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EP0448605A4 - Use of basic amino acids to solubilize immunoglobulins - Google Patents

Use of basic amino acids to solubilize immunoglobulins

Info

Publication number
EP0448605A4
EP0448605A4 EP19900900689 EP90900689A EP0448605A4 EP 0448605 A4 EP0448605 A4 EP 0448605A4 EP 19900900689 EP19900900689 EP 19900900689 EP 90900689 A EP90900689 A EP 90900689A EP 0448605 A4 EP0448605 A4 EP 0448605A4
Authority
EP
European Patent Office
Prior art keywords
solubilize
immunoglobulins
amino acids
basic amino
basic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19900900689
Other versions
EP0448605A1 (en
Inventor
Christopher P. Prior
Bill Moellering
Barbara Tipton
Garance Prior
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Biotech Inc
Original Assignee
Invitron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Invitron Corp filed Critical Invitron Corp
Publication of EP0448605A1 publication Critical patent/EP0448605A1/en
Publication of EP0448605A4 publication Critical patent/EP0448605A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP19900900689 1988-12-15 1989-12-06 Use of basic amino acids to solubilize immunoglobulins Withdrawn EP0448605A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28515488A 1988-12-15 1988-12-15
US285154 1988-12-15

Publications (2)

Publication Number Publication Date
EP0448605A1 EP0448605A1 (en) 1991-10-02
EP0448605A4 true EP0448605A4 (en) 1991-11-21

Family

ID=23092978

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19900900689 Withdrawn EP0448605A4 (en) 1988-12-15 1989-12-06 Use of basic amino acids to solubilize immunoglobulins

Country Status (5)

Country Link
EP (1) EP0448605A4 (en)
JP (1) JPH04502914A (en)
AU (1) AU4803890A (en)
CA (1) CA2005119A1 (en)
WO (1) WO1990006764A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5180820A (en) * 1989-08-30 1993-01-19 Barde Yves Alain Brain-derived neurotrophic factor
NZ243084A (en) * 1991-06-12 1995-08-28 Regeneron Pharma Production and recovery of recombinant neurotrophins, genes for a modified lamb signal sequence, fusion genes and plasmids
US5389529A (en) * 1991-06-12 1995-02-14 Regeneron Pharmaceuticals, Inc. Modified lamβ signal sequence and processes for producing recombinant neurotrophins
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
EP1314437B1 (en) 2000-08-11 2014-06-25 Chugai Seiyaku Kabushiki Kaisha Stabilized antibody-containing preparations
NZ532896A (en) * 2001-11-08 2007-08-31 Pdl Biopharma Inc Stable liquid pharmaceutical formulation of IGG antibodies including daclizumab and fontolizumab
EP1551875A4 (en) * 2002-06-21 2006-06-28 Biogen Idec Inc Buffered formulations for concentrating antibodies and methods of use thereof
US8080642B2 (en) 2003-05-16 2011-12-20 Vical Incorporated Severe acute respiratory syndrome DNA compositions and methods of use
US20060051347A1 (en) 2004-09-09 2006-03-09 Winter Charles M Process for concentration of antibodies and therapeutic products thereof
JO3000B1 (en) * 2004-10-20 2016-09-05 Genentech Inc Antibody Formulations.
PT2616090T (en) 2010-09-17 2023-10-16 Takeda Pharmaceuticals Co Stabilization of immunoglobulins through aqueous formulation with histidine at weak acidic to neutral ph

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0035616A1 (en) * 1980-02-14 1981-09-16 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Production of immunoglobulin having a high monomer content

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4362661A (en) * 1979-08-09 1982-12-07 Teijin Limited Immunoglobulin composition having a high monomer content, and process for production thereof
EP0156169B1 (en) * 1984-02-29 1991-12-18 Asahi Kasei Kogyo Kabushiki Kaisha An aqueous solution of a tissue plasminogen activator dissolved therein at an increased concentration and a method
JPS60243028A (en) * 1984-04-28 1985-12-03 Kyowa Hakko Kogyo Co Ltd Solubilization of interferon
US4597966A (en) * 1985-01-09 1986-07-01 Ortho Diagnostic Systems, Inc. Histidine stabilized immunoglobulin and method of preparation
JPH0672105B2 (en) * 1985-10-02 1994-09-14 持田製薬株式会社 Thrombolytic agent and manufacturing method thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0035616A1 (en) * 1980-02-14 1981-09-16 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Production of immunoglobulin having a high monomer content

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 8, no. 46 (C-212)(1483) February 29, 1984 & JP-A-58 206 531 (TEIJIN K.K.) December 1, 1983 *
See also references of WO9006764A1 *

Also Published As

Publication number Publication date
WO1990006764A1 (en) 1990-06-28
JPH04502914A (en) 1992-05-28
AU4803890A (en) 1990-07-10
CA2005119A1 (en) 1990-06-15
EP0448605A1 (en) 1991-10-02

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 19910617

AK Designated contracting states

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Designated state(s): AT BE CH DE ES FR GB IT LI LU NL SE

A4 Supplementary search report drawn up and despatched

Effective date: 19910930

AK Designated contracting states

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RIN1 Information on inventor provided before grant (corrected)

Inventor name: PRIOR, GARANCE

Inventor name: TIPTON, BARBARA

Inventor name: MOELLERING, BILL

Inventor name: PRIOR, CHRISTOPHER, P.

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: CENTOCOR INC.

17Q First examination report despatched

Effective date: 19920915

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19930326