EP0575339A4 - Analogs of acidic fibroblast growth factor having enhanced stability and biological activity. - Google Patents

Analogs of acidic fibroblast growth factor having enhanced stability and biological activity.

Info

Publication number: EP0575339A4
Authority: EP; European Patent Office
Prior art keywords: analogs; growth factor; biological activity; fibroblast growth; enhanced stability
Prior art date: 1990-12-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP92902895A

Other languages

German (de)

French (fr)

Other versions

EP0575339A1 (en

Inventor

Tsutomu Arakawa

Gary Michael Fox

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Amgen Inc

Original Assignee

Amgen Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-12-18

Filing date

1992-07-17

Publication date

1995-04-05

1992-07-17 Application filed by Amgen Inc filed Critical Amgen Inc

1993-12-29 Publication of EP0575339A1 publication Critical patent/EP0575339A1/en

1995-04-05 Publication of EP0575339A4 publication Critical patent/EP0575339A4/en

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
- C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Physics & Mathematics (AREA)
Toxicology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Animal Behavior & Ethology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EP92902895A 1990-12-18 1992-07-17 Analogs of acidic fibroblast growth factor having enhanced stability and biological activity. Withdrawn EP0575339A4 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US63245690A	1990-12-18	1990-12-18
US632456		1990-12-18

Publications (2)

Publication Number	Publication Date
EP0575339A1 EP0575339A1 (en)	1993-12-29
EP0575339A4 true EP0575339A4 (en)	1995-04-05

Family

ID=24535601

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP92902895A Withdrawn EP0575339A4 (en)	1990-12-18	1992-07-17	Analogs of acidic fibroblast growth factor having enhanced stability and biological activity.

Country Status (9)

Country	Link
EP (1)	EP0575339A4 (en)
JP (1)	JPH06503962A (en)
KR (1)	KR930703439A (en)
AU (1)	AU663067B2 (en)
CA (1)	CA2098484A1 (en)
IE (1)	IE914393A1 (en)
IL (1)	IL100418A0 (en)
NZ (1)	NZ241021A (en)
WO (1)	WO1992011360A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2717495B1 (en) *	1994-03-18	1996-04-12	Rhone Poulenc Rorer Sa	Recombinant viruses, preparation and use in gene therapy.
EP0786000A1 (en) *	1994-10-13	1997-07-30	Amgen Inc.	Analogs of acidic fibroblast growth factor having enhanced stability and biological activity
JP3877226B2 (en) *	1994-10-13	2007-02-07	アムジエン・インコーポレーテツド	Purification method of keratinocyte growth factor
JP2733207B2 (en) *	1995-05-18	1998-03-30	工業技術院長	Pharmaceutical composition containing fibroblast growth factor chimeric protein
US6743422B1 (en)	1996-10-15	2004-06-01	Amgen, Inc.	Keratinocyte growth factor-2 products
CA2365434A1 (en) *	1999-04-15	2000-10-26	St. Elizabeth's Medical Center Of Boston	Angiogenic growth factors for treatment of peripheral neuropathy
US7125856B1 (en)	1999-04-15	2006-10-24	St. Elizabeth's Medical Center Of Boston, Inc.	Angiogenic growth factors for treatment of peripheral neuropathy
US20070134204A1 (en) *	2005-12-09	2007-06-14	Henrich Cheng	Method for treating nerve injury and vector construct for the same
US20100286042A1 (en) *	2007-10-12	2010-11-11	National Institute Of Advanced Industrial Science And Technology	Medicinal Composition Containing Highly Functionalized Chimeric Protein

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0298723A1 (en) *	1987-07-07	1989-01-11	California Biotechnology, Inc.	Recombinant fibroblast growth factors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS62270597A (en) *	1986-03-07	1987-11-24	プレジデント・アンド・フエロウズ・オブ・ハ−バ−ド・カレジ	Human kind 1 heparin bondable growth factor
NZ226543A (en) *	1987-10-22	1992-02-25	Merck & Co Inc	Recombinant mutant acidic fibroblast growth factor
DE3909009A1 (en) *	1989-03-18	1990-09-20	Schloemann Siemag Ag	CONTINUOUS CASTING SYSTEM FOR CASTING PROFILES

1991
- 1991-12-17 CA CA002098484A patent/CA2098484A1/en not_active Abandoned
- 1991-12-17 JP JP4503720A patent/JPH06503962A/en active Pending
- 1991-12-17 IE IE439391A patent/IE914393A1/en not_active Application Discontinuation
- 1991-12-17 NZ NZ241021A patent/NZ241021A/en unknown
- 1991-12-17 WO PCT/US1991/009441 patent/WO1992011360A1/en not_active Application Discontinuation
- 1991-12-17 AU AU91524/91A patent/AU663067B2/en not_active Ceased
- 1991-12-18 IL IL100418A patent/IL100418A0/en unknown
1992
- 1992-07-17 EP EP92902895A patent/EP0575339A4/en not_active Withdrawn
1993
- 1993-06-17 KR KR1019930701853A patent/KR930703439A/en not_active Application Discontinuation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0298723A1 (en) *	1987-07-07	1989-01-11	California Biotechnology, Inc.	Recombinant fibroblast growth factors

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ARAKAWA, T. ET AL.: "PRODUCTION AND CHARACTERIZATION OF AN ANALOG OF ACIDIC FIBROBLAST GROWTH FACTOR WITH ENHANCED STABILITY AND BIOLOGICAL ACTIVITY.", PROTEIN ENG 6 (5). 1993. 541-546 *
BAIRD, A. ET AL.: "Receptor- and heparin-binding domains of basic fibroblast growth factor", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 85, April 1988 (1988-04-01), WASHINGTON US, pages 2324 - 2328 *
LESZCZYNSKI, J. & ROSE, G.: "Loops in globular proteins: a novel category of secondary structure", SCIENCE, vol. 234, 14 November 1986 (1986-11-14), LANCASTER, PA US, pages 849 - 855 *
See also references of WO9211360A1 *

Also Published As

Publication number	Publication date
AU663067B2 (en)	1995-09-28
CA2098484A1 (en)	1992-06-19
AU9152491A (en)	1992-07-22
NZ241021A (en)	1993-12-23
EP0575339A1 (en)	1993-12-29
KR930703439A (en)	1993-11-30
JPH06503962A (en)	1994-05-12
IE914393A1 (en)	1992-07-01
WO1992011360A1 (en)	1992-07-09
IL100418A0 (en)	1992-09-06

Publication	Publication Date	Title
EP0527781A4 (en)	1993-05-26	Methods and formulations for stabilizing fibroblast growth factor
GB8618374D0 (en)	1986-09-03	Biological vascular prostheses
DK2490A (en)	1990-03-06	RECOMBINANT FIBROBLAST GROWTH FACTORS
ATA53492A (en)	1998-05-15	USE OF CICLOSPORIN FOR PULMONAL ADMINISTRATION
AU2818189A (en)	1989-06-14	Analogs of fibroblast growth factor
EP0229750A3 (en)	1989-10-25	Human preproinsulin-like growth factor i
ZA919259B (en)	1992-08-26	Active fragments of fibroblast growth factor
ATE198275T1 (en)	2001-01-15	SUBCUTANEOUS IMPLANTS CONSISTING OF NOMGESTROL DERIVATIVES
IL83062A (en)	1993-07-08	Cloning and expression of acidic fibroblast growth factor
EP0550035A3 (en)	1993-09-22	Composition of stabilized fibroblast growth factor
EP0575339A4 (en)	1995-04-05	Analogs of acidic fibroblast growth factor having enhanced stability and biological activity.
AU3828195A (en)	1996-08-07	Analogs of acidic fibroblast growth factor having enhanced stability and biological activity
EP0466780A4 (en)	1992-08-26	Megakaryocyte growth promoting activity
IL81990A0 (en)	1987-10-20	Compounds and pharmaceutical preparations having calcium regulatory activity
EP0522080A4 (en)	1993-04-28	High level expression of basic fibroblast growth factor having a homogeneous n-terminus
NZ219544A (en)	1991-02-26	Efomycin g and its use for promoting animal growth
EP0494369A3 (en)	1993-01-13	Sterilization of growth factors
GB2223496B (en)	1992-05-27	Synthetic gene encoding mature human acid fibroblast growth factor
DE69121210D1 (en)	1996-09-05	THERAPEUTIC USE OF THE FIBROBLAST GROWTH FACTOR
GB8609161D0 (en)	1986-05-21	Human fibroblast growth factor
GB2223495B (en)	1992-05-20	Synthetic gene encoding basic fibroblast growth factor
IE883495L (en)	1989-05-24	Analogs of fibroblast growth factor
ZA875048B (en)	1988-01-15	Cloning and expression of acidic fibroblast growth factor
ZA888764B (en)	1989-08-30	Analogs of fibroblast growth factor
NO884109D0 (en)	1988-09-15	PREPARATION OF FIBROBLAST GROWTH FACTOR.

Legal Events

Date	Code	Title	Description
1993-11-12	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1993-12-29	17P	Request for examination filed	Effective date: 19930616
1993-12-29	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE
1995-03-29	RHK1	Main classification (correction)	Ipc: C12N 15/12
1995-04-05	A4	Supplementary search report drawn up and despatched	Effective date: 19950215
1995-04-05	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE
1997-04-02	17Q	First examination report despatched	Effective date: 19970217
1997-11-21	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
1998-01-07	18D	Application deemed to be withdrawn	Effective date: 19970628