ECSP088348A - Composiciones de suplemento de hierro con tolerancia mejorada - Google Patents
Composiciones de suplemento de hierro con tolerancia mejoradaInfo
- Publication number
- ECSP088348A ECSP088348A EC2008008348A ECSP088348A ECSP088348A EC SP088348 A ECSP088348 A EC SP088348A EC 2008008348 A EC2008008348 A EC 2008008348A EC SP088348 A ECSP088348 A EC SP088348A EC SP088348 A ECSP088348 A EC SP088348A
- Authority
- EC
- Ecuador
- Prior art keywords
- iron
- effective amount
- patient
- absorb
- composition
- Prior art date
Links
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title abstract 14
- 229910052742 iron Inorganic materials 0.000 title abstract 7
- 239000000203 mixture Substances 0.000 title abstract 7
- 239000013589 supplement Substances 0.000 title abstract 3
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical class [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 abstract 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 2
- 206010022971 Iron Deficiencies Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 208000015710 Iron-Deficiency Anemia Diseases 0.000 abstract 1
- 102000004338 Transferrin Human genes 0.000 abstract 1
- 108090000901 Transferrin Proteins 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 229960005070 ascorbic acid Drugs 0.000 abstract 1
- 235000010323 ascorbic acid Nutrition 0.000 abstract 1
- 239000011668 ascorbic acid Substances 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 150000004676 glycans Chemical class 0.000 abstract 1
- 230000007246 mechanism Effects 0.000 abstract 1
- 230000008288 physiological mechanism Effects 0.000 abstract 1
- 229920001282 polysaccharide Polymers 0.000 abstract 1
- 239000005017 polysaccharide Substances 0.000 abstract 1
- 229940078042 polysaccharide iron complex Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 210000000813 small intestine Anatomy 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 239000012581 transferrin Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/721—Dextrans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Obesity (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Los inventores han encontrado que administrando una composición de suplemento férrico oral, que contiene las sales de hierro ferrosas y el PlC, proporciona un inesperadamente bien tolerado método para tratar la anemia por deficiencia férrica, y proporciona una composición que puede administrarse a una amplia variedad de pacientes, sin tener en cuenta su habilidad de absorber hierro a través de un mecanismo fisiológico particular. Particularmente, las composiciones de la invención proporcionan niveles terapéuticos de hierro en la sangre, con tolerancia inesperadamente incrementada, independiente de la habilidad del paciente de absorber hierro vía un mecanismo de absorción particular. Si el paciente es incapaz de absorber hierro ferrroso (por ejemplo, debido a bajos niveles de ácido ascórbico, efectos gastrointestinales colaterales, etc.), entonces hierro suficiente está disponible a través del PlC administrado en la composición de la invención. Si el paciente es incapaz de absorber el PlC debido a insuficiente transferrina en el intestino delgado, entonces suficiente hierro está disponible a través del hierro ferrroso administrado.Como resultado de este descubrimiento, la presente invención se relaciona a una composición de suplemento de hierro oralmente administrable, para el tratamiento o profiláctica de deficiencia férrica, comprendiendo:una cantidad eficaz de sal de hierro ferrroso farmacéuticamente aceptable; yuna cantidad eficaz de complejo de hierro polisacárido.La invención también se relaciona a un método para el tratamiento o profiláctica de deficiencia férrica, comprendiendo:la administración al paciente en necesidad de ello una cantidad eficaz de una composición que comprenda:una cantidad eficaz de sal de hierro ferrrosa farmacéuticamente aceptable; y una cantidad eficaz de complejo férrico polisacárido.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/243,043 US20070077313A1 (en) | 2005-10-04 | 2005-10-04 | Toleration iron supplement compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP088348A true ECSP088348A (es) | 2008-07-30 |
Family
ID=37902204
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2008008348A ECSP088348A (es) | 2005-10-04 | 2008-04-04 | Composiciones de suplemento de hierro con tolerancia mejorada |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20070077313A1 (es) |
| EP (1) | EP1945032A4 (es) |
| CA (1) | CA2624619C (es) |
| CR (1) | CR9857A (es) |
| CU (1) | CU23776B7 (es) |
| EC (1) | ECSP088348A (es) |
| HN (1) | HN2008000582A (es) |
| SV (1) | SV2009002862A (es) |
| TW (1) | TWI358299B (es) |
| WO (1) | WO2007044180A2 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7658938B2 (en) | 1999-02-22 | 2010-02-09 | Merrion Reasearch III Limited | Solid oral dosage form containing an enhancer |
| EP2007397B1 (en) * | 2006-04-07 | 2013-07-24 | Merrion Research III Limited | Solid oral dosage form containing an enhancer |
| BRPI0912384A2 (pt) * | 2008-05-07 | 2015-10-13 | Merrion Res Iii Ltd | composição, e, método para preparar uma composição |
| TWI480286B (zh) * | 2009-02-25 | 2015-04-11 | Merrion Res Iii Ltd | 雙膦酸鹽類組合物及藥物遞送 |
| US20110182985A1 (en) * | 2010-01-28 | 2011-07-28 | Coughlan David C | Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof |
| WO2011120033A1 (en) * | 2010-03-26 | 2011-09-29 | Merrion Research Iii Limited | Pharmaceutical compositions of selective factor xa inhibitors for oral administration |
| CN103476419A (zh) * | 2011-01-07 | 2013-12-25 | 梅里翁第三研究有限公司 | 口服投药的含铁药物组合物 |
| CN102167752B (zh) * | 2011-05-23 | 2012-08-08 | 华南理工大学 | 一种水溶性大豆多糖亚铁配合物的制备方法 |
| EP3157516A4 (en) | 2014-06-22 | 2017-12-13 | Dexcel Pharma Technologies Ltd. | Pharmaceutical compositions comprising ferric citrate and methods for the production thereof |
| ES2975708T3 (es) | 2015-01-29 | 2024-07-12 | Novo Nordisk As | Comprimidos que comprenden agonista del GLP-1 y recubrimiento entérico |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3821192A (en) * | 1971-08-18 | 1974-06-28 | Central Pharmacal Co | Process for preparing an iron-saccharide complex |
| IT1251702B (it) * | 1991-10-16 | 1995-05-19 | Mediolanum Farmaceutici Srl | Complessi del ferro con la conalbumina e i suoi derivati |
| ATE446108T1 (de) * | 1999-04-09 | 2009-11-15 | Amag Pharmaceuticals Inc | Hitzebeständige umhüllte kolloidale eisenoxide |
| US20030190355A1 (en) * | 2002-04-05 | 2003-10-09 | Hermelin Marc S. | Modified release minerals |
| US7994217B2 (en) * | 2002-05-02 | 2011-08-09 | Xanodyne Pharmaceuticals, Inc. | Prenatal multivitamin/multimineral supplement |
| EP1542658B1 (en) * | 2002-08-15 | 2010-12-29 | Euro-Celtique S.A. | Pharmaceutical compositions comprising an opioid analgesic |
| CN1933873A (zh) * | 2004-03-19 | 2007-03-21 | 沃纳奇尔科特公司 | 延长周期的多相口服避孕方法 |
| US7585527B2 (en) * | 2005-09-19 | 2009-09-08 | Bala Venkataraman | Composition and method for treating iron deficiency anemia |
-
2005
- 2005-10-04 US US11/243,043 patent/US20070077313A1/en not_active Abandoned
-
2006
- 2006-09-14 WO PCT/US2006/035975 patent/WO2007044180A2/en active Application Filing
- 2006-09-14 CA CA2624619A patent/CA2624619C/en active Active
- 2006-09-14 EP EP06824970A patent/EP1945032A4/en not_active Ceased
- 2006-09-22 TW TW095135061A patent/TWI358299B/zh active
-
2008
- 2008-04-01 CR CR9857A patent/CR9857A/es unknown
- 2008-04-03 HN HN2008000582A patent/HN2008000582A/es unknown
- 2008-04-04 CU CU20080054A patent/CU23776B7/es active IP Right Grant
- 2008-04-04 SV SV2008002862A patent/SV2009002862A/es unknown
- 2008-04-04 EC EC2008008348A patent/ECSP088348A/es unknown
-
2010
- 2010-11-08 US US12/941,571 patent/US20110052722A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| SV2009002862A (es) | 2009-01-27 |
| HN2008000582A (es) | 2011-11-09 |
| TWI358299B (en) | 2012-02-21 |
| CA2624619A1 (en) | 2007-04-19 |
| EP1945032A4 (en) | 2009-04-15 |
| EP1945032A2 (en) | 2008-07-23 |
| US20070077313A1 (en) | 2007-04-05 |
| CR9857A (es) | 2008-07-29 |
| CA2624619C (en) | 2018-03-13 |
| CU23776B7 (es) | 2012-02-15 |
| WO2007044180A2 (en) | 2007-04-19 |
| US20110052722A1 (en) | 2011-03-03 |
| CU20080054A7 (es) | 2010-08-30 |
| WO2007044180A3 (en) | 2007-07-12 |
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