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EP1042498A4 - A method of finding agonist and antagonist to human 11cb splice variant - Google Patents

A method of finding agonist and antagonist to human 11cb splice variant

Info

Publication number
EP1042498A4
EP1042498A4 EP98962869A EP98962869A EP1042498A4 EP 1042498 A4 EP1042498 A4 EP 1042498A4 EP 98962869 A EP98962869 A EP 98962869A EP 98962869 A EP98962869 A EP 98962869A EP 1042498 A4 EP1042498 A4 EP 1042498A4
Authority
EP
European Patent Office
Prior art keywords
agonist
antagonist
finding
human
splice variant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98962869A
Other languages
German (de)
French (fr)
Other versions
EP1042498A1 (en
Inventor
Robert S Ames Jr
Henry M Sarau
James J Foley
Derk Bergsma
Catherine E Ellis
Jon K Chambers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/984,288 external-priority patent/US6033872A/en
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP1042498A1 publication Critical patent/EP1042498A1/en
Publication of EP1042498A4 publication Critical patent/EP1042498A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
EP98962869A 1997-12-03 1998-12-02 A method of finding agonist and antagonist to human 11cb splice variant Withdrawn EP1042498A4 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US984288 1997-12-03
US08/984,288 US6033872A (en) 1996-12-11 1997-12-03 Polynucleotides encoding a novel human 11cb splice variant
US7374798P 1998-02-05 1998-02-05
US73747P 1998-02-05
US6050498A 1998-04-15 1998-04-15
US60504 1998-04-15
PCT/US1998/025497 WO1999028492A1 (en) 1997-12-03 1998-12-02 A method of finding agonist and antagonist to human 11cb splice variant

Publications (2)

Publication Number Publication Date
EP1042498A1 EP1042498A1 (en) 2000-10-11
EP1042498A4 true EP1042498A4 (en) 2003-05-07

Family

ID=27369862

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98962869A Withdrawn EP1042498A4 (en) 1997-12-03 1998-12-02 A method of finding agonist and antagonist to human 11cb splice variant

Country Status (3)

Country Link
EP (1) EP1042498A4 (en)
JP (1) JP2001525178A (en)
WO (1) WO1999028492A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1802000A (en) * 1998-12-28 2000-07-24 Takeda Chemical Industries Ltd. Screening method
US6221613B1 (en) 1998-12-31 2001-04-24 Synaptic Pharmaceutical Corporation DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof
WO2001005947A1 (en) 1999-07-14 2001-01-25 Merck & Co., Inc. Melanin-concentrating hormone receptor
GB9929772D0 (en) * 1999-12-16 2000-02-09 Smithkline Beecham Plc New use
JP4780365B2 (en) * 2000-07-05 2011-09-28 武田薬品工業株式会社 MCH receptor antagonist / agonist screening method
DE60143525D1 (en) 2000-07-05 2011-01-05 Takeda Pharmaceutical PROCESS FOR SCREENING MHC RECEPTOR ANTAGONISTS OR AGONISTS
EP1305341A1 (en) 2000-07-21 2003-05-02 Merck & Co., Inc. Dog melanin-concentrating hormone receptor
US7078484B2 (en) 2001-04-19 2006-07-18 Neurogen Corporation Melanin concentrating hormone receptors
US7078187B2 (en) 2001-04-19 2006-07-18 Neurogen Corporation Melanin concentrating hormone receptors
US6809104B2 (en) 2001-05-04 2004-10-26 Tularik Inc. Fused heterocyclic compounds
CA2449011A1 (en) 2001-05-31 2002-12-05 Merck & Co., Inc. Rhesus monkey, dog and ferret melanin-concentrating hormone type 2 receptor
US20040248129A1 (en) * 2001-09-24 2004-12-09 Carina Tan Rhesus monkey, dog and feeret melanin-concentrating hormone type 1 receptor
PL376659A1 (en) 2002-11-06 2006-01-09 Tularik Inc. Fused heterocyclic compounds
TW201536767A (en) 2013-07-09 2015-10-01 Takeda Pharmaceutical Heterocyclic compound

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0871669A4 (en) * 1994-12-16 2000-02-09 Smithkline Beecham Corp Human somatostatin-like receptor

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHAMBERS J ET AL: "Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1.", NATURE. ENGLAND 15 JUL 1999, vol. 400, no. 6741, 15 July 1999 (1999-07-15), pages 261 - 265, XP002224988, ISSN: 0028-0836 *
DATABASE EMBL [online] 1 October 1997 (1997-10-01), XP002224878, retrieved from EMBL Database accession no. AF008650 *
LAKAYE B ET AL: "CLONING OF THE RAT BRAIN CDNA ENCODING FOR THE SLC-1 G PROTEIN- COUPLED RECEPTOR REVEALS THE PRESENCE OF AN INTRON IN THE GENE", BIOCHIMICA ET BIOPHYSICA ACTA, AMSTERDAM, NL, vol. 1401, no. 2, 1998, pages 216 - 220, XP000856696, ISSN: 0006-3002 *
See also references of WO9928492A1 *

Also Published As

Publication number Publication date
WO1999028492A1 (en) 1999-06-10
EP1042498A1 (en) 2000-10-11
JP2001525178A (en) 2001-12-11

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20000703

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): BE CH DE DK FR GB IT LI NL

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: SMITHKLINE BEECHAM CORPORATION

A4 Supplementary search report drawn up and despatched

Effective date: 20030326

17Q First examination report despatched

Effective date: 20030721

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20040201