'une de ses extrémités d'un bouchon 3 tripartite.With reference to the Figure 4 , the straw 1 consists of a tube segment 2 provided at one of its ends with a tripartite plug 3.

La partie externe 31, qui n'est pas en contact avec du liquide contenu dans la paillette, est une tresse en substance fibreuse.The outer portion 31, which is not in contact with the liquid contained in the straw, is a braid of fibrous substance.

La partie interne 33, en contact avec du liquide contenu dans la paillette, est constituée d'un noyau 43 en matière thermoplastique gainé par des fils en une gaine 53. Le noyau 43 comporte une tresse centrale 63.The inner part 33, in contact with the liquid contained in the straw, consists of a core 43 of thermoplastic material sheathed by wires in a sheath 53. The core 43 comprises a central braid 63.

La partie intermédiaire 32 est constituée de poudre gélifiante 7.The intermediate portion 32 consists of gelling powder 7.

En référence à la Figure 5, la paillette 1 se compose d'un segment de tube 2 muni à l'une de ses extrémités d'un bouchon 3 monobloc.With reference to the Figure 5 , the straw 1 consists of a tube segment 2 provided at one of its ends with a plug 3 monobloc.

Le bouchon 3 est constitué d'un noyau 4 en matière thermoplastique gainé par des fils constituant une gaine 5. Les fils de la gaine 5 sont imprégnés d'une poudre gélifiante 7.The plug 3 consists of a core 4 made of thermoplastic material sheathed by wires constituting a sheath 5. The wires of the sheath 5 are impregnated with a gelling powder 7.

En référence à la Figure 6, la paillette 1 se compose d'un segment de tube 2 muni à l'une de ses extrémités d'un bouchon 3 monobloc.With reference to the Figure 6 , the straw 1 consists of a tube segment 2 provided at one of its ends with a plug 3 monobloc.

Le bouchon 3 est constitué d'un noyau 4 en matière thermoplastique gainé par des fils constituant une gaine 5 et comprenant une tresse centrale 6 en fils synthétiques imprégnée de poudre gélifiante 7.The plug 3 consists of a core 4 made of thermoplastic material sheathed by wires forming a sheath 5 and comprising a central braid 6 made of synthetic threads impregnated with gelling powder 7.

Les fils constituant la gaine 5 sont imprégnés de poudre gélifiante.The son constituting the sheath 5 are impregnated with gelling powder.

L'homme du métier comprendra que bien que l'invention ait été décrite et illustrée pour des modes de réalisation particuliers, de nombreuses variantes peuvent être envisagées tout en restant dans le cadre de l'invention tel que défini dans les revendications annexées.Those skilled in the art will understand that although the invention has been described and illustrated for particular embodiments, many alternatives may be contemplated while remaining within the scope of the invention as defined in the appended claims.

Claims (17)

  1. A straw (1) for the conservation of small quantities of substances, in particular biological substances, said straw comprising a segment of tube (2) provided, inside one end, with a stopper (3) including gel powder (7), wherein said straw stopper includes a thermoplastics material core (4, 43) sheathed with filaments constituting a sheath (5, 53).
  2. The straw according to claim 1, wherein said filaments of said sheath (5, 53) are synthetic filaments.
  3. The straw according to claim 2, wherein said synthetic filaments are polyester filaments.
  4. The straw according to any one of claims 1 to 3, wherein said sheath (5) takes the form of a braid.
  5. The straw according to any one of claims 1 to 4, wherein said stopper (3) is a three-part stopper comprising an external part which is not in direct contact with said liquid contained in said straw and an internal part which is in contact with said liquid contained in said straw, said external and internal parts having between them an intermediate part consisting of gel powder.
  6. The straw according to any one of claims 1 to 4, wherein said stopper (3) is a one-piece stopper.
  7. The straw according to claim 5, wherein said three-part stopper (3) comprises an external part (31) comprising a thermoplastics material core (41) sheathed by filaments constituting a sheath (51), an internal part (33) comprising a thermoplastics material core (43) sheathed with filaments constituting a sheath (53), and an intermediate part (32) consisting of gel powder (7).
  8. The straw according to claim 5, wherein said three-part stopper (3) comprises an external part (31) comprising a fibrous substance plug, an internal part (33) comprising a thermoplastics material core (43) sheathed with filaments constituting a sheath (53), and an intermediate part (32) consisting of gel powder (7).
  9. The straw according to claim 5, wherein said three-part stopper (3) comprises an external part (31) comprising a fibrous substance plug, an internal part (33) comprising a thermoplastics material core (43) sheathed with filaments constituting a sheath (53), said core including a bore (8), and an intermediate part (32) consisting of gel powder (7).
  10. The straw according to claim 5, wherein said three-part stopper (3) comprises an external part (31) comprising a fibrous substance plug, an internal part (33) comprising a thermoplastics material core (43) sheathed with filaments constituting a sheath (53), said core including a central braid (63), and an intermediate part consisting of gel powder (7).
  11. The straw according to claim 6, wherein said one-piece stopper comprises a thermoplastics material core (4) sheathed with filaments constituting a sheath (5) impregnated with a gel powder (7).
  12. The straw according to claim 6, wherein said one-piece stopper comprises a thermoplastics material core (4) sheathed with filaments constituting a sheath (5) and including a central braid (6) impregnated with gel powder (7).
  13. The straw according to any one of claims 1 to 12, wherein said filaments of said sheath are white.
  14. The straw according to any one of claims 1 to 12, wherein said filaments of said sheath are colored, constituting a color-coded indicator of the contents of said straw.
  15. The straw according to any one of claims 1 to 12, wherein said core is colored, constituting a color-coded indicator of the contents of said straw.
  16. The straw according to any one of claims 1 to 12, wherein said gel powder is colored, constituting a color-coded indicator of the contents of said straw.
  17. The straw according to any one of claims 1 to 16, wherein said gel powder is selected from alginates and polyvinyl alcohol.
EP02291120.0A 2001-05-07 2002-05-03 Straw for the preservation of small amounts of substances, notably of biological liquids Expired - Lifetime EP1256329B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0106080A FR2824255B1 (en) 2001-05-07 2001-05-07 STRAW FOR THE PRESERVATION OF SMALL QUANTITIES OF SUBSTANCES, ESPECIALLY BIOLOGICAL LIQUIDS
FR0106080 2001-05-07

Publications (2)

Publication Number Publication Date
EP1256329A1 EP1256329A1 (en) 2002-11-13
EP1256329B1 true EP1256329B1 (en) 2016-12-07

Family

ID=8863052

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02291120.0A Expired - Lifetime EP1256329B1 (en) 2001-05-07 2002-05-03 Straw for the preservation of small amounts of substances, notably of biological liquids

Country Status (12)

Country Link
US (1) US7056727B2 (en)
EP (1) EP1256329B1 (en)
JP (1) JP4118593B2 (en)
KR (1) KR20020085824A (en)
CN (1) CN1277527C (en)
CA (1) CA2383281C (en)
FR (1) FR2824255B1 (en)
MX (1) MXPA02004542A (en)
PL (1) PL203867B1 (en)
RU (1) RU2233783C2 (en)
TW (1) TW544309B (en)
UA (1) UA70389C2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2198804A1 (en) 2008-12-18 2010-06-23 IMV Technologies Straw for the conservation of a predetermined dose of a liquid base substance, in particular a biological substance
FR3004332B1 (en) * 2013-04-11 2018-03-02 Imv Technologies STRAW FOR PRESERVING A PREDETERMINED DOSE OF A LIQUID-BASED SUBSTANCE, IN PARTICULAR PURE OR DILUTED ANIMAL SEED
FR3011731B1 (en) 2013-10-15 2016-10-28 Imv Tech (EN) STRAW FOR THE PRESERVATION OF A PREDETERMINED DOSE OF LIQUID-BASED SUBSTANCES, IN PARTICULAR PURE OR DILUTED ANIMAL SEED; AND TOGETHER THE COMPRISING
FR3011732B1 (en) * 2013-10-15 2016-09-09 Imv Tech (EN) STRAW FOR THE PRESERVATION OF A PREDETERMINED DOSE OF LIQUID-BASED SUBSTANCES, IN PARTICULAR PURE OR DILUTED ANIMAL SEED; AND TOGETHER THE COMPRISING
FR3017793B1 (en) * 2014-02-21 2019-08-23 Imv Technologies PAILLETTE FOR PRESERVING A PREDETERMINED DOSE OF A LIQUID-BASED SUBSTANCE, IN PARTICULAR A BIOLOGICAL SUBSTANCE
FR3017792B1 (en) * 2014-02-21 2019-08-23 Imv Technologies PAILLETTE FOR PRESERVING A PREDETERMINED DOSE OF A LIQUID-BASED SUBSTANCE, IN PARTICULAR A BIOLOGICAL SUBSTANCE
FR3021522A1 (en) 2014-05-28 2015-12-04 Imv Technologies STRAW FOR THE PRESERVATION OF A PREDETERMINED DOSE OF LIQUID-BASED SUBSTANCES, IN PARTICULAR DILUTED ANIMAL SEED; DILUTION MEDIUM FOR GIVING SUCH A SUBSTANCE; AND SYSTEM COMPRISING THEM
FR3034980B1 (en) 2015-04-20 2017-05-12 Imv Tech SPRAY FOR PRESERVING A PREDETERMINED DOSE OF LIQUID-BASED SUBSTANCE
FR3036954B1 (en) 2015-06-03 2017-07-14 Imv Tech STRAW FOR PRESERVING A PREDETERMINED DOSE OF LIQUID-BASED SUBSTANCE, AND INJECTION DEVICE AND METHOD FOR CARRYING OUT THE SAME
EP3120928A1 (en) * 2015-07-24 2017-01-25 Centre National De La Recherche Scientifique Fluidic devices with at least one actionnable fiber
EP3120927A1 (en) * 2015-07-24 2017-01-25 Centre National De La Recherche Scientifique Entangled fluidic device
FR3046715B1 (en) * 2016-01-19 2018-02-16 Imv Technologies DEVICE FOR PRESERVING A PREDETERMINED DOSE OF A LIQUID-BASED SUBSTANCE AND A RANGE OF SUCH DEVICES
FR3074419B1 (en) 2017-12-05 2019-12-27 Imv Technologies GLITTER FOR THE CRYOGENIC PRESERVATION OF A DOSE OF LIQUID-BASED SUBSTANCE, ASSEMBLY COMPRISING SAME AND METHOD FOR EMPTYING THE GLITTER
KR20240015455A (en) 2022-07-27 2024-02-05 성원메디칼 주식회사 Device for frozen keeping animal semen

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE498210A (en) 1949-09-20
CH511976A (en) * 1969-05-16 1971-08-31 Brinex S A Wick intended to be cut into sections of stoppering tubes for conditioning aqueous solutions as well as process and machine for its manufacture
JPS63500571A (en) 1985-07-16 1988-03-03 ゼネラル　ポリメリツク　コ−ポレ−シヨン Flow rate control device and device using the flow rate control device
EP0304358B1 (en) * 1987-07-22 1992-03-04 Robert Cassou Storing tube for small quantites of substances, especially biological ones, and its use in a fertilisation process
US4925060A (en) * 1989-08-17 1990-05-15 Gustafson Keith W Cork for cryogenic dry shipper
US5279606A (en) * 1991-08-28 1994-01-18 Habley Medical Technology Corporation Non-reactive composite sealing barrier
JPH0722717A (en) 1993-06-30 1995-01-24 Ibiden Co Ltd Printed wiring board
JPH08862A (en) 1994-06-20 1996-01-09 Janome Sewing Mach Co Ltd Sewing machine capable of fitting seam guide
FR2753367B1 (en) 1996-09-19 1998-12-04 Lecointe Pascal STORAGE STRAW OF A LIQUID BIOLOGICAL SUBSTANCE AND FILLING METHOD THEREOF
FR2762210B1 (en) * 1997-04-21 1999-07-02 Instr Medecine Veterinaire GLITTER WITH A FULL MICROPOROUS FIBER CAP
FR2771284B1 (en) * 1997-11-24 2000-08-18 Instr Medecine Veterinaire GLITTER WITH ADAPTER INSERT
JPH11276912A (en) * 1998-03-27 1999-10-12 Mitsubishi Chemical Engineering Corp Glass appliance and glass filter as well as their production
JP2000051248A (en) * 1998-08-03 2000-02-22 Fujihira Kogyo Kk Plug body of straw tube

Also Published As

Publication number Publication date
FR2824255B1 (en) 2004-02-06
PL203867B1 (en) 2009-11-30
UA70389C2 (en) 2004-10-15
US7056727B2 (en) 2006-06-06
TW544309B (en) 2003-08-01
MXPA02004542A (en) 2002-11-20
RU2002111842A (en) 2004-01-20
PL353725A1 (en) 2002-11-18
KR20020085824A (en) 2002-11-16
JP2002369742A (en) 2002-12-24
US20020183653A1 (en) 2002-12-05
CN1277527C (en) 2006-10-04
FR2824255A1 (en) 2002-11-08
EP1256329A1 (en) 2002-11-13
CA2383281A1 (en) 2002-11-07
RU2233783C2 (en) 2004-08-10
CA2383281C (en) 2007-06-26
CN1383795A (en) 2002-12-11
JP4118593B2 (en) 2008-07-16

Similar Documents

Publication Publication Date Title
EP1256329B1 (en) Straw for the preservation of small amounts of substances, notably of biological liquids
CA2382339C (en) Straw for the preservation of small quantities of substances, in particular biological fluids
FR2752696A1 (en) LIQUID OR SEMI-LIQUID PRODUCT APPLICATOR AND APPLICATION ASSEMBLY USING SUCH APPLICATOR
EP0917863B1 (en) Tube with a stop composed of two parts
EP0917862B1 (en) Tube having an insert adapter
FR2537550A3 (en) CONTAINER CONTAINING FLUID SUBSTANCES, FOR USE WITH SMALL MANUAL PUMPS FOR THE DELIVERY OF SUCH SUBSTANCES
EP3148479B1 (en) Straw for preserving a predefined dose of a liquid substance, in particular diluted animal semen; and system comprising such a straw and a dilution medium for producing such a substance
FR2846128A1 (en) Straw for cryogenic preservation of biological materials, e.g. semen, comprises an inner tube and a coaxial outer tube that carries identifiers, welded together at the ends
FR2787011A1 (en) Pipette
FR2517540A1 (en) PACKAGE CONTAINING A HYGIENIC PAD
FR2655948A1 (en) CONTAINER STRUCTURE OF SYNTHETIC MATERIAL PERMEABLE WITH AT LEAST ONE OF THE COMPONENTS OF ITS CONTENT.
WO2000013980A1 (en) Shoulder design for tube
FR3017792B1 (en) PAILLETTE FOR PRESERVING A PREDETERMINED DOSE OF A LIQUID-BASED SUBSTANCE, IN PARTICULAR A BIOLOGICAL SUBSTANCE
FR2758973A1 (en) FILLING TIP FOR BIOLOGICAL LIQUID PACKAGING ELEMENTS, IN PARTICULAR FOR ARTIFICIAL INSEMINATION

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI

17P Request for examination filed

Effective date: 20030425

AKX Designation fees paid

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

17Q First examination report despatched

Effective date: 20100128

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

INTG Intention to grant announced

Effective date: 20160607

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE PATENT HAS BEEN GRANTED

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: IMV TECHNOLOGIES

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

Free format text: NOT ENGLISH

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

Ref country code: AT

Ref legal event code: REF

Ref document number: 851056

Country of ref document: AT

Kind code of ref document: T

Effective date: 20161215

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

Free format text: LANGUAGE OF EP DOCUMENT: FRENCH

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 60248534

Country of ref document: DE

REG Reference to a national code

Ref country code: NL

Ref legal event code: FP

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20161207

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK05

Ref document number: 851056

Country of ref document: AT

Kind code of ref document: T

Effective date: 20161207

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 16

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20161207

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20161207

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20161207

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170531

Ref country code: IT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20161207

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20170407

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 60248534

Country of ref document: DE

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20170908

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20161207

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20170503

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20161207

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170531

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170531

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170503

REG Reference to a national code

Ref country code: BE

Ref legal event code: MM

Effective date: 20170531

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170503

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170503

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 17

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170531

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NL

Payment date: 20190412

Year of fee payment: 18

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20161207

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20161207

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20161207

REG Reference to a national code

Ref country code: NL

Ref legal event code: MM

Effective date: 20200601

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20200601

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20210507

Year of fee payment: 20

Ref country code: FR

Payment date: 20210527

Year of fee payment: 20

REG Reference to a national code

Ref country code: DE

Ref legal event code: R071

Ref document number: 60248534

Country of ref document: DE