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EE04524B1 - S-nitrosotioolid kui ained vereringeh„irete raviks - Google Patents

S-nitrosotioolid kui ained vereringeh„irete raviks

Info

Publication number
EE04524B1
EE04524B1 EEP200100389A EEP200100389A EE04524B1 EE 04524 B1 EE04524 B1 EE 04524B1 EE P200100389 A EEP200100389 A EE P200100389A EE P200100389 A EEP200100389 A EE P200100389A EE 04524 B1 EE04524 B1 EE 04524B1
Authority
EE
Estonia
Prior art keywords
nitrosothiols
agents
treatment
circulatory disorders
circulatory
Prior art date
Application number
EEP200100389A
Other languages
English (en)
Estonian (et)
Inventor
Repolles Moliner Jos�
Salas Perez-Rasilla Eduardo
Pubill Coy Francisco
Cerda Riudavets Juan-Antonio
Negrie Rofes Cristina
Cabeza Llorente Lydia
Ferrer Siso Alicia
Trias Adroher Nuria
Carbo Banus Marcel.Li
Murat Moreno Jes�s
Michelena Llaguno Pedro
Original Assignee
Lacer, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lacer, S.A. filed Critical Lacer, S.A.
Publication of EE200100389A publication Critical patent/EE200100389A/xx
Publication of EE04524B1 publication Critical patent/EE04524B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/54—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
EEP200100389A 1999-01-27 2000-01-19 S-nitrosotioolid kui ained vereringeh„irete raviks EE04524B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES009900159A ES2147162B1 (es) 1999-01-27 1999-01-27 "s-nitrosotioles como agentes para el tratamiento de disfunciones circulatorias".
PCT/ES2000/000019 WO2000044714A1 (es) 1999-01-27 2000-01-19 S-nitrosotioles como agentes para el tratamiento de disfunciones circulatorias

Publications (2)

Publication Number Publication Date
EE200100389A EE200100389A (et) 2002-12-16
EE04524B1 true EE04524B1 (et) 2005-08-15

Family

ID=8307080

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200100389A EE04524B1 (et) 1999-01-27 2000-01-19 S-nitrosotioolid kui ained vereringeh„irete raviks

Country Status (37)

Country Link
US (1) US6800612B2 (xx)
EP (1) EP1157987B1 (xx)
JP (1) JP3795330B2 (xx)
KR (1) KR100671878B1 (xx)
CN (1) CN1166631C (xx)
AP (1) AP1439A (xx)
AT (1) ATE249428T1 (xx)
AU (1) AU764725B2 (xx)
BG (1) BG64983B1 (xx)
BR (1) BR0007395B1 (xx)
CA (1) CA2359027C (xx)
CU (1) CU23098A3 (xx)
CZ (1) CZ298871B6 (xx)
DE (2) DE10083902T1 (xx)
DK (1) DK1157987T3 (xx)
EA (1) EA003577B1 (xx)
EE (1) EE04524B1 (xx)
ES (2) ES2147162B1 (xx)
GB (1) GB2363604B (xx)
GE (1) GEP20043220B (xx)
HK (1) HK1043586A1 (xx)
HR (1) HRP20010562B1 (xx)
HU (1) HUP0105203A3 (xx)
ID (1) ID29777A (xx)
IL (1) IL144381A (xx)
IS (1) IS2153B (xx)
MX (1) MXPA01007570A (xx)
NO (1) NO326806B1 (xx)
NZ (1) NZ513162A (xx)
OA (1) OA11823A (xx)
PL (1) PL202372B1 (xx)
PT (1) PT1157987E (xx)
RS (1) RS50072B (xx)
SI (1) SI1157987T1 (xx)
TR (1) TR200102003T2 (xx)
WO (1) WO2000044714A1 (xx)
ZA (1) ZA200106182B (xx)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2173044B1 (es) * 2001-03-13 2004-01-16 Lacer Sa Derivados de glicina, n-(n-l-gamma-glutamil-3-(nitrosotio)-l-valil) y sus aplicaciones.
WO2005030135A2 (en) * 2003-09-26 2005-04-07 Nitromed, Inc. Nitrosated glutamic acid compounds, compositions and methods of use
EP1939179A1 (en) * 2006-12-28 2008-07-02 Lacer, S.A. Stable S-nitrosothiols, method of synthesis and use
PL2197417T3 (pl) 2007-10-17 2012-08-31 Pharmagenix Ag Kompozycja farmaceutyczna zawierająca S-nitrozoglutation i polisacharyd

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US37839A (en) * 1863-03-03 Improved spoke-machine
GB1567561A (en) 1977-01-18 1980-05-14 Ucb Sa Amino-spiro(oxa-(orthia)cycloalkane-penam) - carboxylic acids
GB2052497B (en) 1979-06-25 1983-06-29 Ucb Sa 6 - amino - spiro - (penam - 2,4' - piperidine) - 3 - carboxylic acid derivatives
DE3805965A1 (de) 1988-02-25 1989-09-07 Tamas Geb Szenasi Eszter Verwendung der pflanze euphorbia hirta l. und ihrer extrakte sowie ihrer wirkstoffe
US5025001A (en) 1988-06-15 1991-06-18 Brigham And Women's Hospital S-nitroso derivatives of ACE inhibitors and the use thereof
DE69008454T2 (de) * 1989-08-07 1994-08-25 Takeda Chemical Industries Ltd Nitrolsothiolderivate, ihre Herstellung und Verwendung.
US5232913A (en) 1990-04-26 1993-08-03 Senju Pharmaceutical Co., Ltd. Antihepatopathic composition
US5187305A (en) * 1990-11-26 1993-02-16 Glaxo Inc. S-nitroso-N-alkonoylpenicillamines
CA2125037C (en) 1991-11-14 2001-02-20 Jonathan Stamler Nitrosylation of protein sh groups and amino acid residues as a therapeutic modality
NZ248332A (en) 1992-08-07 1995-01-27 Sankyo Co Hiv protease inhibitor and its use
EP1393723A3 (en) * 1993-09-17 2004-10-20 The Brigham And Women's Hospital, Inc. Use of nitric oxide-adducts to prevent thrombosis on artificial and vascular surfaces
US5728705A (en) 1993-10-04 1998-03-17 The Trustees Of Columbia University In The City Of New York Method of inducing vasorelaxation to treat pulmonary hypertension
CA2175467A1 (en) 1993-11-02 1995-05-11 David A. Wink, Jr. Use of nitric oxide releasing compounds as protective agents in ischemia reperfusion injury
GB9423868D0 (en) 1994-11-25 1995-01-11 Wellcome Found Compounds for use in medicine
US6627738B2 (en) 1995-09-15 2003-09-30 Duke University No-modified hemoglobins and uses therefor
AU6782198A (en) 1997-03-27 1998-10-20 Trustees Of Boston University Novel antiplatelet agent

Also Published As

Publication number Publication date
CZ298871B6 (cs) 2008-02-27
HRP20010562A2 (en) 2002-08-31
BG105824A (en) 2002-06-28
NO20013385D0 (no) 2001-07-06
CN1337946A (zh) 2002-02-27
PL202372B1 (pl) 2009-06-30
PT1157987E (pt) 2004-01-30
BR0007395B1 (pt) 2010-11-16
AU764725B2 (en) 2003-08-28
IS6020A (is) 2001-07-23
EA003577B1 (ru) 2003-06-26
RS50072B (sr) 2009-01-22
HK1043586A1 (zh) 2002-09-20
HRP20010562B1 (en) 2010-08-31
AP1439A (en) 2005-06-27
CA2359027A1 (en) 2000-08-03
HUP0105203A2 (en) 2002-06-29
GEP20043220B (en) 2004-04-26
DE60005154T2 (de) 2004-07-08
MXPA01007570A (es) 2003-05-14
CZ20012678A3 (cs) 2001-10-17
ES2147162B1 (es) 2001-03-16
JP2002535385A (ja) 2002-10-22
CN1166631C (zh) 2004-09-15
KR100671878B1 (ko) 2007-01-19
NZ513162A (en) 2003-01-31
ES2206178T3 (es) 2004-05-16
TR200102003T2 (tr) 2001-12-21
EA200100823A1 (ru) 2002-02-28
IL144381A0 (en) 2002-05-23
DE60005154D1 (de) 2003-10-16
US20020058629A1 (en) 2002-05-16
HUP0105203A3 (en) 2002-08-28
ATE249428T1 (de) 2003-09-15
NO20013385L (no) 2001-09-17
DK1157987T3 (da) 2003-11-24
IL144381A (en) 2005-08-31
JP3795330B2 (ja) 2006-07-12
EP1157987B1 (en) 2003-09-10
YU53601A (sh) 2004-03-12
AU3046000A (en) 2000-08-18
ID29777A (id) 2001-10-11
AP2001002247A0 (en) 2001-09-30
BR0007395A (pt) 2001-10-30
WO2000044714A1 (es) 2000-08-03
NO326806B1 (no) 2009-02-16
OA11823A (en) 2005-08-16
EP1157987A1 (en) 2001-11-28
PL349006A1 (en) 2002-06-17
ES2147162A1 (es) 2000-08-16
SI1157987T1 (en) 2004-02-29
US6800612B2 (en) 2004-10-05
EE200100389A (et) 2002-12-16
GB0120581D0 (en) 2001-10-17
IS2153B (is) 2006-10-13
GB2363604B (en) 2003-09-10
GB2363604A (en) 2002-01-02
KR20010101767A (ko) 2001-11-14
CA2359027C (en) 2008-10-28
ZA200106182B (en) 2002-10-28
BG64983B1 (bg) 2006-11-30
DE10083902T1 (de) 2002-01-10
CU23098A3 (es) 2005-11-18

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Legal Events

Date Code Title Description
HC1A Change of owner name
KB4A Valid patent at the end of a year

Effective date: 20051231

KB4A Valid patent at the end of a year

Effective date: 20061231

KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

KB4A Valid patent at the end of a year

Effective date: 20101231

MM4A Lapsed by not paying the annual fees

Effective date: 20110119