EE200100324A - Meetod aktiivse lümfotoksiin-beeta retseptori immunoglobuliinsete kimäärsete valkude kõrgtasemel ekspressiooniks ja puhastamiseks - Google Patents
Meetod aktiivse lümfotoksiin-beeta retseptori immunoglobuliinsete kimäärsete valkude kõrgtasemel ekspressiooniks ja puhastamiseksInfo
- Publication number
- EE200100324A EE200100324A EEP200100324A EEP200100324A EE200100324A EE 200100324 A EE200100324 A EE 200100324A EE P200100324 A EEP200100324 A EE P200100324A EE P200100324 A EEP200100324 A EE P200100324A EE 200100324 A EE200100324 A EE 200100324A
- Authority
- EE
- Estonia
- Prior art keywords
- purification
- level expression
- chimeric proteins
- beta receptor
- lymphotoxin beta
- Prior art date
Links
- 102000037865 fusion proteins Human genes 0.000 title abstract 2
- 108020001507 fusion proteins Proteins 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000000746 purification Methods 0.000 title abstract 2
- 108060003951 Immunoglobulin Proteins 0.000 title 1
- 102000018170 Lymphotoxin beta Receptor Human genes 0.000 title 1
- 108010091221 Lymphotoxin beta Receptor Proteins 0.000 title 1
- 102000018358 immunoglobulin Human genes 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11275298P | 1998-12-17 | 1998-12-17 | |
PCT/US1999/029873 WO2000036092A2 (en) | 1998-12-17 | 1999-12-16 | METHOD FOR THE HIGH LEVEL EXPRESSION OF ACTIVE LYMPHOTOXIN-β RECEPTOR IMMUNOGLOBULIN CHIMERIC PROTEINS AND THEIR PURIFICATION |
Publications (1)
Publication Number | Publication Date |
---|---|
EE200100324A true EE200100324A (et) | 2002-10-15 |
Family
ID=22345666
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EEP200100324A EE200100324A (et) | 1998-12-17 | 1999-12-16 | Meetod aktiivse lümfotoksiin-beeta retseptori immunoglobuliinsete kimäärsete valkude kõrgtasemel ekspressiooniks ja puhastamiseks |
Country Status (27)
Country | Link |
---|---|
US (3) | US7585946B2 (et) |
EP (3) | EP1141248B1 (et) |
JP (4) | JP4878676B2 (et) |
KR (3) | KR20070091227A (et) |
CN (2) | CN100387708C (et) |
AT (1) | ATE536372T1 (et) |
AU (2) | AU777232B2 (et) |
BR (1) | BR9916325B1 (et) |
CA (1) | CA2354539A1 (et) |
CY (1) | CY1117003T1 (et) |
CZ (1) | CZ20012156A3 (et) |
DK (2) | DK1141248T3 (et) |
EA (1) | EA005270B1 (et) |
EE (1) | EE200100324A (et) |
ES (1) | ES2554482T5 (et) |
HK (2) | HK1038244A1 (et) |
HU (1) | HUP0200064A2 (et) |
IL (3) | IL143670A0 (et) |
IS (1) | IS5959A (et) |
NO (1) | NO20012991L (et) |
NZ (3) | NZ538599A (et) |
PT (1) | PT2374872E (et) |
SG (1) | SG123531A1 (et) |
SI (1) | SI2374872T2 (et) |
SK (1) | SK8552001A3 (et) |
TR (2) | TR200504220T2 (et) |
WO (1) | WO2000036092A2 (et) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5925351A (en) * | 1995-07-21 | 1999-07-20 | Biogen, Inc. | Soluble lymphotoxin-β receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of immunological disease |
US7060667B1 (en) * | 1998-01-30 | 2006-06-13 | Biogen Idec Ma, Inc. | Treatment of follicular lymphomas using inhibitors of the LT pathway |
IL142284A0 (en) * | 1998-10-09 | 2002-03-10 | Biogen Inc | A pharmaceutical composition containing an agent which blocks the binding of lymphotoxin-b to its receptor |
US20020168367A1 (en) * | 2000-04-28 | 2002-11-14 | Planet Biotechnology Incorporated | Novel immunoadhesins for treating and preventing viral and bacterial diseases |
CN101643512A (zh) | 2000-04-28 | 2010-02-10 | 行星生物技术有限公司 | 预防鼻病毒感染的新型免疫粘附素 |
IL156910A0 (en) * | 2001-01-16 | 2004-02-08 | Regeneron Pharma | Isolating cells expressing secreted proteins |
US20090137416A1 (en) | 2001-01-16 | 2009-05-28 | Regeneron Pharmaceuticals, Inc. | Isolating Cells Expressing Secreted Proteins |
CN100473664C (zh) * | 2002-12-20 | 2009-04-01 | 拜奥根Idec马萨诸塞公司 | 多价淋巴毒素β受体激动剂及其治疗用途 |
US7541164B2 (en) | 2002-12-23 | 2009-06-02 | Bristol-Myers Squibb Company | Mammalian cell culture processes for protein production |
PL377603A1 (pl) | 2002-12-23 | 2006-02-06 | Bristol-Myers Squibb Company | Poprawa jakości produktu w hodowlach komórek ssaczych do wytwarzania białka |
WO2005024012A1 (en) * | 2003-09-11 | 2005-03-17 | Novozymes A/S | Increased expression of a modified polypeptide |
WO2005063813A2 (en) * | 2003-12-23 | 2005-07-14 | Applied Research Systems Ars Holding N.V. | Process for the production of tumor necrosis factor-binding proteins |
US20110038854A1 (en) * | 2006-03-30 | 2011-02-17 | University Of Medicine And Dentistry Of New Jersey | Strategy for homo- or hetero-dimerization of various proteins in solution and in cell |
WO2008063776A2 (en) | 2006-10-12 | 2008-05-29 | Genentech, Inc. | Antibodies to lymphotoxin-alpha |
EP2311481A3 (en) * | 2006-10-20 | 2013-10-16 | Biogen Idec MA Inc. | Treatment of demyelinating disorders with soluble lymphotoxin-beta-receptor |
WO2008112325A2 (en) * | 2007-03-15 | 2008-09-18 | Biogen Idec Ma Inc. | Treatment of autoimmune disorders |
US8338376B2 (en) | 2006-10-20 | 2012-12-25 | Biogen Idec Ma Inc. | Compositions comprising variant LT-B-R-IG fusion proteins |
TW200902708A (en) | 2007-04-23 | 2009-01-16 | Wyeth Corp | Methods of protein production using anti-senescence compounds |
MX2010009398A (es) * | 2008-02-29 | 2010-11-12 | Biogen Idec Inc | Proteinas de fusion de inmunoglobulinas purificadas y los metodos para su purificacion. |
US9540426B2 (en) | 2009-10-06 | 2017-01-10 | Bristol-Myers Squibb Company | Mammalian cell culture processes for protein production |
SG185014A1 (en) | 2010-04-26 | 2012-11-29 | Novartis Ag | Improved cell cultivation process |
EP2723759A4 (en) * | 2011-06-24 | 2015-01-28 | Reddys Lab Ltd Dr | PURIFICATION OF CHIMERIC PROTEIN |
US9279014B2 (en) * | 2011-08-17 | 2016-03-08 | Ares Trading S.A. | Methods for preparing an active TNFR-Fc fusion protein |
JP2015531244A (ja) | 2012-10-15 | 2015-11-02 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | タンパク質を製造するための哺乳動物細胞培養方法 |
TWI864338B (zh) | 2012-11-14 | 2024-12-01 | 美商再生元醫藥公司 | 重組細胞表面捕捉蛋白質 |
CN114853903A (zh) | 2015-06-30 | 2022-08-05 | 桑福德伯纳姆普利斯医学发现研究所 | Btla融合蛋白激动剂及其用途 |
KR101936049B1 (ko) | 2015-10-15 | 2019-01-08 | (주)알테오젠 | IgG Fc 도메인을 가지는 융합 단백질의 생산방법 |
CN105400721A (zh) * | 2015-12-11 | 2016-03-16 | 湖南农业大学 | 一种快速筛选具有抗菌活性芽孢杆菌的方法 |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2906096A (en) | 1953-12-14 | 1959-09-29 | Pacific Ind Mfg Co | Precision control system for press brakes or the like |
JP2810744B2 (ja) | 1989-07-04 | 1998-10-15 | ノボ ノルディスク アクティーゼルスカブ | F▲viii▼活性を有する蛋白質および/またはf▲viii▼誘導体の製造法 |
US5605690A (en) * | 1989-09-05 | 1997-02-25 | Immunex Corporation | Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor |
AU8228891A (en) | 1990-06-27 | 1992-01-23 | Biogen, Inc. | Surface complexed lymphotoxin |
US7030080B2 (en) | 1990-06-27 | 2006-04-18 | Biogen, Inc. | Lymphotoxin-β, lymphotoxin-β complexes, pharmaceutical preparations and therapeutic uses thereof |
US5670149A (en) | 1990-06-27 | 1997-09-23 | Biogen, Inc. | Lymphotoxin-β, Lymphotoxin-β complexes, pharmaceutical preparations and therapeutic uses thereof |
CA2109602C (en) | 1990-07-10 | 2002-10-01 | Gregory P. Winter | Methods for producing members of specific binding pairs |
NZ240718A (en) * | 1990-11-30 | 1996-10-28 | Bio Technology General Corp | Somatotropin analogues carrying mutations in the alpha-helix-1 region |
US5656272A (en) | 1991-03-18 | 1997-08-12 | New York University Medical Center | Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies |
IE922437A1 (en) | 1991-07-25 | 1993-01-27 | Idec Pharma Corp | Recombinant antibodies for human therapy |
US5447851B1 (en) * | 1992-04-02 | 1999-07-06 | Univ Texas System Board Of | Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells |
US5643570A (en) * | 1992-05-19 | 1997-07-01 | Xoma Corporation | BPI-immunoglobulin fusion proteins |
CA2123593C (en) * | 1992-09-15 | 2000-03-14 | Craig A. Smith | Method of treating tnf-dependent inflammation using tumor necrosis factor antagonists |
WO1994006478A1 (en) | 1992-09-22 | 1994-03-31 | Medin Corporation | A system for securing medical tools for sterilization |
CA2150262C (en) | 1992-12-04 | 2008-07-08 | Kaspar-Philipp Holliger | Multivalent and multispecific binding proteins, their manufacture and use |
US5691196A (en) * | 1992-12-31 | 1997-11-25 | American Cyanamid Company | Recombinant nucleic acid containing a response element |
US5429746A (en) | 1994-02-22 | 1995-07-04 | Smith Kline Beecham Corporation | Antibody purification |
US5856179A (en) | 1994-03-10 | 1999-01-05 | Genentech, Inc. | Polypeptide production in animal cell culture |
US5726039A (en) | 1994-07-21 | 1998-03-10 | Yissum Research Development Co. Of The Hebrew University Of Jerusalem | Vectors and transformed host cells for recombinant protein production at reduced temperatures |
US5541087A (en) | 1994-09-14 | 1996-07-30 | Fuji Immunopharmaceuticals Corporation | Expression and export technology of proteins as immunofusins |
US6312691B1 (en) | 1996-01-26 | 2001-11-06 | Jeffrey L. Browning | Lymphotoxin-α/β complexes and anti-lympotoxin-β receptor antibodies as anti-tumor agents |
US5705364A (en) * | 1995-06-06 | 1998-01-06 | Genentech, Inc. | Mammalian cell culture process |
US5721121A (en) | 1995-06-06 | 1998-02-24 | Genentech, Inc. | Mammalian cell culture process for producing a tumor necrosis factor receptor immunoglobulin chimeric protein |
US5925351A (en) | 1995-07-21 | 1999-07-20 | Biogen, Inc. | Soluble lymphotoxin-β receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of immunological disease |
US6291207B1 (en) * | 1995-07-28 | 2001-09-18 | Northwestern University | Herpes virus entry receptor protein |
JP4306813B2 (ja) | 1995-09-19 | 2009-08-05 | アスビオファーマ株式会社 | 動物細胞の新規培養方法 |
HRP970224A2 (en) | 1996-05-08 | 1998-04-30 | Hoffmann La Roche | TREATMENT OF ASTHMA WITH TNFR-Ig |
US6040560A (en) * | 1996-10-22 | 2000-03-21 | Philip Morris Incorporated | Power controller and method of operating an electrical smoking system |
DK0954333T3 (da) * | 1996-10-25 | 2006-10-23 | Biogen Idec Inc | Oplöselige lymfotoksin-beta-receptorer, anti-lymfotoksinreceptor-antistoffer og anti-lymfotoksin-ligandantistoffer som terapeutiske midler til behandling af immunologiske sygdomme |
US7255854B1 (en) | 1996-10-25 | 2007-08-14 | Biogen, Inc. | Use of lymphotoxin-β receptor blocking agents for the treatment of antibody mediated immunological diseases |
WO1998018824A1 (en) | 1996-10-30 | 1998-05-07 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor-like 2 |
JP2001526632A (ja) * | 1996-12-12 | 2001-12-18 | ジェネンテク,インコーポレイテッド | Hvemポリペプチドとその用途 |
US6221608B1 (en) * | 1997-01-22 | 2001-04-24 | Ortho Pharmaceutical Corporation | Methods for identifying erythropoietin receptor binding protein |
US7060667B1 (en) | 1998-01-30 | 2006-06-13 | Biogen Idec Ma, Inc. | Treatment of follicular lymphomas using inhibitors of the LT pathway |
JP2002511264A (ja) * | 1998-04-16 | 2002-04-16 | ジェネンテック・インコーポレーテッド | 組織プラスミノーゲン活性化因子プロ配列を使用するグリコシル化タンパク質の分泌 |
EP1092037B1 (en) | 1998-05-29 | 2005-12-28 | Genentech, Inc. | Cell culture process for producing glycoproteins |
IL142284A0 (en) | 1998-10-09 | 2002-03-10 | Biogen Inc | A pharmaceutical composition containing an agent which blocks the binding of lymphotoxin-b to its receptor |
US7294481B1 (en) | 1999-01-05 | 2007-11-13 | Immunex Corporation | Method for producing recombinant proteins |
US9086881B2 (en) | 2012-06-29 | 2015-07-21 | Intel Corporation | Mechanism for facilitating write tracking for following data eye movements across changing thermal conditions in memory systems |
-
1999
- 1999-11-16 TR TR2005/042202005/04220T patent/TR200504220T2/xx unknown
- 1999-12-16 DK DK99967350.2T patent/DK1141248T3/da active
- 1999-12-16 AT AT99967350T patent/ATE536372T1/de active
- 1999-12-16 CN CNB998156957A patent/CN100387708C/zh not_active Expired - Fee Related
- 1999-12-16 IL IL14367099A patent/IL143670A0/xx unknown
- 1999-12-16 PT PT100112127T patent/PT2374872E/pt unknown
- 1999-12-16 SI SI9931079T patent/SI2374872T2/sl unknown
- 1999-12-16 HU HU0200064A patent/HUP0200064A2/hu unknown
- 1999-12-16 BR BRPI9916325-0A patent/BR9916325B1/pt not_active IP Right Cessation
- 1999-12-16 ES ES10011212T patent/ES2554482T5/es not_active Expired - Lifetime
- 1999-12-16 SK SK855-2001A patent/SK8552001A3/sk unknown
- 1999-12-16 KR KR1020077017658A patent/KR20070091227A/ko not_active Ceased
- 1999-12-16 WO PCT/US1999/029873 patent/WO2000036092A2/en active Application Filing
- 1999-12-16 JP JP2000588341A patent/JP4878676B2/ja not_active Expired - Lifetime
- 1999-12-16 NZ NZ538599A patent/NZ538599A/en not_active IP Right Cessation
- 1999-12-16 EA EA200100670A patent/EA005270B1/ru not_active IP Right Cessation
- 1999-12-16 KR KR1020067009941A patent/KR100732934B1/ko not_active Expired - Fee Related
- 1999-12-16 KR KR1020017007475A patent/KR20020013482A/ko not_active Application Discontinuation
- 1999-12-16 EP EP99967350A patent/EP1141248B1/en not_active Expired - Lifetime
- 1999-12-16 CZ CZ20012156A patent/CZ20012156A3/cs unknown
- 1999-12-16 EP EP15183033.8A patent/EP3006563A1/en not_active Withdrawn
- 1999-12-16 TR TR2001/01703T patent/TR200101703T2/xx unknown
- 1999-12-16 NZ NZ529276A patent/NZ529276A/en active IP Right Revival
- 1999-12-16 DK DK10011212.7T patent/DK2374872T4/en active
- 1999-12-16 EE EEP200100324A patent/EE200100324A/et unknown
- 1999-12-16 NZ NZ549623A patent/NZ549623A/en not_active IP Right Cessation
- 1999-12-16 AU AU23644/00A patent/AU777232B2/en not_active Ceased
- 1999-12-16 SG SG200200026A patent/SG123531A1/en unknown
- 1999-12-16 CA CA002354539A patent/CA2354539A1/en not_active Abandoned
- 1999-12-16 CN CNA2008100903968A patent/CN101289512A/zh active Pending
- 1999-12-16 EP EP10011212.7A patent/EP2374872B2/en not_active Expired - Lifetime
-
2001
- 2001-01-23 US US09/767,370 patent/US7585946B2/en not_active Expired - Fee Related
- 2001-05-31 IS IS5959A patent/IS5959A/is unknown
- 2001-06-15 NO NO20012991A patent/NO20012991L/no not_active Application Discontinuation
- 2001-12-19 HK HK01108887.8A patent/HK1038244A1/xx not_active IP Right Cessation
-
2005
- 2005-01-07 AU AU2005200042A patent/AU2005200042B2/en not_active Ceased
-
2009
- 2009-08-17 US US12/542,614 patent/US8283138B2/en not_active Expired - Fee Related
-
2010
- 2010-03-30 JP JP2010079856A patent/JP2010158252A/ja not_active Withdrawn
- 2010-05-11 IL IL205698A patent/IL205698A/en not_active IP Right Cessation
-
2012
- 2012-07-19 US US13/553,604 patent/US8709759B2/en not_active Expired - Fee Related
-
2013
- 2013-02-12 JP JP2013024500A patent/JP5777171B2/ja not_active Expired - Lifetime
- 2013-12-01 IL IL229738A patent/IL229738A0/en unknown
-
2014
- 2014-09-12 JP JP2014186243A patent/JP2014239697A/ja not_active Withdrawn
-
2015
- 2015-11-26 CY CY20151101065T patent/CY1117003T1/el unknown
-
2016
- 2016-10-11 HK HK16111728.8A patent/HK1223398A1/zh unknown
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