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EE200100075A - 2-asendatud 1-piperidüülbensimidasoolühendid kui ORL-1 retseptori agonistid - Google Patents

2-asendatud 1-piperidüülbensimidasoolühendid kui ORL-1 retseptori agonistid

Info

Publication number
EE200100075A
EE200100075A EEP200100075A EEP200100075A EE200100075A EE 200100075 A EE200100075 A EE 200100075A EE P200100075 A EEP200100075 A EE P200100075A EE P200100075 A EEP200100075 A EE P200100075A EE 200100075 A EE200100075 A EE 200100075A
Authority
EE
Estonia
Prior art keywords
piperidylbenzimidazole
orl
substituted
compounds
receptor agonists
Prior art date
Application number
EEP200100075A
Other languages
English (en)
Inventor
Ito Fumitaka
Noguchi Hirohide
Kondo Hiroshi
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of EE200100075A publication Critical patent/EE200100075A/et

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56Nitrogen atoms
    • C07D211/58Nitrogen atoms attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EEP200100075A 1998-08-06 1999-07-05 2-asendatud 1-piperidüülbensimidasoolühendid kui ORL-1 retseptori agonistid EE200100075A (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IBPCT/IB98/01206 1998-08-06
PCT/IB1999/001239 WO2000008013A2 (en) 1998-08-06 1999-07-05 2-substituted-1-piperidyl benzimidazole compounds as orl1-receptor agonists

Publications (1)

Publication Number Publication Date
EE200100075A true EE200100075A (et) 2002-06-17

Family

ID=11004738

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200100075A EE200100075A (et) 1998-08-06 1999-07-05 2-asendatud 1-piperidüülbensimidasoolühendid kui ORL-1 retseptori agonistid

Country Status (44)

Country Link
US (1) US6172067B1 (et)
EP (1) EP1102762B1 (et)
JP (1) JP3367945B2 (et)
CN (1) CN1317968A (et)
AP (1) AP2001002063A0 (et)
AR (1) AR018686A1 (et)
AT (1) ATE227716T1 (et)
AU (1) AU749166B2 (et)
BG (1) BG105301A (et)
BR (1) BR9912778A (et)
CA (1) CA2339621C (et)
CZ (1) CZ2001397A3 (et)
DE (1) DE69903953T2 (et)
DK (1) DK1102762T3 (et)
EA (1) EA200100104A1 (et)
EE (1) EE200100075A (et)
ES (1) ES2185357T3 (et)
GE (1) GEP20033000B (et)
GT (1) GT199900125A (et)
HK (1) HK1040188A1 (et)
HN (1) HN1999000105A (et)
HR (1) HRP20010089B1 (et)
HU (1) HUP0103567A3 (et)
ID (1) ID27212A (et)
IL (1) IL141029A0 (et)
IS (1) IS5812A (et)
MA (1) MA26659A1 (et)
NO (1) NO20010603L (et)
NZ (1) NZ509299A (et)
OA (1) OA11590A (et)
PA (1) PA8477701A1 (et)
PE (1) PE20000868A1 (et)
PL (1) PL346211A1 (et)
PT (1) PT1102762E (et)
SI (1) SI1102762T1 (et)
SK (1) SK1602001A3 (et)
SV (1) SV1999000099A (et)
TN (1) TNSN99142A1 (et)
TR (1) TR200100403T2 (et)
TW (1) TW513424B (et)
UY (1) UY25659A1 (et)
WO (1) WO2000008013A2 (et)
YU (1) YU8201A (et)
ZA (1) ZA200100900B (et)

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SE9902987D0 (sv) 1999-08-24 1999-08-24 Astra Pharma Prod Novel compounds
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EP1122257B1 (en) * 2000-01-05 2005-10-12 Pfizer Inc. Benzimidazole compounds as ORL1-receptor agonists
GB2359081A (en) 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active thiazolopyrimidines
GB2359078A (en) * 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
GB2359551A (en) 2000-02-23 2001-08-29 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
GB0005642D0 (en) 2000-03-10 2000-05-03 Astrazeneca Uk Ltd Chemical compounds
SE0003828D0 (sv) 2000-10-20 2000-10-20 Astrazeneca Ab Novel compounds
AU2403802A (en) * 2000-11-15 2002-05-27 Banyu Pharma Co Ltd Benzimidazole derivatives
GB0104050D0 (en) 2001-02-19 2001-04-04 Astrazeneca Ab Chemical compounds
GB0107228D0 (en) 2001-03-22 2001-05-16 Astrazeneca Ab Chemical compounds
SE0101322D0 (sv) 2001-04-12 2001-04-12 Astrazeneca Ab Novel compounds
SI1385515T1 (sl) 2001-04-18 2008-12-31 Euro Celtique Sa Spiropirazolne spojine
EP1997818A3 (en) * 2001-04-18 2009-04-08 Euro-Celtique S.A. Quinolinone derivatives and their use to treat pain
EP2033644A1 (en) 2001-04-18 2009-03-11 Euro-Celtique S.A. Spiroindene and spiroindane compounds
DE60232752D1 (de) * 2001-04-18 2009-08-06 Euro Celtique Sa 1-(4-amino-cyclohexyl)-1,3-dihydro-2h-benzimidazole-2-on derivate und verwandte verbindungen als nociceptin analoge und orl1 liganden zur behandlung von schmerz
SI1385518T1 (sl) * 2001-04-18 2009-02-28 Euro Celtique Sa Benzimidazolonske spojine
US20030040479A1 (en) * 2001-07-02 2003-02-27 Omeros Corporation Rotational intrathecal analgesia method and device
WO2003004034A1 (en) * 2001-07-02 2003-01-16 Omeros Corporation Method for inducing analgesia comprising administration alternatively of an opioid receptor agonist and an opioid receptor like receptor 1 agonist for and an implantable infusion pump
SE0102716D0 (sv) * 2001-08-14 2001-08-14 Astrazeneca Ab Novel compounds
SE0103818D0 (sv) 2001-11-15 2001-11-15 Astrazeneca Ab Chemical compounds
AU2002360561A1 (en) * 2001-12-11 2003-06-23 Sepracor, Inc. 4-substituted piperidines, and methods of use thereof
JP4056977B2 (ja) 2002-03-29 2008-03-05 田辺三菱製薬株式会社 睡眠障害治療薬
GB0221829D0 (en) * 2002-09-20 2002-10-30 Astrazeneca Ab Novel compound
GB0221828D0 (en) 2002-09-20 2002-10-30 Astrazeneca Ab Novel compound
DE10252665A1 (de) 2002-11-11 2004-06-03 Grünenthal GmbH 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate
DE10252666A1 (de) 2002-11-11 2004-08-05 Grünenthal GmbH N-Piperidyl-cyclohexan-Derivate
SE0301369D0 (sv) 2003-05-09 2003-05-09 Astrazeneca Ab Chemical compounds
GB0315203D0 (en) * 2003-06-28 2003-08-06 Celltech R&D Ltd Chemical compounds
US8067603B2 (en) 2003-09-25 2011-11-29 Solvay Pharmaceuticals B.V. Benzimidazolone and quinazolinone derivatives as agonists on human ORL1 receptors
GB0328243D0 (en) * 2003-12-05 2004-01-07 Astrazeneca Ab Methods
US20050228023A1 (en) * 2003-12-19 2005-10-13 Sri International Agonist and antagonist ligands of the nociceptin receptor
JPWO2006038738A1 (ja) * 2004-10-08 2008-05-15 武田薬品工業株式会社 受容体機能調節剤
WO2006074991A1 (en) 2005-01-11 2006-07-20 Neurosearch A/S Novel 2-amino benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels
JP2009541454A (ja) * 2006-07-03 2009-11-26 ノイロサーチ アクティーゼルスカブ モノアミン再摂取阻害剤及びカリウムチャネル活性剤の併用
DK2076506T3 (da) 2007-01-16 2011-01-10 Purdue Pharma Lp Heterocyklisk substituerede piperidiner som ORL-1-ligander
MX379353B (es) * 2007-08-31 2025-03-10 Purdue Pharmal P Compuesto de piperidina tipo quinoxalina sustituida y uso de los mismos.
US8119661B2 (en) * 2007-09-11 2012-02-21 Astrazeneca Ab Piperidine derivatives and their use as muscarinic receptor modulators
DK2324013T6 (en) 2008-07-21 2014-12-15 Purdue Pharma Lp Substituted bridged piperidine compounds of quinoxalintype and uses thereof
US9115127B2 (en) 2010-08-05 2015-08-25 Amgen Inc. Benzimidazole and azabenzimidazole compounds that inhibit anaplastic lymphoma kinase
MX346043B (es) 2012-01-06 2017-03-03 Novus Int Inc Tensioactivos basados en sulfoxido.
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JO3300B1 (ar) 2012-06-06 2018-09-16 Novartis Ag مركبات وتركيبات لتعديل نشاط egfr
CN107753462B (zh) 2012-07-12 2021-01-08 诺华丝国际股份有限公司 用于保护生物活性剂的基质和层组合物
US9085561B2 (en) * 2012-07-30 2015-07-21 Purdue Pharma L.P. Cyclic urea- or lactam-substituted quinoxaline-type piperidines as ORL-1 modulators
WO2014102594A2 (en) * 2012-12-27 2014-07-03 Purdue Pharma L.P. Substituted benzimidazole-type piperidine compounds and uses thereof
EP2976077A4 (en) 2013-03-22 2016-11-30 Scripps Research Inst SUBSTITUTED BENZIMIDAZOLE AS NOCICEPTIN RECEPTOR MODULATORS
CA2943220C (en) * 2014-03-20 2024-01-16 Capella Therapeutics, Inc. Benzimidazole derivatives as erbb tyrosine kinase inhibitors for the treatment of cancer
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ID29137A (id) 1998-07-27 2001-08-02 Schering Corp Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1

Also Published As

Publication number Publication date
UY25659A1 (es) 2000-02-23
YU8201A (sh) 2003-07-07
DE69903953D1 (de) 2002-12-19
CZ2001397A3 (cs) 2002-05-15
IS5812A (is) 2001-01-16
BR9912778A (pt) 2001-09-25
IL141029A0 (en) 2002-02-10
PA8477701A1 (es) 2000-09-29
ATE227716T1 (de) 2002-11-15
EP1102762A2 (en) 2001-05-30
SI1102762T1 (en) 2003-04-30
AP2001002063A0 (en) 2001-03-31
TNSN99142A1 (fr) 2005-11-10
DK1102762T3 (da) 2002-12-16
NZ509299A (en) 2003-05-30
US6172067B1 (en) 2001-01-09
HRP20010089A2 (en) 2002-02-28
GEP20033000B (en) 2003-06-25
ES2185357T3 (es) 2003-04-16
NO20010603L (no) 2001-04-05
ZA200100900B (en) 2002-08-28
PL346211A1 (en) 2002-01-28
AU749166B2 (en) 2002-06-20
SK1602001A3 (en) 2002-09-10
BG105301A (en) 2001-12-29
EP1102762B1 (en) 2002-11-13
TW513424B (en) 2002-12-11
PE20000868A1 (es) 2000-08-31
MA26659A1 (fr) 2004-12-20
CA2339621A1 (en) 2000-02-17
PT1102762E (pt) 2003-02-28
HK1040188A1 (zh) 2002-05-31
AR018686A1 (es) 2001-11-28
AU4385999A (en) 2000-02-28
HUP0103567A3 (en) 2003-01-28
WO2000008013A2 (en) 2000-02-17
OA11590A (en) 2004-08-18
NO20010603D0 (no) 2001-02-05
WO2000008013A3 (en) 2000-03-23
HN1999000105A (es) 2000-11-11
SV1999000099A (es) 2000-09-05
TR200100403T2 (tr) 2001-07-23
JP3367945B2 (ja) 2003-01-20
GT199900125A (es) 2001-01-27
CA2339621C (en) 2005-04-05
ID27212A (id) 2001-03-08
HUP0103567A2 (hu) 2002-02-28
DE69903953T2 (de) 2003-03-27
HRP20010089B1 (en) 2003-04-30
CN1317968A (zh) 2001-10-17
EA200100104A1 (ru) 2001-08-27
JP2002522431A (ja) 2002-07-23

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