EP0668770A4 - - Google Patents

Info

Publication number: EP0668770A4
Authority: EP; European Patent Office
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP92911434A

Other versions

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-04-24

Filing date

1992-04-15

Publication date

1995-09-27

1992-04-15 Application filed filed Critical

1995-08-30 Publication of EP0668770A1 publication Critical patent/EP0668770A1/de

1995-09-27 Publication of EP0668770A4 publication Critical patent/EP0668770A4/xx

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/66—Thymopoietins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/70—Enkephalins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06156—Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C07K5/0825—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Glp-amino acid; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1021—Tetrapeptides with the first amino acid being acidic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Toxicology (AREA)
Endocrinology (AREA)
Gastroenterology & Hepatology (AREA)
Heart & Thoracic Surgery (AREA)
Zoology (AREA)
Cardiology (AREA)
Hematology (AREA)
Diabetes (AREA)
Anesthesiology (AREA)
Child & Adolescent Psychology (AREA)
Rheumatology (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Pulmonology (AREA)

EP92911434A 1991-04-24 1992-04-15 Alpha-substituierte polypeptide und therapeutischer aktivität Withdrawn EP0668770A1 (de)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US69075591A	1991-04-24	1991-04-24
US690755		1991-04-24
US85208692A	1992-03-20	1992-03-20
US852086		1992-03-20
PCT/US1992/003119 WO1992019254A1 (en)	1991-04-24	1992-04-15	α-SUBSTITUTED POLYPEPTIDES HAVING THERAPEUTIC ACTIVITY

Publications (2)

Publication Number	Publication Date
EP0668770A1 EP0668770A1 (de)	1995-08-30
EP0668770A4 true EP0668770A4 (de)	1995-09-27

Family

ID=27104664

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP92911434A Withdrawn EP0668770A1 (de)	1991-04-24	1992-04-15	Alpha-substituierte polypeptide und therapeutischer aktivität

Country Status (8)

Country	Link
EP (1)	EP0668770A1 (de)
JP (1)	JPH06507402A (de)
AU (1)	AU1907292A (de)
CA (1)	CA2106764A1 (de)
IE (1)	IE921321A1 (de)
NZ (1)	NZ242441A (de)
PT (1)	PT100422A (de)
WO (1)	WO1992019254A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH08500818A (ja) *	1992-06-01	1996-01-30	マガイニンファーマシューティカルズ，インコーポレーテッド	Ｎ末端置換を有する生物活性ペプチド
WO1994009031A1 (en) *	1992-10-19	1994-04-28	Warner-Lambert Company	Analogues of cholecystokinin (30-33) containing an alpha-substituted aminoacid
FR2700472B1 (fr)	1993-01-19	1995-02-17	Rhone Poulenc Rorer Sa	Association synergisante ayant un effet antagoniste des récepteurs NK1 et NK2.
EP0728145A1 (de) *	1993-11-01	1996-08-28	Ciba-Geigy Japan Limited	Endothelin rezeptor antagoniste
US5610145A (en) *	1994-04-15	1997-03-11	Warner-Lambert Company	Tachykinin antagonists
US5554644A (en) *	1994-06-08	1996-09-10	Warner-Lambert Company	Tachykinin (NK2) antagonists
FR2735687B1 (fr) *	1995-06-21	1997-08-14	Sederma Sa	Nouvelles compositions cosmetiques amincissantes
WO1998007744A1 (fr) *	1996-08-23	1998-02-26	Sederma S.A.	Peptides synthetiques et leur utilisation dans les compositions cosmetiques ou dermopharmaceutiques
IL137820A (en)	2000-08-10	2009-06-15	S I S Shulov Inst For Science	Pharmaceutical composition for topical administration comprising an analgesic peptide
US6593362B2 (en)	2001-05-21	2003-07-15	Guilford Pharmaceuticals Inc.	Non-peptidic cyclophilin binding compounds and their use
WO2006049681A2 (en) *	2004-08-30	2006-05-11	Bayer Pharmaceuticals Corporation	Selective neuropeptide y2 receptor agonists
EP2190456A2 (de) *	2007-09-11	2010-06-02	Mondobiotech Laboratories AG	Verwendung von beta-melanotropin als therapeutisches mittel, z.b. zur behandlung von aids oder alzheimer
HUP0700782A3 (en) *	2007-12-05	2009-11-30	Biostatin Gyogyszerkutato Fejl	Novel peptides and amino acid derivatives, pharmaceutical compositions containing the same and use of the compounds
KR101782671B1 (ko)	2011-03-28	2017-09-27	에스.아이.에스. 슐로브 이노베이티브 사이언스 리미티드	피부 질환을 치료하는 방법

Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0007615A2 (de) *	1978-07-24	1980-02-06	Merck & Co. Inc.	Verfahren zur Herstellung von Aminosäuren und Estern
EP0146266A2 (de) *	1983-11-18	1985-06-26	Ortho Pharmaceutical Corporation	Enzymwiderstandsfähige immunomodulatorische Peptide
EP0342962A2 (de) *	1988-05-19	1989-11-23	Immunobiology Research Institute, Inc.	Peptide mit T-Zellen-Helfer-Wirksamkeit
EP0405537A1 (de) *	1989-06-29	1991-01-02	Warner-Lambert Company	N-substituierte Cycloalkyl- und Polycycloalkyl-alpha-substituierte Trp-Phe- und Phenethylaminderivate

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4689318A (en) *	1985-08-29	1987-08-25	The Salk Institute For Biological Studies	GRF analogs
US5098995A (en) *	1987-05-22	1992-03-24	The Salk Institute For Biological Studies	GRF Analogs VIIA

1992
- 1992-04-15 JP JP4511401A patent/JPH06507402A/ja active Pending
- 1992-04-15 CA CA002106764A patent/CA2106764A1/en not_active Abandoned
- 1992-04-15 EP EP92911434A patent/EP0668770A1/de not_active Withdrawn
- 1992-04-15 AU AU19072/92A patent/AU1907292A/en not_active Abandoned
- 1992-04-15 WO PCT/US1992/003119 patent/WO1992019254A1/en not_active Application Discontinuation
- 1992-04-22 NZ NZ242441A patent/NZ242441A/en unknown
- 1992-04-23 IE IE132192A patent/IE921321A1/en not_active Application Discontinuation
- 1992-04-23 PT PT100422A patent/PT100422A/pt not_active Application Discontinuation

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0007615A2 (de) *	1978-07-24	1980-02-06	Merck & Co. Inc.	Verfahren zur Herstellung von Aminosäuren und Estern
EP0146266A2 (de) *	1983-11-18	1985-06-26	Ortho Pharmaceutical Corporation	Enzymwiderstandsfähige immunomodulatorische Peptide
EP0342962A2 (de) *	1988-05-19	1989-11-23	Immunobiology Research Institute, Inc.	Peptide mit T-Zellen-Helfer-Wirksamkeit
EP0405537A1 (de) *	1989-06-29	1991-01-02	Warner-Lambert Company	N-substituierte Cycloalkyl- und Polycycloalkyl-alpha-substituierte Trp-Phe- und Phenethylaminderivate

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
D.ROSSI ET AL.: "Hydrolysis of N-phenylacetyl-alpha-amino acids by benzylpenicillinacylase", EXPERIENTIA, vol. 41, no. 1, 1985, BASEL, pages 35 - 37 *
G.A.HEAVNER ET AL.: "Biologically Active Analogs of Thermopentin with Enhanced Enzymatic Stability", PEPTIDES, vol. 7, 1986, USA, pages 1015 - 1019 *
H.BRÜCKNER ET AL.: "Determination of Non-Protein alpha-Alkyl-apha-Amino Acids by Reserved-Phase High-Performance Liquid Chromatography in Comparison With Ion-Exchange And Capillary Gas Cromatography", J.CHROMATOGEPHY, vol. 386, 1987, pages 251 - 272 *
See also references of WO9219254A1 *

Also Published As

Publication number	Publication date
PT100422A (pt)	1993-09-30
JPH06507402A (ja)	1994-08-25
CA2106764A1 (en)	1992-10-25
WO1992019254A1 (en)	1992-11-12
NZ242441A (en)	1995-02-24
AU1907292A (en)	1992-12-21
EP0668770A1 (de)	1995-08-30
IE921321A1 (en)	1992-11-04

Publication	Publication Date	Title
DE4291263T1 (de)	1993-06-03
DK0520893T3 (de)	1997-02-10
EP0524030A3 (de)	1995-03-22
EP0501508A3 (de)	1995-05-10
DE4290402T1 (de)	1993-04-01
DE4291109T1 (de)	1993-04-01
FR2685458B1 (de)	1994-07-13
FR2681006B1 (de)	1995-06-02
FR2671640B1 (de)	1994-12-02
FR2673091B1 (de)	1994-12-16
DE4292012T1 (de)	1993-07-15
JPH04100746U (de)	1992-08-31
DK152591D0 (de)	1991-08-28
JPH0495512U (de)	1992-08-19
ECSM91557U (de)	1992-03-27
JPH0498567U (de)	1992-08-26
JPH04100161U (de)	1992-08-28
ECSM91562U (de)	1992-03-27
AU1144992A (de)	1992-06-18
EP0527319A3 (de)	1994-03-23
EP0497617A3 (de)	1994-03-30
EP0519753A3 (de)	1994-03-30
EP0495611A3 (de)	1994-01-05
EP0498213A3 (de)	1994-01-12
EP0521349A3 (de)	1994-01-19

Legal Events

Date	Code	Title	Description
1995-07-14	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1995-08-30	17P	Request for examination filed	Effective date: 19931019
1995-08-30	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE
1995-09-27	A4	Supplementary search report drawn up and despatched	Effective date: 19950812
1995-09-27	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE
1996-01-10	RHK1	Main classification (correction)	Ipc: A61K 38/00
1996-04-19	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
1996-06-05	18D	Application deemed to be withdrawn	Effective date: 19951030