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EP0543997A4 - Novel methotrexate derivative - Google Patents

Novel methotrexate derivative

Info

Publication number
EP0543997A4
EP0543997A4 EP19910914615 EP91914615A EP0543997A4 EP 0543997 A4 EP0543997 A4 EP 0543997A4 EP 19910914615 EP19910914615 EP 19910914615 EP 91914615 A EP91914615 A EP 91914615A EP 0543997 A4 EP0543997 A4 EP 0543997A4
Authority
EP
European Patent Office
Prior art keywords
methotrexate derivative
novel
novel methotrexate
ch2so
po3h2
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP19910914615
Other versions
EP0543997A1 (en
EP0543997B1 (en
Inventor
Nobuhiro Ohi
Hiroharu Matsuoka
Katsuhito Miyamoto
Hiroshi Suzuki
Nobuaki Kato
Keiichiro Tsuji
Yasuhisa Takeda
Masahiko Mihara
Hiromichi Nishina
Shin Shimaoka
Kenichi Akamatsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP3228158A external-priority patent/JPH04352785A/en
Priority claimed from JP3247141A external-priority patent/JPH04368385A/en
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of EP0543997A1 publication Critical patent/EP0543997A1/en
Publication of EP0543997A4 publication Critical patent/EP0543997A4/en
Application granted granted Critical
Publication of EP0543997B1 publication Critical patent/EP0543997B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A compound represented by general formula (A), which is useful as a medicine because it has potent antirheumatic, psoriasis curing and anticancer actions and a reduced toxicity, wherein R<1> represents CH2, CH2CH2, CH2O, CH2S or CH2SO; R<2> represents hydrogen, C1 to C4 lower alkyl or benzyl; R<3> represents COOR<4>, NHCOR<5>, CONR<6>R<7>, PO3H2 or SO3H; and n represents an integer of 1 to 4. <CHEM> <IMAGE>
EP91914615A 1990-08-14 1991-08-14 Derivatives of methotrexate with antirheumatic activity Expired - Lifetime EP0543997B1 (en)

Applications Claiming Priority (34)

Application Number Priority Date Filing Date Title
JP21469190 1990-08-14
JP214691/90 1990-08-14
JP21469190 1990-08-14
JP21563990 1990-08-15
JP21563990 1990-08-15
JP215639/90 1990-08-15
JP25346690 1990-09-21
JP253466/90 1990-09-21
JP25346690 1990-09-21
JP293107/90 1990-10-30
JP29310790 1990-10-30
JP29310790 1990-10-30
JP33184590 1990-11-29
JP331845/90 1990-11-29
JP33184590 1990-11-29
JP18062691 1991-04-19
JP18062691 1991-04-19
JP180626/91 1991-04-19
JP18594391 1991-04-23
JP185943/91 1991-04-23
JP18594391 1991-04-23
JP228158/91 1991-05-30
JP3228158A JPH04352785A (en) 1991-05-30 1991-05-30 New methotrexate derivative
JP22815891 1991-05-30
JP24714191 1991-06-12
JP247141/91 1991-06-12
JP3247141A JPH04368385A (en) 1991-06-12 1991-06-12 Novel methotrexate derivative
JP258301/91 1991-07-03
JP25830191 1991-07-03
JP25830191 1991-07-03
JP27904791 1991-07-30
JP27904791 1991-07-30
JP279047/91 1991-07-30
PCT/JP1991/001078 WO1992003436A1 (en) 1990-08-14 1991-08-14 Novel methotrexate derivative

Publications (3)

Publication Number Publication Date
EP0543997A1 EP0543997A1 (en) 1993-06-02
EP0543997A4 true EP0543997A4 (en) 1993-12-29
EP0543997B1 EP0543997B1 (en) 1999-12-08

Family

ID=27582227

Family Applications (1)

Application Number Title Priority Date Filing Date
EP91914615A Expired - Lifetime EP0543997B1 (en) 1990-08-14 1991-08-14 Derivatives of methotrexate with antirheumatic activity

Country Status (13)

Country Link
US (1) US5354753A (en)
EP (1) EP0543997B1 (en)
CN (1) CN1032858C (en)
AT (1) ATE187455T1 (en)
AU (1) AU8333291A (en)
CA (1) CA2088665C (en)
DE (1) DE69131835T2 (en)
DK (1) DK0543997T3 (en)
ES (1) ES2141710T3 (en)
GR (1) GR3032704T3 (en)
HU (2) HU223948B1 (en)
SG (1) SG49917A1 (en)
WO (1) WO1992003436A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0632038B1 (en) * 1992-01-27 2001-08-22 Chugai Seiyaku Kabushiki Kaisha Methotrexate derivative
DK0676399T3 (en) * 1992-12-25 2000-03-20 Chugai Pharmaceutical Co Ltd Methotrexate derivatives
CN1124136C (en) * 1995-03-27 2003-10-15 中外制药株式会社 Drug containing methotrexate derivative
US6080737A (en) * 1996-03-19 2000-06-27 Chugai Seiyaku Kabushiki Kaisha Uveitis remedy
AU2001239549A1 (en) * 2000-03-24 2001-10-03 Akzo Nobel N.V. Keratinocyte growth inhibitors and hydroxamic acid derivatives
US7229986B2 (en) 2000-05-16 2007-06-12 Takeda Pharmaceutical Company Ltd. Melanin-concentrating hormone antagonist
JP5504179B2 (en) 2008-03-03 2014-05-28 トスク インコーポレーティッド Methotrexate adjuvant and method of use thereof for reducing toxicity
US8703811B2 (en) * 2008-05-07 2014-04-22 Genzyme Corporation Small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase
EP2551262A4 (en) 2010-03-24 2014-01-15 Ajinomoto Kk GLUTAMATE DERIVATIVES OR SALTS THEREOF

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *

Also Published As

Publication number Publication date
GR3032704T3 (en) 2000-06-30
CA2088665C (en) 2001-05-01
CA2088665A1 (en) 1992-02-15
WO1992003436A1 (en) 1992-03-05
US5354753A (en) 1994-10-11
HU9300264D0 (en) 1993-04-28
HU211481A9 (en) 1995-11-28
EP0543997A1 (en) 1993-06-02
ES2141710T3 (en) 2000-04-01
HUT64974A (en) 1994-03-28
SG49917A1 (en) 1998-06-15
CN1059725A (en) 1992-03-25
ATE187455T1 (en) 1999-12-15
HU223948B1 (en) 2005-03-29
DK0543997T3 (en) 2000-04-10
DE69131835D1 (en) 2000-01-13
DE69131835T2 (en) 2000-06-15
CN1032858C (en) 1996-09-25
AU8333291A (en) 1992-03-17
EP0543997B1 (en) 1999-12-08

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