Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
  • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q7/00—Preparations for affecting hair growth
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
  • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
  • A61K8/9783—Angiosperms [Magnoliophyta]
  • A61K8/9789—Magnoliopsida [dicotyledons]
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P17/00—Drugs for dermatological disorders
  • A61P17/14—Drugs for dermatological disorders for baldness or alopecia

Definitions

• the invention relates to plant extracts used for combating hair loss, a process for preparing them, and their use for combating hair loss and promoting their regrowth.
• compositions are obtained from a specific combination of plants which is treated by decoction and distillation by entrainment in water vapor and provides an aqueous composition of plant extracts which can be used as it is or transformed into an oily composition. with vegetable oil or a mixture of vegetable oils.
• the association or mixture of plants contains, as essential constituents,
• Lower proportions of plants with an astringent or nourishing character can be used, and in particular for their astringent role, up to 10% of Rosa gallica or from 1 to 5% of cloves (nails and bark), and for their nourishing role up to 10% of cinquefoil or up to 15% of acorn (crushed). These percentages are expressed relative to the total weight of the base combination.
• cypress leaves and fruits
• the percentages are chosen so that the total mixture contains at least 20%.
• zyzyphus and the cloves will be ground, for example in a rotary grinder, until a powder with an average particle size of 0.5 mm is obtained while the cypress (leaves and fruits) will be ground, for example manually pestle and mortar, until a coarse paste is obtained.
• the absence of grinding apparently does not allow the extraction of the plant elements constituting some of the active principles of the hair compositions of the invention.
• the aqueous composition After cooling, the aqueous composition can be used directly as a treatment composition. It can also be transformed into an oily composition according to the following treatment.
• the aqueous composition is added to approximately once its weight of vegetable oils, preferably chosen from olive oil, sesame oil and bay oil or their mixtures.
• vegetable oils preferably chosen from olive oil, sesame oil and bay oil or their mixtures.
• sesame oil containing from 10 to 50% of olive oil or a mixture of at least 30% sesame oil and olive oil and laurel oil in variable proportions.
• the whole is brought to 100 ° C. under moderate conditions and with stirring to remove the water in about three hours. Avoid heating above 100 ° C in order not to deteriorate the active ingredients contained in the composition. Moderate conditions are necessary so as not to entrain the active ingredients with the evaporating water.
• the operation of extracting the active ingredients with a vegetable oil can also be carried out at temperatures below 100 ° C. or at ambient temperature with laboratory extractors.
• the oily composition thus obtained is ready for use after cooling.
• the above aqueous and oily compositions constitute oily lotions and preparations which can be used as such but they can be used to prepare shampoos, emulsions or be liposomal, microencapsulated, etc.
• the cosmetic treatment consists in massaging the clean and dry scalp with, at each application, 2 to 5 g of an oily or aqueous composition. It is recommended to carry out a hyperemiant brushing beforehand in order to prepare the scalp for the treatment. After massage, leave on for at least one to two hours. This minimum duration, however, allows the treatment to be applied in the evening and shampoo before bedtime. In the case where an aqueous composition is used, the shampoo is not even necessary since the composition dries quickly, is not greasy and allows styling.
• the application is daily at the start of treatment then will be spaced up to twice a week and will continue as long as necessary.
• Example 1 After four to five weeks, there is a considerable slowdown in the fall and a slight regrowth. Significant regrowth was seen after five / six months in subjects with old alopecia, some even having an aggravating genetic factor.
• the preparation of the aqueous and oily compositions of the invention will be described in more detail in the examples below.
• the zyzyphus and the cloves were previously ground in a rotary grinder to obtain a powder with a particle size of 0.5 mm, while the cypress is crushed with a pestle and mortar until a paste forms. coarse.
• the plants are introduced into a flask equipped with a thermometer and a refrigerant. Double their weight, 420 g of water, is added and the mixture is heated under moderate conditions to evaporate half of the water in about 5 hours. The residual contents of the flask are discarded and 220 ml of an aqueous extract containing water and the distilled compounds are collected by stripping with steam.
• the extract obtained can be used directly as an aqueous composition for treating hair loss or else transformed into an oily composition as described below.
• Aqueous extracts and then oily compositions are prepared using the plant products and the oils indicated in the following table in the proportions (in% by weight) also indicated in the table.
• Each of the aqueous and oily compositions obtained in Examples 1, 2 and 3 A to 3F is used to treat the scalp of patients with old or recent alopecia.
• the dose can range from 2 to 5 g
• the scalp is massaged 2 to 3 minutes before leaving for two hours.
• the application is made, for practical reasons, in the evening and the oily compositions are removed before bedtime by shampoo.
• aqueous compositions can also be removed by shampoo but this is not essential because they dry quickly and do not grease the scalp.

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• Health & Medical Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Veterinary Medicine (AREA)
• Public Health (AREA)
• General Health & Medical Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• Engineering & Computer Science (AREA)
• Microbiology (AREA)
• Birds (AREA)
• Epidemiology (AREA)
• Mycology (AREA)
• Botany (AREA)
• Biotechnology (AREA)
• Dermatology (AREA)
• Chemical & Material Sciences (AREA)
• Chemical Kinetics & Catalysis (AREA)
• General Chemical & Material Sciences (AREA)
• Medicinal Chemistry (AREA)
• Bioinformatics & Cheminformatics (AREA)
• Pharmacology & Pharmacy (AREA)
• Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
• Organic Chemistry (AREA)
• Cosmetics (AREA)
• Medicines Containing Plant Substances (AREA)

Applications Claiming Priority (3)

Publications (1)

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ID=9525904

Family Applications (1)

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• 1998
  • 1998-04-30 FR FR9805488A patent/FR2778105B1/fr not_active Expired - Fee Related
• 1999
  • 1999-04-21 EP EP99914637A patent/EP1073405A1/de not_active Ceased
  • 1999-04-21 CA CA002329758A patent/CA2329758A1/fr not_active Abandoned
  • 1999-04-21 AU AU33375/99A patent/AU3337599A/en not_active Abandoned
  • 1999-04-21 JP JP2000546741A patent/JP2002513742A/ja not_active Withdrawn
  • 1999-04-21 KR KR1020007012075A patent/KR20010024982A/ko not_active Application Discontinuation
  • 1999-04-21 WO PCT/FR1999/000946 patent/WO1999056713A1/fr not_active Application Discontinuation

Non-Patent Citations (1)

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