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EP0572969A1 - Inhalator - Google Patents

Inhalator Download PDF

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Publication number
EP0572969A1
EP0572969A1 EP93108776A EP93108776A EP0572969A1 EP 0572969 A1 EP0572969 A1 EP 0572969A1 EP 93108776 A EP93108776 A EP 93108776A EP 93108776 A EP93108776 A EP 93108776A EP 0572969 A1 EP0572969 A1 EP 0572969A1
Authority
EP
European Patent Office
Prior art keywords
blow
housing
cylinder
base plate
opening
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP93108776A
Other languages
German (de)
French (fr)
Other versions
EP0572969B1 (en
Inventor
Egon Schwab
Hans-Joachim Loos
Günter Ziegert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of EP0572969A1 publication Critical patent/EP0572969A1/en
Application granted granted Critical
Publication of EP0572969B1 publication Critical patent/EP0572969B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A61M15/0025—Mouthpieces therefor with caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/07—General characteristics of the apparatus having air pumping means
    • A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
    • A61M2205/073—Syringe, piston type

Definitions

  • the invention relates to an inhaler for inhaling powdered pharmaceutical substances several times.
  • Inhalation devices of the type mentioned are known.
  • a disadvantage of these devices is their complicated mechanical structure and the tendency to form conglomerates due to atmospheric moisture, which can penetrate into their duct system.
  • the invention seeks to remedy this.
  • the invention solves the problem by an inhaler with the features of claim 1.
  • the swirling of the medicinal substances in the blow-out channel can also be improved by radially running bores in the mouthpiece and an atomizing device in the blow-out channel.
  • the drug supply can be checked through a window in the pantry.
  • the inhaler In addition to practical handling, the inhaler enables optimal dosing accuracy. It can be adapted to the metering requirements by simply changing the metering wheel. It is maintenance-free and is easy to clean.
  • the housing (13) has an intermediate base (21) and is closed with a cover (17) and a base plate (14).
  • a rotary cap (4) On the lid (17) is supported by a spring (12) a rotary cap (4), the edge of which is the upper edge of the Housing wall includes.
  • the rotary cap (4) has an axially arranged cylinder (7) which projects through the cover (17), the intermediate floor (21) and a frame (20) into the housing (13).
  • the cylinder (7) is at the same time a drive shaft for a metering wheel (1) which has metering chambers (22) and which is arranged between the intermediate base (21) and frame (20) concentrically with the cylinder (7) in the housing (13).
  • the housing (13) has a storage chamber (2) for the medicinal substance, which in turn can be contained in a cartridge.
  • the storage chamber is provided with a viewing window (3) and has an opening (23), the cross section of which corresponds to that of the metering chamber (22).
  • the base plate (14) is provided with a radially extending mouthpiece (9) which contains a blow-out channel (6) with a valve (8).
  • the blow-out channel (6) can be closed on one side with a cap (15) and opens at the other end into a hollow piston (16) which extends from the base plate (14) into the cylinder (7).
  • the outlet channel (6) is connected in terms of flow to the interior of the cylinder (7) via an opening (24) and valve (8).
  • the frame (20) has a shaft (5) which connects the metering chambers (22) to the blow-out channel (6) via a corresponding opening (25) in the mouthpiece (9).
  • the mouthpiece (9) can be provided with radially extending bores (10) which open into the blow-out channel (6).
  • Blow-out channel (6) can have an atomizing device (sieve plate) (11). The drug falls through opening (23) from the storage chamber (2) into the metering chamber (22) of the metering wheel (1). By turning the rotating cap (4), the metered quantity of powder is transported to the outlet shaft (5) and falls through it through the opening (25) into the blow-out channel (6).
  • the application is carried out by pressing down the rotating cap (4) until it stops, which compresses the air in the cylinder (7) to a defined pressure.
  • valve (8) opens and releases the compressed air.
  • the air flows forcibly into the blow-out channel (6), in which the powder deposited there is whirled up by the air flow and blown in the direction of the mouthpiece (9).
  • the mouthpiece (9) there are side bores (10) which, when inhaled by the patient, produce an injector effect in the blow-out channel.
  • Powder conglomerates such as those found in fine powders, are flung against the sieve plate (11) by the air flow, which can be increased by the injector action, where they are broken and micronized.
  • the base plate (14) with mouthpiece (9) is removable, so that the latter can be cleaned if necessary.
  • the inhaler is provided with a lock (e.g. a coupling which disengages when the rotating cap is depressed - not shown), so that it can only be dosed again when the blow-out process has ended.
  • the rotary cap (4) is brought back into the starting position by the spring (12) after the blow-out process.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Weting (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

In the inhaler for the repeated inhalation of medicinal powders a metering wheel having metering chambers (22) between the intermediate floor (21) and a surround (20) which is supported on the bottom plate (14) is located in a housing (13) having a rotating cap (4). The rotating cap (4) which is supported by a spring (12) on the lid (17) has an axially arranged cylinder (7) which projects through the lid (17), the intermediate floor (21) and the surround (20) into the housing (13) and serves as the drive shaft for the metering wheel (1). The housing (13) is provided with a storage chamber (2) whose floor part (intermediate floor (21)) has an opening (23), the cross-section of which corresponds to that of the metering chambers (22). The base plate (14) is provided with a mouthpiece (9) located in a radial direction and having a blow-out duct (6) which has a valve (8) and opens into a hollow piston (16) which is fastened on the base plate (14), extends into the cylinder (7) and connects the blow-out duct (6) to the interior of the cylinder (7) via an opening (24). The surround (20) has a shaft (5) which connects the metering chambers (22) to the blow-out duct (6) via an opening (25) in the mouthpiece (9). <IMAGE>

Description

Die Erfindung betrifft einen Inhalator zum mehrfachen Inhalieren von pulverförmigen Arzneistoffen.The invention relates to an inhaler for inhaling powdered pharmaceutical substances several times.

Inhalationsgeräte der genannten Art sind bekannt. Nachteilig bei diesen Geraten ist ihr komplizierter mechanischer Aufbau sowie die Neigung zur Bildung von Konglomeraten infolge Luftfeuchtigkeit, die in ihr Kanalsystem eindringen kann. Hier will die Erfindung Abhilfe schaffen.Inhalation devices of the type mentioned are known. A disadvantage of these devices is their complicated mechanical structure and the tendency to form conglomerates due to atmospheric moisture, which can penetrate into their duct system. The invention seeks to remedy this.

Die Erfindung löst die Aufgabe durch einen Inhalator mit den Merkmalen des Schutzanspruchs 1.The invention solves the problem by an inhaler with the features of claim 1.

Die Verwirbelung der Arzneistoffe im Ausblaskanal kann noch durch radial verlaufende Bohrungen im Mundstück und eine Zerstäubereinrichtung im Ausblaskanal verbessert werden. Der Arzneistoffvorrat kann durch ein Sichtfenster in der Vorratskammer kontrolliert werden.The swirling of the medicinal substances in the blow-out channel can also be improved by radially running bores in the mouthpiece and an atomizing device in the blow-out channel. The drug supply can be checked through a window in the pantry.

Neben praktischer Handhabung ermöglicht der Inhalator eine optimale Dosiergenauigkeit. Er kann durch einfaches Wechseln des Dosierrades den Dosiererfordernissen angepaßt werden. Er ist wartungsfrei und läßt sich leicht reinigen.In addition to practical handling, the inhaler enables optimal dosing accuracy. It can be adapted to the metering requirements by simply changing the metering wheel. It is maintenance-free and is easy to clean.

Ein Ausführungsbeispiel der Erfindung ist in der Figur dargestellt und wird im folgenden näher beschrieben:
Das Gehäuse (13) besitzt einen Zwischenboden (21) und ist mit einem Deckel (17) und einer Bodenplatte (14) verschlossen. Auf dem Deckel (17) stützt sich über eine Feder (12) eine Drehkappe (4) ab, deren Rand den oberen Rand der Gehäusewand umfaßt. Die Drehkappe (4) weist einen axial angeordneten Zylinder (7) auf, der durch den Deckel (17), den Zwischenboden (21) und eine Zarge (20) in das Gehäuse (13) ragt. Der Zylinder (7) ist gleichzeitig Antriebswelle für ein Dosierrad (1), das Dosierkammern (22) aufweist und das zwischen Zwischenboden (21) und Zarge (20) konzentrisch zum Zylinder (7) im Gehäuse (13) angeordnet ist. Das Gehäuse (13) weist eine Vorratskammer (2) für den Arzneistoff auf, der seinerseits in einer Kartusche enthalten sein kann. Die Vorratskammer ist mit einem Sichtfenster (3) versehen und weist eine Öffnung (23) auf, deren Querschnitt dem der Dosierkammer (22) entspricht. Die Bodenplatte (14) ist mit einem sich radial erstreckenden Mundstück (9) versehen, das einen Ausblaskanal (6) mit Ventil (8) enthält. Der Ausblaskanal (6) ist auf einer Seite mit einer Kappe (15) verschließbar und mündet mit dem anderen Ende in einen Hohlkolben (16), der sich von der Bodenplatte (14) ausgehend in den Zylinder (7) erstreckt. Über eine Öffnung (24) und Ventil (8) ist der Auslaßkanal (6) strömungsmäßig mit dem Innenraum des Zylinders (7) verbunden. Die Zarge (20) weist einen Schacht (5) auf, der die Dosierkammern (22) mit dem Ausblaskanal (6) über eine entsprechende Öffnung (25) im Mundstück (9) verbindet. Das Mundstück (9) kann mit radial verlaufenden Bohrungen (10) versehen sein, die in Ausblaskanal (6) münden. Ausblaskanal (6) kann eine Zerstäubereinrichtung (Siebplatte) (11) aufweisen. Der Arzneistoff fällt durch Öffnung (23) aus der Vorratskammer (2) in die Dosierkammer (22) des Dosierrades (1). Durch Drehen der Drehkappe (4) wird die dosierte Menge Pulver zum Austrittsschacht (5) transportiert und fällt durch diesen über Öffnung (25) in den Ausblaskanal (6). Die Applikation erfolgt durch Niederdrücken der Drehkappe (4) bis zum Anschlag, wodurch die im Zylinder (7) befindliche Luft bis zu einem definierten Druck komprimiert wird. Nach Erreichen des Druckes öffnet Ventil (8) und gibt die komprimierte Luft frei. Die Luft strömt zwangsweise in den Ausblaskanal (6), in welchem das dort deponierte Pulver vom Luftstrom aufgewirbelt und in Richtung des Mundstücks (9) geblasen wird. Im Mundstuck (9) befinden sich Seitenbohrungen (10), welche beim Inhalieren durch den Patienten im Ausblaskanal eine Injektorwirkung erzeugen. Pulverkonglomerate, wie sie bei feinen Pulvern vorkommen, werden durch den Luftstrom, der durch die Injektorwirkung verstärkt werden kann, gegen Siebplatte (11) geschleudert, dort zerschlagen und mikronisiert. Die Bodenplatte (14) mit Mundstück (9) ist abnehmbar, so daß letzteres bei Bedarf gereinigt werden kann. Um eine Doppeldosierung zu verhindern, ist der Inhalator mit einer Sperre (z. B. einer Kupplung, die bei Niederdrücken der Drehkappe ausrastet - nicht dargstellt) versehen, so daß erst wieder neu dosiert werden kann, wenn der Ausblasvorgang beendet ist. Die Drehkappe (4) wird nach dem Ausblasvorgang durch Feder (12) wieder in die Ausgangsposition gebracht.An embodiment of the invention is shown in the figure and is described in more detail below:
The housing (13) has an intermediate base (21) and is closed with a cover (17) and a base plate (14). On the lid (17) is supported by a spring (12) a rotary cap (4), the edge of which is the upper edge of the Housing wall includes. The rotary cap (4) has an axially arranged cylinder (7) which projects through the cover (17), the intermediate floor (21) and a frame (20) into the housing (13). The cylinder (7) is at the same time a drive shaft for a metering wheel (1) which has metering chambers (22) and which is arranged between the intermediate base (21) and frame (20) concentrically with the cylinder (7) in the housing (13). The housing (13) has a storage chamber (2) for the medicinal substance, which in turn can be contained in a cartridge. The storage chamber is provided with a viewing window (3) and has an opening (23), the cross section of which corresponds to that of the metering chamber (22). The base plate (14) is provided with a radially extending mouthpiece (9) which contains a blow-out channel (6) with a valve (8). The blow-out channel (6) can be closed on one side with a cap (15) and opens at the other end into a hollow piston (16) which extends from the base plate (14) into the cylinder (7). The outlet channel (6) is connected in terms of flow to the interior of the cylinder (7) via an opening (24) and valve (8). The frame (20) has a shaft (5) which connects the metering chambers (22) to the blow-out channel (6) via a corresponding opening (25) in the mouthpiece (9). The mouthpiece (9) can be provided with radially extending bores (10) which open into the blow-out channel (6). Blow-out channel (6) can have an atomizing device (sieve plate) (11). The drug falls through opening (23) from the storage chamber (2) into the metering chamber (22) of the metering wheel (1). By turning the rotating cap (4), the metered quantity of powder is transported to the outlet shaft (5) and falls through it through the opening (25) into the blow-out channel (6). The application is carried out by pressing down the rotating cap (4) until it stops, which compresses the air in the cylinder (7) to a defined pressure. When the pressure is reached, valve (8) opens and releases the compressed air. The air flows forcibly into the blow-out channel (6), in which the powder deposited there is whirled up by the air flow and blown in the direction of the mouthpiece (9). In the mouthpiece (9) there are side bores (10) which, when inhaled by the patient, produce an injector effect in the blow-out channel. Powder conglomerates, such as those found in fine powders, are flung against the sieve plate (11) by the air flow, which can be increased by the injector action, where they are broken and micronized. The base plate (14) with mouthpiece (9) is removable, so that the latter can be cleaned if necessary. In order to prevent double dosing, the inhaler is provided with a lock (e.g. a coupling which disengages when the rotating cap is depressed - not shown), so that it can only be dosed again when the blow-out process has ended. The rotary cap (4) is brought back into the starting position by the spring (12) after the blow-out process.

Claims (3)

Inhalator zum mehrfachen Inhalieren von pulverförmigen Arzneistoffen, dadurch gekennzeichnet, daß a) in einem Gehäuse (13), das eine Drehkappe (4), einen Deckel (17), einen Zwischenboden (21) und eine Bodenplatte (14) aufweist, ein Dosierrad mit Dosierkammern (22) zwischen dem Zwischenboden (21) und einer Zarge (20), die sich auf der Bodenplatte (14) abstützt, angeordnet ist, b) die Drehkappe (4), die durch eine Feder (12) auf dem Deckel (17) abgestützt ist, einen axial angeordneten Zylinder (7) aufweist, der durch den Deckel (17), den Zwischenboden (21) und die Zarge (20) in das Gehäuse (13) ragt und Antriebswelle für das Dosierrad (1) ist, c) das Gehäuse (13) mit einer Vorratskammer (2) versehen ist, deren Bodenteil (Zwischenboden (21)) eine Öffnung (23) aufweist, deren Querschnitt dem der Dosierkammern (22) entspricht, d) die Bodenplatte (14) mit einem in radialer Richtung angeordneten Mundstück (9) versehen ist, das einen Ausblaskanal (6) mit Ventil (8) aufweist, der in einen Hohlkolben (16) mündet, der an der Bodenplatte (14) befestigt ist und sich in den Zylinder (7) erstreckt und über eine Öffnung (24) den Ausblaskanal (6) mit dem Innenraum des Zylinders (7) verbindet und e) die Zarge (20) einen Schacht (5) aufweist, der die Dosierkammern (22) mit dem Ausblaskanal (6) über eine Öffnung (25) im Mundstück (9) verbindet. Inhaler for multiple inhalation of powdered drugs, characterized in that a) in a housing (13) which has a rotary cap (4), a cover (17), an intermediate floor (21) and a base plate (14), a metering wheel with metering chambers (22) between the intermediate floor (21) and one Frame (20), which is supported on the base plate (14), is arranged, b) the rotary cap (4), which is supported on the cover (17) by a spring (12), has an axially arranged cylinder (7) which is supported by the cover (17), the intermediate floor (21) and the frame ( 20) protrudes into the housing (13) and is the drive shaft for the metering wheel (1), c) the housing (13) is provided with a storage chamber (2), the bottom part (intermediate bottom (21)) of which has an opening (23), the cross section of which corresponds to that of the metering chambers (22), d) the base plate (14) is provided with a mouthpiece (9) arranged in the radial direction, which has a blow-out channel (6) with valve (8) which opens into a hollow piston (16) which is attached to the base plate (14) and extends into the cylinder (7) and connects the exhaust duct (6) to the interior of the cylinder (7) via an opening (24) and e) the frame (20) has a shaft (5) which connects the metering chambers (22) with the blow-out channel (6) via an opening (25) in the mouthpiece (9). Inhalator nach Anspruch 1, dadurch gekennzeichnet, daß das Mundstück (9) mit radial verlaufenden Bohrungen (10) versehen und im Ausblaskanal (6) eine Zerstäubereinrichtung (11) angeordnet ist.Inhaler according to claim 1, characterized in that the mouthpiece (9) is provided with radially extending bores (10) and an atomizing device (11) is arranged in the blow-out channel (6). Inhalator nach Anspruch 1 oder 2, dadurch gekennzeichnet, daß die Vorratskammer (2) mit einem Sichtfenster (3) versehen ist.Inhaler according to claim 1 or 2, characterized in that the storage chamber (2) is provided with a viewing window (3).
EP93108776A 1992-06-05 1993-06-01 Inhalator Expired - Lifetime EP0572969B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4218517 1992-06-05
DE4218517 1992-06-05

Publications (2)

Publication Number Publication Date
EP0572969A1 true EP0572969A1 (en) 1993-12-08
EP0572969B1 EP0572969B1 (en) 1996-09-11

Family

ID=6460434

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93108776A Expired - Lifetime EP0572969B1 (en) 1992-06-05 1993-06-01 Inhalator

Country Status (10)

Country Link
US (1) US5383850A (en)
EP (1) EP0572969B1 (en)
JP (1) JP3510647B2 (en)
AT (1) ATE142515T1 (en)
DE (1) DE59303719D1 (en)
DK (1) DK0572969T3 (en)
ES (1) ES2092727T3 (en)
FI (1) FI110064B (en)
GR (1) GR3021212T3 (en)
NO (1) NO304876B1 (en)

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US5522385A (en) * 1994-09-27 1996-06-04 Aradigm Corporation Dynamic particle size control for aerosolized drug delivery

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AU684779B2 (en) * 1993-05-12 1998-01-08 Teijin Limited Device and method for dispensing powdered medicine in multiple doses
FR2738153B1 (en) * 1995-09-04 1998-01-02 Valois INHALATION APPARATUS FOR DELIVERING PRECISE AND REPRODUCIBLE DOSES OF POWDERY PRODUCT
US5669378A (en) * 1995-12-21 1997-09-23 Pera; Ivo Inhaling device
US5875776A (en) * 1996-04-09 1999-03-02 Vivorx Pharmaceuticals, Inc. Dry powder inhaler
RU2123465C1 (en) * 1997-11-18 1998-12-20 Жерновский Александр Владимирович Powder-like material feeder
US6223746B1 (en) * 1998-02-12 2001-05-01 Iep Pharmaceutical Devices Inc. Metered dose inhaler pump
CN100341483C (en) 2000-02-28 2007-10-10 维克丘拉有限公司 Improvements in or relating to delivery of oral drugs
US6457471B1 (en) * 2000-06-30 2002-10-01 Medihale Ltd. Dual-purpose medical device for upper airway treatment and methods for using same
FI20011317A0 (en) * 2001-06-20 2001-06-20 Orion Corp The powder inhaler
ITMO20030229A1 (en) * 2003-08-07 2005-02-08 Roberto Oliva INHALER FOR POWDER PREPARATIONS.
CN101939040B (en) * 2007-12-20 2014-11-05 阿斯利康(瑞典)有限公司 Device and method for deaggregating powder
MX2011013368A (en) 2009-07-01 2012-01-20 Astrazeneca Ab Dispenser and method for entraining powder in an airflow.
CN111973848B (en) * 2020-07-13 2022-09-02 四川省人民医院 Inhalant device
EP4382154A1 (en) * 2022-12-05 2024-06-12 Uimei Srls Device for administering a predefined quantity of a compound to a patient

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WO1991006333A1 (en) * 1989-11-01 1991-05-16 Novo Nordisk A/S Manually operated dispenser for dispensing a predetermined amount of powdered substance
EP0451745A1 (en) * 1990-04-12 1991-10-16 CHIESI FARMACEUTICI S.p.A. Device for the administration of powdered medicinal substances

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5522385A (en) * 1994-09-27 1996-06-04 Aradigm Corporation Dynamic particle size control for aerosolized drug delivery
US5957124A (en) * 1994-09-27 1999-09-28 Aradigm Corporation Dynamic particle size control for aerosolized drug delivery

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ATE142515T1 (en) 1996-09-15
FI110064B (en) 2002-11-29
JP3510647B2 (en) 2004-03-29
EP0572969B1 (en) 1996-09-11
NO932050L (en) 1993-12-06
ES2092727T3 (en) 1996-12-01
FI932544A0 (en) 1993-06-03
GR3021212T3 (en) 1996-12-31
NO304876B1 (en) 1999-03-01
FI932544A7 (en) 1993-12-06
NO932050D0 (en) 1993-06-04
JPH0639038A (en) 1994-02-15
DK0572969T3 (en) 1997-02-24
DE59303719D1 (en) 1996-10-17
US5383850A (en) 1995-01-24

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