|
US20030114503A1
(en)
*
|
1997-06-16 |
2003-06-19 |
Pfizer Inc. |
Farnesyl transferase inhibitors in combination with HMG CoA reductase inhibitors for the treatment of cancer
|
|
TR200003882T2
(tr)
*
|
1998-07-06 |
2001-06-21 |
Janssen Pharmaceutica N.V. |
Artropatilerin tedavisi için farnesil protein transferaz inhibitörleri.
|
|
KR20010072991A
(ko)
*
|
1998-08-27 |
2001-07-31 |
실버스타인 아써 에이. |
항암제로서 유용한 알키닐-치환된 퀴놀린-2-온 유도체
|
|
JP3494409B2
(ja)
*
|
1998-08-27 |
2004-02-09 |
ファイザー・プロダクツ・インク |
抗がん剤として有用なアルキニル置換キノリン−２−オン誘導体
|
|
CA2362394C
(en)
|
1999-02-11 |
2006-01-17 |
Pfizer Products Inc. |
Heteroaryl-substituted quinolin-2-one derivatives useful as anticancer agents
|
|
HN2000000266A
(es)
|
2000-01-21 |
2001-05-21 |
Pfizer Prod Inc |
Compuesto anticanceroso y metodo de separacion de enantiomeros util para sintetizar dicho compuesto.
|
|
US6838467B2
(en)
|
2000-02-24 |
2005-01-04 |
Janssen Pharmaceutica N. V. |
Dosing regimen
|
|
JO2361B1
(en)
|
2000-06-22 |
2006-12-12 |
جانسين فارماسيوتيكا ان. في |
Enaniumer 1,2-anylated quinoline inhibitor for the transporter - farnesyl
|
|
ATE409189T1
(de)
|
2000-09-25 |
2008-10-15 |
Janssen Pharmaceutica Nv |
Farnesyl transferase-hemmende 6- heterocyclylmethyl-chinolin und chinazol-derivate
|
|
ATE321038T1
(de)
|
2000-09-25 |
2006-04-15 |
Janssen Pharmaceutica Nv |
Chinolin- und chinazolinderivate und deren verwendung als farnesyl transferase inhibitoren
|
|
WO2002024687A1
(en)
*
|
2000-09-25 |
2002-03-28 |
Janssen Pharmaceutica N.V. |
Farnesyl transferase inhibiting 6-heterocyclylmethyl quinolinone derivatives
|
|
AU2001293829A1
(en)
|
2000-09-25 |
2002-04-02 |
Janssen Pharmaceutica N.V. |
Farnesyl transferase inhibiting 6-((substituted phenyl)methyl)-quinoline and quinazoline derivatives
|
|
AU2002214056A1
(en)
|
2000-11-21 |
2002-06-03 |
Janssen Pharmaceutica N.V. |
Farnesyl transferase inhibiting benzoheterocyclic derivatives
|
|
MXPA03005525A
(es)
*
|
2000-12-19 |
2003-10-06 |
Pfizer Prod Inc |
Formas cristalinas de sales de 2,3-dihidroxibutanodioato de 6-[(4-cloro -fenil)- hidroxi-(3 -metil-3h-imidazol -4-il)-metil] -4-(3-etinil-fenil) -1-metil-1h -quinolein-2 -ona, y metodo de produccion.
|
|
JP4351445B2
(ja)
|
2000-12-27 |
2009-10-28 |
ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ |
ファルネシルトランスフェラーゼを阻害する４−置換−キノリンおよびキナゾリン誘導体
|
|
US6645966B2
(en)
*
|
2001-01-22 |
2003-11-11 |
Schering Corporation |
Treatment of malaria with farnesyl protein transferase inhibitors
|
|
KR100849042B1
(ko)
*
|
2001-03-12 |
2008-07-29 |
얀센 파마슈티카 엔.브이. |
이미다졸 화합물의 제조 방법
|
|
US20020151563A1
(en)
*
|
2001-03-29 |
2002-10-17 |
Pfizer Inc. |
Farnesyl transferase inhibitors in combination with HMG CoA reductase inhibitors for the inhibition of abnormal cell growth
|
|
WO2002080895A2
(en)
*
|
2001-04-06 |
2002-10-17 |
Schering Corporation |
Treatment of malaria with farsenyl protein transferase inhibitors
|
|
EP1404329A4
(en)
*
|
2001-06-04 |
2006-11-02 |
Cytovia Inc |
QUINOLINONES 4-ARYL-3- (3-ARYL-1-OXO-2-PROPENYL) -2 (1H) -US SUBSTITUTED, AND ANALOGUES AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS, AND RELATIVE USE
|
|
EP1408971A4
(en)
|
2001-06-21 |
2006-01-25 |
Ariad Pharma Inc |
NEW QUINOLINES AND THEIR USES
|
|
US6740757B2
(en)
*
|
2001-08-29 |
2004-05-25 |
Pfizer Inc |
Enantiomers of 6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3h-imidazol-4-yl)-methyl]-4-[3-(3-hydroxy-3-methyl-but-1-ynyl)-phenyl]-1-methyl-1h-quinolin-2-one and salts thereof, useful in the treatment of cancer
|
|
AU2002358677B2
(en)
|
2001-12-19 |
2008-02-07 |
Janssen Pharmaceutica N.V. |
1,8-annelated quinoline derivatives substituted with carbon-linked triazoles as farnesyl transferase inhibitors
|
|
JP4450628B2
(ja)
|
2002-03-22 |
2010-04-14 |
ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ |
ファルネシルトランスフェラーゼインヒビターとして使用するためのベンジルイミダゾリル置換２−キノリンおよびキナゾリン誘導体
|
|
JP4384505B2
(ja)
|
2002-04-15 |
2009-12-16 |
ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ |
ファルネシルトランスフェラーゼを阻害する炭素連結イミダゾールもしくはトリアゾール置換三環状キナゾリン誘導体
|
|
BR0317548A
(pt)
*
|
2002-12-19 |
2005-11-22 |
Pfizer |
Compostos de indazole e composições farmacêuticas para a inibição de proteìnas-cinases e métodos para o seu uso
|
|
CA2546727C
(en)
|
2003-11-20 |
2012-10-02 |
Children's Hospital Medical Center |
Gtpase inhibitors and methods of use
|
|
WO2005089515A2
(en)
*
|
2004-03-18 |
2005-09-29 |
The Brigham And Women's Hospital, Inc. |
Methods for the treatment of synucleinopathies
|
|
WO2005094830A1
(en)
*
|
2004-03-30 |
2005-10-13 |
Pfizer Products Inc. |
Combinations of signal transduction inhibitors
|
|
MX2007002312A
(es)
|
2004-08-26 |
2007-04-16 |
Pfizer |
Compuestos de aminoheteroarilo enantiomericamente puros como inhibidores de proteina quinasa.
|
|
BRPI0514537B8
(pt)
*
|
2004-08-26 |
2021-05-25 |
Pfizer |
compostos de aminoeteroarila substituídos com pirazol e composição farmacêutica que os compreende
|
|
BRPI0514687A
(pt)
*
|
2004-08-26 |
2008-06-17 |
Pfizer |
compostos amino heteroarila como inibidores de proteìna tirosina cinase
|
|
PT1815247E
(pt)
|
2004-11-05 |
2013-04-23 |
Janssen Pharmaceutica Nv |
Uso terapêutico de inibidores de farnesiltransferase e métodos para monitorizar a eficácia do mesmo
|
|
US20060107555A1
(en)
*
|
2004-11-09 |
2006-05-25 |
Curtis Marc D |
Universal snow plow adapter
|
|
US20060281788A1
(en)
|
2005-06-10 |
2006-12-14 |
Baumann Christian A |
Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor
|
|
AU2006275528B2
(en)
|
2005-07-29 |
2012-03-08 |
Children's Hospital Medical Center |
GTPase inhibitors and methods of use and crystal structure of Rac-1 GTPase
|
|
RS54393B1
(en)
|
2005-09-07 |
2016-04-28 |
Amgen Fremont Inc. |
HUMAN MONOCLONAL ANTIBODIES ON KINASE-1 SIMILAR TO ACTIVE RECEPTOR
|
|
DK1926996T3
(da)
|
2005-09-20 |
2012-01-23 |
Osi Pharmaceuticals Llc |
Biologiske markører, som er prædiktive for anti-cancer-reaktion på insulinlignende vækstfaktor-1-receptorkinasehæmmere
|
|
US20070213366A1
(en)
|
2005-12-23 |
2007-09-13 |
Justman Craig J |
Treatment of Synucleinopathies
|
|
TW200812615A
(en)
|
2006-03-22 |
2008-03-16 |
Hoffmann La Roche |
Tumor therapy with an antibody for vascular endothelial growth factor and an antibody for human epithelial growth factor receptor type 2
|
|
PL2021335T3
(pl)
|
2006-04-20 |
2011-10-31 |
Janssen Pharmaceutica Nv |
Związki heterocykliczne jako inhibitory kinazy C-FMS
|
|
EP2016074B1
(en)
|
2006-04-20 |
2016-01-13 |
Janssen Pharmaceutica N.V. |
Inhibitors of c-fms kinase
|
|
US8697716B2
(en)
|
2006-04-20 |
2014-04-15 |
Janssen Pharmaceutica Nv |
Method of inhibiting C-KIT kinase
|
|
JP4383525B2
(ja)
|
2006-05-09 |
2009-12-16 |
ファイザー・プロダクツ・インク |
シクロアルキルアミノ酸誘導体およびその医薬組成物
|
|
PL2056874T3
(pl)
|
2006-08-21 |
2013-02-28 |
Hoffmann La Roche |
Leczenie nowotworu przeciwciałem przeciw VEGF
|
|
US20100184803A1
(en)
*
|
2007-03-09 |
2010-07-22 |
Link Medicine Corporation |
Treatment of Lysosomal Storage Diseases
|
|
JO3240B1
(ar)
|
2007-10-17 |
2018-03-08 |
Janssen Pharmaceutica Nv |
c-fms مثبطات كيناز
|
|
US8232402B2
(en)
|
2008-03-12 |
2012-07-31 |
Link Medicine Corporation |
Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
|
|
DE102008022221A1
(de)
*
|
2008-05-06 |
2009-11-12 |
Universität des Saarlandes |
Inhibitoren der humanen Aldosteronsynthase CYP11B2
|
|
US20100331363A1
(en)
*
|
2008-11-13 |
2010-12-30 |
Link Medicine Corporation |
Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
|
|
WO2010057006A1
(en)
|
2008-11-13 |
2010-05-20 |
Link Medicine Corporation |
Azaquinolinone derivatives and uses thereof
|
|
US20110060005A1
(en)
*
|
2008-11-13 |
2011-03-10 |
Link Medicine Corporation |
Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
|
|
WO2010099139A2
(en)
|
2009-02-25 |
2010-09-02 |
Osi Pharmaceuticals, Inc. |
Combination anti-cancer therapy
|
|
US20110171124A1
(en)
|
2009-02-26 |
2011-07-14 |
Osi Pharmaceuticals, Inc. |
In situ methods for monitoring the EMT status of tumor cells in vivo
|
|
WO2010099138A2
(en)
|
2009-02-27 |
2010-09-02 |
Osi Pharmaceuticals, Inc. |
Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
|
|
WO2010099363A1
(en)
|
2009-02-27 |
2010-09-02 |
Osi Pharmaceuticals, Inc. |
Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
|
|
US8465912B2
(en)
|
2009-02-27 |
2013-06-18 |
OSI Pharmaceuticals, LLC |
Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
|
|
EP2519826A2
(en)
|
2010-03-03 |
2012-11-07 |
OSI Pharmaceuticals, LLC |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
|
WO2011109584A2
(en)
|
2010-03-03 |
2011-09-09 |
OSI Pharmaceuticals, LLC |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
|
WO2012116040A1
(en)
|
2011-02-22 |
2012-08-30 |
OSI Pharmaceuticals, LLC |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors in hepatocellular carcinoma
|
|
US9896730B2
(en)
|
2011-04-25 |
2018-02-20 |
OSI Pharmaceuticals, LLC |
Use of EMT gene signatures in cancer drug discovery, diagnostics, and treatment
|
|
WO2013152252A1
(en)
|
2012-04-06 |
2013-10-10 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
|
US9980942B2
(en)
|
2012-05-02 |
2018-05-29 |
Children's Hospital Medical Center |
Rejuvenation of precursor cells
|
|
US9303046B2
(en)
|
2012-08-07 |
2016-04-05 |
Janssen Pharmaceutica Nv |
Process for the preparation of heterocyclic ester derivatives
|
|
JOP20180012A1
(ar)
|
2012-08-07 |
2019-01-30 |
Janssen Pharmaceutica Nv |
عملية السلفنة باستخدام نونافلوروبوتانيسولفونيل فلوريد
|
|
US9180185B2
(en)
|
2013-01-11 |
2015-11-10 |
Hoffman-La Roche Inc. |
Combination therapy of anti-HER3 antibodies
|
|
US10028503B2
(en)
|
2014-06-18 |
2018-07-24 |
Children's Hospital Medical Center |
Platelet storage methods and compositions for same
|
|
PT3385395T
(pt)
|
2015-08-17 |
2020-05-06 |
Kura Oncology Inc |
Métodos de tratamento de doentes com cancro usando inibidores da farnesiltransferase
|
|
EA201891304A1
(ru)
|
2015-12-03 |
2019-01-31 |
Агиос Фармасьютикалс, Инк. |
ИНГИБИТОРЫ MAT2A ДЛЯ ЛЕЧЕНИЯ MTAP-null ЗЛОКАЧЕСТВЕННЫХ ОПУХОЛЕЙ
|
|
WO2017184968A1
(en)
|
2016-04-22 |
2017-10-26 |
Kura Oncology, Inc. |
Methods of selecting cancer patients for treatment with farnesyltransferase inhibitors
|
|
BR112019009000A2
(pt)
|
2016-11-03 |
2019-07-16 |
Kura Oncology Inc |
método para tratar um carcinoma refratário, método de tratamento de scchn, método de tratamento de carcinoma de células escamosas, método de tratamento para scc
|
|
US11471538B2
(en)
|
2017-02-10 |
2022-10-18 |
INSERM (Institut National de la Santéet de la Recherche Medicale) |
Methods and pharmaceutical compositions for the treatment of cancers associated with activation of the MAPK pathway
|
|
SG11201907594TA
(en)
|
2017-02-21 |
2019-09-27 |
Kura Oncology Inc |
Methods of treating cancer with farnesyltransferase inhibitors
|
|
US10137121B2
(en)
|
2017-02-21 |
2018-11-27 |
Kura Oncology, Inc. |
Methods of treating cancer with farnesyltransferase inhibitors
|
|
EP3664804A4
(en)
|
2017-08-07 |
2021-04-14 |
Kura Oncology, Inc. |
METHOD OF TREATMENT OF CANCER WITH FERN SYL TRANSFERASE INHIBITORS
|
|
US10806730B2
(en)
|
2017-08-07 |
2020-10-20 |
Kura Oncology, Inc. |
Methods of treating cancer with farnesyltransferase inhibitors
|
|
WO2019113269A1
(en)
|
2017-12-08 |
2019-06-13 |
Kura Oncology, Inc. |
Methods of treating cancer patients with farnesyltransferase inhibitors
|
|
AU2019372141A1
(en)
|
2018-11-01 |
2021-05-27 |
Kura Oncology, Inc. |
Methods of treating cancer with farnesyltransferase inhibitors
|
|
TW202038953A
(zh)
|
2018-12-21 |
2020-11-01 |
美商庫拉腫瘤技術股份有限公司 |
鱗狀細胞癌之治療
|
|
US20220142983A1
(en)
|
2019-03-01 |
2022-05-12 |
Kura Oncology, Inc. |
Methods of treating cancer with farnesyltransferase inhibitors
|
|
WO2020190604A1
(en)
|
2019-03-15 |
2020-09-24 |
Kura Oncology, Inc. |
Methods of treating cancer patients with farnesyltransferase inhibitors
|
|
WO2020205486A1
(en)
|
2019-03-29 |
2020-10-08 |
Kura Oncology, Inc. |
Methods of treating squamous cell carcinomas with farnesyltransferase inhibitors
|
|
WO2020205387A1
(en)
|
2019-04-01 |
2020-10-08 |
Kura Oncology, Inc. |
Methods of treating cancer with farnesyltransferase inhibitors
|
|
US20220305001A1
(en)
|
2019-05-02 |
2022-09-29 |
Kura Oncology, Inc. |
Methods of treating acute myeloid leukemia with farnesyltransferase inhibitors
|
|
CN114450027A
(zh)
|
2019-08-16 |
2022-05-06 |
儿童医院医疗中心 |
用cdc42特异性抑制剂治疗受试者的方法
|
|
WO2021155006A1
(en)
|
2020-01-31 |
2021-08-05 |
Les Laboratoires Servier Sas |
Inhibitors of cyclin-dependent kinases and uses thereof
|