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EE9600030A - N-(3-bensofuranüül)karbamiidderivaadid, nende valmistamismeetod, kasutamine ravimite valmistamiseks, nimetatud ühendeid sisaldavad ravimid ja nende valmistamismeetod - Google Patents

N-(3-bensofuranüül)karbamiidderivaadid, nende valmistamismeetod, kasutamine ravimite valmistamiseks, nimetatud ühendeid sisaldavad ravimid ja nende valmistamismeetod

Info

Publication number
EE9600030A
EE9600030A EE9600030A EE9600030A EE9600030A EE 9600030 A EE9600030 A EE 9600030A EE 9600030 A EE9600030 A EE 9600030A EE 9600030 A EE9600030 A EE 9600030A EE 9600030 A EE9600030 A EE 9600030A
Authority
EE
Estonia
Prior art keywords
preparation
medicaments
benzofuranyl
compounds
manufacture
Prior art date
Application number
EE9600030A
Other languages
English (en)
Other versions
EE03921B1 (et
Inventor
Br�unlich Gabriele
Fischer Rdiger
Es-Sayed Mazen
Henning Rolf
Sperzel Michael
Schlemmer Karl-Heinz
Nielsch Ulrich
Tudhope Stephen
Sturton Graham
S. Abram Trevor
F. Fitzgerald Mary
Original Assignee
Bayer Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Aktiengesellschaft filed Critical Bayer Aktiengesellschaft
Publication of EE9600030A publication Critical patent/EE9600030A/et
Publication of EE03921B1 publication Critical patent/EE03921B1/et

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/06Free radical scavengers or antioxidants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/86Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • AIDS & HIV (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Cosmetics (AREA)
EE9600030A 1995-03-06 1996-03-05 N-(3-bensofuranüül)karbamiidderivaadid, nende valmistamismeetod ja kasutamine EE03921B1 (et)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9504460.8A GB9504460D0 (en) 1995-03-06 1995-03-06 N-(3-Benzofuranyl)urea-derivatives

Publications (2)

Publication Number Publication Date
EE9600030A true EE9600030A (et) 1996-10-15
EE03921B1 EE03921B1 (et) 2002-12-16

Family

ID=10770709

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9600030A EE03921B1 (et) 1995-03-06 1996-03-05 N-(3-bensofuranüül)karbamiidderivaadid, nende valmistamismeetod ja kasutamine

Country Status (42)

Country Link
US (2) US6399657B1 (et)
EP (1) EP0731099B1 (et)
JP (1) JP3204901B2 (et)
KR (2) KR100405579B1 (et)
CN (2) CN1134419A (et)
AR (1) AR002710A1 (et)
AT (1) ATE193704T1 (et)
BG (2) BG100396A (et)
BR (1) BR9600930A (et)
CA (1) CA2170824A1 (et)
CO (1) CO4370145A1 (et)
CZ (1) CZ66796A3 (et)
DE (1) DE69608721T2 (et)
DK (1) DK0731099T3 (et)
DZ (1) DZ1998A1 (et)
EE (1) EE03921B1 (et)
ES (1) ES2147320T3 (et)
FI (1) FI960998A (et)
GB (1) GB9504460D0 (et)
GR (1) GR3034240T3 (et)
HK (1) HK1013285A1 (et)
HR (1) HRP960071B1 (et)
HU (1) HU222282B1 (et)
IL (1) IL117349A (et)
MA (1) MA23815A1 (et)
MY (1) MY117526A (et)
NO (1) NO313672B1 (et)
NZ (1) NZ286107A (et)
PE (1) PE43597A1 (et)
PL (1) PL189206B1 (et)
PT (1) PT731099E (et)
RO (1) RO116622B1 (et)
RU (1) RU2162845C2 (et)
SI (1) SI0731099T1 (et)
SK (1) SK281817B6 (et)
SV (1) SV1996000015A (et)
TN (1) TNSN96035A1 (et)
TR (1) TR199600177A2 (et)
TW (1) TW336934B (et)
UA (1) UA46714C2 (et)
YU (1) YU49359B (et)
ZA (1) ZA961774B (et)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9312853D0 (en) 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
US5922751A (en) 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
US5591776A (en) 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
GB9504460D0 (en) * 1995-03-06 1995-04-26 Bayer Ag N-(3-Benzofuranyl)urea-derivatives
US6166041A (en) 1995-10-11 2000-12-26 Euro-Celtique, S.A. 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
GB9525262D0 (en) * 1995-12-11 1996-02-07 Bayer Ag Heterocyclylcarbonyl substituted benzofuranyl-ureas
US6075016A (en) 1996-04-10 2000-06-13 Euro-Celtique S.A. 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
GB9614718D0 (en) 1996-07-12 1996-09-04 Bayer Ag 3-ureido-pyridofurans and -pyridothiophenes
JPH10168095A (ja) * 1996-12-10 1998-06-23 Cci Corp 炎症性腸疾患予防および治療剤
JP2002529444A (ja) * 1998-11-12 2002-09-10 アリアド・ファーマシューティカルズ・インコーポレイテッド 二環式シグナル伝達阻害剤、それを含む組成物とその用途
GB2350110A (en) * 1999-05-17 2000-11-22 Bayer Ag Pharmaceutically active benzofurans
GB2350112A (en) * 1999-05-17 2000-11-22 Bayer Ag Pharmaceutically active cycloalkyl ketones
GB2350111A (en) * 1999-05-17 2000-11-22 Bayer Ag Oligohydroxyl substituted 3-urea-benzofuran and pyridofuran derivatives
GB2350109A (en) * 1999-05-17 2000-11-22 Bayer Ag Pharmaceutically active benzofuranyl sulfonates
PL373373A1 (en) 2002-02-22 2005-08-22 Bayer Pharmaceuticals Corporation Benzofuran and benzothiophene derivatives useful in the treatment of hyper-proliferative disorders
US7144885B2 (en) 2002-02-22 2006-12-05 Bayer Pharmaceuticals Corporation Fused tricyclic heterocycles useful for treating hyper-proliferative disorders
CN1738797A (zh) * 2002-11-19 2006-02-22 阿基里昂药品公司 取代的芳基硫脲和相关的化合物,病毒复制的抑制剂
US7186725B2 (en) 2003-01-03 2007-03-06 Genzyme Corporation Anti-inflammatory compositions and methods
TW200528459A (en) * 2004-01-06 2005-09-01 Achillion Pharmaceuticals Inc Azabenzofuran substituted thioureas; inhibitors of viral replication
TW200600492A (en) * 2004-05-18 2006-01-01 Achillion Pharmaceuticals Inc Substituted aryl acylthioureas and related compounds; inhibitors of viral replication
JPWO2006137350A1 (ja) * 2005-06-22 2009-01-15 キッセイ薬品工業株式会社 新規なフロピリジン誘導体、それを含有する医薬組成物およびそれらの用途
CN101484166B (zh) 2006-07-05 2012-09-05 奈科明有限责任公司 用于治疗炎症性肺部疾病的HMG-CoA还原酶抑制剂与磷酸二酯酶4抑制剂的组合
WO2012123353A1 (en) 2011-03-17 2012-09-20 Algiax Pharmaceuticals Gmbh Novel use of benzofuranylsulfonates
WO2013156232A1 (en) * 2012-04-16 2013-10-24 Algiax Pharmaceuticals Gmbh Use of benzofuranylsulfonates in neuropathic pain
AU2015233686B2 (en) 2014-03-18 2019-07-11 Algiax Pharmaceuticals Gmbh 2-Cyano-3-cyclopropyl-3-hydroxy-N-aryl-thioacrylamide derivatives
EP3165224A1 (en) 2015-11-09 2017-05-10 Albert-Ludwigs-Universität Freiburg Use of pde4 inhibitors for the prophylaxis and/or therapy of dyslipoproteinaemia and related disorders
WO2017089347A1 (en) 2015-11-25 2017-06-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas
JP6788966B2 (ja) * 2015-12-24 2020-11-25 丸善製薬株式会社 化粧料
EP4020024A1 (en) 2020-12-22 2022-06-29 Paul Scherrer Institut Method for producing high aspect ratio fan-shaped optics

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU559687B2 (en) * 1981-07-01 1987-03-19 Upjohn Company, The Pyridinyl-and imidazolyl-benzofurane and benzothiophenes
EP0146243A1 (en) * 1983-10-31 1985-06-26 Merck Frosst Canada Inc. Lipoxygenase inhibitors
US4933351A (en) * 1983-10-31 1990-06-12 Merck Frosst Canada, Inc. Benzofuran 2-carbox amides useful as inhibitors of leukoriene biosynthesis
US4822803A (en) * 1983-10-31 1989-04-18 Merck Frosst Canada, Inc. Benzofuran 2-carboxylic acid hydrazides useful as inhibitors of leukotriene biosynthesis
US4663347A (en) 1983-10-31 1987-05-05 Merck Frosst Canada, Inc. Benzofuran 2-carboxylic acid esters useful as inhibitors of leukotriene biosynthesis
US5087638A (en) * 1984-06-20 1992-02-11 Merck Frosst Canada, Inc. Benzofuran derivatives
GB9200623D0 (en) * 1992-01-13 1992-03-11 Bayer Ag Benzofuranyl and thiophenyl-methylthio-alkanecarboxylic acid derivatives
GB9309324D0 (en) * 1993-05-06 1993-06-16 Bayer Ag Venzofuranyl-and-thiophenyl-alkanecarboxyclic acids derivatives
GB9504460D0 (en) * 1995-03-06 1995-04-26 Bayer Ag N-(3-Benzofuranyl)urea-derivatives

Also Published As

Publication number Publication date
DK0731099T3 (da) 2000-09-25
NO960884L (no) 1996-09-09
US6399657B1 (en) 2002-06-04
EP0731099A1 (en) 1996-09-11
YU49359B (sh) 2005-09-19
KR960034194A (ko) 1996-10-22
SI0731099T1 (en) 2000-08-31
US20030109578A1 (en) 2003-06-12
SK29796A3 (en) 1996-10-02
JP3204901B2 (ja) 2001-09-04
NZ286107A (en) 1998-08-26
CN1176651C (zh) 2004-11-24
DE69608721T2 (de) 2000-10-05
MY117526A (en) 2004-07-31
JPH08253466A (ja) 1996-10-01
RO116622B1 (ro) 2001-04-30
PL313070A1 (en) 1996-09-16
SK281817B6 (sk) 2001-08-06
BG62732B1 (bg) 2000-06-30
TW336934B (en) 1998-07-21
UA46714C2 (uk) 2002-06-17
HU9600549D0 (en) 1996-04-29
ES2147320T3 (es) 2000-09-01
ZA961774B (en) 1996-09-17
HK1013285A1 (en) 1999-08-20
GB9504460D0 (en) 1995-04-26
HRP960071A2 (en) 1997-12-31
PT731099E (pt) 2000-11-30
NO960884D0 (no) 1996-03-05
IL117349A (en) 2002-09-12
PL189206B1 (pl) 2005-07-29
TNSN96035A1 (fr) 2005-03-15
IL117349A0 (en) 1996-07-23
ATE193704T1 (de) 2000-06-15
NO313672B1 (no) 2002-11-11
DE69608721D1 (de) 2000-07-13
PE43597A1 (es) 1997-12-26
YU13396A (sh) 1999-06-15
AR002710A1 (es) 1998-04-29
MA23815A1 (fr) 1996-10-01
CN1313284A (zh) 2001-09-19
BG100396A (bg) 1996-12-31
CN1134419A (zh) 1996-10-30
DZ1998A1 (fr) 2002-07-20
CA2170824A1 (en) 1996-09-07
RU2162845C2 (ru) 2001-02-10
TR199600177A2 (tr) 1996-10-21
FI960998A (fi) 1996-09-07
GR3034240T3 (en) 2000-12-29
AU705667B2 (en) 1999-05-27
EP0731099B1 (en) 2000-06-07
HUP9600549A3 (en) 1998-04-28
EE03921B1 (et) 2002-12-16
HUP9600549A2 (en) 1997-07-28
CZ66796A3 (en) 1996-09-11
HU222282B1 (hu) 2003-05-28
AU4582896A (en) 1996-09-19
HRP960071B1 (en) 2001-04-30
KR100438633B1 (ko) 2004-07-02
CO4370145A1 (es) 1996-10-07
BR9600930A (pt) 1997-12-30
SV1996000015A (es) 1997-02-17
US6677372B2 (en) 2004-01-13
KR100405579B1 (ko) 2004-03-19
FI960998A0 (fi) 1996-03-04

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