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EP0822983A4 - Apopain - Google Patents

Apopain

Info

Publication number
EP0822983A4
EP0822983A4 EP96913801A EP96913801A EP0822983A4 EP 0822983 A4 EP0822983 A4 EP 0822983A4 EP 96913801 A EP96913801 A EP 96913801A EP 96913801 A EP96913801 A EP 96913801A EP 0822983 A4 EP0822983 A4 EP 0822983A4
Authority
EP
European Patent Office
Prior art keywords
apopain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96913801A
Other languages
German (de)
French (fr)
Other versions
EP0822983A1 (en
Inventor
Douglas K Miller
Nancy A Thornberry
Donald W Nicholson
Ambereen Ali
John P Vaillancourt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Frosst Canada and Co
Merck and Co Inc
Original Assignee
Merck Frosst Canada and Co
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Frosst Canada and Co, Merck and Co Inc filed Critical Merck Frosst Canada and Co
Publication of EP0822983A1 publication Critical patent/EP0822983A1/en
Publication of EP0822983A4 publication Critical patent/EP0822983A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • C12N9/6475—Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1021—Tetrapeptides with the first amino acid being acidic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EP96913801A 1995-04-21 1996-04-17 Apopain Withdrawn EP0822983A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42655795A 1995-04-21 1995-04-21
US426557 1995-04-21
PCT/US1996/005282 WO1996033268A1 (en) 1995-04-21 1996-04-17 Apopain

Publications (2)

Publication Number Publication Date
EP0822983A1 EP0822983A1 (en) 1998-02-11
EP0822983A4 true EP0822983A4 (en) 2004-12-15

Family

ID=23691273

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96913801A Withdrawn EP0822983A4 (en) 1995-04-21 1996-04-17 Apopain

Country Status (4)

Country Link
EP (1) EP0822983A4 (en)
JP (1) JPH11504209A (en)
CA (1) CA2218679A1 (en)
WO (1) WO1996033268A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6538121B1 (en) 1994-11-01 2003-03-25 Human Genome Sciences, Inc. Interleukin-1 β converting enzyme like apoptosis protease-3 and 4
US6835555B1 (en) 1994-11-01 2004-12-28 Human Genome Sciences, Inc. Interleukin-1 β converting enzyme like apoptosis protease-3 and 4
WO1997031018A1 (en) * 1996-02-23 1997-08-28 Merck & Co., Inc. Crystal structure of apopain and uses thereof
US6180402B1 (en) * 1996-11-20 2001-01-30 Qlt Inc. Method for inhibiting apoptosis induced by photodynamic therapy using a cysteine or serine protease inhibitor
US5834228A (en) * 1997-02-13 1998-11-10 Merck & Co., Inc. Method for identifying inhibitors for apopain based upon the crystal structure of the apopain: Ac-DEVD-CHO complex
GB2324529A (en) * 1997-02-21 1998-10-28 Merck & Co Inc A combinatorial library based on a tetrapeptide substituted with aminomethylcoumarin for characterizing proteases
DE19820328A1 (en) * 1998-05-07 1999-11-11 Roche Diagnostics Gmbh Method and reagent for the detection of apoptotic cells or a protease activated during apoptosis
US6380193B1 (en) 1998-05-15 2002-04-30 Guilford Pharmaceuticals Inc. Fused tricyclic compounds, methods and compositions for inhibiting PARP activity
EP1077946A1 (en) * 1998-05-15 2001-02-28 Guilford Pharmaceuticals Inc. Fused tricyclic compounds which inhibit parp activity
US6462019B1 (en) * 1998-07-10 2002-10-08 Osteoscreen, Inc. Inhibitors of proteasomal activity and production for stimulating bone growth
US6902721B1 (en) 1998-07-10 2005-06-07 Osteoscreen, Inc. Inhibitors of proteasomal activity for stimulating bone growth
US6303374B1 (en) * 2000-01-18 2001-10-16 Isis Pharmaceuticals Inc. Antisense modulation of caspase 3 expression
DE10006889A1 (en) * 2000-02-16 2001-09-06 Procorde Gmbh Use of inhibitors of caspase-3 or the caspase-activated deoxyribonuclease (CAD) for the treatment of heart diseases
WO2002033058A2 (en) * 2000-10-20 2002-04-25 Inpharmatica Limited Novel cysteine proteases and uses thereof
CN109563144B (en) 2016-06-01 2023-03-28 雅斯娜 Compound (I)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996013603A1 (en) * 1994-11-01 1996-05-09 Human Genome Sciences, Inc. INTERLEUKIN-1 β CONVERTING ENZYME LIKE APOPTOSIS PROTEASE-3 AND 4
WO1996025501A2 (en) * 1995-02-13 1996-08-22 The Regents Of The University Of Michigan Method and composition for regulating apoptosis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996013603A1 (en) * 1994-11-01 1996-05-09 Human Genome Sciences, Inc. INTERLEUKIN-1 β CONVERTING ENZYME LIKE APOPTOSIS PROTEASE-3 AND 4
WO1996025501A2 (en) * 1995-02-13 1996-08-22 The Regents Of The University Of Michigan Method and composition for regulating apoptosis

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
FERNANDES-ALNEMRI T ET AL: "MCH3, A NOVEL HUMAN APOPTOTIC CYSTEINE PROTEASE HIGHLY RELATED TO CPP32", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 55, no. 24, 15 December 1995 (1995-12-15), pages 6045 - 6052, XP000614740, ISSN: 0008-5472 *
KAUFMANN S H ET AL: "SPECIFIC PROTEOLYTIC CLEAVAGE OF POLY(ADP-RIBOSE) POLYMERASE: AN EARLY MARKER OF CHEMOTHERAPY-INDUCED APOPTOSIS", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 53, no. 17, 1 September 1993 (1993-09-01), pages 3976 - 3985, XP001160867, ISSN: 0008-5472 *
LAZEBNIK Y A ET AL: "Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE.", NATURE. 22 SEP 1994, vol. 371, no. 6495, 22 September 1994 (1994-09-22), pages 346 - 347, XP001183582, ISSN: 0028-0836 *
NICHOLSON D W ET AL: "IDENTIFICATION AND INHIBITION OF THE ICE/CED-3 PROTEASE NECESSARY FOR MAMMALIAN APOPTOSIS", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 376, no. 6535, 6 July 1995 (1995-07-06), pages 37 - 43, XP000574812, ISSN: 0028-0836 *
See also references of WO9633268A1 *
TEWARI M ET AL: "YAMACPP32BETA, A MAMMALIAN HOMOLOG OF CED-3, IS A CRMA-INHIBITABLE PROTEASE THAT CLEAVES THE DEATH SUBSTRATE POLY(ADP-RIBOSE)POLYMERASE", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 81, 2 June 1995 (1995-06-02), pages 801 - 809, XP002013933, ISSN: 0092-8674 *
THORNBERRY N A ET AL: "A NOVEL HETERODIMERIC CYSTEINE PROTEASE IS REQUIRED FOR INTERLEUKIN-1BETA PROCESSING IN MONOCYTES", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 356, 30 April 1992 (1992-04-30), pages 768 - 774, XP000986114, ISSN: 0028-0836 *

Also Published As

Publication number Publication date
EP0822983A1 (en) 1998-02-11
CA2218679A1 (en) 1996-10-24
JPH11504209A (en) 1999-04-20
WO1996033268A1 (en) 1996-10-24

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19971121

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: MERCK FROSST CANADA & CO.

Owner name: MERCK & CO., INC.

A4 Supplementary search report drawn up and despatched

Effective date: 20041102

17Q First examination report despatched

Effective date: 20041215

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20050626