EP0663827A4 - TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS. - Google Patents

TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS.

Info

Publication number: EP0663827A4
Authority: EP; European Patent Office
Prior art keywords: receptor antagonists; oxytocin receptor; tocolytic oxytocin; tocolytic; antagonists
Prior art date: 1992-10-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP93923134A

Other languages

German (de)

French (fr)

Other versions

EP0663827A1 (en

Inventor

Ben E Evans

Douglas W Hobbs

Joseph M Pawluczyk

Douglas J Pettibone

Kenneth E Rittle

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck and Co Inc

Original Assignee

Merck and Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-10-07

Filing date

1993-09-27

Publication date

1995-11-15

1993-09-27 Application filed by Merck and Co Inc filed Critical Merck and Co Inc

1995-07-26 Publication of EP0663827A1 publication Critical patent/EP0663827A1/en

1995-11-15 Publication of EP0663827A4 publication Critical patent/EP0663827A4/en

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Processing Of Meat And Fish (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

EP93923134A 1992-10-07 1993-09-27 TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS. Withdrawn EP0663827A4 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US95793892A	1992-10-07	1992-10-07
US957938		1992-10-07
PCT/US1993/009152 WO1994007496A1 (en)	1992-10-07	1993-09-27	Tocolytic oxytocin receptor antagonists

Publications (2)

Publication Number	Publication Date
EP0663827A1 EP0663827A1 (en)	1995-07-26
EP0663827A4 true EP0663827A4 (en)	1995-11-15

Family

ID=25500372

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP93923134A Withdrawn EP0663827A4 (en)	1992-10-07	1993-09-27	TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS.

Country Status (5)

Country	Link
EP (1)	EP0663827A4 (en)
JP (1)	JPH08502474A (en)
AU (1)	AU5292393A (en)
CA (1)	CA2143117A1 (en)
WO (1)	WO1994007496A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE216580T1 (en) *	1993-07-16	2002-05-15	Merck & Co Inc	BENZOXAZINONE AND BENZOPYRIMIDINONE PIPERIDINYL COMPOUNDS AS TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS
JPH09500133A (en) *	1993-07-16	1997-01-07	メルクエンドカンパニーインコーポレーテッド	Substituted piperazinyl camphor derivatives as antagonists of oxytocin
US5464788A (en) *	1994-03-24	1995-11-07	Merck & Co., Inc.	Tocolytic oxytocin receptor antagonists
US5707985A (en) *	1995-06-07	1998-01-13	Tanabe Seiyaku Co. Ltd.	Naphthyl-, quinolyl- and isoquinolyl- sulfonamide derivatives as cell adhesion modulators
WO1998046569A1 (en) *	1997-04-11	1998-10-22	Sumitomo Pharmaceuticals Co., Ltd.	Benzene derivatives
GB9819860D0 (en)	1998-09-12	1998-11-04	Zeneca Ltd	Chemical compounds
IL153710A0 (en)	2000-07-05	2003-07-06	Ortho Mcneil Pharm Inc	Nonpeptide substituted spirobenzoazepines as vasopressin antagonists
BRPI0409078A (en)	2003-04-04	2006-04-18	Merck & Co Inc	compound, methods for treating or preventing disorders, diseases or conditions responsive to melanocortin-4 receptor activation, for treating or preventing obesity, for treating or preventing an obesity-related disorder, for treating or preventing of diabetes mellitus, for the treatment or prevention of male or female sexual dysfunction and for the treatment or prevention of erectile dysfunction, pharmaceutical composition, methods for the treatment of erectile dysfunction in a mammal, for the treatment of diabetes in a mammal and for obesity treatment in a mammal, and, use of a compound
JP5252614B2 (en)	2003-06-17	2013-07-31	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	Substituted spirobenzazepine
DE102005000666B3 (en)	2005-01-04	2006-10-05	Sanofi-Aventis Deutschland Gmbh	Sulfonylpyrrolidines, process for their preparation and their use as pharmaceuticals
AU2007299818B2 (en)	2006-09-22	2012-08-02	Janssen Pharmaceutica N.V.	Spiro benzazepines used as vasopressin antagonists
EP2076517A1 (en)	2006-09-22	2009-07-08	Janssen Pharmaceutica N.V.	Spiro benzazepines as vasopressin antagonists
RU2009119394A (en)	2006-12-07	2011-01-20	Ф. Хоффманн-Ля Рош Аг (Ch)	SPIRO-PIPERIDINE DERIVATIVES AS V1A RECEPTOR ANTAGONISTS
CA2673307A1 (en)	2006-12-22	2008-07-03	F. Hoffman-La Roche Ag	Spiro-piperidine derivatives
AU2007338116B2 (en)	2006-12-22	2012-04-26	F. Hoffmann-La Roche Ag	Spiro-piperidine derivatives
US20100022572A1 (en)	2008-07-18	2010-01-28	Kowa Company, Ltd.	Novel spiro compound and medicine comprising the same
AU2011225095C1 (en) *	2010-03-11	2017-01-19	Sumitomo Dainippon Pharma Co., Ltd.	N-Acyl cyclic amine derivative or pharmaceutically acceptable salt thereof
US11717499B2 (en) *	2011-06-28	2023-08-08	Sandra Eve Reznik	Administration of N,N-dimethylacetamide for the treatment of preterm birth
JP5715605B2 (en) *	2011-09-14	2015-05-07	大日本住友製薬株式会社	Pharmaceutical comprising N-acyl cyclic amine derivative or pharmaceutically acceptable salt thereof
WO2014024993A1 (en) *	2012-08-09	2014-02-13	国立大学法人京都大学	Piperazine derivative and use thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0444945A2 (en) *	1990-03-02	1991-09-04	Merck & Co. Inc.	Use of spirocyclic compounds as oxytocin antagonists
EP0486280A2 (en) *	1990-11-13	1992-05-20	Merck & Co. Inc.	Piperidinylcamphorsulfonyl oxytocin antagonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8917069D0 (en) *	1989-07-26	1989-09-13	Merck Sharp & Dohme	Therapeutic agents
US5091387A (en) *	1990-03-02	1992-02-25	Merck & Co., Inc.	Spirocyclic oxytocin antagonists
EP0445974A3 (en) *	1990-03-05	1992-04-29	Merck Sharp & Dohme Ltd.	Spirocyclic antipsychotic agents

1993
- 1993-09-27 EP EP93923134A patent/EP0663827A4/en not_active Withdrawn
- 1993-09-27 WO PCT/US1993/009152 patent/WO1994007496A1/en not_active Ceased
- 1993-09-27 AU AU52923/93A patent/AU5292393A/en not_active Abandoned
- 1993-09-27 JP JP6509222A patent/JPH08502474A/en active Pending
- 1993-09-27 CA CA002143117A patent/CA2143117A1/en not_active Abandoned

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0444945A2 (en) *	1990-03-02	1991-09-04	Merck & Co. Inc.	Use of spirocyclic compounds as oxytocin antagonists
EP0486280A2 (en) *	1990-11-13	1992-05-20	Merck & Co. Inc.	Piperidinylcamphorsulfonyl oxytocin antagonists

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9407496A1 *

Also Published As

Publication number	Publication date
WO1994007496A1 (en)	1994-04-14
JPH08502474A (en)	1996-03-19
CA2143117A1 (en)	1994-04-14
AU5292393A (en)	1994-04-26
EP0663827A1 (en)	1995-07-26

Publication	Publication Date	Title
DE69202186D1 (en)	1995-06-01	N-substituted-4-phenyl-piperidine opioid antagonists.
EP0663827A4 (en)	1995-11-15	TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS.
DE69327720D1 (en)	2000-03-02	ENDOTHELIN RECEPTOR ANTAGONISTS
FI961804A7 (en)	1996-04-30	Endothelin receptor antagonists
FI933810L (en)	1994-03-04	Receptor antagonists av exiterbara aminosyror
FI971685A7 (en)	1997-08-13	Tachykinin antagonists
FI930774A7 (en)	1993-08-25	Endothelin sulfonamide antagonists
FI924405A0 (en)	1992-09-30	LHRH antagonists.
EE9600186A (en)	1997-08-15	Neurokinin (tachylquinine) antagonists
EP0627087A4 (en)	1996-10-30	HYDROPHONE ARRANGEMENT.
FI932518A7 (en)	1993-12-04	Angiotensin II antagonists
NO932005D0 (en)	1993-06-02	Angiotensin II antagonists
EP0486280A3 (en)	1992-12-09	Piperidinylcamphorsulfonyl oxytocin antagonists
FI922143A7 (en)	1992-05-12	MUSCARIN RECEPTOR ANTAGONIST.
DZ1773A1 (en)	2002-02-17	Endothelin receptor antagonists.
FI960516L (en)	1996-08-07	Substituted biphenylsulfonamide dientothelin antagonists
EP0729472A4 (en)	1997-03-19	OXYTOCIN ANTAGONISTS COMPRISING PIPERIDINYLCAMPHOSULFONYL
EP0684823A4 (en)	1997-07-09	FIBRINOGENIC RECEPTOR ANTAGONISTS.
DE69204920D1 (en)	1995-10-26	Angiotensin II antagonists.
NO179550C (en)	1996-10-30	Tachykinin receptor antagonists
NO944013D0 (en)	1994-10-21	Endothelin Antagonists II
FI911686A0 (en)	1991-04-09	The rectifying boom
NO862406D0 (en)	1986-06-17	Vasopressin antagonists.
NO930262D0 (en)	1993-01-26	Bombesin ANTAGONISTS
FI930108A0 (en)	1993-01-12	Imidazopyridine-PAF antagonists

Legal Events

Date	Code	Title	Description
1995-06-09	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1995-07-26	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE
1995-08-16	17P	Request for examination filed	Effective date: 19950508
1995-11-15	A4	Supplementary search report drawn up and despatched	Effective date: 19951002
1995-11-15	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE
1999-08-25	17Q	First examination report despatched	Effective date: 19990708
2000-03-24	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2000-05-10	18D	Application deemed to be withdrawn	Effective date: 19991119