ECSP056246A - DERIVADOS DE PIRROLO [3,4-c]PIRAZOL ACTIVOS COMO INHIBIDORES DE QUINASA - Google Patents
DERIVADOS DE PIRROLO [3,4-c]PIRAZOL ACTIVOS COMO INHIBIDORES DE QUINASAInfo
- Publication number
- ECSP056246A ECSP056246A EC2005006246A ECSP056246A ECSP056246A EC SP056246 A ECSP056246 A EC SP056246A EC 2005006246 A EC2005006246 A EC 2005006246A EC SP056246 A ECSP056246 A EC SP056246A EC SP056246 A ECSP056246 A EC SP056246A
- Authority
- EC
- Ecuador
- Prior art keywords
- pirazol
- assets
- derivatives
- pirrolo
- quinase
- Prior art date
Links
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical class C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002074 deregulated effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
- QBMRFAZXVYJCCO-UHFFFAOYSA-N pyrrolo[3,4-c]pyrazole Chemical class N1=NC=C2C=NC=C21 QBMRFAZXVYJCCO-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se divulgan derivados de pirrolo[3,4-c]pirazol de fórmula (I) y sus sales farmacéuticamente aceptables, según se define en la memoria, un procedimiento para su preparación y composiciones farmacéuticas que los comprenden, los compuestos de la invención pueden ser útiles, en terapia, en el tratamiento de enfermedades asociadas con una actividad desregulada de la proteína quinasa, como el cáncer.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48581403P | 2003-07-09 | 2003-07-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP056246A true ECSP056246A (es) | 2006-04-19 |
Family
ID=34062099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2005006246A ECSP056246A (es) | 2003-07-09 | 2005-12-22 | DERIVADOS DE PIRROLO [3,4-c]PIRAZOL ACTIVOS COMO INHIBIDORES DE QUINASA |
Country Status (41)
| Country | Link |
|---|---|
| US (2) | US7141568B2 (es) |
| EP (1) | EP1644376B1 (es) |
| JP (1) | JP4728232B2 (es) |
| KR (1) | KR101075711B1 (es) |
| CN (1) | CN100564380C (es) |
| AP (1) | AP2214A (es) |
| AR (1) | AR050045A1 (es) |
| AT (1) | ATE480540T1 (es) |
| AU (1) | AU2004255347B2 (es) |
| BR (1) | BRPI0411868B8 (es) |
| CA (1) | CA2531759C (es) |
| CR (1) | CR8171A (es) |
| CY (1) | CY1110832T1 (es) |
| DE (1) | DE602004029045D1 (es) |
| DK (1) | DK1644376T3 (es) |
| DO (1) | DOP2004000949A (es) |
| EA (1) | EA009462B1 (es) |
| EC (1) | ECSP056246A (es) |
| ES (1) | ES2349780T3 (es) |
| GE (1) | GEP20084395B (es) |
| GT (2) | GT200400133AA (es) |
| HN (1) | HN2004000232A (es) |
| IL (1) | IL172923A (es) |
| IS (1) | IS2843B (es) |
| MA (1) | MA28064A1 (es) |
| ME (1) | MEP51908A (es) |
| MX (1) | MXPA06000362A (es) |
| MY (1) | MY139072A (es) |
| NO (1) | NO332361B1 (es) |
| NZ (1) | NZ544514A (es) |
| PA (1) | PA8606201A1 (es) |
| PE (1) | PE20050325A1 (es) |
| PL (1) | PL1644376T3 (es) |
| PT (1) | PT1644376E (es) |
| RS (2) | RS20060004A (es) |
| SI (1) | SI1644376T1 (es) |
| TN (1) | TNSN06009A1 (es) |
| TW (1) | TWI343382B (es) |
| UA (1) | UA81682C2 (es) |
| WO (1) | WO2005005427A1 (es) |
| ZA (1) | ZA200600095B (es) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK1882003A3 (en) * | 2000-08-10 | 2003-06-03 | Pharmacia Italia Spa | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
| AU2004276341B2 (en) * | 2003-09-23 | 2011-04-14 | Vertex Pharmaceuticals Incorporated | Pyrazolopyrrole derivatives as protein kinase inhibitors |
| JP2007514759A (ja) * | 2003-12-19 | 2007-06-07 | タケダ サン ディエゴ インコーポレイテッド | キナーゼ阻害剤 |
| WO2005105788A1 (en) * | 2004-04-23 | 2005-11-10 | Takeda San Diego, Inc. | Indole derivatives and use thereof as kinase inhibitors |
| US7550598B2 (en) * | 2004-08-18 | 2009-06-23 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| US7713973B2 (en) * | 2004-10-15 | 2010-05-11 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| PT1838718E (pt) | 2005-01-10 | 2011-08-17 | Pfizer | Pirrolopirazoles, inibidores potentes da quinase |
| US8119655B2 (en) * | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| TW200808311A (en) * | 2006-03-30 | 2008-02-16 | Nerviano Medical Sciences Srl | Use of a kinase inhibitor for the treatment of particular resistant tumors |
| WO2008017465A1 (en) * | 2006-08-10 | 2008-02-14 | F. Hoffmann-La Roche Ag | Bicyclic lactam derivatives, their manufacture and use as pharmaceutical agents |
| BRPI0719883A2 (pt) | 2006-10-09 | 2015-05-05 | Takeda Pharmaceutical | Inibidores de quinase |
| EP2223925A1 (en) * | 2006-10-09 | 2010-09-01 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| JP5547487B2 (ja) * | 2006-11-03 | 2014-07-16 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | 抗癌化合物の投与方法 |
| CL2009001158A1 (es) * | 2008-05-15 | 2009-10-23 | Nerviano Medical Sciences Srl | Compuestos derivados de los acidos carboxilicos, tales como 5,6-dihiro-4h-pirrolo[3,4-c]pirazol, furo[3,2-c]pirazol, tieno[2,3-c]pirazol, 4,5,6,7-tetrahidropirazol[4,3-c]piridina e indazol; composicion farmaceutica; y su uso en el tratamiento de trastornos proliferativos celulares asociados a la actividad de proteina quinasa alterada, tal como el cancer. |
| US20100022553A1 (en) * | 2008-07-24 | 2010-01-28 | Nerviano Medical Sciences S.R.L. | Therapeutic Combination Comprising an Aurora Kinase Inhibitor and Imatinib |
| US20110129467A1 (en) * | 2008-07-24 | 2011-06-02 | Nerviano Medical Sciences S.R.L. | Therapeutic combination comprising an aurora kinase inhibitor and antiproliferative agents |
| WO2010009967A1 (en) * | 2008-07-24 | 2010-01-28 | Nerviano Medical Sciences S.R.L. | Therapeutic combination comprising an aurora kinase inhibitor and an antineoplastic agent |
| KR101741168B1 (ko) | 2008-12-22 | 2017-05-29 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 오로라 키나아제 억제제 및 항ｃｄ 항체의 병용 |
| EA025352B1 (ru) | 2011-12-12 | 2016-12-30 | Др. Редди'С Лабораториз Лтд. | ЗАМЕЩЕННЫЕ СОЕДИНЕНИЯ ПИРАЗОЛО[1,5-a]ПИРИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ ТРОПОМИОЗИН-РЕЦЕПТОРНОЙ КИНАЗЫ (Trk) |
| CN104072498B (zh) * | 2013-03-26 | 2016-12-28 | 沈阳药科大学 | （R）‑N‑[5‑(2‑甲氧基‑2‑苯基乙酰基)‑1,4,5,6‑四氢吡咯并[3,4‑c]吡唑‑3‑基]‑4‑(4‑甲基哌嗪‑1‑基)苯甲酰胺的合成方法 |
| JP6525474B2 (ja) | 2013-12-06 | 2019-06-05 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | オーロラキナーゼ阻害剤と抗ｃｄ３０抗体の併用 |
| CA2953177C (en) | 2014-06-23 | 2019-07-23 | Dr. Reddy's Laboratories Ltd. | Substituted imidazo[1,2-a]pyridine compounds useful for the treatment of pain |
| JP6787314B2 (ja) | 2015-06-15 | 2020-11-18 | 宇部興産株式会社 | 置換ジヒドロピロロピラゾール誘導体 |
| JP2018524292A (ja) | 2015-07-21 | 2018-08-30 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | オーロラキナーゼインヒビターと化学療法剤の投与 |
| CN107337674B (zh) * | 2016-04-29 | 2019-09-20 | 江苏吉贝尔药业股份有限公司 | 用于dpp-iv抑制剂的四氢吡喃胺衍生物、其药物组合物和制剂以及用途 |
| US11874276B2 (en) | 2018-04-05 | 2024-01-16 | Dana-Farber Cancer Institute, Inc. | STING levels as a biomarker for cancer immunotherapy |
| WO2021041532A1 (en) | 2019-08-26 | 2021-03-04 | Dana-Farber Cancer Institute, Inc. | Use of heparin to promote type 1 interferon signaling |
| CN113563346A (zh) * | 2021-08-19 | 2021-10-29 | 守恒(厦门)医疗科技有限公司 | 吡咯[3,4-c]并吡唑二酰胺类衍生物及其在抗肿瘤药物中的应用 |
| WO2023196959A1 (en) | 2022-04-07 | 2023-10-12 | Eli Lilly And Company | Process for making a kras g12c inhibitor |
| CN119546309A (zh) | 2022-04-08 | 2025-02-28 | 伊莱利利公司 | 包括kras g12c抑制剂和aurora a抑制剂的治疗方法 |
| WO2024006424A1 (en) | 2022-06-30 | 2024-01-04 | Eli Lilly And Company | Kras g12c inhibitor for treating cancer |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2717380B1 (fr) * | 1994-03-15 | 1996-04-26 | Oreal | Compositions cosmétiques contenant un mélange synergétique de polymères conditionneurs. |
| GB9911053D0 (en) | 1999-05-12 | 1999-07-14 | Pharmacia & Upjohn Spa | 4,5,6,7-tetrahydroindazole derivatives process for their preparation and their use as antitumour agents |
| DE19932144A1 (de) * | 1999-07-09 | 2001-01-11 | Basf Ag | Mikrokapselzubereitungen und Mikrokapseln enthaltende Wasch- und Reinigungsmittel |
| US6387900B1 (en) | 1999-08-12 | 2002-05-14 | Pharmacia & Upjohn S.P.A. | 3(5)-ureido-pyrazole derivatives process for their preparation and their use as antitumor agents |
| US7034049B1 (en) | 1999-08-12 | 2006-04-25 | Pharmacia Italia S.P.A. | 3(5)-amino-pyrazole derivatives, process for their preparation and their use as antitumor agents |
| SK1882003A3 (en) | 2000-08-10 | 2003-06-03 | Pharmacia Italia Spa | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
| FR2815032B1 (fr) | 2000-10-10 | 2003-08-08 | Pf Medicament | Nouveaux derives d'aminophenyle piperazine ou d'amino phenyle piperide inhibiteurs de proteines prenyl transferase ainsi que leurs preparations |
| AU2002215053A1 (en) | 2000-11-27 | 2002-06-24 | Pharmacia Italia S.P.A. | Phenylacetamido- pyrazole derivatives and their use as antitumor agents |
| CA2434066A1 (en) | 2001-01-26 | 2002-09-12 | Pharmacia Italia S.P.A. | Chromane derivatives, process for their preparation and their use as antitumor agents |
| ES2380054T3 (es) | 2001-09-26 | 2012-05-08 | Pfizer Italia S.R.L. | Derivados de aminoindazol activos como inhibidores de quinasas, procedimientos para su preparación, y composiciones farmacéuticas que los contienen |
| BR0312924A (pt) | 2002-07-25 | 2005-07-12 | Pharmacia Italia Spa | Biciclo-pirazóis ativos como inibidores de quinase, processo para sua preparação e composições farmacêuticas compreendendo os mesmos |
-
2004
- 2004-07-01 US US10/882,493 patent/US7141568B2/en not_active Expired - Lifetime
- 2004-07-08 NZ NZ544514A patent/NZ544514A/xx not_active IP Right Cessation
- 2004-07-08 EA EA200600209A patent/EA009462B1/ru not_active IP Right Cessation
- 2004-07-08 CA CA2531759A patent/CA2531759C/en not_active Expired - Fee Related
- 2004-07-08 ME MEP-519/08A patent/MEP51908A/xx unknown
- 2004-07-08 CN CNB2004800195930A patent/CN100564380C/zh not_active Expired - Fee Related
- 2004-07-08 SI SI200431502T patent/SI1644376T1/sl unknown
- 2004-07-08 BR BRPI0411868A patent/BRPI0411868B8/pt not_active IP Right Cessation
- 2004-07-08 MX MXPA06000362A patent/MXPA06000362A/es active IP Right Grant
- 2004-07-08 PL PL04763132T patent/PL1644376T3/pl unknown
- 2004-07-08 DK DK04763132.0T patent/DK1644376T3/da active
- 2004-07-08 RS YUP-2006/0004A patent/RS20060004A/sr unknown
- 2004-07-08 AP AP2006003480A patent/AP2214A/xx active
- 2004-07-08 PE PE2004000657A patent/PE20050325A1/es not_active Application Discontinuation
- 2004-07-08 JP JP2006518148A patent/JP4728232B2/ja not_active Expired - Fee Related
- 2004-07-08 DE DE602004029045T patent/DE602004029045D1/de not_active Expired - Lifetime
- 2004-07-08 EP EP04763132A patent/EP1644376B1/en not_active Expired - Lifetime
- 2004-07-08 GE GEAP20049209A patent/GEP20084395B/en unknown
- 2004-07-08 ES ES04763132T patent/ES2349780T3/es not_active Expired - Lifetime
- 2004-07-08 RS RS20060004A patent/RS52155B/sr unknown
- 2004-07-08 PT PT04763132T patent/PT1644376E/pt unknown
- 2004-07-08 WO PCT/EP2004/007515 patent/WO2005005427A1/en not_active Ceased
- 2004-07-08 AT AT04763132T patent/ATE480540T1/de active
- 2004-07-08 KR KR1020067000310A patent/KR101075711B1/ko not_active Expired - Fee Related
- 2004-07-08 AU AU2004255347A patent/AU2004255347B2/en not_active Ceased
- 2004-07-08 TW TW093120474A patent/TWI343382B/zh not_active IP Right Cessation
- 2004-07-09 PA PA20048606201A patent/PA8606201A1/es unknown
- 2004-07-09 MY MYPI20042753A patent/MY139072A/en unknown
- 2004-07-09 GT GT200400133AK patent/GT200400133AA/es unknown
- 2004-07-09 GT GT200400133A patent/GT200400133A/es unknown
- 2004-07-09 HN HN2004000232A patent/HN2004000232A/es unknown
- 2004-07-09 DO DO2004000949A patent/DOP2004000949A/es unknown
- 2004-07-12 AR ARP040102447A patent/AR050045A1/es active IP Right Grant
- 2004-08-07 UA UAA200601248A patent/UA81682C2/ru unknown
-
2005
- 2005-12-22 EC EC2005006246A patent/ECSP056246A/es unknown
- 2005-12-22 IS IS8192A patent/IS2843B/is unknown
- 2005-12-29 IL IL172923A patent/IL172923A/en active IP Right Grant
-
2006
- 2006-01-03 ZA ZA200600095A patent/ZA200600095B/en unknown
- 2006-01-05 CR CR8171A patent/CR8171A/es unknown
- 2006-01-06 NO NO20060113A patent/NO332361B1/no not_active IP Right Cessation
- 2006-01-09 TN TNP2006000009A patent/TNSN06009A1/fr unknown
- 2006-01-09 MA MA28721A patent/MA28064A1/fr unknown
- 2006-08-11 US US11/503,256 patent/US7582628B2/en not_active Expired - Lifetime
-
2010
- 2010-10-18 CY CY20101100924T patent/CY1110832T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ECSP056246A (es) | DERIVADOS DE PIRROLO [3,4-c]PIRAZOL ACTIVOS COMO INHIBIDORES DE QUINASA | |
| MXPA05012573A (es) | Derivados de pirazolo-quinazolina, procedimiento para su preparacion y su uso como inhibidores de cinasa. | |
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