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EE200300408A - Aktiivsete valkude saagise suurendamine - Google Patents

Aktiivsete valkude saagise suurendamine

Info

Publication number
EE200300408A
EE200300408A EEP200300408A EEP200300408A EE200300408A EE 200300408 A EE200300408 A EE 200300408A EE P200300408 A EEP200300408 A EE P200300408A EE P200300408 A EEP200300408 A EE P200300408A EE 200300408 A EE200300408 A EE 200300408A
Authority
EE
Estonia
Prior art keywords
increasing
yield
active proteins
proteins
preparations
Prior art date
Application number
EEP200300408A
Other languages
English (en)
Inventor
M. Sassenfeld Helmut
L. Remmele Richard Jr.
E. Mccoy Rebecca
Original Assignee
Immunex Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunex Corporation filed Critical Immunex Corporation
Publication of EE200300408A publication Critical patent/EE200300408A/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Measurement Of Radiation (AREA)
EEP200300408A 2001-02-23 2002-02-22 Aktiivsete valkude saagise suurendamine EE200300408A (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27103301P 2001-02-23 2001-02-23
PCT/US2002/005645 WO2002068455A2 (en) 2001-02-23 2002-02-22 Efficient recovery of correctly refolded proteins

Publications (1)

Publication Number Publication Date
EE200300408A true EE200300408A (et) 2003-12-15

Family

ID=23033913

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200300408A EE200300408A (et) 2001-02-23 2002-02-22 Aktiivsete valkude saagise suurendamine

Country Status (21)

Country Link
US (2) US7157557B2 (et)
EP (1) EP1366062B1 (et)
JP (1) JP2005505494A (et)
KR (1) KR20040052481A (et)
CN (1) CN1547586A (et)
AT (1) ATE517909T1 (et)
AU (1) AU2002255600B2 (et)
BG (1) BG108087A (et)
CA (1) CA2438094C (et)
CZ (1) CZ20032208A3 (et)
EE (1) EE200300408A (et)
ES (1) ES2370235T3 (et)
HK (1) HK1059267A1 (et)
HU (1) HUP0303246A2 (et)
IL (1) IL157446A0 (et)
MX (1) MXPA03007563A (et)
PL (1) PL374045A1 (et)
RU (1) RU2316563C2 (et)
SK (1) SK10472003A3 (et)
WO (1) WO2002068455A2 (et)
ZA (1) ZA200305909B (et)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1366062B1 (en) * 2001-02-23 2011-07-27 Immunex Corporation Efficient recovery of correctly refolded proteins
WO2005019434A2 (en) 2003-08-26 2005-03-03 The Regents Of The University Of Colorado, A Body Corporate Serine protease inhibitors for treatment of bacterial infections
US7928205B2 (en) * 2004-10-22 2011-04-19 Amgen Inc. Methods for refolding of recombinant antibodies
EP1805205A1 (en) * 2004-10-22 2007-07-11 Amgen Inc. Methods for refolding polypeptides
JP2008528006A (ja) * 2005-01-28 2008-07-31 アポロ ライフ サイエンシズ リミテッド 分子およびそのキメラ分子
EP1888637A2 (en) 2005-05-19 2008-02-20 Amgen Inc. Compositions and methods for increasing the stability of antibodies
WO2006138181A2 (en) 2005-06-14 2006-12-28 Amgen Inc. Self-buffering protein formulations
WO2006134173A2 (en) * 2005-06-17 2006-12-21 Novo Nordisk Health Care Ag Selective reduction and derivatization of engineered proteins comprising at least one non-native cysteine
RU2385877C1 (ru) 2005-12-22 2010-04-10 Дженентек, Инк. Рекомбинантное получение связывающих гепарин белков
US9012605B2 (en) 2006-01-23 2015-04-21 Amgen Inc. Crystalline polypeptides
US20080125580A1 (en) 2006-07-14 2008-05-29 Genentech, Inc. Refolding of Recombinant Proteins
JP5623743B2 (ja) 2006-10-20 2014-11-12 アムジエン・インコーポレーテツド 安定なポリペプチド製剤
HUE061746T2 (hu) 2007-07-09 2023-08-28 Genentech Inc Diszulfidkötés redukciójának megelõzése polipeptidek rekombináns elõállítása során
AU2008298904B2 (en) * 2007-09-14 2014-10-16 Amgen Inc. Homogeneous antibody populations
MX2011013898A (es) 2009-06-22 2012-05-22 Amgen Inc Proteínas replegadas que usan un estado de oxido-reduccion quimicamente controlado.
MX2011013417A (es) 2009-06-25 2012-03-29 Amgen Inc Procesos de purificacion por captura para proteinas expresadas en un sistema no mamifero.
EP2483289B2 (en) 2009-10-02 2025-03-26 Biogen MA Inc. Methods of preventing and removing trisulfide bonds
CN102770458A (zh) * 2009-12-02 2012-11-07 阿塞勒隆制药公司 用于增加Fc融合蛋白的血清半寿期的组合物和方法
JP6219170B2 (ja) 2011-02-07 2017-10-25 セレニス セラピューティクス ホールディング エスアー リポタンパク質複合体ならびにその製造および使用
WO2012170938A1 (en) 2011-06-08 2012-12-13 Acceleron Pharma Inc. Compositions and methods for increasing serum half-life
EP2723370A4 (en) 2011-06-24 2015-06-03 Univ Colorado Regents COMPOSITIONS, PROCESS AND USE OF ALPHA-1-ANTITRYPHIN FUSION MOLECULES
KR20140137347A (ko) 2012-01-10 2014-12-02 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 알파-1 안티트립신 융합 분자용 조성물, 방법 및 용도
US9353165B2 (en) * 2012-07-25 2016-05-31 Grifols, S.A. Purification of cell culture derived alpha1 protease inhibitor
WO2014020069A1 (en) 2012-08-02 2014-02-06 F. Hoffmann-La Roche Ag Method for producing monomeric and multimeric molecules and uses thereof
SMT201800163T1 (it) 2012-09-11 2018-05-02 Coherus Biosciences Inc Etanercept correttamente ripiegato ad alta purezza ed eccellente resa
JP6608705B2 (ja) 2013-03-08 2019-11-20 ジェンザイム・コーポレーション 治療用タンパク質の連続的な精製
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
TWI709570B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析法及製法
AR103172A1 (es) * 2014-12-22 2017-04-19 Novartis Ag Reducción selectiva de residuos de cisteina en anticuerpos il-17
KR102413592B1 (ko) 2016-10-21 2022-06-27 암젠 인크 약학적 제형 및 그의 제조 방법
JP2021536353A (ja) 2018-08-31 2021-12-27 ジェンザイム・コーポレーション 無菌クロマトグラフィー樹脂および製造方法におけるその使用
WO2020077212A1 (en) 2018-10-11 2020-04-16 Amgen Inc. Downstream processing of bispecific antibody constructs
WO2022140389A1 (en) 2020-12-22 2022-06-30 Amgen Inc. Cell culture method
CN118047854B (zh) * 2024-02-26 2024-08-02 武汉鹰达生物科技有限公司 一种人载脂蛋白a-i的分离纯化方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5453363A (en) * 1985-10-23 1995-09-26 Boehringer Mannheim Gmbh Process for the activation of t-PA or Ing after genetic expression in prokaryotes
US4766205A (en) * 1985-11-13 1988-08-23 Beatrice Companies, Inc. Method for isolation of recombinant polypeptides in biologically active forms
EP0293785A3 (en) * 1987-05-29 1990-05-02 Oncogen Limited Partnership Cloning and expression of simian transforming growth factor-ss1
US4970067A (en) * 1988-12-12 1990-11-13 Helene Curtis, Inc. Method and composition to condition hair and impart semi-permanent hair set retention properties
GB8927546D0 (en) * 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
AU648214B2 (en) * 1991-12-31 1994-04-14 Lucky Limited Recombinant gene coding for human alpha interferon and expression vector thereof, etc.
US5447851B1 (en) * 1992-04-02 1999-07-06 Univ Texas System Board Of Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells
JPH08502661A (ja) * 1993-08-04 1996-03-26 チバ−ガイギー アクチェンゲゼルシャフト 高分子量デスルファトヒルジン
US6310185B1 (en) * 1994-03-08 2001-10-30 Memorial Sloan Kettering Cancer Center Recombinant human anti-Lewis Y antibodies
AU2603995A (en) 1994-05-25 1995-12-18 University Of Nebraska Board Of Regents Biologically active glycoprotein hormones produced in procaryotic cells
HUT76666A (en) 1994-07-22 1997-10-28 Hoffmann La Roche Pharmaceutical compositions comprising a chimaeric tnf binding protein
US5879673A (en) * 1996-01-25 1999-03-09 Genentech, Inc. Administration of thrombopoietin on a single day only
US5935824A (en) * 1996-01-31 1999-08-10 Technologene, Inc. Protein expression system
US6808902B1 (en) 1999-11-12 2004-10-26 Amgen Inc. Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules
FR2803303B1 (fr) * 2000-01-04 2002-05-10 Aventis Pasteur Glycoproteine d'enveloppe du vih modifiee chimiquement
EP1366062B1 (en) * 2001-02-23 2011-07-27 Immunex Corporation Efficient recovery of correctly refolded proteins

Also Published As

Publication number Publication date
ZA200305909B (en) 2004-06-04
HUP0303246A2 (hu) 2003-12-29
CZ20032208A3 (cs) 2004-01-14
US7544784B2 (en) 2009-06-09
AU2002255600B2 (en) 2008-01-24
ATE517909T1 (de) 2011-08-15
SK10472003A3 (sk) 2004-03-02
PL374045A1 (en) 2005-09-19
IL157446A0 (en) 2004-03-28
CA2438094C (en) 2011-10-11
JP2005505494A (ja) 2005-02-24
HK1059267A1 (en) 2004-06-25
CA2438094A1 (en) 2002-09-06
CN1547586A (zh) 2004-11-17
US20070270577A1 (en) 2007-11-22
KR20040052481A (ko) 2004-06-23
US7157557B2 (en) 2007-01-02
MXPA03007563A (es) 2003-12-11
EP1366062B1 (en) 2011-07-27
WO2002068455A2 (en) 2002-09-06
BG108087A (bg) 2005-04-30
EP1366062A2 (en) 2003-12-03
RU2316563C2 (ru) 2008-02-10
WO2002068455A3 (en) 2003-09-18
US20020182665A1 (en) 2002-12-05
ES2370235T3 (es) 2011-12-13
RU2003127830A (ru) 2005-04-10

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