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ECSP088824A - Prolinamidas sustituidas, su preparación y su uso como medicamentos - Google Patents

Prolinamidas sustituidas, su preparación y su uso como medicamentos

Info

Publication number
ECSP088824A
ECSP088824A EC2008008824A ECSP088824A ECSP088824A EC SP088824 A ECSP088824 A EC SP088824A EC 2008008824 A EC2008008824 A EC 2008008824A EC SP088824 A ECSP088824 A EC SP088824A EC SP088824 A ECSP088824 A EC SP088824A
Authority
EC
Ecuador
Prior art keywords
medicines
preparation
prolinamides
substituted
substituted prolinamides
Prior art date
Application number
EC2008008824A
Other languages
English (en)
Inventor
Kai Gerlach
Roland Pfau
Henning Priepke
Wolfgang Wienen
Annette Maria Schuler-Metz
Georg Dahmann
Herbert Nar
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of ECSP088824A publication Critical patent/ECSP088824A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Son objeto de la presente invención nuevas prolinamidas sustituidas de la fórmula general (I) (I)en donde D, L, E, G, J, M, R3, R4, R5 y R13 se definen como en la descripción, sus tautómeros, sus enantiómeros, sus diastereómeros, sus mezclas y sus sales, en especial sus sales fisiológicamente tolerables con ácidos o bases inorgánicos u orgánicos, que presentan valiosas propiedades.
EC2008008824A 2006-05-16 2008-10-15 Prolinamidas sustituidas, su preparación y su uso como medicamentos ECSP088824A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06113977 2006-05-16
EP07102566 2007-02-16

Publications (1)

Publication Number Publication Date
ECSP088824A true ECSP088824A (es) 2008-11-27

Family

ID=38646563

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2008008824A ECSP088824A (es) 2006-05-16 2008-10-15 Prolinamidas sustituidas, su preparación y su uso como medicamentos

Country Status (24)

Country Link
US (1) US7807693B2 (es)
EP (1) EP2051975B1 (es)
JP (1) JP5263686B2 (es)
KR (1) KR101422456B1 (es)
AR (1) AR060945A1 (es)
AU (1) AU2007251614B2 (es)
BR (1) BRPI0711648A2 (es)
CA (1) CA2653753C (es)
CL (1) CL2007001391A1 (es)
DK (1) DK2051975T3 (es)
EA (1) EA200802210A1 (es)
EC (1) ECSP088824A (es)
ES (1) ES2395538T3 (es)
HK (1) HK1131140A1 (es)
IL (1) IL195245A (es)
MX (1) MX2008014499A (es)
MY (1) MY146623A (es)
NO (1) NO20084530L (es)
NZ (1) NZ573573A (es)
PE (1) PE20080702A1 (es)
PL (1) PL2051975T3 (es)
TW (1) TW200813047A (es)
UY (1) UY30352A1 (es)
WO (1) WO2007131982A2 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1975165A1 (de) 2007-03-27 2008-10-01 Boehringer Ingelheim Pharma GmbH & Co. KG Substituierte Pyrrolidinamide, deren Herstellung und deren Verwendung als Arzneimittel
EP2220079A2 (en) 2007-11-15 2010-08-25 Boehringer Ingelheim International GmbH Substituted amides, manufacturing and use thereof as medicaments
US20110046130A1 (en) * 2008-03-31 2011-02-24 Evotec Ag Tetrahydronaphthyridines and aza derivatives thereof as histamine h3 receptor antagonists
GB201209138D0 (en) 2012-05-24 2012-07-04 Ono Pharmaceutical Co Compounds
JP6052527B2 (ja) 2013-02-21 2016-12-27 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ジヒドロプテリジノンｉ
JP6337750B2 (ja) * 2013-11-22 2018-06-06 小野薬品工業株式会社 化合物
EA031804B1 (ru) 2014-02-03 2019-02-28 Вайтаи Фармасьютиклз, Инк. Дигидропирролопиридиновые ингибиторы ror-гамма
NZ762034A (en) * 2014-03-07 2022-02-25 Biocryst Pharm Inc Human plasma kallikrein inhibitors
UA118989C2 (uk) 2014-10-14 2019-04-10 Вітае Фармасьютікалс, Інк. Дигідропіролопіридинові інгібітори ror-гамма
US9663515B2 (en) 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
US9845308B2 (en) 2014-11-05 2017-12-19 Vitae Pharmaceuticals, Inc. Isoindoline inhibitors of ROR-gamma
EP3078378B1 (en) 2015-04-08 2020-06-24 Vaiomer Use of factor xa inhibitors for regulating glycemia
EP3331876B1 (en) 2015-08-05 2020-10-07 Vitae Pharmaceuticals, LLC Modulators of ror-gamma
EP3377482B1 (en) 2015-11-20 2021-05-12 Vitae Pharmaceuticals, LLC Modulators of ror-gamma
TW202220968A (zh) 2016-01-29 2022-06-01 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
US9481674B1 (en) 2016-06-10 2016-11-01 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
WO2019018975A1 (en) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. INHIBITORS OF ROR GAMMA
US10913739B2 (en) 2017-07-24 2021-02-09 Vitae Pharmaceuticals, LLC (121374) Inhibitors of RORγ
CN114646701B (zh) * 2022-03-01 2023-09-29 浙江国邦药业有限公司 一种l-脯氨酰胺中有关物质的hplc测试方法
WO2024214038A1 (en) * 2023-04-14 2024-10-17 Pfizer Inc. Glucose-dependent insulinotropic polypeptide receptor antagonists and uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7030141B2 (en) * 2001-11-29 2006-04-18 Christopher Franklin Bigge Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade
JP3975254B2 (ja) * 2002-07-25 2007-09-12 日野自動車株式会社 チャイルドシート用アンカの取付構造
CA2521069C (en) 2003-04-03 2012-09-18 Merck Patent Gesellschaft Mit Beschraenkter Haftung Pyrrolidino-1,2-dicarboxy-1-(phenylamide)-2-(4-(3-oxo-morpholino-4-yl)-phenylamide) derivatives and related compounds for use as inhibitors of coagulation factor xa in the treatment of thrombo-embolic diseases
DE10329457A1 (de) 2003-04-03 2005-01-20 Merck Patent Gmbh Ethinylprolinderivate
JP5015593B2 (ja) 2003-06-18 2012-08-29 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 血栓症の治療のための凝固因子ＸａおよびＶＩＩａの阻害剤としての１−［（４−エチニルフェニル）］−２−［（フェニル）］−ピロリジン−１，２−ジカルボキサミド誘導体
ES2223277B1 (es) 2003-06-19 2006-03-01 Fernando Bouffard Fita Composicion anestesica para administracion topica.
DE10358814A1 (de) 2003-12-16 2005-07-21 Merck Patent Gmbh Prolinylarylacetamide
DE102004014945A1 (de) 2004-03-26 2005-10-13 Merck Patent Gmbh Prolinylderivate
US7453002B2 (en) * 2004-06-15 2008-11-18 Bristol-Myers Squibb Company Five-membered heterocycles useful as serine protease inhibitors
DE102004045796A1 (de) 2004-09-22 2006-03-23 Merck Patent Gmbh Arzneimittel enthaltend Carbonylverbindungen sowie deren Verwendung
WO2006108709A1 (en) 2005-04-11 2006-10-19 Glaxo Group Limited 3-sulfonylamino-pyrrolidine-2-one derivatives as factor xa inhibitors
EP1907388A1 (en) 2005-07-15 2008-04-09 F. Hoffmann-Roche AG Novel heteroaryl fused cyclic amines

Also Published As

Publication number Publication date
AR060945A1 (es) 2008-07-23
JP2009537483A (ja) 2009-10-29
AU2007251614B2 (en) 2013-01-17
US7807693B2 (en) 2010-10-05
WO2007131982A3 (de) 2008-01-10
KR101422456B1 (ko) 2014-07-23
CA2653753A1 (en) 2007-11-22
PL2051975T3 (pl) 2013-01-31
AU2007251614A1 (en) 2007-11-22
PE20080702A1 (es) 2008-07-10
WO2007131982A2 (de) 2007-11-22
ES2395538T3 (es) 2013-02-13
MX2008014499A (es) 2008-11-27
KR20090017523A (ko) 2009-02-18
UY30352A1 (es) 2008-01-02
US20080139605A1 (en) 2008-06-12
CA2653753C (en) 2013-09-24
TW200813047A (en) 2008-03-16
EP2051975B1 (de) 2012-09-12
IL195245A (en) 2012-09-24
JP5263686B2 (ja) 2013-08-14
DK2051975T3 (da) 2012-10-15
NO20084530L (no) 2008-12-12
BRPI0711648A2 (pt) 2011-11-29
CL2007001391A1 (es) 2008-01-18
IL195245A0 (en) 2009-09-22
HK1131140A1 (en) 2010-01-15
EA200802210A1 (ru) 2009-06-30
MY146623A (en) 2012-09-14
EP2051975A2 (de) 2009-04-29
NZ573573A (en) 2011-10-28

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