EP0817619A4 - NEW POLY- (LACTIDE / GLUCOLIDE) MICROSPHERES WITH EXTENDED RELEASE "WITHOUT BREAKING" - Google Patents

NEW POLY- (LACTIDE / GLUCOLIDE) MICROSPHERES WITH EXTENDED RELEASE "WITHOUT BREAKING"

Info

Publication number: EP0817619A4
Authority: EP; European Patent Office
Prior art keywords: glucolide; lactide; microspheres; breaking; extended release
Prior art date: 1996-01-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

EP96944247A

Other languages

German (de)

French (fr)

Other versions

EP0817619A1 (en

Inventor

Ramasubbu Jeyanthi

Hamont John F Van

Phil Friden

Robert H Reid

F Donald Roberts

Charles E Mcqueen

Jean A Setterstrom

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

United States Department of the Army

Original Assignee

United States Department of the Army

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-01-24

Filing date

1996-11-18

Publication date

1999-02-03

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25744089&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP0817619(A4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1996-11-18 Application filed by United States Department of the Army filed Critical United States Department of the Army

1998-01-14 Publication of EP0817619A1 publication Critical patent/EP0817619A1/en

1999-02-03 Publication of EP0817619A4 publication Critical patent/EP0817619A4/en

Status Ceased legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Zoology (AREA)
Marine Sciences & Fisheries (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EP96944247A 1996-01-24 1996-11-18 NEW POLY- (LACTIDE / GLUCOLIDE) MICROSPHERES WITH EXTENDED RELEASE "WITHOUT BREAKING" Ceased EP0817619A4 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US59097396A	1996-01-24	1996-01-24
US590973		1996-01-24
PCT/US1996/019440 WO1997026869A1 (en)	1996-01-24	1996-11-18	Novel 'burst-free' sustained release poly-(lactide/glycolide) microspheres
CNB961947683A CN100391445C (en)	1996-01-24	1996-11-18	Novel 'burst-free' sustained release poly-(lactide/glycolide) mi crospheres

Publications (2)

Publication Number	Publication Date
EP0817619A1 EP0817619A1 (en)	1998-01-14
EP0817619A4 true EP0817619A4 (en)	1999-02-03

Family

ID=25744089

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP96944247A Ceased EP0817619A4 (en)	1996-01-24	1996-11-18	NEW POLY- (LACTIDE / GLUCOLIDE) MICROSPHERES WITH EXTENDED RELEASE "WITHOUT BREAKING"

Country Status (8)

Country	Link
EP (1)	EP0817619A4 (en)
JP (1)	JPH11509862A (en)
CN (1)	CN100391445C (en)
AP (1)	AP665A (en)
AU (1)	AU722884B2 (en)
BR (1)	BR9607752B1 (en)
NZ (1)	NZ325561A (en)
WO (1)	WO1997026869A1 (en)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7033608B1 (en) *	1995-05-22	2006-04-25	The United States Of America As Represented By The Secretary Of The Army	“Burst-free” sustained release poly-(lactide/glycolide) microspheres
TW577759B (en) *	1997-04-18	2004-03-01	Ipsen Pharma Biotech	Sustained release compositions in the form of microcapsules or implants and the process for their preparation
CN1075945C (en) *	1998-02-26	2001-12-12	中国科学院化学研究所	High-polymer encapsulated insulin microsome and its preparation method and use
CN1073412C (en) *	1998-03-19	2001-10-24	中国科学院化学研究所	Method for prepn. of macromolecule microcapsule
US7217770B2 (en) *	2000-05-17	2007-05-15	Samyang Corporation	Stable polymeric micelle-type drug composition and method for the preparation thereof
US6726918B1 (en)	2000-07-05	2004-04-27	Oculex Pharmaceuticals, Inc.	Methods for treating inflammation-mediated conditions of the eye
EP1339438B1 (en)	2000-11-29	2005-10-19	Allergan Inc.	Preventing transplant rejection in the eye
US20050048099A1 (en)	2003-01-09	2005-03-03	Allergan, Inc.	Ocular implant made by a double extrusion process
US20040137059A1 (en) *	2003-01-09	2004-07-15	Thierry Nivaggioli	Biodegradable ocular implant
US20050244469A1 (en)	2004-04-30	2005-11-03	Allergan, Inc.	Extended therapeutic effect ocular implant treatments
US7799336B2 (en)	2004-04-30	2010-09-21	Allergan, Inc.	Hypotensive lipid-containing biodegradable intraocular implants and related methods
US7993634B2 (en)	2004-04-30	2011-08-09	Allergan, Inc.	Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods
US9498457B2 (en)	2004-04-30	2016-11-22	Allergan, Inc.	Hypotensive prostamide-containing biodegradable intraocular implants and related implants
US8722097B2 (en)	2004-04-30	2014-05-13	Allergan, Inc.	Oil-in-water method for making polymeric implants containing a hypotensive lipid
GB0517673D0 (en) *	2005-08-31	2005-10-05	Astrazeneca Ab	Formulation
GB0517674D0 (en) *	2005-08-31	2005-10-05	Astrazeneca Ab	Formulation
CN101007169B (en) *	2006-01-23	2011-05-25	珠海市嘉族生物科技有限公司	A microcapsule of egg yolk immunoglobulin, preparing process and use thereof
KR100816065B1 (en)	2006-11-27	2008-03-24	동국제약 주식회사	Method for preparing sustained release microcapsules with excellent initial release control characteristics and microcapsules prepared by the same
US8889173B2 (en) *	2008-04-18	2014-11-18	Warsaw Orthopedic, Inc.	Alpha adrenergic receptor agonists for treatment of pain and/or inflammation
US8956641B2 (en) *	2008-04-18	2015-02-17	Warsaw Orthopedic, Inc.	Alpha adrenergic receptor agonists for treatment of inflammatory diseases
CN101612111B (en) *	2008-06-24	2011-11-23	上海医药工业研究院	Sustained-release microspheres of nomegestrol acetate or analogues thereof, preparation method and use thereof
KR20100037389A (en) *	2008-10-01	2010-04-09	연세대학교 산학협력단	Solid microstructure with multi-controlled release and process for preparing the same
USRE49251E1 (en)	2010-01-04	2022-10-18	Mapi Pharma Ltd.	Depot systems comprising glatiramer or pharmacologically acceptable salt thereof
CN102357080B (en) *	2011-11-04	2014-07-16	无锡中科光远生物材料有限公司	Intelligent multifunctional hollow microsphere capable of quickly releasing medicine in acid environment and preparation method for intelligent multifunctional hollow microsphere
US10675376B2 (en)	2012-05-24	2020-06-09	Ethicon Llc	Mechanically strong absorbable polymeric blend compositions of precisely controllable absorption rates, processing methods, and products therefrom
FI3010962T4 (en) *	2013-06-20	2023-05-04		Preparation of polylactide-polyglycolide microparticles having a sigmoidal release profile
US20170022256A1 (en) *	2015-07-23	2017-01-26	General Biologicals Corporation	Anti-fungal and anti-bacterial peptide and therapeutic method using same
US12097292B2 (en)	2016-08-28	2024-09-24	Mapi Pharma Ltd.	Process for preparing microparticles containing glatiramer acetate
FI3506921T3 (en)	2016-08-31	2023-07-21	Mapi Pharma Ltd	Depot systems comprising glatiramer acetate
MX2019010174A (en)	2017-03-26	2019-10-15	Mapi Pharma Ltd	Glatiramer depot systems for treating progressive forms of multiple sclerosis.
CN113384536B (en) *	2020-03-14	2024-04-02	鲁南制药集团股份有限公司	Sustained release galanthamine pamoate particles for injection and preparation method thereof
CN115025290A (en) *	2022-06-15	2022-09-09	浙江天妍生物科技有限公司	Degradable microsphere and production process thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0052510A2 (en) *	1980-11-18	1982-05-26	Syntex (U.S.A.) Inc.	Microencapsulation of water soluble polypeptides
DE4005415A1 (en) *	1990-02-21	1991-08-22	Boehringer Ingelheim Kg	Polyester based on hydroxy-carboxylic acids, esp. alpha-hydroxy acids - obtd. by reaction of acids or oligomers in condensn. catalyst, esp. phosgene, carbonyl:di:imidazole, di:cyclo:hexyl:carbo:di:imide
EP0463194A1 (en) *	1990-06-23	1992-01-02	Boehringer Ingelheim Kg	Process for the preparation of poly(D,L-lactide) and its use as a drug carrier
DE4235312A1 (en) *	1991-10-23	1993-04-29	Boehringer Ingelheim Kg	Semi-solid mixts. of D- or L-lactic acid oligomer or polymer - used e.g. as resorbable implants, or bone waxes
US5410016A (en) *	1990-10-15	1995-04-25	Board Of Regents, The University Of Texas System	Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
DE19513659A1 (en) *	1995-03-10	1996-09-12	Boehringer Mannheim Gmbh	Microparticle formulations of aggregation-sensitive polypeptides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4622244A (en) *	1979-09-04	1986-11-11	The Washington University	Process for preparation of microcapsules
US4623588A (en) *	1984-02-06	1986-11-18	Biotek, Inc.	Controlled release composite core coated microparticles
ATE223702T1 (en) *	1993-10-22	2002-09-15	Genentech Inc	METHOD AND COMPOSITIONS FOR MICROCAPSULATING ADJUVANTS
GB9412273D0 (en) *	1994-06-18	1994-08-10	Univ Nottingham	Administration means

1996
- 1996-11-18 EP EP96944247A patent/EP0817619A4/en not_active Ceased
- 1996-11-18 CN CNB961947683A patent/CN100391445C/en not_active Expired - Fee Related
- 1996-11-18 JP JP9526833A patent/JPH11509862A/en active Pending
- 1996-11-18 AU AU14104/97A patent/AU722884B2/en not_active Ceased
- 1996-11-18 BR BRPI9607752-2A patent/BR9607752B1/en not_active IP Right Cessation
- 1996-11-18 AP APAP/P/1997/001088A patent/AP665A/en active
- 1996-11-18 NZ NZ325561A patent/NZ325561A/en not_active IP Right Cessation
- 1996-11-18 WO PCT/US1996/019440 patent/WO1997026869A1/en not_active Ceased

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0052510A2 (en) *	1980-11-18	1982-05-26	Syntex (U.S.A.) Inc.	Microencapsulation of water soluble polypeptides
DE4005415A1 (en) *	1990-02-21	1991-08-22	Boehringer Ingelheim Kg	Polyester based on hydroxy-carboxylic acids, esp. alpha-hydroxy acids - obtd. by reaction of acids or oligomers in condensn. catalyst, esp. phosgene, carbonyl:di:imidazole, di:cyclo:hexyl:carbo:di:imide
EP0463194A1 (en) *	1990-06-23	1992-01-02	Boehringer Ingelheim Kg	Process for the preparation of poly(D,L-lactide) and its use as a drug carrier
US5410016A (en) *	1990-10-15	1995-04-25	Board Of Regents, The University Of Texas System	Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
DE4235312A1 (en) *	1991-10-23	1993-04-29	Boehringer Ingelheim Kg	Semi-solid mixts. of D- or L-lactic acid oligomer or polymer - used e.g. as resorbable implants, or bone waxes
DE19513659A1 (en) *	1995-03-10	1996-09-12	Boehringer Mannheim Gmbh	Microparticle formulations of aggregation-sensitive polypeptides

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
R. JEYANTHI ET AL.: "NOVEL BURST FREE PROGRAMMABLE BIODEGRADABLE MICROSPHERES FOR CONTROLLED RELEASE OF POLYPEPTIDES", PROC. INT. SYMP. CONTROL. RELEASE BIOACT. MATER. (1996), July 1996 (1996-07-01), KYOTO, pages 351 - 352, XP002086331 *
See also references of WO9726869A1 *

Also Published As

Publication number	Publication date
AP665A (en)	1998-08-19
CN100391445C (en)	2008-06-04
CN1188408A (en)	1998-07-22
JPH11509862A (en)	1999-08-31
EP0817619A1 (en)	1998-01-14
AP9701088A0 (en)	1997-10-31
WO1997026869A1 (en)	1997-07-31
BR9607752A (en)	1999-11-30
AU1410497A (en)	1997-08-20
BR9607752B1 (en)	2009-05-05
AU722884B2 (en)	2000-08-10
NZ325561A (en)	1999-06-29

Publication	Publication Date	Title
EP0817619A4 (en)	1999-02-03	NEW POLY- (LACTIDE / GLUCOLIDE) MICROSPHERES WITH EXTENDED RELEASE "WITHOUT BREAKING"
DE59805530D1 (en)	2002-10-17	OVERLOAD CLUTCH
NO991757D0 (en)	1999-04-14	SMA alarm
DE69801385D1 (en)	2001-09-27	Overload clutch
NO20000916L (en)	2000-04-14	Biodegradable lactone copolymers
DE69806764D1 (en)	2002-08-29	CLUTCH LOCK
NO20000014D0 (en)	2000-01-03	Groat-inhibiting polymers
EP1027046A4 (en)	2002-04-03	GONADOTHROPHIN RELEASE HORMONE ANTAGONISTS
FR2795145B1 (en)	2002-05-03	CLUTCH MECHANISM
DK1334725T3 (en)	2007-06-11	Ostroprogestative contraceptive
NO993944L (en)	1999-10-18	release mechanism
DE69721277D1 (en)	2003-05-28	SLOW RELEASE PESTICIDE FORMULA
DE69724800D1 (en)	2003-10-16	OVERLOAD CLUTCH ARRANGEMENT
PT958285E (en)	2004-05-31	BENZOEE \| ISOINDOIS AND BENZOHH \| TRICYCYCLIC ISOKINOLINS
NO993662D0 (en)	1999-07-28	polymers
IT1297942B1 (en)	1999-12-20	IGNITION SYSTEM
FR2752698B1 (en)	1999-02-12	ROTATING CASE MECHANISM
FR2797232B1 (en)	2006-04-28	ACTUATING DEVICE
FR2765286B1 (en)	2000-11-24	CLUTCH DEVICE
IT1293191B1 (en)	1999-02-16	LIGHTING DEVICE.
DE69805581D1 (en)	2002-07-04	breaking device
FR2787160B1 (en)	2005-09-30	ACTUATING DEVICE
LU90452B1 (en)	2001-03-28	-Tanch-it- device
DK67698A (en)	1998-05-19	Melt Blowing Device
DE69823079D1 (en)	2004-05-19	bite indicators

Legal Events

Date	Code	Title	Description
1997-11-28	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1998-01-14	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
1998-04-01	17P	Request for examination filed	Effective date: 19980130
1999-02-03	A4	Supplementary search report drawn up and despatched	Effective date: 19981216
1999-02-03	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2000-04-20	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED
2000-06-07	18R	Application refused	Effective date: 19991209