ECSP034747A - CARRIER WITH SOLID FIBRINOGEN AND SOLID THROMBIN - Google Patents
CARRIER WITH SOLID FIBRINOGEN AND SOLID THROMBINInfo
- Publication number
- ECSP034747A ECSP034747A EC2003004747A ECSP034747A ECSP034747A EC SP034747 A ECSP034747 A EC SP034747A EC 2003004747 A EC2003004747 A EC 2003004747A EC SP034747 A ECSP034747 A EC SP034747A EC SP034747 A ECSP034747 A EC SP034747A
- Authority
- EC
- Ecuador
- Prior art keywords
- carrier
- thrombin
- solid
- fibrinogen
- xiiia
- Prior art date
Links
- 239000007787 solid Substances 0.000 title 2
- FBPFZTCFMRRESA-ZXXMMSQZSA-N D-iditol Chemical compound OC[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-ZXXMMSQZSA-N 0.000 title 1
- 108010049003 Fibrinogen Proteins 0.000 title 1
- 102000008946 Fibrinogen Human genes 0.000 title 1
- 108090000190 Thrombin Proteins 0.000 title 1
- 229940012952 fibrinogen Drugs 0.000 title 1
- 229960004072 thrombin Drugs 0.000 title 1
Landscapes
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se refiere a una composición absorbible lista para usarse para pegar tejidos, cerrar tejidos y hemostasis, que consta esencialmente de un portador recubierto con componentes humanos solidamente fijados de adhesivo de fibrina: fibrogeno humano y trombina humana. Esta combinación fija se puede aplicar directamente, por ejemplo, a la superficie de una herida. En contacto con la sangre, fluidos corporales o solución salina fisiológica, el mecanismo de este sistema mimetiza la etapa final de la casada de coagulación, en la que la trombina catalizar la conversión de fibriogeno en fibrinas y la activación del factor XIII para dar una XIIIa. El factor XIIIa, una vez formado, estabiliza el coagula de fibrina por reticulación covalente. Como un adhesivo de dos componentes, la superficie de la herida y el portador se pegan entre si por polimeración. Durante este procedimiento, que dura aproximadamente de 3 a 5 minutos, la composición de la invención se degradan enzimaticamente en aproximadamente 4-6 meses después de la aplicación.The present invention relates to an absorbable composition ready to be used to glue tissues, close tissues and hemostasis, consisting essentially of a carrier coated with solidly fixed components of fibrin adhesive: human fibrogen and human thrombin. This fixed combination can be applied directly, for example, to the surface of a wound. In contact with blood, body fluids or physiological saline solution, the mechanism of this system mimics the final stage of the married coagulation, in which the thrombin catalyzes the conversion of fibrinogen into fibrins and the activation of factor XIII to give XIIIa . Factor XIIIa, once formed, stabilizes the fibrin coagula by covalent crosslinking. As a two component adhesive, the wound surface and the carrier are glued together by polymerization. During this procedure, which lasts approximately 3 to 5 minutes, the composition of the invention degrades enzymatically in approximately 4-6 months after application.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200100135 | 2001-01-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP034747A true ECSP034747A (en) | 2004-01-28 |
Family
ID=34560110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2003004747A ECSP034747A (en) | 2001-01-25 | 2003-08-25 | CARRIER WITH SOLID FIBRINOGEN AND SOLID THROMBIN |
Country Status (4)
| Country | Link |
|---|---|
| EC (1) | ECSP034747A (en) |
| UA (2) | UA74046C2 (en) |
| UY (1) | UY27139A1 (en) |
| ZA (3) | ZA200305592B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112891610A (en) * | 2021-01-25 | 2021-06-04 | 上海利康瑞生物工程有限公司 | Pig-derived fibrin-electrostatic spinning nanofiber antibacterial hemostatic patch and preparation method thereof |
-
2002
- 2002-01-25 UA UA2003087941A patent/UA74046C2/en unknown
- 2002-01-25 UY UY27139A patent/UY27139A1/en not_active Application Discontinuation
- 2002-01-25 UA UA2003087940A patent/UA74045C2/en unknown
-
2003
- 2003-07-18 ZA ZA200305592A patent/ZA200305592B/en unknown
- 2003-07-18 ZA ZA200305591A patent/ZA200305591B/en unknown
- 2003-07-18 ZA ZA200305588A patent/ZA200305588B/en unknown
- 2003-08-25 EC EC2003004747A patent/ECSP034747A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200305592B (en) | 2004-10-18 |
| ZA200305588B (en) | 2004-10-18 |
| UA74045C2 (en) | 2005-10-17 |
| UA74046C2 (en) | 2005-10-17 |
| ZA200305591B (en) | 2004-10-18 |
| UY27139A1 (en) | 2002-08-30 |
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