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EP1037628A4 - Methods for preventing restenosis using tocotrienols - Google Patents

Methods for preventing restenosis using tocotrienols

Info

Publication number
EP1037628A4
EP1037628A4 EP98960259A EP98960259A EP1037628A4 EP 1037628 A4 EP1037628 A4 EP 1037628A4 EP 98960259 A EP98960259 A EP 98960259A EP 98960259 A EP98960259 A EP 98960259A EP 1037628 A4 EP1037628 A4 EP 1037628A4
Authority
EP
European Patent Office
Prior art keywords
tocotrienols
methods
preventing restenosis
restenosis
preventing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98960259A
Other languages
German (de)
French (fr)
Other versions
EP1037628A1 (en
Inventor
Ronald H Lane
Frederick H Schneider
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lipogenics Inc
Original Assignee
Lipogenics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lipogenics Inc filed Critical Lipogenics Inc
Publication of EP1037628A1 publication Critical patent/EP1037628A1/en
Publication of EP1037628A4 publication Critical patent/EP1037628A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Prostheses (AREA)
EP98960259A 1997-11-17 1998-11-17 Methods for preventing restenosis using tocotrienols Withdrawn EP1037628A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97170397A 1997-11-17 1997-11-17
US971703 1997-11-17
PCT/US1998/024606 WO1999025336A1 (en) 1997-11-17 1998-11-17 Methods for preventing restenosis using tocotrienols

Publications (2)

Publication Number Publication Date
EP1037628A1 EP1037628A1 (en) 2000-09-27
EP1037628A4 true EP1037628A4 (en) 2002-08-21

Family

ID=25518699

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98960259A Withdrawn EP1037628A4 (en) 1997-11-17 1998-11-17 Methods for preventing restenosis using tocotrienols

Country Status (6)

Country Link
EP (1) EP1037628A4 (en)
JP (1) JP2001522880A (en)
AU (1) AU746369B2 (en)
CA (1) CA2310232A1 (en)
ID (1) ID26335A (en)
WO (1) WO1999025336A1 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6864280B2 (en) * 2000-03-31 2005-03-08 Eisai Co., Ltd. γ-Tocotrienol-containing diuretics
US7713546B1 (en) * 2001-04-03 2010-05-11 Soft Gel Technologies, Inc. Corosolic acid formulation and its application for weight-loss management and blood sugar balance
DE10115740A1 (en) 2001-03-26 2002-10-02 Ulrich Speck Preparation for restenosis prophylaxis
DK1521603T3 (en) 2002-07-12 2011-04-18 Cook Inc Coated medical device
DE10244847A1 (en) 2002-09-20 2004-04-01 Ulrich Prof. Dr. Speck Medical device for drug delivery
WO2005039443A2 (en) 2003-10-21 2005-05-06 Medlogics Device Corporation Gamma-tocopherol therapy for restenosis prevention
US8124127B2 (en) 2005-10-15 2012-02-28 Atrium Medical Corporation Hydrophobic cross-linked gels for bioabsorbable drug carrier coatings
US9012506B2 (en) 2004-09-28 2015-04-21 Atrium Medical Corporation Cross-linked fatty acid-based biomaterials
US9801982B2 (en) 2004-09-28 2017-10-31 Atrium Medical Corporation Implantable barrier device
US9000040B2 (en) 2004-09-28 2015-04-07 Atrium Medical Corporation Cross-linked fatty acid-based biomaterials
WO2007011385A2 (en) 2004-09-28 2007-01-25 Atrium Medical Corporation Heat cured gel and method of making
US8263102B2 (en) 2004-09-28 2012-09-11 Atrium Medical Corporation Drug delivery coating for use with a stent
HUE033304T2 (en) 2005-06-01 2017-11-28 Bioelectron Tech Corp Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
US9278161B2 (en) 2005-09-28 2016-03-08 Atrium Medical Corporation Tissue-separating fatty acid adhesion barrier
US9427423B2 (en) 2009-03-10 2016-08-30 Atrium Medical Corporation Fatty-acid based particles
JP5374162B2 (en) 2006-02-22 2013-12-25 エジソン ファーマシューティカルズ， インコーポレイテッド Modulation of redox-activated therapeutic side chain variants and energy biomarkers for the treatment of mitochondrial diseases and other conditions
WO2008057344A2 (en) 2006-11-06 2008-05-15 Atrium Medical Corporation Coated surgical mesh
US9492596B2 (en) 2006-11-06 2016-11-15 Atrium Medical Corporation Barrier layer with underlying medical device and one or more reinforcing support structures
US9192697B2 (en) 2007-07-03 2015-11-24 Hemoteq Ag Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
BRPI0918139B1 (en) 2008-09-10 2024-04-30 Ptc Therapeutics, Inc COMPOSITION, MEDICAL OR FUNCTIONAL FOOD, FOOD OR DIETARY SUPPLEMENT FOR TREATMENT OF PERVASIVE DEVELOPMENTAL DISORDERS WITH REDOX-ACTIVE THERAPEUTICS
EP2451496B1 (en) 2009-07-10 2015-07-22 Boston Scientific Scimed, Inc. Use of nanocrystals for a drug delivery balloon
US10080821B2 (en) 2009-07-17 2018-09-25 Boston Scientific Scimed, Inc. Nucleation of drug delivery balloons to provide improved crystal size and density
US20110038910A1 (en) 2009-08-11 2011-02-17 Atrium Medical Corporation Anti-infective antimicrobial-containing biomaterials
EA028677B1 (en) 2009-08-26 2017-12-29 Биоэлектрон Текнолоджи Корпорейшн Method for the treatment, prevention and/or amelioration of neuronal damage associated with cerebral ischemia
WO2012009707A2 (en) 2010-07-16 2012-01-19 Atrium Medical Corporation Composition and methods for altering the rate of hydrolysis of cured oil-based materials
WO2012031236A1 (en) 2010-09-02 2012-03-08 Boston Scientific Scimed, Inc. Coating process for drug delivery balloons using heat-induced rewrap memory
WO2013028208A1 (en) 2011-08-25 2013-02-28 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
US9867880B2 (en) 2012-06-13 2018-01-16 Atrium Medical Corporation Cured oil-hydrogel biomaterial compositions for controlled drug delivery
EP2877171A4 (en) * 2012-07-19 2016-01-13 Univ Ohio State METHOD FOR ENHANCING COAGULATION PATHOLOGIES AND MATERIALS AND ASSOCIATED METHODS
AU2016369616B2 (en) 2015-12-17 2021-03-25 Ptc Therapeutics, Inc. Fluoroalkyl, fluoroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4333794A1 (en) * 1993-10-04 1995-04-06 Carl Heinrich Dr Weischer Acetylsalicylic acid derivatives for controlling states of inflammation and pain and for the prophylaxis and therapy of thrombosis
EP0669132A1 (en) * 1994-02-23 1995-08-30 van der Kraaij, Antonius Marinus Maria Pharmaceutical composition of vitamin E and acetylsalicylate for treatment and prevention of atherosclerosis
US5591772A (en) * 1991-11-22 1997-01-07 Lipogenics, Inc. Tocotrienols and tocotrienol-like compounds and methods for their use

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5591772A (en) * 1991-11-22 1997-01-07 Lipogenics, Inc. Tocotrienols and tocotrienol-like compounds and methods for their use
DE4333794A1 (en) * 1993-10-04 1995-04-06 Carl Heinrich Dr Weischer Acetylsalicylic acid derivatives for controlling states of inflammation and pain and for the prophylaxis and therapy of thrombosis
EP0669132A1 (en) * 1994-02-23 1995-08-30 van der Kraaij, Antonius Marinus Maria Pharmaceutical composition of vitamin E and acetylsalicylate for treatment and prevention of atherosclerosis

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
AZZI A ET AL: "MODULATION OF CELL PROLIFERATION BY TOCOPHEROLS AND TOCOTRIENOLS: ROLE IN ARTERIOSCLEROSIS", LIPID SOLUBLE ANTIOXIDANTS: BIOCHEMISTRY AND CLINICAL APPLICATIONS, BIRKHAEUSER VERLAG, BASEL, CH, 1992, pages 123 - 133, XP008004536 *
GELLER M R ET AL: "Palmvitee-induced carotid plaque regression in humans.", STROKE (26, NO. 1, 162, 1995) CODEN: SJCCA7 ISSN: 0039-2499, XP008004540 *
KARPEN C W ET AL: "TOCOTRIENOL-INDUCED INHIBITION OF PLATELET THROMBUS FORMATION AND PLATELET AGGREGATION IN A STENOSEL CORONARY ARTERY CANINE MODEL", CIRCULATION, AMERICAN HEART ASSOCIATION, DALLAS, TX, US, vol. 4, PART 2, no. 90, 14 November 1994 (1994-11-14), pages 1181, XP008004384, ISSN: 0009-7322 *
KOOYENGA D ET AL: "ANTIOXIDANT EFFECTS OF TOCOTRIENOLS IN PATIENTS WITH CAROTID STENOSIS", JOURNAL OF INVESTIGATIVE MEDICINE, AMERICAN FEDERATION FOR CLINICAL RESEARCH,, US, vol. 3, no. 44, 3 May 1996 (1996-05-03), pages 245A, XP008004383, ISSN: 1081-5589 *
PACKER L: "INTERACTIONS AMONG ANTIOXIDANTS IN HEALTH AND DISEASE: VITAMIN E AND ITS REDOX CYCLE", PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY & MEDICINE, ACADEMIC PRESS INC. NEW YORK, US, vol. 2, no. 200, June 1992 (1992-06-01), pages 271 - 276, XP001073940, ISSN: 0037-9727 *
QURESHI A A ET AL: "NOVEL TOCOTRIENOLS OF RICE BRAN MODULATE CARDIOVASCULAR DISEASE RISK PARAMETERS OF HYPERCHOLESTEROLEMIC HUMANS", JOURNAL OF NUTRITIONAL BIOCHEMISTRY, BUTTERWORTH PUBLISHERS, STONEHAM, GB, vol. 8, no. 5, May 1997 (1997-05-01), pages 290 - 298, XP001026694, ISSN: 0955-2863 *
See also references of WO9925336A1 *
TOMEO A C ET AL: "ANTIOXIDANT EFFECTS OF PV IN HYPERLIPIDEMIC SUBJECTS WITH CAROTID ARTERY STENOSIS", CLINICAL RESEARCH, THOROFARE, NJ, US, vol. 2, no. 42, 29 April 1994 (1994-04-29), pages 158A, XP008004385, ISSN: 0009-9279 *
TOMEO ET AL.: "Antioxidant effects of vitamin E and gamma-tocotrienol in hyperlipidemic subjects with carotid artery stenosis - A preliminary report", CLIN. RES., vol. 42, no. 1, - 1994, pages 29a, XP008004386 *

Also Published As

Publication number Publication date
ID26335A (en) 2000-12-14
EP1037628A1 (en) 2000-09-27
WO1999025336A1 (en) 1999-05-27
JP2001522880A (en) 2001-11-20
AU1590299A (en) 1999-06-07
CA2310232A1 (en) 1999-05-27
AU746369B2 (en) 2002-04-18

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