EP0850057A4 - PHARMACEUTICAL COMPOUNDS - Google Patents

PHARMACEUTICAL COMPOUNDS

Info

Publication number: EP0850057A4
Authority: EP; European Patent Office
Prior art keywords: pharmaceutical compounds; pharmaceutical; compounds
Prior art date: 1995-08-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP96929780A

Other languages

German (de)

French (fr)

Other versions

EP0850057A1 (en

Inventor

Richard E Moore

Vinod F Patel

James E Ray

John E Toth

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

University of Hawaii at Manoa

Wayne State University

Original Assignee

University of Hawaii at Manoa

Wayne State University

Eli Lilly and Co

University of Hawaii at Hilo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-08-30

Filing date

1996-08-30

Publication date

2001-04-11

1996-08-30 Application filed by University of Hawaii at Manoa, Wayne State University, Eli Lilly and Co, University of Hawaii at Hilo filed Critical University of Hawaii at Manoa

1998-07-01 Publication of EP0850057A1 publication Critical patent/EP0850057A1/en

2001-04-11 Publication of EP0850057A4 publication Critical patent/EP0850057A4/en

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Peptides Or Proteins (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

EP96929780A 1995-08-30 1996-08-30 PHARMACEUTICAL COMPOUNDS Withdrawn EP0850057A4 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US293595P	1995-08-30	1995-08-30
US2935		1995-08-30
PCT/US1996/013855 WO1997007798A1 (en)	1995-08-30	1996-08-30	Pharmaceutical compounds

Publications (2)

Publication Number	Publication Date
EP0850057A1 EP0850057A1 (en)	1998-07-01
EP0850057A4 true EP0850057A4 (en)	2001-04-11

Family

ID=21703268

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
EP96929780A Withdrawn EP0850057A4 (en)	1995-08-30	1996-08-30	PHARMACEUTICAL COMPOUNDS
EP96932217A Withdrawn EP0850316A4 (en)	1995-08-30	1996-08-30	CRYPTOPHYCINS OBTAINED FROM AN ABERRANT BIOSYNTHESIS

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
EP96932217A Withdrawn EP0850316A4 (en)	1995-08-30	1996-08-30	CRYPTOPHYCINS OBTAINED FROM AN ABERRANT BIOSYNTHESIS

Country Status (6)

Country	Link
EP (2)	EP0850057A4 (en)
JP (2)	JP2000507805A (en)
AU (2)	AU709828B2 (en)
BR (1)	BR9610214A (en)
CA (2)	CA2230540A1 (en)
WO (2)	WO1997007798A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU709828B2 (en) *	1995-08-30	1999-09-09	University Of Hawaii	Cryptophycins from aberrant biosynthesis
WO1997023211A1 (en) *	1995-12-22	1997-07-03	Eli Lilly And Company	Pharmaceutical compounds
US6680311B1 (en)	1996-08-30	2004-01-20	Eli Lilly And Company	Cryptophycin compounds
AU722492B2 (en) *	1996-08-30	2000-08-03	University Of Hawaii	Pharmaceutical compounds
WO1998008506A1 (en) *	1996-08-30	1998-03-05	Eli Lilly And Company	Pharmaceutical compounds
EP0932601A4 (en) *	1996-08-30	2000-02-02	Lilly Co Eli	PROCESS FOR THE PREPARATION OF PHARMACEUTICAL COMPOUNDS
BR9711695A (en) *	1996-09-06	2000-03-08	Lilly Co Eli	Process for preparing pharmaceutical compounds
US6020512A (en) *	1996-09-06	2000-02-01	Eli Lilly And Company	Process and novel intermediates
CA2281107A1 (en) *	1997-02-26	1998-09-03	Eli Lilly And Company	Tripeptide and tetrapeptide pharmaceutical compounds
NZ336918A (en) *	1997-02-26	2001-11-30	Lilly Co Eli	Selective epoxidation process for preparing pharmaceutical compounds comprising Cryptophycin 52
EP0870506A1 (en) *	1997-04-11	1998-10-14	Eli Lilly And Company	Compositions comprising a cryptophycin compound in combination with a synchronizing or activating agent for treating cancer
EP0870501A1 (en) *	1997-04-11	1998-10-14	Eli Lilly And Company	Use of specific cryptophycin derivatives for the manufacture of a medicament in the treatment of fungal infections
US6180679B1 (en) *	1998-04-07	2001-01-30	Eli Lilly And Company	Method for treating fungal infections
US6103913A (en) *	1998-10-16	2000-08-15	Eli Lilly And Company	Process for preparing enollactone derivatives
US6376230B1 (en)	1998-10-16	2002-04-23	Eli Lilly And Company	Stereoselective process for producing intermediates of cryptophycins
EP1229934B1 (en)	1999-10-01	2014-03-05	Immunogen, Inc.	Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
WO2003077906A1 (en) *	2002-03-18	2003-09-25	Nihon University	Cyclic etheramine derivatives as medicaments for malignant tumors
EP1751279A4 (en)	2004-05-05	2008-03-19	Univ Minnesota	NUCLEIC ACIDS AND POLYPEPTIDES INVOLVED IN CRYPTOPHYCIN PRODUCTION
WO2007000994A1 (en) *	2005-06-28	2007-01-04	Chugai Seiyaku Kabushiki Kaisha	Method of producing compound having anti-hcv action
CN103724290B (en) *	2013-11-15	2015-04-29	浙江大学	Cyclopeptide compound clavatustide A as well as producing strain, preparation method and application thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4845086A (en) *	1988-08-09	1989-07-04	Merck & Co., Inc.	Antifungal agent
WO1996040184A1 (en) *	1995-03-07	1996-12-19	University Of Hawaii	New cryptophycins from synthesis
WO1996039829A1 (en) *	1995-06-07	1996-12-19	University Of Hawaii	New cryptophycins
WO1997008334A1 (en) *	1995-08-30	1997-03-06	University Of Hawaii	Cryptophycins from aberrant biosynthesis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4946835A (en) *	1988-07-15	1990-08-07	Merck & Co., Inc.	Antifungal fermentation product and method
US4868208A (en) *	1988-07-15	1989-09-19	Merck & Co., Inc.	Antifungal agent and method
US4845085A (en) *	1988-08-09	1989-07-04	Merck & Co., Inc.	Antifungal agent

1996
- 1996-08-30 AU AU71090/96A patent/AU709828B2/en not_active Ceased
- 1996-08-30 EP EP96929780A patent/EP0850057A4/en not_active Withdrawn
- 1996-08-30 WO PCT/US1996/013855 patent/WO1997007798A1/en not_active Application Discontinuation
- 1996-08-30 BR BR9610214A patent/BR9610214A/en not_active Application Discontinuation
- 1996-08-30 JP JP9510664A patent/JP2000507805A/en active Pending
- 1996-08-30 CA CA002230540A patent/CA2230540A1/en not_active Abandoned
- 1996-08-30 WO PCT/US1996/014670 patent/WO1997008334A1/en not_active Application Discontinuation
- 1996-08-30 EP EP96932217A patent/EP0850316A4/en not_active Withdrawn
- 1996-08-30 CA CA002246117A patent/CA2246117A1/en not_active Abandoned
- 1996-08-30 JP JP9510549A patent/JP2000501067A/en active Pending
- 1996-08-30 AU AU69048/96A patent/AU6904896A/en not_active Abandoned

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4845086A (en) *	1988-08-09	1989-07-04	Merck & Co., Inc.	Antifungal agent
WO1996040184A1 (en) *	1995-03-07	1996-12-19	University Of Hawaii	New cryptophycins from synthesis
WO1996039829A1 (en) *	1995-06-07	1996-12-19	University Of Hawaii	New cryptophycins
WO1997008334A1 (en) *	1995-08-30	1997-03-06	University Of Hawaii	Cryptophycins from aberrant biosynthesis

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BARROW, RUSSELL A. ET AL: "Total Synthesis of Cryptophycins. Revision of the Structures of Cryptophycins A and C", J. AM. CHEM. SOC. (1995), 117(9), 2479-90, XP002066281 *
KOBAYASHI, MOTOMASA ET AL: "The absolute stereostructure of arenastatin A, a potent cytotoxic depsipeptide from the Okinawan marine sponge Dysidea arenaria", CHEM. PHARM. BULL. (1994), 42(10), 2196-8, XP002159595 *
See also references of WO9707798A1 *
TRIMURTULU, GOLAKOTI ET AL: "Total Structures of Cryptophycins, Potent Antitumor Depsipeptides from th Blue-Green Alga Nostoc sp. Strain GSV 224", J. AM. CHEM. SOC. (1994), 116(11), 4729-37, XP002159594 *

Also Published As

Publication number	Publication date
EP0850316A4 (en)	2000-08-23
JP2000507805A (en)	2000-06-27
WO1997008334A1 (en)	1997-03-06
CA2230540A1 (en)	1997-03-06
AU6904896A (en)	1997-03-19
BR9610214A (en)	1999-06-15
AU7109096A (en)	1997-03-19
JP2000501067A (en)	2000-02-02
EP0850316A1 (en)	1998-07-01
AU709828B2 (en)	1999-09-09
EP0850057A1 (en)	1998-07-01
CA2246117A1 (en)	1997-03-06
WO1997007798A1 (en)	1997-03-06

Publication	Publication Date	Title
BR9610153A (en)	1999-01-05	Pharmaceutical formulations
BR9611626A (en)	1999-06-01	Pharmaceutical formulations
FI973243L (en)	1997-08-06	New pharmaceutical combination
NO20004345D0 (en)	2000-09-01	Pharmaceutical composition
DE69629755D1 (en)	2003-10-09	Irbesartan-containing medicine
MA26673A1 (en)	2004-12-20	PHARMACEUTICAL COMPOUNDS
ATE187063T1 (en)	1999-12-15	DRUG
EP0850057A4 (en)	2001-04-11	PHARMACEUTICAL COMPOUNDS
NO981008D0 (en)	1998-03-06	Pharmaceutical formulation
BR9600809A (en)	1997-12-23	Medication
DE69614407D1 (en)	2001-09-13	PHARMACEUTICAL COMPOSITIONS
NO973610D0 (en)	1997-08-05	New pharmaceutical preparation
LV11727A (en)	1997-04-20	Pharmaceutical composition
DZ1926A1 (en)	2002-02-17	Pharmaceutical formulations.
EP0923564A4 (en)	1999-12-08	PHARMACEUTICAL COMPOUNDS
FI973280L (en)	1997-08-08	Pharmaceutical composition
PT850048E (en)	2004-09-30	PHARMACEUTICAL GRANULES
NO973611D0 (en)	1997-08-05	New pharmaceutical preparation
FI951155L (en)	1995-09-15	Pharmaceutical preparation
DE59610423D1 (en)	2003-06-12	PARTICULAR MEDICINE
NO965448D0 (en)	1996-12-18	Pharmaceutical compounds
BR9605777A (en)	1998-08-25	Pharmaceutical composition
BR9605131A (en)	1998-07-07	Pharmaceutical composition
BR9603673A (en)	1998-05-19	Pharmaceutical combination preparation comprising ketoprofen
SE9502453D0 (en)	1995-07-06	Drug formulations

Legal Events

Date	Code	Title	Description
1998-05-15	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1998-07-01	17P	Request for examination filed	Effective date: 19980226
1998-07-01	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI NL PT SE
2001-04-11	A4	Supplementary search report drawn up and despatched	Effective date: 20010222
2001-04-11	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI NL PT SE
2003-09-03	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: WAYNE STATE UNIVERSITY Owner name: UNIVERSITY OF HAWAII
2003-10-08	17Q	First examination report despatched	Effective date: 20030826
2004-05-28	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2004-07-14	18D	Application deemed to be withdrawn	Effective date: 20040106