EP0483152A4 - A method of reducing body weight and food intake using a dopamine d2 receptor agonist - Google Patents

A method of reducing body weight and food intake using a dopamine d2 receptor agonist

Info

Publication number: EP0483152A4
Authority: EP; European Patent Office
Prior art keywords: dopamine; body weight; receptor agonist; food intake; reducing body
Prior art date: 1989-05-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP19900906612

Other versions

EP0483152A1 (en

Inventor

James D. Belluzzi

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Whitby Research Inc

Original Assignee

Whitby Research Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-09

Filing date

1990-04-19

Publication date

1992-12-02

1990-04-19 Application filed by Whitby Research Inc filed Critical Whitby Research Inc

1992-05-06 Publication of EP0483152A1 publication Critical patent/EP0483152A1/en

1992-12-02 Publication of EP0483152A4 publication Critical patent/EP0483152A4/en

Status Withdrawn legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

EP19900906612 1989-05-09 1990-04-19 A method of reducing body weight and food intake using a dopamine d2 receptor agonist Withdrawn EP0483152A4 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US34909189A	1989-05-09	1989-05-09
US349091		1989-05-09

Publications (2)

Publication Number	Publication Date
EP0483152A1 EP0483152A1 (en)	1992-05-06
EP0483152A4 true EP0483152A4 (en)	1992-12-02

Family

ID=23370872

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP19900906612 Withdrawn EP0483152A4 (en)	1989-05-09	1990-04-19	A method of reducing body weight and food intake using a dopamine d2 receptor agonist

Country Status (3)

Country	Link
EP (1)	EP0483152A4 (en)
AU (1)	AU5439890A (en)
WO (1)	WO1990013294A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10041478A1 (en)	2000-08-24	2002-03-14	Sanol Arznei Schwarz Gmbh	New pharmaceutical composition
DE10041479A1 (en) *	2000-08-24	2002-03-14	Sanol Arznei Schwarz Gmbh	New pharmaceutical composition for the administration of N-0923
DE10148233A1 (en) *	2001-09-28	2003-04-10	Boehringer Ingelheim Pharma	Compounds to reduce excessive food intake
WO2003097046A1 (en)	2002-05-17	2003-11-27	Duke University	Method for treating obesity
EP2316456B1 (en)	2003-04-29	2017-06-14	Orexigen Therapeutics, Inc.	Compositions for affecting weight loss comprising an opioid antagonist and bupropion
BRPI0506829A (en)	2004-01-13	2007-05-29	Univ Duke	Anticonvulsant and antipsychotic drug compositions and methods for their use to affect weight loss
JP5180092B2 (en)	2005-11-22	2013-04-10	オレキシジェン・セラピューティクス・インコーポレーテッド	Compositions and methods for increasing insulin sensitivity
US8916195B2 (en)	2006-06-05	2014-12-23	Orexigen Therapeutics, Inc.	Sustained release formulation of naltrexone
AU2007319472B2 (en)	2006-11-09	2013-01-17	Nalpropion Pharmaceuticals Llc	Methods Of Administering Weight Loss Medications
US20110144145A1 (en)	2008-05-30	2011-06-16	Orexigen Therapeutics, Inc.	Methods for treating visceral fat conditions
EP2346811B1 (en) *	2008-10-13	2012-08-15	Interquim, S.A	Process for the preparation of optically active (s)-(-)-2-(n-propylamino)-5-methoxytetraline and (s)-(-)-2-(n-propylamino)-5-hydroxytetraline compounds
KR101841442B1 (en)	2010-01-11	2018-03-23	오렉시젠 세러퓨틱스 인크.	Methods of providing weight loss therapy in patients with major depression
RS63569B1 (en)	2012-06-06	2022-10-31	Nalpropion Pharmaceuticals Llc	Composition for use in a method of treating overweight and obesity in patients with high cardiovascular risk
WO2024260959A1 (en)	2023-06-19	2024-12-26	Inke, S.A.	Process for preparing optically active secondary amines and their use as intermediates

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4189494A (en) *	1975-11-06	1980-02-19	Sandoz Ltd.	Reducing free fatty acid of the blood and suppressing appetite
US4564628A (en) *	1983-01-03	1986-01-14	Nelson Research & Development Co.	Substituted 2-aminotetralins

1990
- 1990-04-19 EP EP19900906612 patent/EP0483152A4/en not_active Withdrawn
- 1990-04-19 AU AU54398/90A patent/AU5439890A/en not_active Abandoned
- 1990-04-19 WO PCT/US1990/002135 patent/WO1990013294A1/en not_active Application Discontinuation

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 162, no. 1, 14th March 1989, pages 143-150, Elsevier Science Publishers B.V. (Biomedical Division); W. TIMMERMAN et al.: "Microdialysis and striatal dopamine release: stereoselective actions of the enantiomers of N-0437" *
PHYSIOLOGY & BEHAVIOR, vol. 44, nos. 4-5, 1988, pages 545-553, Pergamon Press plc, US; I.N. RUSK et al.: "Profile of the selective dopamine D-2 receptor agonist N-0437: its effects on palatability- and deprivation-induced feeding, and operant responding for food" *
See also references of WO9013294A1 *
SOC. NEUROSCI. ABSTR., vol. 12, 1986, page 1557, abstract no. 420.18; I. RUSK et al.: "Dopamine D1 and D2 receptors in relation to palatable food consumption in the rat" *
SOC. NEUROSCI. ABSTR., vol. 14, no. 1, 1988, page 614, abstract no. 249.6; I.N. RUSK et al.: "Microstructural analysis of feeding suppression and other behavioral changes induced by N-0437, a selective dopamine D2 agonist" *

Also Published As

Publication number	Publication date
AU5439890A (en)	1990-11-29
EP0483152A1 (en)	1992-05-06
WO1990013294A1 (en)	1990-11-15

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EP0483152A4 (en)	1992-12-02	A method of reducing body weight and food intake using a dopamine d2 receptor agonist
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Legal Events

Date	Code	Title	Description
1992-03-20	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1992-05-06	17P	Request for examination filed	Effective date: 19911114
1992-05-06	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB IT LI LU NL SE
1992-12-02	A4	Supplementary search report drawn up and despatched	Effective date: 19921014
1992-12-02	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB IT LI LU NL SE
1994-10-26	17Q	First examination report despatched	Effective date: 19940913
1995-06-20	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
1995-08-09	18D	Application deemed to be withdrawn	Effective date: 19950124