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EP0521460B1 - Pointe de transfert et prélèvement - Google Patents

Pointe de transfert et prélèvement Download PDF

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Publication number
EP0521460B1
EP0521460B1 EP19920111057 EP92111057A EP0521460B1 EP 0521460 B1 EP0521460 B1 EP 0521460B1 EP 19920111057 EP19920111057 EP 19920111057 EP 92111057 A EP92111057 A EP 92111057A EP 0521460 B1 EP0521460 B1 EP 0521460B1
Authority
EP
European Patent Office
Prior art keywords
flow
channel
shut
syringe
flow channel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP19920111057
Other languages
German (de)
English (en)
Other versions
EP0521460A1 (fr
Inventor
Von Brand Axel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP0521460A1 publication Critical patent/EP0521460A1/fr
Application granted granted Critical
Publication of EP0521460B1 publication Critical patent/EP0521460B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2058—Connecting means having multiple connecting ports
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2058—Connecting means having multiple connecting ports
    • A61J1/2062—Connecting means having multiple connecting ports with directional valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2068—Venting means
    • A61J1/2072—Venting means for internal venting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2068—Venting means
    • A61J1/2075—Venting means for external venting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2079—Filtering means
    • A61J1/2082—Filtering means for gas filtration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2079—Filtering means
    • A61J1/2086—Filtering means for fluid filtration

Definitions

  • the invention relates to a device, in particular for medical purposes, with a carrier plate and, connected thereto, diametrically arranged piercing mandrels through which two flow channels are guided.
  • a device is referred to in technical terminology, for example, as a transfer spike or transfer device.
  • the field of application for the present invention is in particular medical technology.
  • a first container which holds the liquid, in particular a bottle or a bag
  • a second Container in particular a container holding a substance to be dissolved, in particular a bottle or a bag.
  • the medical device with the piercing spikes is inserted into the sealing plugs, each of which seals the two containers and is made of rubber or the like, i.e. the sealing plugs are pierced by means of the piercing spikes, so that a flow connection between the two containers is created via one of the two flow channels, while the other flow channel serves to equalize the pressure between the two containers.
  • the liquid-receiving container is held upward, so that the liquid can pass into the container to be dissolved, the air in this container flows through the venting channel into the empty container.
  • the device with the emptied container was separated from the now filled container and the dissolved substance was removed by means of a syringe provided with a cannula.
  • the plug of the container had to be pierced by the cannula.
  • the additional cannula with protective cap and separate packaging mean that additional effort is required to remove the dissolved substance from the container.
  • Additional manipulations using a separate cannula and inserting the same into the rubber stopper of the container deliver additional particles and fragments of the dissolved substance.
  • the same cannula is used for the patient that was previously used to pierce the rubber stopper of the container.
  • a device for transferring liquids for the purpose of dissolving a substance
  • a device is known, see, for example, EP-A-0 426 403, which has two piercing mandrels into which the two flow channels are integrated, this device being made entirely of plastic.
  • a device which has four Has piercing mandrels, with two piercing mandrels arranged diametrically to one another being assigned a flow channel for the liquid transfer or the venting.
  • the spikes consist of metal, so that the spikes are cannulas.
  • the device has a shut-off element cooperating with one of the flow channels, which releases the flow through the flow channel in an open position and blocks the flow through the flow channel in a blocking position, with a liquid removal channel of the device in in the blocking position Flow connection with a section of the flow channel open to a piercing tip, and the liquid removal channel opens into a connecting piece.
  • the mixing of different liquids that is to say at a point in time at which a connection of the two containers through two flow channels is no longer necessary, at least one flow channel of the shut-off element, wherein the shut-off element in the locked position establishes a flow connection between a section of the flow channel that is open to a puncture tip and a liquid removal channel of the device, through which the dissolved liquid can then be removed.
  • the liquid extraction channel itself opens into a connection piece, which is designed in particular as a connection canoe, for syringes or transfer systems. It goes without saying that the liquid extraction channel can also open into several connecting pieces.
  • the advantage of the invention is therefore that a separate cannula with the problem of additional particles by pushing through the rubber stopper is not necessary. This saves additional packaging, disposal, handling and costs. At the same time, the invention precludes the user from using the same cannula for the rubber stopper as for the patient.
  • shut-off element interacts only with one flow channel
  • the other flow channel remains open in the locked position of the shut-off element.
  • a backflow of the dissolved liquid from the container located at the top when the dissolved liquid is removed into the empty container below is excluded because the air in this container cannot flow out because of the section of the flow channel which is closed by the shut-off element and is assigned to the empty container.
  • shut-off element also interacts with the other flow channel, the shut-off element opening the flow through the other flow channel in the open position and blocking the flow through the other flow channel in the blocking position, with an outward position in the blocking position open ventilation channel of the device in flow connection with a section of the other flow channel open to a puncture syringe of the associated piercing mandrel.
  • the shut-off element With the shut-off element, the sections of the two flow channels opening into the lower, empty container can thus be completely shut off, and liquid can be removed when the valve is ventilated via the channel sections of the two flow channels assigned to the upper container holding the dissolved substance, as well as the liquid removal channel and the ventilation channel emptying container instead.
  • the device expediently has two diametrically arranged piercing pins.
  • the outlet openings of the one flow channel in the area of the piercing tip of the one piercing mandrel should be arranged at a distance from the piercing tip of the other piercing mandrel, and the outlet openings of the other flow channel should be arranged in the area of the piercing tip of the other piercing mandrel and spaced from the piercing tip of the one piercing mandrel.
  • the device is to be connected to the two containers in such a way that after the substance has been released, that is to say before the dissolved substance has been removed, the liquid removal channel is assigned to the section of the flow channel whose outlet opening is lower than the outlet opening of the associated other flow channel.
  • the piercing spikes should extend perpendicular to the plane of the carrier plate, which is usually the main plane thereof.
  • the shut-off element is designed as a slide element which is slidably mounted in the carrier plate, the slide element having two through bores which form channel sections of the two flow channels in the open position of the slide element, and furthermore the slide element forms the liquid removal channel and has the ventilation channel which, in the blocking position, comes into flow connection with the flow channel sections of a piercing mandrel.
  • the sections of the flow channels leading to the lower, empty container are blocked in the blocking position of the blocking element and the liquid is removed from the upper container or its container Ventilation only via the channel sections of the two flow channels assigned to the upper container and the liquid extraction channel and the ventilation channel.
  • a special embodiment of the invention provides that the slide element assumes its blocking position in the inserted position. If one assumes that a syringe for removing the dissolved liquid is primarily connected to the connecting piece of the slide element and that the connecting piece is oriented in the sliding direction of the slide element, the transfer of the slide element into its locked position can be accomplished by a pronounced insertion movement of the syringe into the connecting piece .
  • a second embodiment of the principle of the invention described at the outset provides that the shut-off element is designed as a tap with two T passages, with a first and a second outlet of the respective passage in the open position of the tap being in flow connection with one of the flow channels of the piercing pins and the third Outlet is closed by the carrier plate, and in the blocking position of the tap, the first outlet of the respective passage is closed by the carrier plate and the second and the third outlet of the respective passage are in flow communication with the channel section of a piercing mandrel and the liquid extraction channel or the ventilation channel.
  • the connection between the container to be emptied and the liquid extraction channel or the ventilation channel is effected by turning the valve into its locked position.
  • the tap has two T-passages, but in principle it would be sufficient to provide one T-passageway which can be brought into operative connection with the flow channel serving for the withdrawal of liquid, while the other passage is straight could be so that it blocks the assigned flow channel when the valve is in the blocking position and thus does not allow ventilation of the container from which the dissolved substance can be removed.
  • the dissolved substance would have to be removed from the assigned container against increasing negative pressure. A pressure equalization would be possible after removing the syringe from the connector after swiveling the container downwards beforehand.
  • a third embodiment of the principle of the invention described in the introduction provides that a valve is integrated into the liquid removal channel, in particular a lip valve, which allows a flow through the liquid removal channel to the connecting piece when a negative pressure is applied to the connecting piece side.
  • the liquid removal channel is integrated into the shut-off element, which is also designed as a slide element, and when the slide element is in the blocking position, this interrupts the passage through the assigned flow channel, so that a flow path from the other section of this flow channel through the liquid removal channel and thus when a negative pressure is applied through the valve is possible is.
  • the valve closes off the assigned flow channel in the area of the connecting piece.
  • a fourth embodiment of the principle of the invention described at the outset provides that the connecting piece serves to receive the shut-off element in the form of a conical extension of a syringe or other disposable system, the device wall forming the flow channel at the level of the connecting piece on the opposite side being essentially vertical to the flow path arranged paragraph, which contacts the approach introduced into the connecting piece, such that the approach blocks the flow path to a channel section and opens a flow connection between the flow path to the other channel section and the syringe / disposable system, with the syringe removed by a Cap is closed.
  • a basic, preferred embodiment provides that a filter is integrated in those configurations in which there is a liquid extraction channel and / or a ventilation channel.
  • Figures 1a, 1b and 1c illustrate the problem underlying the invention.
  • a substance in a first container, the bottle 1 is to be dissolved by means of a liquid in the second container, the bottle 2, in the present case water, and the dissolved substance is then removed from the bottle 1 by means of the device 3 according to the invention.
  • Figure 1a shows the device 3 in a highly simplified representation. It has a carrier plate 4 in which a shut-off element 5 designed as a slide is located in the region of the carrier plate 4 is shown in dashed lines, is displaceable in the direction of the double arrows B.
  • the carrier plate 4 On the top and underside, the carrier plate 4 has two piercing mandrels 6 and 7 or 8 and 9 in the form of metal cannulas, the long piercing mandrel 6 being aligned with the short piercing mandrel 8 and the short piercing mandrel 7 being aligned with the long piercing mandrel 9 and thus also the flow channels formed by the piercing mandrels 6 to 9, which cannot be removed from this FIG.
  • the shut-off element 5 also has two through bores 10 and 11, which are aligned with the flow channels of the piercing pins 6 and 8 or 7 and 9 in the extended position of the shut-off element representing the open position. Furthermore, the shut-off element 5 is provided with a liquid removal channel 12 and a ventilation channel 13 which, when the position representing the blocking position of the shut-off element 5 is pushed in, come into connection with the section of the flow channel of the piercing mandrel 6 or the piercing mandrel 7 and the flow channel sections of the piercing mandrels 8 and 9 shut off.
  • the arrangement described so far works as follows:
  • the water-containing bottle 2 is held upwards, so that the water can pass through the short piercing mandrel 7, the through hole 11 and the piercing mandrel 9 into the lower bottle 1 containing the substance to be dissolved, while the bottle 1 corresponds to the filling state in this air through the piercing mandrel 8, the through hole 10 and the long piercing mandrel 6 into the bottle 2.
  • the syringe attachment 17 of a dispensing syringe 18, which is only partially shown, is inserted into a connecting piece 16 in fluid communication with the liquid channel 12, the shut-off element being due to the insertion movement 5 is immediately transferred to the locked position.
  • This state is shown in the illustration in FIG. 1b.
  • the liquid removal channel 12 is thus in flow connection with the piercing mandrel 8, while the ventilation channel 13 is connected to the piercing mandrel 9.
  • the carrier plate 4 with the two bottles 1 and 2 is pivoted about the longitudinal axis of the dispensing syringe 18 by 180 °, so that the bottle 1, which is in water contains dissolved substance, is arranged above, and the empty bottle 2 below.
  • the withdrawal syringe 18 is pulled out, the liquid containing the substance can be removed from the bottle 1 through the short piercing mandrel 8 and the liquid removal channel 12, and air can enter the bottle 1 through the ventilation channel 13 and the long piercing mandrel 9. This state is shown in Figure 1c.
  • the disposable syringe 18 is to be replaced by another one, this can be done, for example, by moving the arrangement into the position according to FIG. 1b before removing the syringe and pivoting the position of FIG. 1c back after the next syringe has been attached.
  • FIGS. 2a and 2b show a modified design of the device 3 according to the invention using a shut-off element 5 designed as a slide.
  • the device 3 consists entirely of plastic.
  • Two diametrically arranged piercing pins 19 and 20 are directly connected to the carrier plate 4, through which the two flow channels 21 and 22 are guided. These flow channels 21 are in the open position shown in FIG. 2a and 22 in flow connection with the through bores 10 and 11 of the shut-off element 5.
  • the piercing mandrel 19 is inserted into the bottle 1 and the piercing mandrel 20 into the bottle 2, so that after the bottle 2 is upward is pivoted, the water can flow from the bottle 2 into the bottle 1 containing the substance to be dissolved.
  • the shut-off element 5 is moved into its locked position and then the arrangement is pivoted through 180 °, so that the bottle 1 containing the water and the substance is arranged at the top.
  • the position of the shut-off element 5 in this end position is shown in FIG. 2 b, according to which in the area of the piercing mandrel 19 the flow channel 21 is in fluid communication with the liquid removal channel 12 over the short channel length and the long channel length of the flow channel 22 via the ventilation channel 13 in the surrounding atmosphere lies.
  • a liquid filter 23 integrated into the shut-off element 5 is provided and, accordingly, an air filter 24 in the transition area between the ventilation channel 13 and the assigned section of the flow channel 22.
  • the liquid removal channel 12 opens into a connecting piece 25 for the Withdrawal syringe 18, further into a connecting piece 26 for a transfer system, not shown, which can be connected to the device 3 and thus to the overall arrangement.
  • the connecting pieces 25 and 26 can optionally be closed by means of caps 27.
  • Two locking elements 28 and 29 arranged on the shut-off element 5 serve to fix the shut-off element in its open position or locked position, in that one of the locking elements 28 or 29 engages in a recess 30 of the carrier plate.
  • the device 3 in accordance with the embodiment described above, has two piercing pins 19 and 20, but there the shut-off element 5 is designed as a tap with two T passages 31 and 32.
  • Each T passage 31 and 32 thus has three outputs 33, 34 and 35, respectively.
  • the bore sections of the T passages 31 and 32 located between the outlets 33 and 34 connect them to the flow channels 21 and 22, respectively, so that when the piercing pins 19 are inserted into the bottles 1 and 2, respectively or 20 overflow the water in the bottle 2 into the bottle 1 and thus can dissolve the substance therein.
  • the device 3 is shown in the relevant position of the shut-off element 5 in FIGS.
  • FIGS. 3b and 3d The blocking position is shown in FIGS. 3b and 3d, according to which the shut-off element 5 is rotated through 90 ° and thus a flow connection is formed between the section of the flow channel 21 assigned to the piercing mandrel 19 via the outlets 35 and 33 to the liquid removal channel 12.
  • the device 3 again has the two piercing mandrels 19 and 20 with the flow channels 21 and 22.
  • the shut-off element 5 designed as a slide is exclusively assigned to one flow channel, namely the flow channel 21.
  • the essentially rotationally symmetrical shut-off element 5, which opens directly into the connecting piece 16 for the dispensing syringe 18, has a projection 36 on the side of the flow channel 21 facing the piercing mandrel 20, which in the open position of the shut-off element 5 extends as far from the partition 37 between the two flow channels 21 and 22 arranged away is that the flow channels 21 and 22 can be flowed through unhindered when dissolving the substance.
  • a lip valve 38 integrated into the shut-off element 5 and pointing towards the connecting piece 16 prevents water from entering the connecting piece 16 when the water is passed over to dissolve the substance.
  • the dispensing syringe 18 is inserted with the syringe attachment 17 into the connecting piece 16, the shut-off element 5 being moved in the direction of the dividing wall 37 during the insertion movement until the projection 36 abuts the dividing wall 37 and the Closes passage through the flow channel 22 in the area of the piercing mandrel 20.
  • a liquid filter 23 is integrated in the shut-off element 5.
  • An anti-rotation device is not shown between the shut-off element 5 and a device attachment 40 serving to guide it.
  • the carrier plate 4 extends essentially perpendicular to the plane of the drawing. Since in this embodiment no separate ventilation duct 13 is provided in the shut-off element 5, the device 3 is particularly suitable for non-rigid containers, for example plastic bags.
  • FIGS. 5a and 5b also have two piercing mandrels 19 and 20 with two flow channels 21 and 22 corresponding to those according to FIGS. 4a and 4b. At about half the length of the flow channel 22, it opens into the connecting piece 16, which is closed with a closure cap.
  • the partition 37 has on the side facing the connecting piece 16 at the level of the connecting piece 16 a shoulder arranged substantially perpendicular to the flow path.
  • the syringe attachment 17 of the withdrawal syringe 18 contacts via an arc of its Front ring the above paragraph 41, with simultaneous sealing of the syringe neck 17 to the neck 16, so that the flow path through the area of the flow channel 21 assigned to the piercing mandrel 20 is blocked. While the liquid can flow unhindered through the piercing pins 19 and 20 when the dispensing syringe 18 is not inserted or when the connecting piece 16 is closed, while venting through the piercing pins at the same time, as shown in FIG Flow channel 21 are removed.
  • the carrier plate 4 extends perpendicular to the plane of the drawing.

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)

Claims (11)

  1. Appareil, notamment pour des utilisations médicales avec une plaque-support et des aiguilles liées à celle-ci en position diamétralement opposées, où passent deux canaux d'écoulement, caractérisé en ce qu'il présente un élément de fermeture (5),coopérant avec un fes canaux d'écoulement qui en une position d'ouverture, libère le passage dans le canal d'écoulement (21 ; 22), et qui dans une position de fermeture empêche le passage dans le canal d'écoulement (21, 22) où en position de fermeture, un canal de prélèvement de liquide (12) de l'appareil (3) vient en communication d'écoulement avec une section ouverte au canal d'écoulement (21 ; 22) vers une pointe de prélèvement (19), ainsi que le canal de prélèvement de liquide (12) débouche dans une tubulure de raccord (16 ; 25, 26).
  2. Appareil selon la revendication 1, caractérisé en ce que l'élément de fermeture (5) coopère aussi avec l'autre canal d'écoulement (22, 21), où l'élément de fermeture (5) en position ouverte libère le passage dans l'autre canal d'écoulement (22, 21) et en position fermée empêche le passage dans l'autre canal d'écoulement (22 ; 21), où en outre en position fermée, un canal d'évent (13) ouvert sur l'extérieur de l'appareil (3) vient en communication d'écoulement avec une section ouverte de l'autre canal d'écoulement (22, 21) vers l'embout (17) d'une seringue (18) ou d'un autre système à usage unique.
  3. Appareil selon la revendication 1 ou 2, caractérisé en ce qu'il présente deux aiguilles (19, 20) en position diamétralement opposée.
  4. Appareil selon la revendication 3, caractérisé en ce que les orifices de sortie de l'un des canaux d'écoulement (21) dans la zône de la pointe d'insertion de l'aiguille (20) présente un intervalle vis-à-vis de la pointe d'insertion de l'autre aiguille (19), ainsi que les orifices de sortie de l'autre canal d'écoulement (22) dans la zône de la pointe d'insertion de l'autre aiguille (19) qui présentent un intervalle vis-à-vis de la pointe d'insertion de l'une des aiguilles (20).
  5. Appareil selon l'une des revendications 1 à 4, caractérisé en ce que les aiguilles (19, 20) s'étendent perpendiculairement par rapport au plan de plaque de la plaque support (5).
  6. Appareil selon l'une des revendications 1 à 5, caractérisé en ce que l'élément de fermeture (5) est en forme d'élément coulissant, qui est logé en coulissement dans la plaque support (4) où l'élément coulissant (5) présente deux trous de passage (10, 11), qui en position ouverte de l'élément coulissant (5) forme les sections de canaux des deux canaux d'écoulement (21, 22), en outre l'élément coulissant (5) présente le canal de prélèvement de liquide (12) et le canal d'évent (13), qui en position fermée aboutissent aux sections de canaux d'une aiguille (19) en liaison d'écoulement .
  7. Appareil selon la revendication 6, caractérisé en ce que l'élément coulissant (5) prend sa position de fermeture en position poussée.
  8. Appareil selon l'une des revendications 1 à 5, caractérisé en ce que l'élément de fermeture (5) est en forme de robinet avec deux passages en T (31, 32), où une première sortie (33) et une deuxième sortie (34) de chaque passage (31 ; 32) en position ouverte du robinet sont en liaison d'écoulement avec l'un des canaux d'écoulement (21, 22) de l'aiguille (19, 22), et la troisième sortie (35) est obturée par la plaque-support (4), de même en position de fermeture du robinet la première sortie (33) de chaque passage (31, 32) est fermée par la plaque-support (4) et la deuxième (34) et la troisième sortie (35) de chaque passage (31 ; 32) est en liaison d'écoulement avec la section de canal d'une aiguille (19) et le canal de prélèvement de liquide (12) ou le canal d'évent (13).
  9. Appareil selon la revendication 1, caractérisé en ce qu'une soupape (38) est intégrée dans le canal de prélèvement de liquide (12), notamment une soupape à lèvre, qui sous l'effet d'une dépression réalisée du côté de la connexion un écoulement se produise dans le canal de prélèvement de liquide (12) vers la tubulure de connexion (16).
  10. Appareil selon l'une des revendications 1 à 9, caractérisé en ce qu'un filtre (23, 24) est intégré dans le canal de prélèvement de liquide (12) et/ou le canal d'évent (13).
  11. Appareil selon la revendication 1, caractérisé en ce que la tubulure de connexion (16) qui sert à recevoir l'élément de fermeture et qui est en forme d'embout conique (17), d'une pointe (18) ou d'un autre système à usage unique, où la paroi d'appareil (37) formant le canal d'écoulement (22) présente à hauteur de la tubulure de connexion (16) sur le côté qui lui est opposé un décrochement (41) disposé sensiblement perpendiculairement au sens d'écoulement, que touche l'embout de seringue (17) inséré dans la tubulure de connexion (16), de sorte que l'embout de seringue (17) obture le passage d'écoulement vers une section de canal et établit une liaison d'écoulement entre le trajet d'écoulement vers l'autre section de canal et la seringue (18), et quand la seringue (18) est enlevée, la tubulure de connexion (16) est obturée par un bouchon (27).
EP19920111057 1991-07-04 1992-06-30 Pointe de transfert et prélèvement Expired - Lifetime EP0521460B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19914122221 DE4122221A1 (de) 1991-07-04 1991-07-04 Transfer- und entnahmespike
DE4122221 1991-07-04

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EP0521460A1 EP0521460A1 (fr) 1993-01-07
EP0521460B1 true EP0521460B1 (fr) 1995-09-13

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AT (1) ATE127679T1 (fr)
DE (2) DE4122221A1 (fr)

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EP1454650A1 (fr) * 2003-03-06 2004-09-08 ZLB Behring GmbH Dispositif de transfer, notamment pour des fluides médicaux
USD655017S1 (en) 2010-06-17 2012-02-28 Yukon Medical, Llc Shroud
US8197459B2 (en) 2003-03-05 2012-06-12 Aventis Behring Gmbh Self-sealing medical fluid transfer device
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US11439571B2 (en) 2011-12-22 2022-09-13 Icu Medical, Inc. Fluid transfer devices and methods of use
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BR112012021134B1 (pt) 2010-02-24 2020-01-21 Medimop Medical Projects Ltd conjunto de transferência de fluido para uso com um primeiro frasco e um segundo frasco para fins de reconstituição e administração de droga líquida
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US9943463B2 (en) 2013-05-10 2018-04-17 West Pharma. Services IL, Ltd. Medical devices including vial adapter with inline dry drug module
CN205626622U (zh) 2013-08-07 2016-10-12 麦迪麦珀医疗工程有限公司 与输液容器一起使用的液体转移装置
USD765837S1 (en) 2013-08-07 2016-09-06 Medimop Medical Projects Ltd. Liquid transfer device with integral vial adapter
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USD757933S1 (en) 2014-09-11 2016-05-31 Medimop Medical Projects Ltd. Dual vial adapter assemblage
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JP6367512B1 (ja) 2015-07-16 2018-08-01 ウエスト・ファーマ．サービシーズ・イスラエル，リミテッド 注射液バイアルへしっかりと入れ子式スナップ嵌めするための液剤移送デバイス
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AT519623A1 (de) * 2017-02-08 2018-08-15 Hubertus Goller Ges M B H Mischvorrichtung
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US7879018B2 (en) 1995-03-20 2011-02-01 Medimop Medical Projects, Ltd. Fluid transfer device
US6238372B1 (en) 1995-03-20 2001-05-29 Medimop Medical Projects Ltd. Fluid control device
US8197459B2 (en) 2003-03-05 2012-06-12 Aventis Behring Gmbh Self-sealing medical fluid transfer device
EP1454650A1 (fr) * 2003-03-06 2004-09-08 ZLB Behring GmbH Dispositif de transfer, notamment pour des fluides médicaux
US8475404B2 (en) 2007-08-21 2013-07-02 Yukon Medical, Llc Vial access and injection system
US8821436B2 (en) 2008-04-01 2014-09-02 Yukon Medical, Llc Dual container fluid transfer device
US9345640B2 (en) 2009-04-14 2016-05-24 Yukon Medical, Llc Fluid transfer device
US11007119B2 (en) 2009-07-29 2021-05-18 Icu Medical, Inc. Fluid transfer devices and methods of use
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USD681230S1 (en) 2011-09-08 2013-04-30 Yukon Medical, Llc Shroud
US11439571B2 (en) 2011-12-22 2022-09-13 Icu Medical, Inc. Fluid transfer devices and methods of use
US11439570B2 (en) 2011-12-22 2022-09-13 Icu Medical, Inc. Fluid transfer devices and methods of use
US12023304B2 (en) 2011-12-22 2024-07-02 Icu Medical, Inc. Fluid transfer devices and methods of use
USD769444S1 (en) 2012-06-28 2016-10-18 Yukon Medical, Llc Adapter device
US11541171B2 (en) 2013-11-25 2023-01-03 Icu Medical, Inc. Methods and systems for filling IV bags with therapeutic fluid
US11135416B2 (en) 2015-12-04 2021-10-05 Icu Medical, Inc. Systems, methods, and components for transferring medical fluids
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US11865295B2 (en) 2015-12-04 2024-01-09 Icu Medical, Inc. Systems, methods, and components for transferring medical fluids
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USD874644S1 (en) 2016-07-19 2020-02-04 Icu Medical, Inc. Medical fluid transfer system
US11020541B2 (en) 2016-07-25 2021-06-01 Icu Medical, Inc. Systems, methods, and components for trapping air bubbles in medical fluid transfer modules and systems
US11951293B2 (en) 2016-07-25 2024-04-09 Icu Medical, Inc. Systems, methods, and components for trapping air bubbles in medical fluid transfer modules and systems
US11583637B2 (en) 2016-07-25 2023-02-21 Icu Medical, Inc. Systems, methods, and components for trapping air bubbles in medical fluid transfer modules and systems
US11590057B2 (en) 2020-04-03 2023-02-28 Icu Medical, Inc. Systems, methods, and components for transferring medical fluids
US11674614B2 (en) 2020-10-09 2023-06-13 Icu Medical, Inc. Fluid transfer device and method of use for same

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DE59203648D1 (de) 1995-10-19
ATE127679T1 (de) 1995-09-15
DE4122221A1 (de) 1993-03-18
EP0521460A1 (fr) 1993-01-07

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