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EP0939634A4 - Antagonistes du recepteur il-8 - Google Patents

Antagonistes du recepteur il-8

Info

Publication number
EP0939634A4
EP0939634A4 EP97938426A EP97938426A EP0939634A4 EP 0939634 A4 EP0939634 A4 EP 0939634A4 EP 97938426 A EP97938426 A EP 97938426A EP 97938426 A EP97938426 A EP 97938426A EP 0939634 A4 EP0939634 A4 EP 0939634A4
Authority
EP
European Patent Office
Prior art keywords
receptor antagonists
antagonists
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97938426A
Other languages
German (de)
English (en)
Other versions
EP0939634A1 (fr
Inventor
Deborah Lynn Bryan
John Gerald Gleason
Katherine L Widdowson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP0939634A1 publication Critical patent/EP0939634A1/fr
Publication of EP0939634A4 publication Critical patent/EP0939634A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
EP97938426A 1996-08-15 1997-08-15 Antagonistes du recepteur il-8 Withdrawn EP0939634A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2397296P 1996-08-15 1996-08-15
US23972P 1996-08-15
PCT/US1997/014582 WO1998006398A1 (fr) 1996-08-15 1997-08-15 Antagonistes du recepteur il-8

Publications (2)

Publication Number Publication Date
EP0939634A1 EP0939634A1 (fr) 1999-09-08
EP0939634A4 true EP0939634A4 (fr) 2001-02-21

Family

ID=21818184

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97938426A Withdrawn EP0939634A4 (fr) 1996-08-15 1997-08-15 Antagonistes du recepteur il-8

Country Status (3)

Country Link
EP (1) EP0939634A4 (fr)
JP (1) JP2000516620A (fr)
WO (1) WO1998006398A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997049400A1 (fr) 1996-06-27 1997-12-31 Smithkline Beecham Corporation Antagonistes des recepteurs d'il-8
GB9908410D0 (en) 1999-04-13 1999-06-09 Pfizer Ltd Pyridines
AR029637A1 (es) * 1999-05-28 2003-07-10 Smithkline Beecham Corp Compuestos de guanidina, antagonistas de los receptores de la il-8, una composicion farmaceutica que los contiene y el uso de los mismos para la manufactura de un medicamento
EP1268554A2 (fr) * 2000-03-31 2003-01-02 IPF Pharmaceuticals GmbH Medicament et moyen diagnostique pour analyser le proteome de surface de cellules tumorales et inflammatoires, et pour traiter des maladies tumorales et inflammatoires, de preference au moyen d'une analyse specifique des recepteurs de chimiokines et de l'interaction de ligands recepteurs de chimioki
TW200418812A (en) 2002-10-29 2004-10-01 Smithkline Beecham Corp IL-8 receptor antagonists
WO2004074260A1 (fr) * 2003-02-21 2004-09-02 Kyowa Hakko Kogyo Co., Ltd. Dérivés de pyrimidine
JP2007537272A (ja) 2004-05-12 2007-12-20 シェーリング　コーポレイション Ｃｘｃｒ１およびｃｘｃｒ２ケモカインアンタゴニスト
US7893089B2 (en) 2006-04-21 2011-02-22 GlaxoSmithKline, LLC IL-8 receptor antagonists
CN101495113A (zh) 2006-04-21 2009-07-29 史密丝克莱恩比彻姆公司 Il-8受体拮抗剂

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0392802A2 (fr) * 1989-04-11 1990-10-17 Beecham Group p.l.c. Préparation d'analogues de l'urée et leur emploi dans des maladies bronchiales, cérébro-vasculaires et neuronales
WO1994004499A1 (fr) * 1992-08-13 1994-03-03 The Upjohn Company Des cyanoguanidines, agents bloquants du canal potassium
WO1994022807A1 (fr) * 1993-04-07 1994-10-13 Neurosearch A/S Derives ureiques et amidiques et leur utilisation dans la regulation des canaux a potassium des membranes cellulaires
WO1995007934A2 (fr) * 1993-09-14 1995-03-23 Chiron Corporation Inhibiteurs de il8
EP0652228A1 (fr) * 1993-05-12 1995-05-10 American Cyanamid Company Uréthanes et urées qui indusent la formation des cytokmer
WO1996025157A1 (fr) * 1995-02-17 1996-08-22 Smithkline Beecham Corporation Antagonistes des recepteurs d'il-8

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05294935A (ja) * 1991-03-15 1993-11-09 Green Cross Corp:The アミノピリジン系化合物

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0392802A2 (fr) * 1989-04-11 1990-10-17 Beecham Group p.l.c. Préparation d'analogues de l'urée et leur emploi dans des maladies bronchiales, cérébro-vasculaires et neuronales
WO1994004499A1 (fr) * 1992-08-13 1994-03-03 The Upjohn Company Des cyanoguanidines, agents bloquants du canal potassium
WO1994004500A1 (fr) * 1992-08-13 1994-03-03 The Upjohn Company Cyanoguanidines utilisees comme inhibiteurs de canal de potassium
WO1994022807A1 (fr) * 1993-04-07 1994-10-13 Neurosearch A/S Derives ureiques et amidiques et leur utilisation dans la regulation des canaux a potassium des membranes cellulaires
EP0652228A1 (fr) * 1993-05-12 1995-05-10 American Cyanamid Company Uréthanes et urées qui indusent la formation des cytokmer
WO1995007934A2 (fr) * 1993-09-14 1995-03-23 Chiron Corporation Inhibiteurs de il8
WO1996025157A1 (fr) * 1995-02-17 1996-08-22 Smithkline Beecham Corporation Antagonistes des recepteurs d'il-8

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9806398A1 *

Also Published As

Publication number Publication date
WO1998006398A1 (fr) 1998-02-19
EP0939634A1 (fr) 1999-09-08
JP2000516620A (ja) 2000-12-12

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