Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q7/00—Preparations for affecting hair growth
  • A61Q7/02—Preparations for inhibiting or slowing hair growth
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
  • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
  • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
  • A61B18/203—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
  • A61K8/0241—Containing particulates characterized by their shape and/or structure
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
  • B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
  • B23K26/00—Working by laser beam, e.g. welding, cutting or boring
  • B23K26/18—Working by laser beam, e.g. welding, cutting or boring using absorbing layers on the workpiece, e.g. for marking or protecting purposes
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B17/00—Surgical instruments, devices or methods
  • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
  • A61B2017/22082—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
  • A61B2017/22085—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance light-absorbing
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
  • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
  • A61B2018/00452—Skin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
  • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
  • A61B2018/00452—Skin
  • A61B2018/00476—Hair follicles
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
  • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
  • A61K2800/41—Particular ingredients further characterized by their size
  • A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
  • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
  • A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
  • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
  • A61K2800/81—Preparation or application process involves irradiation

Definitions

• the invention relates to a method for preventing hair regrowth and / or destroying hair using a composition intended to be applied to the skin before a laser treatment comprising microparticles of determined size comprising at least one chromophore.
• the object of the present invention is therefore to propose a hair removal method which overcomes the drawbacks described above.
• Its purpose is to propose a hair removal process which makes it possible to target the pilosebaceous unit with particles: - ionizable in a few laser shots in the case of the use of laser radiation of shorter emission duration at 50 ⁇ s, which reduces the risk of irreversible damage to the peri-follicular tissues, that is to say those which surround the follicle, while allowing damage and / or killing of the cells responsible for hair growth;
• the present invention which relates to a method for preventing hair regrowth and / or destroying hair, characterized in that it comprises the following steps:
• a composition is applied to a surface of the skin, where the hairs are found, comprising, in a physiologically acceptable medium, microparticles, at least 80% by weight of which have a diameter of between 3 ⁇ m and 10 ⁇ m, comprising chromophores,
• the composition applied in (1) which is still on the surface of the skin is removed, (3) optionally, a composition comprising a solvent for the chromophores used in step (1) is applied to said skin surface ), (4) at least one laser beam is applied to said surface of the skin in one or more shots, the emitted wavelength of which is absorbed by the chromophores of the composition applied in step (1) and the light energy and duration of emission are sufficient to damage and / or kill the cells responsible for hair growth.
• the diameter of the microparticles can be measured by light scattering (Coulter counter) or by microscopy followed by image analysis.
• microparticles of determined diameters penetrate into the hair follicle but little through the stratum corneum. This phenomenon is described in patent EP 0375520.
• the microparticles selectively and gradually reach the follicular channel where the chromophores included in these microparticles are ready to absorb the light emitted by the laser.
• the microparticles can be of any kind and obtained by any known method.
• polymers can be formed from polymers. In this case, they can be obtained after a polymerization of monomers or after a dispersion of synthetic or natural preformed polymers.
• the synthetic polymers that can be used can advantageously be chosen from: polymers based on styrene, polyamides, polymers based on ⁇ -alanine, polymers derived from acrylic or methacrylic acid, polyesters derived from lactic acid and / or glycolic.
• the natural polymers can be chosen from proteins (gelatin, albumin, casein, ...) and polysaccharides (alginates, chitosan, ).
• the microparticles used for this present invention can be formed from fatty substances.
• the fatty substances which can be used can advantageously be chosen from alcohol and fatty acid derivatives, such as tristearine, semi-synthetic triglycerides or glycerol monostearate, and fatty alcohols such as cetyl alcohol. Preferably, they have a melting point greater than or equal to 50 ° C.
• Vesicular microparticles can also be used as liposomes and preferably polymerized liposomes whether they are reverse or direct.
• the methods for obtaining these microparticles can be adapted to obtain the desired particle size distribution by properly orienting their manufacturing process or by sieving when the distribution in size is wide.
• the chromophores included in the microparticles can be inside and / or on the surface of the microparticles, provided that their presence does not generate microparticles of particle size distribution outside the scope of the invention. These chromophores can be an integral part of the microparticle or even be the microparticle itself. When the chromophores are the microparticle, these chromophores are preferably of density strictly less than 2.25 g / cm 3 (density of graphite particles).
• the chromophores are inside the microparticles.
• the association of the chromophor (s) with the microparticles can be carried out by any known means.
• microspheres can be prepared simultaneously with the formation of the microparticle or after its formation.
• the chromophores and the polymer are dissolved in an organic solvent immiscible with water.
• the solution is then emulsified in an aqueous phase with a surfactant.
• the microparticles can be impregnated using a solution containing the chromophores, such may be the case with the impregnation of Orgasol (Atochem) polyamide microparticles.
• the chromophores can be any chemical entity which absorbs sufficiently at the wavelength considered, ie any chemical entity which, once it is included in the composition applied according to the invention, transforms the energy light that it absorbs in sufficient energy to damage and / or kill the cells responsible for hair growth. More particularly, they can be of mineral origin, such as carbon black, graphite, black and red iron oxide, or of organic origin, such as melanin, indocyanine green, phthalocyanines and their metal complexes.
• the microparticles comprising the chromophores can be dispersed in any physiologically acceptable medium and not causing the release of said chromophores.
• the dispersing phase can be a hydrophilic, hydrophobic composition or an emulsion.
• the dispersing phase can be in particular in the form of a gel, milk, lotion, ointment, cream or ointment.
• a hydrophilic composition can be an aqueous gel or an alcoholic gel. This can be obtained using a gelling agent, such as crosslinked polyacrylic acid sold under the trade name Carbopol® by the company Goodrich® or the cellulose derivatives sold under the trade name Klucel® by the company Hercules ®.
• a gelling agent such as crosslinked polyacrylic acid sold under the trade name Carbopol® by the company Goodrich® or the cellulose derivatives sold under the trade name Klucel® by the company Hercules ®.
• a hydrophobic composition can consist of oils such as acid esters, such as fatty acid triglycerides, fatty alcohol esters, or mixtures thereof, alkanes, such as petrolatum oil, or alternatively silicones.
• the composition according to the present invention comprises less than 40% by weight, preferably contains from 10 "% to 40% by weight of microparticles, at least 80% have a diameter of between 3 and 10 .mu.m.
• At least 80% of the microparticles comprising at least one chromophore have a diameter of between 4 and 7 ⁇ m.
• step (1) The application of the composition described in step (1) can be carried out by a simple deposition or by a massage. Before step (1), it is possible to envisage depilating or shaving the surface of the skin to be treated, in particular in order to make the hair follicles more accessible.
• the step (2) of removing the composition applied in (1) which is still on the surface of the skin generally consists of a simple cleaning of the surface of the skin, more particularly this cleaning is done with the vehicle (the medium) used of the composition used in (1).
• Cleaning (2) thus makes it possible to remove most of the composition applied in (1) which has not penetrated into the pilosebaceous units (in particular within wrinkles and fine lines).
• the optional step (3) makes it possible to release the chromophores from the microparticles by solubilization and to make them penetrate deeper into the hair follicle, and / or to be more dispersed in the hair follicle. This is particularly interesting in the case of chromophores which are not in particulate form, such as in particular organic chromophores.
• the solvents can be, for example water, C 4 -C 4 alcohols, such as ethanol, propanol, isopropanol, butanol-1, and esters such as ethyl acetate or l butyl acetate.
• any type of laser can be used, preferably a laser emitting light is used at a wavelength between 350 nm and 2.5 ⁇ m.
• lasers examples include the Nd-YAG laser (1064nm or 532nm), the Ho-YAG laser (2.12 ⁇ m), the ruby laser (694nm) and the dye laser (585 nm) and the laser diodes as for example the laser diode (800nm).
• the light energy and the emission time sufficient to damage and / or kill the cells responsible for hair growth can vary to a large extent depending on the type of laser, the chromophores chosen and the composition comprising them.
• the light energy applied is such that the chromophores are ionized, which generates shock waves which will propagate in tissues to the dermal papilla to damage and / or kill the cells responsible for hair growth.
• one of the advantages of the invention is that it is not necessary to fractionate the chromophores, as was the case in the prior art.
• the number of shots necessary to ionize the chromophores is more reduced and this makes it possible to reduce the risks of irreversible lesions of the peri-follicular tissues, that is to say of the tissues which surround the hair follicle.
• this number of shots is less than 5. This is the case, for example, for nanometric carbon particles.
• the light energy applied is such that the chromophores transform the light energy emitted by the laser into thermal energy, this thermal energy then being transmitted by conduction to the dermal papilla to damage and / or kill the cells responsible for hair growth.
• a laser is used having an emission duration less than or equal to 50 ⁇ s.
• the wavelength, the duration of emission and the light energy of the laser radiation are chosen as a function of the absorbance of the composition used comprising the chromophores. More particularly, depending on the composition used comprising the chromophores, these parameters correspond to those allowing little, or even zero, absorption of light by the various constituents of the first layers of the skin and significant absorption by the chromophore used, this having to prevent any irreversible skin damage.
• This significant absorption corresponds to that sufficient to damage and / or kill the cells responsible for hair growth.
• Unwanted irreversible skin lesions correspond in particular to damage to the capillaries located in the dermis by coagulation of hemoglobin or irreversible destruction of melanocytes, langerhan cells, keratinocytes or fibroblasts, in particular by volatilization of chromophores endogenous contained in these cells or their precursors, such as water, melanin or proteins.
• FIGS. 1 to 5 on sheets 1/3 to 3/3 allow to better illustrate the invention, without however limiting its scope. These figures correspond to a schematic representation of a pilosebaceous unit.
• Fig. 1 recalls the structure of the pilosebaceous unit, the hairs being produced by the hair follicles A, cylindrical invaginations of the basal layer of the surface epithelium surrounded by connective tissue. Hair growth takes place inside the hair bulb B, located at the base of the follicle.
• the hair follicle is a tubular structure made up of five concentric layers of epithelial cells. As the hair grows, the epithelial cells surrounding the dermal papilla proliferate to form the four internal layers of the follicle.
• the bulb consists of epithelial cells with high mitotic power. At the level of the bulb all the layers merge. As the hair grows, the epithelial cells surrounding the dermal papilla proliferate to form the four internal layers of the follicle.
• the three internal layers undergo keratinization to form the hair itself.
• the two outer layers form the outer epithelial sheath 1.
• the cells of the innermost layer of the follicle undergo a moderate keratinization resulting in the formation of medulla 2 in the heart of the hair.
• the medulla is surrounded by a thick, very keratinized layer, cortex 3 which forms the most important part of the hair.
• the third layer forms cuticle 4, a thin, hard layer covering the surface of the hair.
• the cells of the fourth layer of the follicle are only slightly keratinized.
• composition described in the example is applied to the surface of the excess skin (Fig. 2). After a light massage of a few minutes, part of the microparticles 8 of calibrated size contained in the formulation will descend along the hair shaft in the ostium 9 to the level of the sebaceous glands. After cleaning the skin surface with the formulation vehicle,
• Fig. 3 the microparticles charged with exogenous chromophores 10 are found only in the ostium.
• the laser used in this example is an Nd: YAG laser emitting radiation of wavelength 1064 nm and having an emission duration of 7-12 ns. At this wavelength, the radiation is very little absorbed by the various constituents of the first layers of the skin and is mainly absorbed by the exogenous chromophore contained in the microparticles.
• Fig. 4 shows the irradiation of the pilosebaceous unit where a small part of the deposited energy 11 is reflected 12 (5%) by the surface of the skin and another part transmitted.
• the photons transmitted in the skin are either scattered 13 (10%) or absorbed by the exogenous chromophore 14.
• Figs. 5A, 5B, 5C describe the interaction between the photons transmitted in the skin and a microparticle.
• Fig. 5A shows a microparticle 15 placed in the ostium 16 located around the hair shaft 17.
• the microparticles used when they are not loaded with exogenous chromophores, absorb little the wavelength used.
• the incorporation of carbon black 18 particles with a particle size centered around 13 nm in the microparticles with a particle size distribution centered at 5 ⁇ m ( ⁇ 1.5 ⁇ m) makes it possible to selectively place fine particles in the pilosebaceous unit. strongly absorbing the wavelength used.
• Fig. 5B describes the absorption of photons transmitted into the skin by carbon particles. Due to their small particle size, the carbon particles sublimate and form a plasma 19 in one to two laser shots. At the border between the plasma and the external medium (the ostium), Fig. 5C, a pressure gradient appears which induces the formation of a shock wave 20 which will spread in adjacent tissues to the hair bulb to damage
• Part B Carbopol 980 aqueous gel (BF Goodrich) 0.9 5% sodium hydroxide 7.3 Water 82.7
• the pigment is dispersed in the oily mixture, then the orgasol microparticles are impregnated with the lipophilic dispersion, this constitutes part A.
• the orgasol microparticles thus charged are then dispersed in the aqueous gel (corresponding to part B ).

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• Health & Medical Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Physics & Mathematics (AREA)
• Optics & Photonics (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Engineering & Computer Science (AREA)
• Surgery (AREA)
• Mechanical Engineering (AREA)
• Birds (AREA)
• Epidemiology (AREA)
• Dermatology (AREA)
• Electromagnetism (AREA)
• Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
• Otolaryngology (AREA)
• Plasma & Fusion (AREA)
• Biomedical Technology (AREA)
• Heart & Thoracic Surgery (AREA)
• Medical Informatics (AREA)
• Molecular Biology (AREA)
• Cosmetics (AREA)
• Radiation-Therapy Devices (AREA)

Applications Claiming Priority (3)

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• 1997
  • 1997-04-29 FR FR9705297A patent/FR2762504B1/fr not_active Expired - Fee Related
• 1998
  • 1998-04-28 EP EP98922884A patent/EP1014876A1/fr not_active Withdrawn
  • 1998-04-28 PL PL98336631A patent/PL336631A1/xx unknown
  • 1998-04-28 WO PCT/FR1998/000850 patent/WO1998048716A1/fr not_active Application Discontinuation
  • 1998-04-28 BR BR9808107-1A patent/BR9808107A/pt not_active IP Right Cessation
  • 1998-04-28 US US09/402,351 patent/US6287549B1/en not_active Expired - Lifetime
  • 1998-04-28 RU RU99125123/14A patent/RU2192295C2/ru not_active IP Right Cessation
  • 1998-04-28 CN CN98804566A patent/CN1253486A/zh active Pending
  • 1998-04-28 NZ NZ337292A patent/NZ337292A/en unknown
  • 1998-04-28 IL IL13196198A patent/IL131961A0/xx unknown
  • 1998-04-28 AU AU75366/98A patent/AU728499B2/en not_active Ceased
  • 1998-04-28 CA CA002285678A patent/CA2285678A1/fr not_active Abandoned
  • 1998-04-28 JP JP10546673A patent/JP2001500529A/ja active Pending
  • 1998-04-28 HU HU0002344A patent/HUP0002344A2/hu unknown
• 1999
  • 1999-10-27 NO NO995246A patent/NO995246L/no not_active Application Discontinuation

Non-Patent Citations (1)

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