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EP0759763A4 - PREVENTION OF HYPERACUTE REPELLATION OF ORGAN TRANSPLANTS FROM PIG TO PRIMATE - Google Patents

PREVENTION OF HYPERACUTE REPELLATION OF ORGAN TRANSPLANTS FROM PIG TO PRIMATE

Info

Publication number
EP0759763A4
EP0759763A4 EP95919185A EP95919185A EP0759763A4 EP 0759763 A4 EP0759763 A4 EP 0759763A4 EP 95919185 A EP95919185 A EP 95919185A EP 95919185 A EP95919185 A EP 95919185A EP 0759763 A4 EP0759763 A4 EP 0759763A4
Authority
EP
European Patent Office
Prior art keywords
repellation
hyperacute
primate
pig
prevention
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95919185A
Other languages
German (de)
French (fr)
Other versions
EP0759763A1 (en
Inventor
Joseph R Leventhal
Jutta Mueller-Derlich
Wolfgang Boehm
Franz A Bieber
Marc Salit
Reiner Spaethe
R Morton Bolman Iii
Arthur J Matas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter International Inc
University of Minnesota Twin Cities
University of Minnesota System
Original Assignee
Baxter International Inc
University of Minnesota Twin Cities
University of Minnesota System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter International Inc, University of Minnesota Twin Cities, University of Minnesota System filed Critical Baxter International Inc
Publication of EP0759763A1 publication Critical patent/EP0759763A1/en
Publication of EP0759763A4 publication Critical patent/EP0759763A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3486—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
    • A61M1/3489—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents by biological cells, e.g. bioreactor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0415—Plasma
    • A61M2202/0417—Immunoglobulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EP95919185A 1994-05-13 1995-05-12 PREVENTION OF HYPERACUTE REPELLATION OF ORGAN TRANSPLANTS FROM PIG TO PRIMATE Withdrawn EP0759763A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US242208 1988-09-09
US24220894A 1994-05-13 1994-05-13
PCT/US1995/006028 WO1995031209A1 (en) 1994-05-13 1995-05-12 Prevention of hyperacute rejection in pig to primate organ transplant

Publications (2)

Publication Number Publication Date
EP0759763A1 EP0759763A1 (en) 1997-03-05
EP0759763A4 true EP0759763A4 (en) 1997-07-30

Family

ID=22913877

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95919185A Withdrawn EP0759763A4 (en) 1994-05-13 1995-05-12 PREVENTION OF HYPERACUTE REPELLATION OF ORGAN TRANSPLANTS FROM PIG TO PRIMATE

Country Status (3)

Country Link
EP (1) EP0759763A4 (en)
AU (1) AU2514595A (en)
WO (1) WO1995031209A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU691297B2 (en) * 1994-05-13 1998-05-14 Miltenyi Biotec Gmbh Sterile and pyrogen-free columns coupled to protein for binding and removal of substances from blood
EP0775493A3 (en) * 1995-11-22 1998-08-12 Baxter International Inc. Extracorporeal xenogeneic organ perfusion following antibody depletion by immunoapheresis
US6464976B1 (en) * 1999-09-07 2002-10-15 Canji, Inc. Methods and compositions for reducing immune response
AU2013204469B2 (en) * 2008-12-19 2015-04-09 Baxalta GmbH Systems and methods for obtaining immunoglobulin from blood
US20100158893A1 (en) * 2008-12-19 2010-06-24 Baxter International Inc. Systems and methods for obtaining immunoglobulin from blood
US20120219633A1 (en) * 2011-02-28 2012-08-30 Pall Corporation Removal of immunoglobulins and leukocytes from biological fluids

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0269279A2 (en) * 1986-11-21 1988-06-01 Imre Corporation Extracorporeal removal of immunoglobulin-G and circulating immune complexes
WO1993003735A1 (en) * 1991-08-23 1993-03-04 Alberta Research Council Methods and compositions for attenuating antibody-mediated xenograft rejection in human recipients
WO1995031727A1 (en) * 1994-05-13 1995-11-23 Therasorb Medizinische Systeme Gmbh Sterile and pyrogen-free columns coupled to protein for binding and removal of substances from blood

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5144013A (en) * 1986-09-24 1992-09-01 Ube Industries, Ltd. Body fluid purifying material and method for purifying body fluid by use thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0269279A2 (en) * 1986-11-21 1988-06-01 Imre Corporation Extracorporeal removal of immunoglobulin-G and circulating immune complexes
WO1993003735A1 (en) * 1991-08-23 1993-03-04 Alberta Research Council Methods and compositions for attenuating antibody-mediated xenograft rejection in human recipients
WO1995031727A1 (en) * 1994-05-13 1995-11-23 Therasorb Medizinische Systeme Gmbh Sterile and pyrogen-free columns coupled to protein for binding and removal of substances from blood

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BENSINGER W.: "Plasma exchange and immunoadsorption for removal of antibodies prior to ABO incompatible bone marrow transplant", ARTIFICIAL ORGANS, vol. 5, no. 3, August 1981 (1981-08-01), pages 254 - 258, XP000673998 *
DANTAL J ET AL: "Effect of plasma protein absorption on protein excretion in kidney-transplant recipients with recurrent nephrotic syndrome.", NEW ENGLAND JOURNAL OF MEDICINE 330 (1). 1994. 7-14, XP000674269 *
FISCHEL R J ET AL: "CARDIAC XENOGRAFTING IN THE PIG-TO-RHESUS MONKEY MODEL MANIPULATION OF ANTIENDOTHELIAL ANTIBODY PROLONGS SURVIVAL.", J HEART LUNG TRANSPLANT 11 (5). 1992. 965-973, XP000673900 *
LEVENTHAL J R ET AL: "Removal of baboon and human antiporcine IgG and IgM natural antibodies by immunoadsorption: Results of in vitro and in vivo studies.", TRANSPLANTATION (BALTIMORE) 59 (2). 1995. 294-300, XP000674258 *
LOVELAND B E ET AL: "CD46 MCP CONFERS PROTECTION FROM LYSIS BY XENOGENETIC ANTIBODIES.", XIVTH INTERNATIONAL CONGRESS OF THE TRANSPLANTATION SOCIETY, PARIS, FRANCE, AUGUST 16-21, 1992. TRANSPLANT PROC 25 (1 BOOK 1-2). 1993. 396-397, XP000673901 *
NEETHLING F A ET AL: "Protection of pig kidney (PK15) cells from the cytotoxic effect of anti- pig antibodies by alpha-galactosyl oligosaccharides.", TRANSPLANTATION (BALTIMORE) 57 (6). 1994. 959-963, XP000674257 *
ORIOL R ET AL: "Carbohydrate antigens of pig tissues reacting with human natural antibodies as potential targets for hyperacute vascular rejection in pig -to-man organ xenotransplantation.", TRANSPLANTATION (BALTIMORE) 56 (6). 1993. 1433-1442, XP000674259 *
PALMER A ET AL: "REMOVAL OF ANTI-HLA ANTIBODIES BY EXTRACORPOREAL IMMUNOADSORPTION TO ENABLE RENAL TRANSPLANTATION.", LANCET 1 (8628). 1989. 10-12, XP002031721 *
SHAPIRO R. ET AL.: "Immunodepletion in Xenotransplantation", JOURNAL OF INVESTIGATIVE SURGERY, vol. 3, no. 1, 1990, pages 39 - 49, XP000673902 *

Also Published As

Publication number Publication date
AU2514595A (en) 1995-12-05
WO1995031209A1 (en) 1995-11-23
EP0759763A1 (en) 1997-03-05

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Legal Events

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