[go: up one dir, main page]

EE03929B1 - Sünteetilised polüsahhariidid, nende valmistamisemeetod ja neid sisaldavad farmatseutilised kompositsioonid - Google Patents

Sünteetilised polüsahhariidid, nende valmistamisemeetod ja neid sisaldavad farmatseutilised kompositsioonid

Info

Publication number
EE03929B1
EE03929B1 EEP199900015A EE9900015A EE03929B1 EE 03929 B1 EE03929 B1 EE 03929B1 EE P199900015 A EEP199900015 A EE P199900015A EE 9900015 A EE9900015 A EE 9900015A EE 03929 B1 EE03929 B1 EE 03929B1
Authority
EE
Estonia
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
synthetic polysaccharides
polysaccharides
Prior art date
Application number
EEP199900015A
Other languages
English (en)
Estonian (et)
Other versions
EE9900015A (et
Inventor
Alexandre Driguez Pierre
Duchaussoy Philippe
Herbert Jean-Marc
Petitou Maurice
Adriaan Anton Van Boeckel Constant
Grootenhuis Peter
Egbertus Maria Basten Johannes
Maria Dreef-Tromp Corn�lia
Original Assignee
Sanofi
Akzo Nobel N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi, Akzo Nobel N.V. filed Critical Sanofi
Publication of EE9900015A publication Critical patent/EE9900015A/xx
Publication of EE03929B1 publication Critical patent/EE03929B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EEP199900015A 1996-07-19 1997-07-18 Sünteetilised polüsahhariidid, nende valmistamisemeetod ja neid sisaldavad farmatseutilised kompositsioonid EE03929B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9609116A FR2751334B1 (fr) 1996-07-19 1996-07-19 Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant
PCT/FR1997/001344 WO1998003554A1 (fr) 1996-07-19 1997-07-18 Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant

Publications (2)

Publication Number Publication Date
EE9900015A EE9900015A (et) 1999-08-16
EE03929B1 true EE03929B1 (et) 2002-12-16

Family

ID=9494266

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP199900015A EE03929B1 (et) 1996-07-19 1997-07-18 Sünteetilised polüsahhariidid, nende valmistamisemeetod ja neid sisaldavad farmatseutilised kompositsioonid

Country Status (35)

Country Link
US (1) US6534481B1 (id)
EP (1) EP0912613B1 (id)
JP (1) JP3345020B2 (id)
KR (1) KR100311857B1 (id)
CN (1) CN1200003C (id)
AR (1) AR008068A1 (id)
AT (1) ATE224917T1 (id)
AU (1) AU726679B2 (id)
BR (1) BR9710739B1 (id)
CA (1) CA2261597C (id)
CZ (1) CZ301009B6 (id)
DE (1) DE69715866T2 (id)
DK (1) DK0912613T3 (id)
EE (1) EE03929B1 (id)
ES (1) ES2184123T3 (id)
FR (1) FR2751334B1 (id)
HU (1) HU223691B1 (id)
ID (1) ID20604A (id)
IL (2) IL128018A0 (id)
IS (1) IS1968B (id)
MY (1) MY124548A (id)
NO (1) NO319682B1 (id)
NZ (1) NZ333721A (id)
PL (1) PL190397B1 (id)
PT (1) PT912613E (id)
RU (1) RU2167163C2 (id)
SA (1) SA99200037B1 (id)
SI (1) SI0912613T1 (id)
SK (1) SK284881B6 (id)
TR (1) TR199900114T2 (id)
TW (1) TW520376B (id)
UA (1) UA61921C2 (id)
WO (1) WO1998003554A1 (id)
YU (1) YU49247B (id)
ZA (1) ZA976340B (id)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2773801B1 (fr) * 1998-01-19 2000-05-12 Sanofi Sa Nouveaux pentasaccharides, procedes pour leurs preparations et compositions pharmaceutiques les contenant
FR2773804B1 (fr) * 1998-01-19 2000-02-18 Sanofi Sa Polysaccharides de synthese, procede pour leur preparation et compositions pharmaceutiques le contenant
FR2814463B1 (fr) * 2000-09-22 2002-11-15 Sanofi Synthelabo Nouveaux polysaccharides a activite antithrombotique comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine
US7138531B2 (en) * 2001-10-15 2006-11-21 Kemin Pharma B.V.B.A. Preparation and use of carbohydrate-based bicyclic ring structures with antimicrobial and cytostatic activity
TWI318202B (en) * 2003-01-30 2009-12-11 Sankyo Co Oligo acid derivatives
UA81657C2 (ru) * 2003-03-04 2008-01-25 Орто-Макнейл Фармасьютикел, Инк. Способ получения противосудорожных производных топирамата
EP1574516A1 (en) * 2004-03-05 2005-09-14 Sanofi-Aventis Antithrombotic compound
US7563780B1 (en) * 2004-06-18 2009-07-21 Advanced Cardiovascular Systems, Inc. Heparin prodrugs and drug delivery stents formed therefrom
FR2874924B1 (fr) 2004-09-09 2006-12-01 Sanofi Aventis Sa Hexadecasaccharides biotinyles, leur preparation et leur utilisation therapeutique
TWI403334B (zh) * 2004-12-23 2013-08-01 Merck Sharp & Dohme 包含生物素殘基之抗血栓雙重抑制劑
TWI376234B (en) * 2005-02-01 2012-11-11 Msd Oss Bv Conjugates of a polypeptide and an oligosaccharide
EP1991271B1 (en) * 2005-10-10 2011-03-09 N.V. Organon Anticoagulant antithrombotic dual inhibitors comprising a biotin label
IL181431A0 (en) * 2007-02-19 2007-07-04 Micha Shemer Fruit juice and puree with a lowered amount of available sugars
AU2008314505C1 (en) * 2007-10-16 2020-11-05 Progen Pg500 Series Pty Ltd Novel sulfated oligosaccharide derivatives
RU2379684C2 (ru) * 2007-11-29 2010-01-20 Федеральное государственное учреждение "Федеральный центр сердца, крови и эндокринологии имени В.А. Алмазова Федерального агентства по высокотехнологичной медицинской помощи" Способ определения антитромботического эффекта ацетилсалициловой кислоты
BRPI0912277A2 (pt) 2008-05-30 2015-12-22 Momenta Pharmaceuticals Inc estruturas sacarídicas e métodos de preparação e utilização dessas estruturas
FR2935386B1 (fr) * 2008-08-26 2010-09-10 Sanofi Aventis Nouveaux polysaccharides a activite antithrombotique comprenant une liaion covalente avec une chaine amine
EP3666786A1 (en) 2009-07-31 2020-06-17 Reliable Biopharmaceutical Corporation Process for preparing fondaparinux sodium and intermediates useful in the synthesis thereof
FR2949115B1 (fr) 2009-08-14 2012-11-02 Sanofi Aventis OLIGOSACCHARIDES N-SULFATES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2949114B1 (fr) 2009-08-14 2011-08-26 Sanofi Aventis OCTASACCHARIDES N-ACYLES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
US8420790B2 (en) 2009-10-30 2013-04-16 Reliable Biopharmaceutical Corporation Efficient and scalable process for the manufacture of Fondaparinux sodium
KR101682466B1 (ko) * 2010-02-01 2016-12-05 롯데정밀화학 주식회사 아세틸화 셀룰로오스 에테르 및 이를 포함하는 물품
EP2614089A1 (fr) 2010-09-10 2013-07-17 Sanofi-Aventis Polysaccharides biotinyles a activite antithrombotique et presentant une stabilite metabolique amelioree
FR2970969B1 (fr) 2011-01-27 2013-10-18 Sanofi Aventis Oligosaccharides 3-o-alkyles activateurs des recepteurs des fgfs, leur preparation et leur application en therapeutique
CN109134555B (zh) * 2017-06-15 2021-09-28 南京正大天晴制药有限公司 抗凝血的五糖类化合物及其制备方法和医药用途
CN109134554B (zh) * 2017-06-15 2021-09-28 南京正大天晴制药有限公司 抗凝血的五糖类化合物及其制备方法和医药用途
CN109134553B (zh) * 2017-06-15 2021-09-28 南京正大天晴制药有限公司 抗凝血的五糖类化合物及其制备方法和医药用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4801583A (en) 1982-01-15 1989-01-31 Choay S.A. Oligosaccharides and their biological applications
EP0300099A1 (en) 1987-07-20 1989-01-25 Akzo N.V. New pentasaccharides
US5382570A (en) 1990-04-23 1995-01-17 Akzo, N.V. Sulfated glycosaminoglycanoid derivatives of the dermatan sulfate and chondroitin sulfate type
US5378829A (en) 1990-04-23 1995-01-03 Akzo N.V. Sulfated glycosaminoglycanoid derivatives of the heparin and heparan sulfate type
CA2061370A1 (en) * 1991-03-13 1992-09-14 Markus Hosang Pharmaceutical preparations
IL102758A (en) 1991-08-23 1997-03-18 Akzo Nv Glycosaminoglycanoid derivatives, their preparation and pharmaceutical compositions comprising them
FR2704226B1 (fr) 1993-04-22 1995-07-21 Sanofi Elf 3-desoxy oligosaccharides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
IT1270823B (it) * 1993-06-04 1997-05-13 Italfarmaco Spa Polisaccaridi ad elevata attivita' antitrombotica e anticoagulante
ES2147216T3 (es) 1993-09-01 2000-09-01 Akzo Nobel Nv Bisconjugados que comprenden dos sacaridos y un grupo de union.
FR2749849B1 (fr) * 1996-06-14 1998-09-04 Sanofi Sa Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
IL128018A0 (en) 1999-11-30
US6534481B1 (en) 2003-03-18
IL128018A (en) 2007-10-31
CA2261597A1 (fr) 1998-01-29
DE69715866T2 (de) 2003-05-28
AR008068A1 (es) 1999-12-09
NZ333721A (en) 2000-08-25
CA2261597C (fr) 2004-12-14
CZ16099A3 (cs) 1999-06-16
ES2184123T3 (es) 2003-04-01
KR100311857B1 (ko) 2001-11-14
SA99200037B1 (ar) 2006-08-23
NO990215D0 (no) 1999-01-18
AU3774797A (en) 1998-02-10
DK0912613T3 (da) 2003-01-27
NO990215L (no) 1999-03-18
IS1968B (is) 2004-12-15
WO1998003554A1 (fr) 1998-01-29
HK1019757A1 (en) 2000-02-25
FR2751334B1 (fr) 1998-10-16
ZA976340B (en) 1999-01-22
PL331259A1 (en) 1999-07-05
IS4945A (is) 1999-01-18
CN1200003C (zh) 2005-05-04
ATE224917T1 (de) 2002-10-15
HUP9902287A1 (hu) 1999-10-28
KR20000067909A (ko) 2000-11-25
PL190397B1 (pl) 2005-12-30
HU223691B1 (hu) 2004-12-28
YU1999A (sh) 2000-03-21
HUP9902287A3 (en) 2001-09-28
SK284881B6 (sk) 2006-02-02
DE69715866D1 (de) 2002-10-31
PT912613E (pt) 2003-01-31
MY124548A (en) 2006-06-30
RU2167163C2 (ru) 2001-05-20
SK5399A3 (en) 2000-05-16
BR9710739A (pt) 1999-08-17
JP3345020B2 (ja) 2002-11-18
EP0912613B1 (fr) 2002-09-25
NO319682B1 (no) 2005-09-05
UA61921C2 (uk) 2003-12-15
ID20604A (id) 1999-01-21
TW520376B (en) 2003-02-11
SI0912613T1 (en) 2003-04-30
AU726679B2 (en) 2000-11-16
FR2751334A1 (fr) 1998-01-23
EP0912613A1 (fr) 1999-05-06
CZ301009B6 (cs) 2009-10-14
TR199900114T2 (xx) 1999-03-22
JP2000500807A (ja) 2000-01-25
CN1228785A (zh) 1999-09-15
YU49247B (sh) 2004-12-31
BR9710739B1 (pt) 2008-11-18
EE9900015A (et) 1999-08-16

Similar Documents

Publication Publication Date Title
EE9900015A (et) Sünteetilised polüsahhariidid, nende valmistamise meetod ja neid sisaldavad farmatseutilised kompositsioonid
EE9500064A (et) Asendatud 1H-imidasoolid, nende valmistamismeetodid ja farmatseutilised kompositsioonid
EE04498B1 (et) Erütromütsiini derivaadid, nende valmistamismeetod ja neid sisaldav farmatseutiline kompositsioon
EE200000168A (et) Karboksamidotiasoolderivaadid, nende valmistamine ja neid sisaldavad farmatseutilised kompositsioonid
EE200000791A (et) Uudsed atsüülpseudopeptiidid, nende valmistamise meetod ja neid sisaldavad farmatseutilised kompositsioonid
FI963566A0 (fi) Uusia piperatsiinijohdoksia, menetelmiä niiden valmistamiseksi ja niitä sisältäviä koostumuksia
EE9700333A (et) Substitueeritud 4-fenüülaminotiasoolid, nende valmistamise meetod ja neid sisaldavad farmakoloogilised kompositsioonid
EE9700323A (et) Taksoidid, meetod nende valmistamiseks ja neid sisaldavad farmatseutilised kompositsioonid
FI953898L (fi) Glysiiniamidijohdannaisia, menetelmiä niiden valmistamiseksi ja niitä sisältäviä lääkeaineita
FI952550A7 (fi) Uudet N-pyridyylikarboksamidit ja johdannaiset, menetelmät niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset
EE9800426A (et) Asendatud 2,4-tiasolidiindiooni derivaadid, nende valmistamismeetodid ja neid sisaldavad farmatseutilised kompositsioonid
FI943688L (fi) Uudet 11-bentsaldoksiimi-17beta-metoksi-27alfa-metoksi-metyyli-estradieenijohdannaiset, menetelmät niiden valmistamiseksi ja näitä sisältävät lääkeaineet
EE03825B1 (et) 2-tsüanoiminoimidasooli derivaadid, nende valmistamismeetod, kasutamine ja farmatseutilised kompositsioonid
EE200000429A1 (et) Sünteetilised polüsahhariidid, nende valmistamismeetodid ja neid sisaldavad farmatseutilised kompositsioonid
FI950625L (fi) Polysubstituoituja 3-asyyliamino-5-fenyyli-1,4-bentsodiatsepiini-2-onijohdannaisia, menetelmä niiden valmistamiseksi ja niitä sisältäviä farmaseuttisia koostumuksia
FI941836A7 (fi) 3-deoksioligosakkaridit, menetelmiä niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset
FI956278A0 (fi) Substituoituja 4-fenyylitiatsolijohdannaisia, menetelmä niiden valmistamiseksi ja niitä sisältäviä farmaseuttisia koostumuksia
EE9800264A (et) Taksoidid, nende valmistamismeetod ja neid sisaldavad farmatseutilised kompositsioonid
FI960316L (fi) Oksatiolaanit, menetelmä niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset
FI955085L (fi) Uudet diosmetiiniyhdisteet, menetelmä niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset
EE03996B1 (et) Farmatseutilised kompositsioonid, nende valmistamismeetod ja kasutamine
FI951091A7 (fi) Uudet alkyyliaminoindaaniyhdisteet, menetelmät niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset
FI944751A7 (fi) Heteroaryylipiperidiinejä, menetelmä niiden valmistamiseksi ja niitä sisältäviä farmaseuttisia koostumuksia
FI972129A0 (fi) 6-metoksi-1H-bentsotriatsoli-5-karboksamidijohdannaisia, menetelmä niiden valmistamiseksi ja niitä sisältäviä lääkekoostumuksia
FI950818L (fi) Uudet substituoidut sulfoniamidit, menetelmä niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset

Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20021231

KB4A Valid patent at the end of a year

Effective date: 20031231

GB1A Change in the ownership or in the address of the owner
KB4A Valid patent at the end of a year

Effective date: 20041231

KB4A Valid patent at the end of a year

Effective date: 20051231

KB4A Valid patent at the end of a year

Effective date: 20061231

KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

KB4A Valid patent at the end of a year

Effective date: 20091231

KB4A Valid patent at the end of a year

Effective date: 20101231