EE200200161A - Asendatud püridiinid ja püridasiinid, nende kasutamine angiogeneesi pärssimiseks ning neid sisaldavfarmatseutiline kompositsioon - Google Patents

Asendatud püridiinid ja püridasiinid, nende kasutamine angiogeneesi pärssimiseks ning neid sisaldavfarmatseutiline kompositsioon

Info

Publication number: EE200200161A
Authority: EE; Estonia
Prior art keywords: pyridazines; pharmaceutical composition; composition containing; inhibiting angiogenesis; substituted pyridines
Prior art date: 1999-09-28

Application number

EEP200200161A

Other languages

English (en)

Inventor

P. Dumas Jacques

J. Boyer Stephen

A. Dixon Julie

Kite Joe Teddy

C. E. Kluender Harold

Lee Wendy

Nagarathnam Dhanapalan

N. Sibley Robert

Su Ning

Original Assignee

Bayer Corporation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-09-28

Filing date

2000-09-26

Publication date

2003-08-15

2000-09-26 Application filed by Bayer Corporation filed Critical Bayer Corporation

2003-08-15 Publication of EE200200161A publication Critical patent/EE200200161A/et

2010-02-15 Publication of EE05258B1 publication Critical patent/EE05258B1/et

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Rheumatology (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Urology & Nephrology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)

EEP200200161A 1999-09-28 2000-09-26 Asendatud pridiinid ja pridasiinid, nende kasutamine angiogeneesi prssimiseks ning neid sisaldav farmatseutiline kompositsioon EE05258B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US40760099A	1999-09-28	1999-09-28
PCT/US2000/026500 WO2001023375A2 (en)	1999-09-28	2000-09-26	Substituted pyridines and pyridazines with angiogenesis inhibiting activity

Publications (2)

Publication Number	Publication Date
EE200200161A true EE200200161A (et)	2003-08-15
EE05258B1 EE05258B1 (et)	2010-02-15

Family

ID=23612752

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200200161A EE05258B1 (et)	1999-09-28	2000-09-26	Asendatud pridiinid ja pridasiinid, nende kasutamine angiogeneesi prssimiseks ning neid sisaldav farmatseutiline kompositsioon

Country Status (36)

Country	Link
EP (1)	EP1228063B1 (et)
JP (1)	JP4919567B2 (et)
KR (3)	KR100895571B1 (et)
CN (3)	CN100422172C (et)
AR (3)	AR025752A1 (et)
AT (1)	ATE422494T1 (et)
AU (1)	AU782820B2 (et)
BG (1)	BG65860B1 (et)
BR (1)	BRPI0014382B8 (et)
CA (1)	CA2385817C (et)
CO (1)	CO5200835A1 (et)
CZ (1)	CZ304767B6 (et)
DE (1)	DE60041548D1 (et)
DO (1)	DOP2000000070A (et)
EE (1)	EE05258B1 (et)
ES (1)	ES2320525T3 (et)
GT (1)	GT200000158A (et)
HK (2)	HK1091818A1 (et)
HR (1)	HRP20020308A2 (et)
HU (1)	HU230223B1 (et)
IL (3)	IL148880A0 (et)
MA (1)	MA25563A1 (et)
MX (1)	MXPA02003156A (et)
MY (3)	MY143377A (et)
NO (1)	NO20021520L (et)
NZ (1)	NZ518589A (et)
PA (1)	PA8503201A1 (et)
PE (1)	PE20010607A1 (et)
PL (1)	PL205957B1 (et)
RS (1)	RS50369B (et)
RU (1)	RU2260008C2 (et)
SK (1)	SK287417B6 (et)
TW (1)	TW593315B (et)
UA (1)	UA75053C2 (et)
WO (1)	WO2001023375A2 (et)
ZA (1)	ZA200202760B (et)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MXPA03000874A (es) *	2000-08-09	2003-06-06	Astrazeneca Ab	Compuestos quimicos.
RU2264389C3 (ru)	2000-10-20	2018-06-01	Эйсай Ар Энд Ди Менеджмент Ко., Лтд.	Азотсодержащие ароматические производные, их применение, лекарственное средство на их основе и способ лечения
EP1467736A2 (en) *	2001-12-21	2004-10-20	Bayer Pharmaceuticals Corporation	Anti-angiogenesis combination therapies comprising pyridazine or pyridine derivatives
TWI299664B (en)	2003-01-06	2008-08-11	Osi Pharm Inc	(2-carboxamido)(3-amino)thiophene compounds
EP1603566B1 (en) *	2003-03-11	2009-01-21	Novartis AG	Use of isoquinoline derivatives for treating cancer and map kinase related diseases
US20070082910A1 (en) *	2003-04-08	2007-04-12	Mitsubishi Pharma Corporation	Specific nad(p)h oxidase inhibitor
CN100450998C (zh)	2003-11-11	2009-01-14	卫材R&D管理有限公司	脲衍生物的制备方法
KR100553398B1 (ko) *	2004-03-12	2006-02-16	한미약품 주식회사	티에노[3,2-ｃ]피리딘 유도체의 제조 방법 및 이에사용되는 중간체
EP1797877A4 (en)	2004-09-13	2010-12-15	Eisai Co Ltd	JOINT USE OF A SULFONAMIDE-BASED COMPOUND AND AN ANGIOGENESIS INHIBITOR
US8772269B2 (en)	2004-09-13	2014-07-08	Eisai R&D Management Co., Ltd.	Use of sulfonamide-including compounds in combination with angiogenesis inhibitors
WO2006030826A1 (ja)	2004-09-17	2006-03-23	Eisai R & D Management Co., Ltd.	医薬組成物
EP2281901B1 (en)	2005-08-02	2013-11-27	Eisai R&D Management Co., Ltd.	Anti-tumour pharmaceutical composition with angiogenesis inhibitors
CA2648957A1 (en)	2006-04-15	2007-10-25	Bayer Healthcare Ag	Compounds for treating pulmonary hypertension
CA2652442C (en)	2006-05-18	2014-12-09	Eisai R & D Management Co., Ltd.	Antitumor agent for thyroid cancer
KR101472600B1 (ko)	2006-08-28	2014-12-15	에자이 알앤드디 매니지먼트 가부시키가이샤	미분화형 위암에 대한 항종양제
WO2008093855A1 (ja)	2007-01-29	2008-08-07	Eisai R & D Management Co., Ltd.	未分化型胃癌治療用組成物
CA2704000C (en)	2007-11-09	2016-12-13	Eisai R&D Management Co., Ltd.	Combination of anti-angiogenic substance and anti-tumor platinum complex
CN101481380B (zh) *	2008-01-08	2012-10-17	浙江医药股份有限公司新昌制药厂	噻吩并哒嗪类化合物及其制备方法、药物组合物及其用途
CN102958523B (zh)	2010-06-25	2014-11-19	卫材R&D管理有限公司	使用具有激酶抑制作用的组合的抗肿瘤剂
WO2012144463A1 (ja)	2011-04-18	2012-10-26	エーザイ・アール・アンド・ディー・マネジメント株式会社	腫瘍治療剤
ES2705950T3 (es)	2011-06-03	2019-03-27	Eisai R&D Man Co Ltd	Biomarcadores para predecir y valorar la capacidad de respuesta de sujetos con cáncer de tiroides y de riñón a compuestos de lenvatinib
US9334239B2 (en)	2012-12-21	2016-05-10	Eisai R&D Management Co., Ltd.	Amorphous form of quinoline derivative, and method for producing same
ES2687968T3 (es)	2013-05-14	2018-10-30	Eisai R&D Management Co., Ltd.	Biomarcadores para pronosticar y evaluar la reactividad de sujetos con cáncer de endometrio a compuestos con lenvatinib
CN103396361B (zh) *	2013-07-24	2016-05-04	中国人民解放军第二军医大学	3,4-二氢异喹啉类抗肿瘤化合物及其制备方法与应用
KR102329681B1 (ko)	2014-08-28	2021-11-23	에자이 알앤드디 매니지먼트 가부시키가이샤	고순도의 퀴놀린 유도체 및 이를 제조하는 방법
US20180028662A1 (en)	2015-02-25	2018-02-01	Eisai R&D Management Co., Ltd.	Method for Suppressing Bitterness of Quinoline Derivative
WO2016140717A1 (en)	2015-03-04	2016-09-09	Merck Sharp & Dohme Corp.	Combination of a pd-1 antagonist and a vegfr/fgfr/ret tyrosine kinase inhibitor for treating cancer
CN104804008B (zh) *	2015-03-27	2016-03-23	亿腾药业（泰州）有限公司	一种工业化生产甲磺酸特拉替尼的方法
US11369623B2 (en)	2015-06-16	2022-06-28	Prism Pharma Co., Ltd.	Anticancer combination of a CBP/catenin inhibitor and an immune checkpoint inhibitor
KR102587702B1 (ko)	2015-08-20	2023-10-12	에자이 알앤드디 매니지먼트 가부시키가이샤	종양 치료제
CN107129502B (zh) *	2017-04-13	2022-08-05	泰州亿腾景昂药业股份有限公司	EOC315 Mod.I晶型化合物及其制备方法
JP2020519576A (ja)	2017-05-16	2020-07-02	エーザイ・アール・アンド・ディー・マネジメント株式会社	肝細胞癌の治療
WO2020219448A1 (en) *	2019-04-22	2020-10-29	Mirati Therapeutics, Inc.	Naphthyridine derivatives as prc2 inhibitors
CN112830932B (zh) *	2020-12-25	2022-04-08	泰州亿腾景昂药业股份有限公司	特拉替尼的游离碱晶型及其制备方法与用途
WO2023081923A1 (en)	2021-11-08	2023-05-11	Frequency Therapeutics, Inc.	Platelet-derived growth factor receptor (pdgfr) alpha inhibitors and uses thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1453897A (fr) *	1965-06-16	1966-07-22		Dérivés du thiophène et de thiéno pyridazines
GB1094044A (en) *	1965-07-12	1967-12-06	Vantorex Ltd	Phthalazine derivatives
FR1516777A (fr) *	1966-08-02	1968-02-05	Innothera Lab Sa	Dérivés du thiazole ainsi que de la thiazolo [4,5-d] pyridazine et leur préparation
GB1293565A (en) *	1969-05-03	1972-10-18	Aspro Nicholas Ltd	Aminophthalazines and pharmaceutical compositions thereof
JPH03106875A (ja) *	1989-09-20	1991-05-07	Morishita Pharmaceut Co Ltd	１―（３―ピリジルメチル）フタラジン誘導体
ES2224130T3 (es) *	1994-08-09	2005-03-01	Eisai Co., Ltd.	Compuesto de piridazina condensada.
CO4950519A1 (es) *	1997-02-13	2000-09-01	Novartis Ag	Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion
CA2339961C (en) *	1998-08-11	2009-01-20	Novartis Ag	Isoquinoline derivatives with angiogenesis inhibiting activity
AU766081B2 (en) *	1999-03-30	2003-10-09	Novartis Ag	Phthalazine derivatives for treating inflammatory diseases
AR025068A1 (es) *	1999-08-10	2002-11-06	Bayer Corp	Pirazinas sustituidas y piridazinas fusionadas, composicion farmaceutica que las comprenden, uso de dichos compuestos para la manufactura de un medicamentocon actividad inhibidora de angiogenesis
PT1254138E (pt) *	2000-02-09	2005-09-30	Novartis Ag	Derivados de piridina que inibem a angiogenese e/ou o receptor de tirosina cinase do vegf

2000
- 2000-09-22 AR ARP000104981A patent/AR025752A1/es not_active Application Discontinuation
- 2000-09-22 GT GT200000158A patent/GT200000158A/es unknown
- 2000-09-22 CO CO00072226A patent/CO5200835A1/es active IP Right Grant
- 2000-09-22 DO DO2000000070A patent/DOP2000000070A/es unknown
- 2000-09-25 PE PE2000001004A patent/PE20010607A1/es not_active Application Discontinuation
- 2000-09-25 PA PA20008503201A patent/PA8503201A1/es unknown
- 2000-09-25 TW TW089119700A patent/TW593315B/zh not_active IP Right Cessation
- 2000-09-25 MY MYPI20051064A patent/MY143377A/en unknown
- 2000-09-25 MY MYPI20051063A patent/MY143580A/en unknown
- 2000-09-25 MY MYPI20004467A patent/MY135058A/en unknown
- 2000-09-26 MX MXPA02003156A patent/MXPA02003156A/es active IP Right Grant
- 2000-09-26 DE DE60041548T patent/DE60041548D1/de not_active Expired - Lifetime
- 2000-09-26 PL PL366342A patent/PL205957B1/pl unknown
- 2000-09-26 CZ CZ2002-1444A patent/CZ304767B6/cs not_active IP Right Cessation
- 2000-09-26 EP EP00978215A patent/EP1228063B1/en not_active Expired - Lifetime
- 2000-09-26 AU AU15696/01A patent/AU782820B2/en not_active Expired
- 2000-09-26 CA CA2385817A patent/CA2385817C/en not_active Expired - Lifetime
- 2000-09-26 EE EEP200200161A patent/EE05258B1/et not_active IP Right Cessation
- 2000-09-26 WO PCT/US2000/026500 patent/WO2001023375A2/en active Application Filing
- 2000-09-26 BR BRPI0014382A patent/BRPI0014382B8/pt not_active IP Right Cessation
- 2000-09-26 KR KR1020087021379A patent/KR100895571B1/ko active IP Right Grant
- 2000-09-26 SK SK591-2002A patent/SK287417B6/sk not_active IP Right Cessation
- 2000-09-26 KR KR1020027003972A patent/KR100890473B1/ko active IP Right Grant
- 2000-09-26 CN CNB2005101271092A patent/CN100422172C/zh not_active Expired - Lifetime
- 2000-09-26 ES ES00978215T patent/ES2320525T3/es not_active Expired - Lifetime
- 2000-09-26 HU HU0202704A patent/HU230223B1/hu not_active IP Right Cessation
- 2000-09-26 JP JP2001526527A patent/JP4919567B2/ja not_active Expired - Lifetime
- 2000-09-26 RU RU2002111414/04A patent/RU2260008C2/ru active
- 2000-09-26 RS YUP-229/02A patent/RS50369B/sr unknown
- 2000-09-26 CN CNB008163693A patent/CN100374435C/zh not_active Expired - Lifetime
- 2000-09-26 CN CNB2005101271105A patent/CN100422173C/zh not_active Expired - Lifetime
- 2000-09-26 IL IL14888000A patent/IL148880A0/xx active IP Right Grant
- 2000-09-26 AT AT00978215T patent/ATE422494T1/de not_active IP Right Cessation
- 2000-09-26 UA UA2002043504A patent/UA75053C2/uk unknown
- 2000-09-26 NZ NZ518589A patent/NZ518589A/en not_active IP Right Cessation
- 2000-09-26 KR KR1020087021380A patent/KR100895572B1/ko active IP Right Grant
2002
- 2002-03-26 NO NO20021520A patent/NO20021520L/no unknown
- 2002-04-09 ZA ZA200202760A patent/ZA200202760B/xx unknown
- 2002-04-10 HR HR20020308A patent/HRP20020308A2/xx not_active IP Right Cessation
- 2002-04-23 BG BG106637A patent/BG65860B1/bg unknown
- 2002-04-26 MA MA26619A patent/MA25563A1/fr unknown
2006
- 2006-11-08 HK HK06112289.9A patent/HK1091818A1/xx not_active IP Right Cessation
- 2006-11-08 HK HK06112290.6A patent/HK1091819A1/xx unknown
2008
- 2008-08-11 IL IL193367A patent/IL193367A/en active IP Right Grant
- 2008-08-11 IL IL193368A patent/IL193368A/en active IP Right Grant
2011
- 2011-07-15 AR ARP110102558A patent/AR082231A2/es unknown
- 2011-07-15 AR ARP110102559A patent/AR082232A2/es unknown

Also Published As

Publication number	Publication date
DE60041548D1 (de)	2009-03-26
YU22902A (sh)	2004-12-31
CA2385817A1 (en)	2001-04-05
NZ518589A (en)	2005-03-24
PE20010607A1 (es)	2001-07-12
CN1769282A (zh)	2006-05-10
MY143580A (en)	2011-05-31
AR082232A2 (es)	2012-11-21
HRP20020308B1 (et)	2013-01-31
AU782820B2 (en)	2005-09-01
JP2003526632A (ja)	2003-09-09
ATE422494T1 (de)	2009-02-15
MA25563A1 (fr)	2002-10-01
BR0014382A (pt)	2003-06-24
EP1228063A2 (en)	2002-08-07
CA2385817C (en)	2010-05-04
IL193367A0 (en)	2009-02-11
IL148880A0 (en)	2002-09-12
KR20080086547A (ko)	2008-09-25
SK5912002A3 (en)	2003-01-09
PA8503201A1 (es)	2002-08-26
HK1091818A1 (en)	2007-01-26
HUP0202704A2 (hu)	2002-12-28
SK287417B6 (sk)	2010-09-07
GT200000158A (es)	2002-03-16
ZA200202760B (en)	2003-10-29
KR100895571B1 (ko)	2009-04-29
CN100422172C (zh)	2008-10-01
KR100895572B1 (ko)	2009-04-29
CN100374435C (zh)	2008-03-12
JP4919567B2 (ja)	2012-04-18
PL205957B1 (pl)	2010-06-30
DOP2000000070A (es)	2002-02-28
HU230223B1 (en)	2015-10-28
RS50369B (sr)	2009-11-10
KR100890473B1 (ko)	2009-03-26
NO20021520L (no)	2002-05-23
CZ20021444A3 (cs)	2002-08-14
HK1091819A1 (en)	2007-01-26
HUP0202704A3 (en)	2003-12-29
PL366342A1 (en)	2005-01-24
TW593315B (en)	2004-06-21
UA75053C2 (en)	2006-03-15
CO5200835A1 (es)	2002-09-27
IL193368A (en)	2011-05-31
BG106637A (bg)	2003-02-28
CN1420879A (zh)	2003-05-28
RU2260008C2 (ru)	2005-09-10
CZ304767B6 (cs)	2014-10-08
BG65860B1 (bg)	2010-03-31
ES2320525T3 (es)	2009-05-25
IL193368A0 (en)	2009-02-11
MY135058A (en)	2008-01-31
CN100422173C (zh)	2008-10-01
AR025752A1 (es)	2002-12-11
HRP20020308A2 (en)	2004-06-30
BRPI0014382B8 (pt)	2021-05-25
KR20020038775A (ko)	2002-05-23
EE05258B1 (et)	2010-02-15
EP1228063B1 (en)	2009-02-11
BR0014382B1 (pt)	2014-04-01
MXPA02003156A (es)	2002-09-30
CN1769283A (zh)	2006-05-10
NO20021520D0 (no)	2002-03-26
WO2001023375A3 (en)	2002-05-02
KR20080091505A (ko)	2008-10-13
MY143377A (en)	2011-05-13
IL193367A (en)	2011-03-31
AR082231A2 (es)	2012-11-21
AU1569601A (en)	2001-04-30
WO2001023375A2 (en)	2001-04-05

Publication	Publication Date	Title
EE200200161A (et)	2003-08-15	Asendatud püridiinid ja püridasiinid, nende kasutamine angiogeneesi pärssimiseks ning neid sisaldavfarmatseutiline kompositsioon
HUP0400558A3 (en)	2010-03-29	Substituted benzene derivatives or salts thereof and pharmaceutical compositions containing them
IL152490A0 (en)	2003-05-29	Pyridine derivatives and pharmaceutical compositions containing the same
HK1042891B (zh)	2004-04-08	苯衍生物、其製備方法以及含有它們的藥用組合物
EE05183B1 (et)	2009-06-15	Asabitsklilised hendid, nende valmistamine ja kasutamine ravimitena ning neid sisaldav farmatseutiline kompositsioon
EE04673B1 (et)	2006-08-15	Kinoliini derivaadid, nende valmistamine ja kasutamine ravimina ning neid sisaldavad farmatseutilised kompositsioonid
EE200100484A (et)	2002-12-16	Bitsüklilised heterotsüklilised ühendid, neid ühendeid sisaldavad farmatseutilised kompositsioonid,ja nende valmistamise meetodid
EE200200065A (et)	2003-04-15	3-aminopürasooli derivaadid, nende valmistamine ja kasutamine vähivastaste toimeainetena ning neid sisaldav farmatseutiline kompositsioon
EE200200138A (et)	2003-06-16	Kinolüülpropüülpiperidiini derivaadid, nende valmistamine ja neid sisaldavad kompositsioonid
HUP0600592A2 (en)	2006-11-28	Substituted imidazopyridines, pharmaceutical compositions containing them and intermediates
EE05001B1 (et)	2008-04-15	Heterotsüklilised ühendid, meetod nende valmistamiseks, neid sisaldav ravimkoostis ning nende kasutamine ravis
HUP0200714A3 (en)	2003-01-28	Pharmaceutical compounds, pharmaceutical compositions containing them and their use
EE05455B1 (et)	2011-08-15	3-heterotskll-asendatud bensolderivaadid ja neid sisaldavad vahendid, nende saamise meetodid ning nende kasutamine herbitsiididena
IL160714A0 (en)	2004-08-31	Heterocyclic substituted 2-(4-phenoxy) pyridine derivatives and pharmaceutical compositions containing the same
EE200300254A (et)	2003-12-15	Heterotsüklilised ühendid, millel on antibakteriaalne toime, nende valmistamismeetod ja neid sisaldavad farmatseutilised kompositsioonid
EE04276B1 (et)	2004-04-15	Kinoliini derivaadid, nende valmistamine ja kasutamine ravimina ning neid sisaldavad farmatseutilised kompositsioonid
EE200200369A (et)	2003-10-15	Asendatud piperidiinid, neid ühendeid sisaldavad ravimid ja meetodid nende valmistamiseks
IL152094A0 (en)	2003-05-29	Ecteinascidin derivatives and pharmaceutical compositions containing the same
HUP0302327A3 (en)	2006-05-29	Ecteinascidin derivatives their use, pharmaceutical compositions containing them
IL140525A0 (en)	2002-02-10	2-aminopyridine derivatives, their use as medicines and pharmaceutical compositions containing them
HUP0203722A3 (en)	2005-03-29	Substituted phenyl-piperazine derivatives, pharmaceutical compositions containing them and their use
HUP0200468A3 (en)	2002-12-28	Resorcinol derivatives and pharmaceutical compositions containing them
HK1049655A1 (en)	2003-05-23	Substituted norbornylamino derivatives, productionand use thereof and medicaments containing them.
EE200100711A (et)	2003-04-15	Naftüridiini derivaadid, nende valmistamismeetod ning neid sisaldav farmatseutiline kompositsioon
EE05192B1 (et)	2009-08-17	Trptamiini derivaadid ja analoogsed hendid ning neid sisaldavad farmatseutilised preparaadid

Legal Events

Date	Code	Title	Description
2010-08-16	GB1A	Change in the ownership or in the address of the owner
2011-02-15	KB4A	Valid patent at the end of a year	Effective date: 20101231
2018-05-15	MM4A	Lapsed by not paying the annual fees	Effective date: 20170926