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EP0612241A4 - Ionic beads useful for controlled release and adsorption. - Google Patents

Ionic beads useful for controlled release and adsorption.

Info

Publication number
EP0612241A4
EP0612241A4 EP92922201A EP92922201A EP0612241A4 EP 0612241 A4 EP0612241 A4 EP 0612241A4 EP 92922201 A EP92922201 A EP 92922201A EP 92922201 A EP92922201 A EP 92922201A EP 0612241 A4 EP0612241 A4 EP 0612241A4
Authority
EP
European Patent Office
Prior art keywords
adsorption
controlled release
beads useful
ionic
ionic beads
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP92922201A
Other versions
EP0612241A1 (en
Inventor
Sergio Nacht
Richard Won
Martin A Katz
Tai Cheng
Christine J Y Liau
Robert P Eury
Michael Froix
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Heron Therapeutics LLC
Original Assignee
Advanced Polymer Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Polymer Systems Inc filed Critical Advanced Polymer Systems Inc
Publication of EP0612241A1 publication Critical patent/EP0612241A1/en
Publication of EP0612241A4 publication Critical patent/EP0612241A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/817Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A61K47/585Ion exchange resins, e.g. polystyrene sulfonic acid resin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241Containing particulates characterized by their shape and/or structure
    • A61K8/0279Porous; Hollow
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8152Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1635Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/54Polymers characterized by specific structures/properties
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/54Polymers characterized by specific structures/properties
    • A61K2800/546Swellable particulate polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/56Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/60Particulates further characterized by their structure or composition
    • A61K2800/65Characterized by the composition of the particulate/core
    • A61K2800/654The particulate/core comprising macromolecular material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Cosmetics (AREA)
  • Colloid Chemistry (AREA)
EP92922201A 1991-10-21 1992-10-19 Ionic beads useful for controlled release and adsorption. Withdrawn EP0612241A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77968191A 1991-10-21 1991-10-21
PCT/US1992/008907 WO1993007862A1 (en) 1991-10-21 1992-10-19 Ionic beads useful for controlled release and adsorption
US779681 2001-02-08

Publications (2)

Publication Number Publication Date
EP0612241A1 EP0612241A1 (en) 1994-08-31
EP0612241A4 true EP0612241A4 (en) 1997-03-05

Family

ID=25117183

Family Applications (1)

Application Number Title Priority Date Filing Date
EP92922201A Withdrawn EP0612241A4 (en) 1991-10-21 1992-10-19 Ionic beads useful for controlled release and adsorption.

Country Status (6)

Country Link
EP (1) EP0612241A4 (en)
JP (1) JP2516322B2 (en)
KR (1) KR100295333B1 (en)
AU (1) AU662181B2 (en)
CA (1) CA2121687A1 (en)
WO (1) WO1993007862A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0121127B1 (en) * 1994-05-09 1997-11-13 강박광 Transdermal drug delivery system having ionic polymer network
AU676971B1 (en) * 1995-08-24 1997-03-27 Dainichiseika Color & Chemicals Mfg. Co. Ltd. Production process of connected microgel particles and articles treated with connected microgel particles
GB9621825D0 (en) * 1996-10-19 1996-12-11 Andaris Ltd Microparticles and their use as therapeutic vehicles
JP4283355B2 (en) * 1997-11-10 2009-06-24 久光製薬株式会社 Pharmaceutical sustained-release agent and sustained-release pharmaceutical composition containing the same
DE69827852T8 (en) 1998-07-30 2006-08-24 The Procter & Gamble Company, Cincinnati HAIR CARE CONTAINING CARBOXYLIC ACID / CARBOXYLATE COPOLYMER AND VISIBLE PARTICLES
US7465766B2 (en) 2004-01-08 2008-12-16 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US8138265B2 (en) 2003-01-10 2012-03-20 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US6982298B2 (en) 2003-01-10 2006-01-03 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US8137688B2 (en) 2003-01-10 2012-03-20 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US7749487B2 (en) 2006-03-10 2010-07-06 Conopco, Inc. Method to assess surfactant adsorption on skin
FR2913597B1 (en) 2007-03-14 2009-10-09 Chanel Parfums Beaute Soc Par COSMETIC USE OF ORGANIC RESINATES
FR2919183B1 (en) * 2007-07-26 2009-11-20 Chanel Parfums Beaute USE OF RESINS FOR STABILIZING COLORANTS.
ES2585483T3 (en) 2008-02-13 2016-10-06 The Cleveland Clinic Foundation Molecular improvement of the extracellular matrix and methods of use
WO2009135029A2 (en) 2008-04-30 2009-11-05 The Cleveland Clinic Foundation Compositions and methods to treat urinary incontinence
JP2015209380A (en) 2014-04-24 2015-11-24 ロレアル Cosmetic composition

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2324204A1 (en) * 1973-05-12 1974-11-28 Basf Ag Ion-exchange beads of uniform size mfr - by radical polymn. of emulsified soln. of water-sol. monomer and cross-linking agent
FR2488908A1 (en) * 1980-08-19 1982-02-26 Nitto Chemical Industry Co Ltd PROCESS FOR THE PREPARATION OF ACRYLAMIDE USING IMMOBILIZED CELLS OF A NEW TYPE
JPS58154709A (en) * 1982-03-09 1983-09-14 Kyoritsu Yuki Kogyo Kenkyusho:Kk Production of cationic, highly water-absorptive resin
JPH01269493A (en) * 1988-04-22 1989-10-26 Kyoritsu Yuki Co Ltd Enzyme immobilization method
EP0369741A2 (en) * 1988-11-16 1990-05-23 Advanced Polymer Systems, Inc. Cationic compositions for topical application
US5022999A (en) * 1987-03-20 1991-06-11 Mitsui-Cyanamid, Ltd. Method of treating starch-containing water

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4224415A (en) * 1958-07-18 1980-09-23 Rohm And Haas Company Polymerization processes and products therefrom
JPS6024807B2 (en) * 1979-02-19 1985-06-14 昭和電工株式会社 Method for producing super absorbent hydrogel
FR2450105A1 (en) * 1979-02-27 1980-09-26 Oreal COMPOSITION AND METHOD FOR TREATING KERATINIC MATERIALS BASED ON FLUORINATED DERIVATIVES
US4564644A (en) * 1982-08-02 1986-01-14 The Dow Chemical Company Ion exchange resins prepared by sequential monomer addition
US4690825A (en) * 1985-10-04 1987-09-01 Advanced Polymer Systems, Inc. Method for delivering an active ingredient by controlled time release utilizing a novel delivery vehicle which can be prepared by a process utilizing the active ingredient as a porogen

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2324204A1 (en) * 1973-05-12 1974-11-28 Basf Ag Ion-exchange beads of uniform size mfr - by radical polymn. of emulsified soln. of water-sol. monomer and cross-linking agent
FR2488908A1 (en) * 1980-08-19 1982-02-26 Nitto Chemical Industry Co Ltd PROCESS FOR THE PREPARATION OF ACRYLAMIDE USING IMMOBILIZED CELLS OF A NEW TYPE
JPS58154709A (en) * 1982-03-09 1983-09-14 Kyoritsu Yuki Kogyo Kenkyusho:Kk Production of cationic, highly water-absorptive resin
US5022999A (en) * 1987-03-20 1991-06-11 Mitsui-Cyanamid, Ltd. Method of treating starch-containing water
JPH01269493A (en) * 1988-04-22 1989-10-26 Kyoritsu Yuki Co Ltd Enzyme immobilization method
EP0369741A2 (en) * 1988-11-16 1990-05-23 Advanced Polymer Systems, Inc. Cationic compositions for topical application

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 113, no. 1, 2 July 1990, Columbus, Ohio, US; abstract no. 2575, page 264; XP002017283 *
PATENT ABSTRACTS OF JAPAN vol. 7, no. 277 (C - 199) 9 December 1983 (1983-12-09) *
See also references of WO9307862A1 *
YOSHITSUGU HIRIKAWA ET ALL.: "Phase Transition of Positively Ionized Gels", MACROMOLECULES, vol. 18, no. 12, 1985, EASTON US, pages 2782 - 2784, XP002017282 *

Also Published As

Publication number Publication date
JP2516322B2 (en) 1996-07-24
WO1993007862A1 (en) 1993-04-29
AU662181B2 (en) 1995-08-24
AU2881592A (en) 1993-05-21
CA2121687A1 (en) 1993-04-29
EP0612241A1 (en) 1994-08-31
KR100295333B1 (en) 2001-09-17
JPH07500596A (en) 1995-01-19
KR940702731A (en) 1994-09-17

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Legal Events

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Inventor name: FROIX, MICHAEL

Inventor name: EURY, ROBERT P.

Inventor name: LIAU, CHRISTINE J.Y.

Inventor name: CHENG, TAI

Inventor name: KATZ, MARTIN A.

Inventor name: WON, RICHARD

Inventor name: NACHT, SERGIO

RIN1 Information on inventor provided before grant (corrected)

Inventor name: FROIX, MICHAEL

Inventor name: EURY, ROBERT P.

Inventor name: LIAU, CHRISTINE J.Y.

Inventor name: CHENG, TAI

Inventor name: KATZ, MARTIN A.

Inventor name: WON, RICHARD

Inventor name: NACHT, SERGIO

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Owner name: ADVANCED POLYMER SYSTEMS, INC.

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