ECSP003721A - A PHARMACEUTICAL COMPOSITION TO BE USED AS AN CONTRACEPTIVE - Google Patents
A PHARMACEUTICAL COMPOSITION TO BE USED AS AN CONTRACEPTIVEInfo
- Publication number
- ECSP003721A ECSP003721A EC2000003721A ECSP003721A ECSP003721A EC SP003721 A ECSP003721 A EC SP003721A EC 2000003721 A EC2000003721 A EC 2000003721A EC SP003721 A ECSP003721 A EC SP003721A EC SP003721 A ECSP003721 A EC SP003721A
- Authority
- EC
- Ecuador
- Prior art keywords
- composition
- daily
- active agent
- dosage units
- pharmaceutical composition
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000003433 contraceptive agent Substances 0.000 title 1
- 230000002254 contraceptive effect Effects 0.000 title 1
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 abstract 3
- 239000013543 active substance Substances 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 abstract 2
- METQSPRSQINEEU-UHFFFAOYSA-N dihydrospirorenone Natural products CC12CCC(C3(CCC(=O)C=C3C3CC33)C)C3C1C1CC1C21CCC(=O)O1 METQSPRSQINEEU-UHFFFAOYSA-N 0.000 abstract 2
- METQSPRSQINEEU-HXCATZOESA-N drospirenone Chemical compound C([C@]12[C@H]3C[C@H]3[C@H]3[C@H]4[C@@H]([C@]5(CCC(=O)C=C5[C@@H]5C[C@@H]54)C)CC[C@@]31C)CC(=O)O2 METQSPRSQINEEU-HXCATZOESA-N 0.000 abstract 2
- 229960004845 drospirenone Drugs 0.000 abstract 2
- 229960002568 ethinylestradiol Drugs 0.000 abstract 2
- MXAZMWGALDAMFV-JBBJNLNBSA-N (8R,9S,13S,14S)-15-ethyl-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol Chemical compound OC1=CC=C2[C@H]3CC[C@]4(C)C(O)CC(CC)[C@H]4[C@@H]3CCC2=C1 MXAZMWGALDAMFV-JBBJNLNBSA-N 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 238000012856 packing Methods 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
La invención se relaciona con una composición farmacéutica que comprende con un primer agente activo, 6B, 7B; 15B, 16B dimetilen-3-oxo-17a pregn-4-en-21, 17-carbolactona (drospirenona) en una cantidad correspondiente a una dosis diaria, a ser administrada con la composición, de desde aproximadamente 2mg a aproximadamente 4mg, y, como un segundo agente activo, 17 a-etinilestradiol (etinilestradiol) en una cantidad correspondiente a una dosis diaria desde aproximadamente 0.01mg a aproximadamente 0,05mg conjuntamente con uno o mas soportes o excipientes farmacéuticamente aceptables. En una realización específica, la composición consiste de un número de unidades de dosificación diarias colocadas en una unidad de empauqe, empaquetadas separadamente y separables individualmente, y proporcionadas para la administarción oral durante un periodo de al menos 21 días consecutivos, comprendiendo dichas unidades de dosificación diaria la combinación de drospirenona y etilestradiol. La composición puede comprender admés 7 o menos unidades de dosificación diaria que no contienen agente activo o que contienen solo etinilestradiol.The invention relates to a pharmaceutical composition comprising a first active agent, 6B, 7B; 15B, 16B dimethylene-3-oxo-17a pregn-4-en-21, 17-carbolactone (drospirenone) in an amount corresponding to a daily dose, to be administered with the composition, from about 2mg to about 4mg, and, as a second active agent, 17 a-ethynylestradiol (ethinyl estradiol) in an amount corresponding to a daily dose from about 0.01mg to about 0.05mg together with one or more pharmaceutically acceptable carriers or excipients. In a specific embodiment, the composition consists of a number of daily dosage units placed in a packing unit, packaged separately and individually separable, and provided for oral administration for a period of at least 21 consecutive days, said dosage units comprising daily the combination of drospirenone and ethylestradiol. The composition may comprise as many as 7 or less daily dosage units that do not contain active agent or that contain only ethinylestradiol.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99202826 | 1999-08-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP003721A true ECSP003721A (en) | 2002-05-23 |
Family
ID=8240592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2000003721A ECSP003721A (en) | 1999-08-31 | 2000-10-18 | A PHARMACEUTICAL COMPOSITION TO BE USED AS AN CONTRACEPTIVE |
Country Status (6)
| Country | Link |
|---|---|
| CN (1) | CN1879632A (en) |
| AR (2) | AR025443A1 (en) |
| CO (1) | CO5200771A1 (en) |
| EC (1) | ECSP003721A (en) |
| PE (1) | PE20010665A1 (en) |
| ZA (2) | ZA200201668B (en) |
-
2000
- 2000-08-30 AR ARP000104515A patent/AR025443A1/en not_active Application Discontinuation
- 2000-08-31 PE PE2000000895A patent/PE20010665A1/en not_active IP Right Cessation
- 2000-08-31 CN CNA2005100992135A patent/CN1879632A/en active Pending
- 2000-08-31 CO CO00065489A patent/CO5200771A1/en not_active Application Discontinuation
- 2000-10-18 EC EC2000003721A patent/ECSP003721A/en unknown
-
2002
- 2002-02-27 ZA ZA200201668A patent/ZA200201668B/en unknown
-
2004
- 2004-03-05 AR ARP040100696A patent/AR043470A2/en not_active Application Discontinuation
-
2005
- 2005-05-25 ZA ZA200404083A patent/ZA200404083B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PE20010665A1 (en) | 2001-06-19 |
| ZA200404083B (en) | 2006-02-22 |
| ZA200201668B (en) | 2004-06-24 |
| AR043470A2 (en) | 2005-07-27 |
| CN1879632A (en) | 2006-12-20 |
| AR025443A1 (en) | 2002-11-27 |
| CO5200771A1 (en) | 2002-09-27 |
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