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EP0951534A4 - Nucleic acid sequence encoding beta-c-4-oxygenase from haematococcus pluvialis for the biosynthesis of astaxanthin - Google Patents

Nucleic acid sequence encoding beta-c-4-oxygenase from haematococcus pluvialis for the biosynthesis of astaxanthin

Info

Publication number
EP0951534A4
EP0951534A4 EP97909944A EP97909944A EP0951534A4 EP 0951534 A4 EP0951534 A4 EP 0951534A4 EP 97909944 A EP97909944 A EP 97909944A EP 97909944 A EP97909944 A EP 97909944A EP 0951534 A4 EP0951534 A4 EP 0951534A4
Authority
EP
European Patent Office
Prior art keywords
oxygenase
astaxanthin
biosynthesis
nucleic acid
acid sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97909944A
Other languages
German (de)
French (fr)
Other versions
EP0951534A1 (en
Inventor
Varda Mann
Joseph Hirschberg
Tamar Lotan
Mark Harker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yissum Research Development Co of Hebrew University of Jerusalem
Original Assignee
Yissum Research Development Co of Hebrew University of Jerusalem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/742,605 external-priority patent/US5965795A/en
Application filed by Yissum Research Development Co of Hebrew University of Jerusalem filed Critical Yissum Research Development Co of Hebrew University of Jerusalem
Publication of EP0951534A1 publication Critical patent/EP0951534A1/en
Publication of EP0951534A4 publication Critical patent/EP0951534A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/825—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving pigment biosynthesis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Nutrition Science (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP97909944A 1996-10-28 1997-10-03 Nucleic acid sequence encoding beta-c-4-oxygenase from haematococcus pluvialis for the biosynthesis of astaxanthin Withdrawn EP0951534A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/742,605 US5965795A (en) 1995-11-24 1996-10-28 Polynucleotide molecule from Haematococcus pluvialis encoding a polypeptide having a beta-C-4-oxygenase activity for biotechnological production of (3S, 3'S) astaxanthin and its specific expression in chromoplasts of higher plants
US742605 1996-10-28
PCT/US1997/017819 WO1998018910A1 (en) 1995-11-24 1997-10-03 Nucleic acid sequence encoding beta-c-4-oxygenase from haematococcus pluvialis for the biosynthesis of astaxanthin

Publications (2)

Publication Number Publication Date
EP0951534A1 EP0951534A1 (en) 1999-10-27
EP0951534A4 true EP0951534A4 (en) 2004-06-09

Family

ID=24985506

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97909944A Withdrawn EP0951534A4 (en) 1996-10-28 1997-10-03 Nucleic acid sequence encoding beta-c-4-oxygenase from haematococcus pluvialis for the biosynthesis of astaxanthin

Country Status (6)

Country Link
EP (1) EP0951534A4 (en)
JP (1) JP2001503264A (en)
CN (1) CN1168824C (en)
AU (1) AU732842B2 (en)
CA (1) CA2269802A1 (en)
PL (1) PL332965A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4296035B2 (en) * 2003-05-21 2009-07-15 アークレイ株式会社 Puncture device
JP4799895B2 (en) * 2004-12-15 2011-10-26 電源開発株式会社 Production method of carotenoid pigment, glycosphingolipid, ubiquinone Q-10
CN1327782C (en) * 2005-03-09 2007-07-25 青岛森淼实业有限公司 Mirco algal food nutrient intensifying agent prescription and its preparing process

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0725137A1 (en) * 1994-08-23 1996-08-07 Kirin Beer Kabushiki Kaisha Keto group introducing enzyme, dna coding for the same, and process for producing ketocarotenoid
US5916791A (en) * 1995-11-24 1999-06-29 Hirschberg; Joseph Polynucleotide molecule from Haematococcus pluvialis encoding a polypeptide having a β--C--4--oxygenase activity for biotechnological production of (3S,3S)astaxanthin

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0725137A1 (en) * 1994-08-23 1996-08-07 Kirin Beer Kabushiki Kaisha Keto group introducing enzyme, dna coding for the same, and process for producing ketocarotenoid
US5916791A (en) * 1995-11-24 1999-06-29 Hirschberg; Joseph Polynucleotide molecule from Haematococcus pluvialis encoding a polypeptide having a β--C--4--oxygenase activity for biotechnological production of (3S,3S)astaxanthin

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 30 November 1997 (1997-11-30), HARKER, M., ET AL.: "H.pluvialis mRA fir beta-carotene C-4 oxygenase", XP002276103, Database accession no. X86782 *
HIRSCHBERG J ET AL: "MOLECULAR GENETICS OF THE CAROTENOID BIOSYNTHESIS PATHWAY IN PLANTSAND ALGAE", PURE & APPLIED CHEMISTRY, PERGAMON PRESS, OXFORD, GB, vol. 69, no. 10, 1997, pages 2151 - 2158, XP000872988, ISSN: 0033-4545 *
HUANG J.-C. ET AL: "Stress-related differential expression of multiple beta-carotene ketolase genes in th eunicellular green alga Haematococcus pluvialis", JOURNAL OF BIOTECHNOLOGY (DOI:10.1016/J.JBIOTEC.2005.09.2002), 2005 *
MAIN LECTURE PRESENTED AT 11TH INTERNATIONAL SYMPOSIUM ON CAROTENOIDS, 18-23 AUGUST 1996 *
MANN V ET AL: "Metabolic engineering of astaxanthin production in tobacco flowers", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, vol. 18, August 2000 (2000-08-01), pages 888 - 892, XP002969628, ISSN: 1087-0156 *
PURE AND APPLIED CHEMISTRY, vol. 69, no. 10, 1997, XP002276102, Retrieved from the Internet <URL:http://www.iupac.org/publications/pac/1997/69_10_index.html> [retrieved on 20040405] *
See also references of WO9818910A1 *

Also Published As

Publication number Publication date
JP2001503264A (en) 2001-03-13
EP0951534A1 (en) 1999-10-27
CN1247565A (en) 2000-03-15
CA2269802A1 (en) 1998-05-07
AU4743697A (en) 1998-05-22
CN1168824C (en) 2004-09-29
PL332965A1 (en) 1999-10-25
AU732842B2 (en) 2001-05-03

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19990527

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

RIC1 Information provided on ipc code assigned before grant

Ipc: 7A 01H 5/00 B

Ipc: 7C 12N 9/02 B

Ipc: 7C 12N 15/82 B

Ipc: 7C 12N 15/53 A

A4 Supplementary search report drawn up and despatched

Effective date: 20040426

17Q First examination report despatched

Effective date: 20041022

RIN1 Information on inventor provided before grant (corrected)

Inventor name: HARKER, MARK

Inventor name: LOTAN, TAMAR

Inventor name: HIRSCHBERG, JOSEPH

Inventor name: MANN, VARDA

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20080611