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EP0819168A4 - Human tumor necrosis factor receptor - Google Patents

Human tumor necrosis factor receptor

Info

Publication number
EP0819168A4
EP0819168A4 EP95914722A EP95914722A EP0819168A4 EP 0819168 A4 EP0819168 A4 EP 0819168A4 EP 95914722 A EP95914722 A EP 95914722A EP 95914722 A EP95914722 A EP 95914722A EP 0819168 A4 EP0819168 A4 EP 0819168A4
Authority
EP
European Patent Office
Prior art keywords
receptor
disclosed
methods
agonists
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95914722A
Other languages
German (de)
French (fr)
Other versions
EP0819168A1 (en
Inventor
John M Greene
Robert D Fleischmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Human Genome Sciences Inc
Original Assignee
Human Genome Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Human Genome Sciences Inc filed Critical Human Genome Sciences Inc
Priority claimed from PCT/US1995/003216 external-priority patent/WO1996028546A1/en
Publication of EP0819168A1 publication Critical patent/EP0819168A1/en
Publication of EP0819168A4 publication Critical patent/EP0819168A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A human TNF receptor and DNA (RNA) encoding such receptor and a procedure for producing such receptor by recombinant techniques is disclosed. Also disclosed are methods for utilizing such receptor for screening for antagonists and agonists to the receptor and for ligands for the receptor. Also disclosed are methods for utilizing such agonists to inhibit the growth of tumors, to stimulate cellular differentiation, to mediate the immune response and anti-viral response, to regulate growth and provide resistance to certain infections. The use of the antagonists as a therapeutic to treat autoimmune diseases, inflammation, septic shock, to inhibit graft-host reactions, and to prevent apoptosis is also disclosed. Also disclosed are diagnostic methods for detecting mutations in the nucleic acid sequence encoding the receptor and for detecting altered levels of the soluble receptor in a sample derived from a host.
EP95914722A 1995-03-15 1995-03-15 Human tumor necrosis factor receptor Withdrawn EP0819168A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1995/003216 WO1996028546A1 (en) 1995-03-15 1995-03-15 Human tumor necrosis factor receptor

Publications (2)

Publication Number Publication Date
EP0819168A1 EP0819168A1 (en) 1998-01-21
EP0819168A4 true EP0819168A4 (en) 2000-11-08

Family

ID=22248816

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95914722A Withdrawn EP0819168A4 (en) 1995-03-15 1995-03-15 Human tumor necrosis factor receptor

Country Status (3)

Country Link
EP (1) EP0819168A4 (en)
JP (1) JPH11503007A (en)
AU (1) AU2159995A (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996026217A1 (en) * 1995-02-20 1996-08-29 Snow Brand Milk Products Co., Ltd. Novel protein and methods for the production of the same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996026217A1 (en) * 1995-02-20 1996-08-29 Snow Brand Milk Products Co., Ltd. Novel protein and methods for the production of the same
EP0816380A1 (en) * 1995-02-20 1998-01-07 Snow Brand Milk Products Co., Ltd. Novel protein and methods for the production of the same

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
C A SMITH ET AL: "A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins", SCIENCE,US,AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, vol. 248, no. 248, 25 May 1990 (1990-05-25), pages 1019 - 1022-1023, XP002107350, ISSN: 0036-8075 *
DATABASE WPI Section Ch Week 199640, Derwent World Patents Index; Class B04, AN 1996-402320, XP002131168 *
KOHNO T ET AL: "A second tumor necrosis factor receptor gene product can shed a naturally occurring tumor necrosis factor inhibitor.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (1990 NOV) 87 (21) 8331-5., XP000872869 *
LEWIS M ET AL: "CLONING AND EXPRESSION OF CDNAS FOR TWO DISTINCT MURINE TUMOR NECROSIS FACTOR RECEPTORS DEMONSTRATE ONE RECEPTOR IS SPECIES SPECIFIC", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,US,NATIONAL ACADEMY OF SCIENCE. WASHINGTON, vol. 88, 1 April 1991 (1991-04-01), pages 2830 - 2834, XP002029051, ISSN: 0027-8424 *
SCHALL T J ET AL: "MOLECULAR CLONING AND EXPRESSION OF A RECEPTOR FOR HUMAN TUMOR NECROSIS FACTOR", CELL,US,CELL PRESS, CAMBRIDGE, NA, vol. 61, 20 April 1990 (1990-04-20), pages 361 - 370, XP002063264, ISSN: 0092-8674 *
See also references of WO9628546A1 *

Also Published As

Publication number Publication date
EP0819168A1 (en) 1998-01-21
AU2159995A (en) 1996-10-02
JPH11503007A (en) 1999-03-23

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