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ECSP12011747A - DERIVATIVE OF FUSED HETEROCYCLIC RING AND USE OF THE SAME - Google Patents

DERIVATIVE OF FUSED HETEROCYCLIC RING AND USE OF THE SAME

Info

Publication number
ECSP12011747A
ECSP12011747A ECSP12011747A ECSP12011747A EC SP12011747 A ECSP12011747 A EC SP12011747A EC SP12011747 A ECSP12011747 A EC SP12011747A EC SP12011747 A ECSP12011747 A EC SP12011747A
Authority
EC
Ecuador
Prior art keywords
heterocyclic ring
fused heterocyclic
derivative
same
ring derivative
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Satoshi Sasaki
Yuta Tanaka
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43627972&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP12011747(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of ECSP12011747A publication Critical patent/ECSP12011747A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Se describe un derivado de anillo heterocíclico fusionado que tiene actividad de inhibición Smo potente, y el uso del derivado de anillo heterocíclico fusionado. Se describen en forma específica un compuesto representado por la fórmula (CI) [en donde cada símbolo es tal como se define en la descripción] o una sal del mismo; y un agente medicinal que comprende el compuesto o un profármaco del mismo, el cual se puede utilizar como un inhibidor Smo o un agente profiláctico o terapéutico para cáncer.A fused heterocyclic ring derivative having potent Smo inhibition activity, and the use of the fused heterocyclic ring derivative is described. A compound represented by the formula (CI) [wherein each symbol is as defined in the description] or a salt thereof is specifically described; and a medicinal agent comprising the compound or a prodrug thereof, which can be used as a Smo inhibitor or a prophylactic or therapeutic agent for cancer.

ECSP12011747 2009-08-26 2012-03-26 DERIVATIVE OF FUSED HETEROCYCLIC RING AND USE OF THE SAME ECSP12011747A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2009195770 2009-08-26
JP2010015644 2010-01-27

Publications (1)

Publication Number Publication Date
ECSP12011747A true ECSP12011747A (en) 2012-05-30

Family

ID=43627972

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP12011747 ECSP12011747A (en) 2009-08-26 2012-03-26 DERIVATIVE OF FUSED HETEROCYCLIC RING AND USE OF THE SAME

Country Status (24)

Country Link
US (1) US8907089B2 (en)
EP (1) EP2471790B1 (en)
JP (1) JP5599802B2 (en)
KR (1) KR20120078703A (en)
CN (1) CN102574851A (en)
AU (1) AU2010287492A1 (en)
BR (1) BR112012004134A2 (en)
CA (1) CA2771833A1 (en)
CL (1) CL2012000461A1 (en)
CR (1) CR20120095A (en)
DO (1) DOP2012000048A (en)
EA (1) EA201270311A1 (en)
EC (1) ECSP12011747A (en)
GE (1) GEP20146075B (en)
IL (1) IL218323A0 (en)
IN (1) IN2012DN02069A (en)
MA (1) MA33589B1 (en)
MX (1) MX2012002419A (en)
NZ (1) NZ598749A (en)
PE (1) PE20121326A1 (en)
SG (1) SG178504A1 (en)
TN (1) TN2012000084A1 (en)
WO (1) WO2011024872A1 (en)
ZA (1) ZA201201795B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5659159B2 (en) * 2009-08-26 2015-01-28 武田薬品工業株式会社 Fused heterocyclic derivatives and uses thereof
KR20150128842A (en) 2013-03-14 2015-11-18 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 Furopyridines as bromodomain inhibitors

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6436965B1 (en) 2000-03-02 2002-08-20 Merck Frosst Canada & Co. PDE IV inhibiting amides, compositions and methods of treatment
WO2002012189A1 (en) 2000-08-09 2002-02-14 Mitsubishi Pharma Corporation Fused bicyclic amide compounds and medicinal use thereof
CA2469435A1 (en) 2001-12-21 2003-07-24 X-Ceptor Therapeutics, Inc. Modulators of lxr
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
AU2003265853A1 (en) 2002-08-29 2004-03-19 Curis, Inc. Hedgehog antagonists, methods and uses related thereto
US8067608B2 (en) 2003-09-29 2011-11-29 The Johns Hopkins University Hedgehog pathway antagonists
US20050203081A1 (en) 2004-02-25 2005-09-15 Jinbo Lee Inhibitors of protein tyrosine phosphatase 1B
GB0420722D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
WO2008057468A1 (en) 2006-11-02 2008-05-15 Curis, Inc. Small organic molecule regulators of cell proliferation
WO2008057469A1 (en) 2006-11-02 2008-05-15 Wyeth Small organic molecule regulators of cell proliferation
HRP20161562T2 (en) 2007-06-29 2017-04-21 Pfizer Inc. BENZIMIDAZOL DERIVATIVES
RU2364597C1 (en) 2007-12-14 2009-08-20 Андрей Александрович Иващенко HETEROCYCLIC INHIBITORS OF Hh-SYGNAL CASCADE, BASED ON THEM MEDICINAL COMPOSITIONS AND METHOD OF TREATING DISEASES INDUCED BY ABBARANT ACTIVITY OF Hh-SIGNAL SYSTEM
JP4685891B2 (en) 2008-02-19 2011-05-18 株式会社ハネックス Separation device
KR101569949B1 (en) 2008-02-26 2015-11-18 다케다 야쿠힌 고교 가부시키가이샤 Fused heterocyclic derivative and use thereof
JP2010015644A (en) 2008-07-04 2010-01-21 Fujitsu Ltd Spindle system, electromagnetic conversion property evaluating apparatus and information storage device
GB0900484D0 (en) 2009-01-13 2009-02-11 Angeletti P Ist Richerche Bio Therapeutic agent

Also Published As

Publication number Publication date
GEP20146075B (en) 2014-04-10
EP2471790B1 (en) 2015-03-18
CR20120095A (en) 2012-06-26
DOP2012000048A (en) 2012-05-15
MA33589B1 (en) 2012-09-01
SG178504A1 (en) 2012-04-27
CL2012000461A1 (en) 2012-10-05
EP2471790A4 (en) 2013-07-31
CA2771833A1 (en) 2011-03-03
US8907089B2 (en) 2014-12-09
KR20120078703A (en) 2012-07-10
IL218323A0 (en) 2012-04-30
EP2471790A1 (en) 2012-07-04
AU2010287492A1 (en) 2012-03-29
JP5599802B2 (en) 2014-10-01
BR112012004134A2 (en) 2017-06-20
EA201270311A1 (en) 2012-09-28
CN102574851A (en) 2012-07-11
IN2012DN02069A (en) 2015-08-21
PE20121326A1 (en) 2012-10-11
JPWO2011024872A1 (en) 2013-01-31
MX2012002419A (en) 2012-04-19
US20120220570A1 (en) 2012-08-30
ZA201201795B (en) 2013-05-29
WO2011024872A1 (en) 2011-03-03
TN2012000084A1 (en) 2013-09-19
NZ598749A (en) 2013-01-25

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