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EP0591426A4 - Sigma receptor ligands and the use thereof - Google Patents

Sigma receptor ligands and the use thereof

Info

Publication number
EP0591426A4
EP0591426A4 EP92914789A EP92914789A EP0591426A4 EP 0591426 A4 EP0591426 A4 EP 0591426A4 EP 92914789 A EP92914789 A EP 92914789A EP 92914789 A EP92914789 A EP 92914789A EP 0591426 A4 EP0591426 A4 EP 0591426A4
Authority
EP
European Patent Office
Prior art keywords
sigma receptor
receptor ligands
treatment
certain
sigma
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP92914789A
Other languages
French (fr)
Other versions
EP0591426A1 (en
Inventor
Richard A Glennon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Virginia Commonwealth University
Original Assignee
Virginia Commonwealth University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/894,771 external-priority patent/US6057371A/en
Application filed by Virginia Commonwealth University filed Critical Virginia Commonwealth University
Publication of EP0591426A1 publication Critical patent/EP0591426A1/en
Publication of EP0591426A4 publication Critical patent/EP0591426A4/en
Withdrawn legal-status Critical Current

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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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    • A61K31/13—Amines
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    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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Abstract

The invention relates to methods for the treatment of central nervous system disorders, gastrointestinal disorders, drug abuse, angina, migraine, hypertension and depression by administering a pharmaceutical composition comprising an effective amount of certain sigma receptor ligands to a patient in need of such treatment. The invention further relates to novel sigma receptor ligands having high binding to the sigma receptor and pharmaceutical compositions thereof. Unexpectedly, certain of the sigma receptor ligands of the present invention have selectivity for the sigma receptor over the DA, PCP and 5-HT1A receptors.
EP92914789A 1991-06-27 1992-06-26 Sigma receptor ligands and the use thereof Withdrawn EP0591426A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US72017391A 1991-06-27 1991-06-27
US720173 1991-06-27
US07/894,771 US6057371A (en) 1989-12-28 1992-06-10 Sigma receptor ligands and the use thereof
US894771 1992-06-10
PCT/US1992/005330 WO1993000313A2 (en) 1991-06-27 1992-06-26 Sigma receptor ligands and the use thereof

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EP0591426A1 EP0591426A1 (en) 1994-04-13
EP0591426A4 true EP0591426A4 (en) 1996-08-21

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AU (1) AU676993B2 (en)
CA (1) CA2111957A1 (en)
IE (1) IE922112A1 (en)
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WO (1) WO1993000313A2 (en)

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